Alzheimer disease and associated disorders最新文献_第3页

The Diagnostic Pathway From Cognitive Impairment to Dementia in Japan: Quantification Using Real-World Data. 日本从认知障碍到痴呆的诊断途径:使用真实世界数据进行量化。

IF 2.1

Alzheimer disease and associated disorders Pub Date : 2019-10-01 DOI: 10.1097/WAD.0000000000000322

Christopher M Black, Baishali M Ambegaonkar, James Pike, Eddie Jones, Joseph Husbands, Rezaul K Khandker

{"title":"The Diagnostic Pathway From Cognitive Impairment to Dementia in Japan: Quantification Using Real-World Data.","authors":"Christopher M Black, Baishali M Ambegaonkar, James Pike, Eddie Jones, Joseph Husbands, Rezaul K Khandker","doi":"10.1097/WAD.0000000000000322","DOIUrl":"https://doi.org/10.1097/WAD.0000000000000322","url":null,"abstract":"Objective: This study aimed to quantify the diagnostic pathway from cognitive impairment (CI) to dementia in Japan.Methods: This was a real-world, cross-sectional survey of patients with CI and their physicians.Results: Data for 1107 patients were provided by 106 physicians. Mean time from initial symptoms to the first consultation was 7.4±6.9 months; 42% of patients had moderate/severe CI at first consultation. Mean time from the first consultation to formal diagnosis was 2.9±11.0 months (1.9±8.8 mo if not referred to a secondary physician, and 5.1±14.6 mo if referred). Time from the first consultation to diagnosis was shorter with more severe CI at first consultation (P=0.0072). The highest proportion of patients were diagnosed by neurologists (45.8%). Tests or scales were used to aid diagnosis in 81.2% of patients. There was no association of disease severity and referral to a secondary physician; 30.9% of patients were referred, the majority (57.7%) to a neurologist.Conclusions: A substantial proportion of patients with dementia in Japan experience CI for some time before consulting a physician. Government policy to increase public understanding and awareness of dementia, and a proposed dementia screening system, should increase the proportion of individuals consulting physicians before disease progression.","PeriodicalId":520551,"journal":{"name":"Alzheimer disease and associated disorders","volume":" ","pages":"346-353"},"PeriodicalIF":2.1,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/WAD.0000000000000322","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37003891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Neuronal Intranuclear Inclusion Disease: A Rare Etiology for Rapidly Progressive Dementia. 神经元核内包涵病:快速进展性痴呆的罕见病因。

IF 2.1

Alzheimer disease and associated disorders Pub Date : 2019-10-01 DOI: 10.1097/WAD.0000000000000312

Nishtha Yadav, Pritam Raja, Safal S Shetty, Saini Jitender, Chandrajit Prasad, Nitish L Kamble, Anita Mahadevan, Netravathi M

{"title":"Neuronal Intranuclear Inclusion Disease: A Rare Etiology for Rapidly Progressive Dementia.","authors":"Nishtha Yadav, Pritam Raja, Safal S Shetty, Saini Jitender, Chandrajit Prasad, Nitish L Kamble, Anita Mahadevan, Netravathi M","doi":"10.1097/WAD.0000000000000312","DOIUrl":"https://doi.org/10.1097/WAD.0000000000000312","url":null,"abstract":"Introduction: Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disorder pathologically characterized by localized neuronal loss, and presence of eosinophilic intranuclear inclusions in neurons and glial cells.Case report: A 50-year-old man presented with rapidly progressive dementia, behavioral changes, gait disturbances, and incontinence of 3 months duration. His brain magnetic resonance imaging showed diffuse T2/FLAIR hyperintensity of basal ganglia, thalami, cerebral peduncles, ventral pons, and supratentorial white matter with a frontal predominance. Hyperintensity was noted along the corticosubcortical junction on diffusion-weighted images. NIID was suspected and the patient underwent triple biopsy of the sural nerve with adjacent skin and biceps biopsy. Biopsy revealed ubiquitin-positive intranuclear inclusions surrounding the myofibers, and vascular smooth muscles suggestive of NIID.Conclusions: NIID is a rare neurodegenerative disorder usually diagnosed postmortem. The rectal and skin biopsy had proved helpful in antemortem diagnosis. We have increased the diagnostic armamentarium by showing the presence of intranuclear inclusions in smooth muscle cells of the muscle. Hence, a high degree of suspicion, magnetic resonance imaging features, with nerve/muscle/skin biopsy can help in diagnosis of NIID.","PeriodicalId":520551,"journal":{"name":"Alzheimer disease and associated disorders","volume":" ","pages":"359-361"},"PeriodicalIF":2.1,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/WAD.0000000000000312","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37243440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Association of TDP-43 Pathology With Domain-specific Literacy in Older Persons. 老年人TDP-43病理学与特定领域读写能力的关系

IF 2.1

Alzheimer disease and associated disorders Pub Date : 2019-10-01 DOI: 10.1097/WAD.0000000000000334

Alifiya Kapasi, Lei Yu, Christopher C Stewart, Julie A Schneider, David A Bennett, Patricia A Boyle

{"title":"Association of TDP-43 Pathology With Domain-specific Literacy in Older Persons.","authors":"Alifiya Kapasi, Lei Yu, Christopher C Stewart, Julie A Schneider, David A Bennett, Patricia A Boyle","doi":"10.1097/WAD.0000000000000334","DOIUrl":"https://doi.org/10.1097/WAD.0000000000000334","url":null,"abstract":"Background: Low health and financial literacy may be an early behavioral manifestation of cognitive impairment, dementia, and accumulating Alzheimer pathology. However, there are limited studies investigating the behavioral features associated with hyperphosphorylated transactive response DNA-binding protein-43 (TDP-43), a common age-related pathology, and even fewer studies investigating the neurobiological basis underlying low literacy in aging.Objective: To test the hypothesis that TDP-43 pathology is associated with lower literacy.Materials and methods: Data came from 293 community-based older persons who were enrolled in 2 ongoing studies of aging. Participants completed literacy and cognitive assessments, consented to brain donation, and underwent detailed neuropathologic evaluation for Alzheimer disease (AD) and TDP-43. Linear regression models assessed the association of TDP-43 with literacy after adjusting for demographics, and AD pathology. Posthoc pairwise comparisons examined whether the level of literacy differed by TDP-43 stage.Results: TDP-43 pathology was associated with lower literacy (estimate=-3.16; SE=0.86; P<0.001), above and beyond demographics and AD pathology, and this association persisted even after additionally adjusting for global cognition (estimate=-1.53; SE=0.74; P=0.038). Further, literacy was lower among persons with neocortical TDP-43 pathology compared with those without TDP-43 pathology.Conclusions: TDP-43 pathology is associated with lower health and financial literacy in old age, above and beyond AD pathology.","PeriodicalId":520551,"journal":{"name":"Alzheimer disease and associated disorders","volume":" ","pages":"315-320"},"PeriodicalIF":2.1,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/WAD.0000000000000334","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37159507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Predictors of Discontinuance of Oral Feeding in Patients With Advanced Alzheimer Dementia and Aspiration Pneumonia in Japan: A Single-center, Retrospective Observational Study. 日本晚期阿尔茨海默氏痴呆和吸入性肺炎患者停止口服喂养的预测因素:一项单中心、回顾性观察研究

IF 2.1

Alzheimer disease and associated disorders Pub Date : 2019-10-01 DOI: 10.1097/WAD.0000000000000316

Nobuhiro Akuzawa, Akihiro Yoshii, Akihiro Ono, Tomohito Kuwako, Takashi Osaki, Sho Osawa, Asuka Jingu, Satoru Watanabe, Ryusei Saito

{"title":"Predictors of Discontinuance of Oral Feeding in Patients With Advanced Alzheimer Dementia and Aspiration Pneumonia in Japan: A Single-center, Retrospective Observational Study.","authors":"Nobuhiro Akuzawa, Akihiro Yoshii, Akihiro Ono, Tomohito Kuwako, Takashi Osaki, Sho Osawa, Asuka Jingu, Satoru Watanabe, Ryusei Saito","doi":"10.1097/WAD.0000000000000316","DOIUrl":"https://doi.org/10.1097/WAD.0000000000000316","url":null,"abstract":"Background: Difficulty with oral feeding, the most commonly observed complication of Alzheimer disease (AD) in its final stages, occurs in 86% of AD patients and may prevent achievement of oral feeding after aspiration pneumonia. However, no reliable indicators of discontinuance of oral feeding have yet been identified. We therefore aimed to identify predictors of discontinuance of oral feeding in postaspiration pneumonia patients with AD.Materials and methods: Relevant clinical and laboratory data of 60 patients with AD admitted to our hospital in Japan for aspiration pneumonia were retrospectively compared between oral feeding and discontinuance groups.Results: The study groups differed in interval since diagnosis of AD, CURB-65 score, pneumonia severity index score, and proportion of patients who died (higher in the discontinuance group) and body mass index (BMI), Mini Mental State Examination (MMSE) score, and functional independence measure score (lower in the discontinuance group). According to multivariate logistic regression analysis of all identified independent variables, only CURB-65 and MMSE scores and BMI are significant predictors of discontinuance of oral feeding after aspiration pneumonia in patients with advanced AD.Conclusions: In patients with advanced AD, discontinuance of oral feeding after aspiration pneumonia may be predicted by CURB-65 and MMSE scores and BMI.","PeriodicalId":520551,"journal":{"name":"Alzheimer disease and associated disorders","volume":" ","pages":"339-345"},"PeriodicalIF":2.1,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/WAD.0000000000000316","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37284256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Awareness in Dementia: Development and Evaluation of a Short Version of the Assessment Scale of Psychosocial Impact of the Diagnosis of Dementia (ASPIDD-s) in Brazil. 痴呆意识:巴西痴呆诊断的社会心理影响评估量表(ASPIDD-s)的开发和评估

IF 2.1

Alzheimer disease and associated disorders Pub Date : 2019-07-01 DOI: 10.1097/WAD.0000000000000306

Marcia C N Dourado, Jerson Laks, Daniel C Mograbi

{"title":"Awareness in Dementia: Development and Evaluation of a Short Version of the Assessment Scale of Psychosocial Impact of the Diagnosis of Dementia (ASPIDD-s) in Brazil.","authors":"Marcia C N Dourado, Jerson Laks, Daniel C Mograbi","doi":"10.1097/WAD.0000000000000306","DOIUrl":"https://doi.org/10.1097/WAD.0000000000000306","url":null,"abstract":"Awareness of disease is defined as the recognition of changes caused by the deficits related to the disease process. We aimed to examine the psychometric properties of the short versions of the Assessment Scale of Psychosocial Impact of the Diagnosis of Dementia (ASPIDD-s), a multidimensional awareness scale. Using a cross-sectional design, we included 201 people with dementia and their family caregivers. The creation of the short versions was based on items with higher loadings on each factor, the correlations between the short versions and demographic or clinical variables and the relevance of the item to the respondent population. Three short versions were created: version 1 and 3, with 12 items and version 2, with 16 items. The short versions correlated very strongly with the full scale and with the 4 factors of the original scale, maintaining the multidimensional nature of the ASPIDD. Loss of awareness was associated with worse quality of life, decreased functionality and cognitive level, and higher caregiver burden across the short versions. Considering the appropriateness of the items and their clinical relevance, we recommend version 3 for use. With only 12 items, the time required for the completion of the scale is short, while maintaining robust psychometric properties.","PeriodicalId":520551,"journal":{"name":"Alzheimer disease and associated disorders","volume":" ","pages":"220-225"},"PeriodicalIF":2.1,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/WAD.0000000000000306","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37131629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Role of Cerebrospinal Fluid Biomarkers and (18)F-florbetapir PET Imaging in the Diagnosis of Primary Progressive Aphasia: A Retrospective Analysis. 脑脊液生物标志物和(18)F-florbetapir PET成像在原发性进行性失语诊断中的作用:回顾性分析

IF 2.1

Alzheimer disease and associated disorders Pub Date : 2019-07-01 DOI: 10.1097/WAD.0000000000000289

Giulia Perini, Matteo Cotta Ramusino, Elena Sinforiani, Diego Franciotta, Giusppe Trifirò, Mauro Ceroni, Alfredo Costa

{"title":"Role of Cerebrospinal Fluid Biomarkers and (18)F-florbetapir PET Imaging in the Diagnosis of Primary Progressive Aphasia: A Retrospective Analysis.","authors":"Giulia Perini, Matteo Cotta Ramusino, Elena Sinforiani, Diego Franciotta, Giusppe Trifirò, Mauro Ceroni, Alfredo Costa","doi":"10.1097/WAD.0000000000000289","DOIUrl":"https://doi.org/10.1097/WAD.0000000000000289","url":null,"abstract":"The use of biomarkers has recently supported the association between Alzheimer disease (AD) pathology and the logopenic variant of primary progressive aphasia (PPA). We aim to investigate possible differences in cerebrospinal fluid (CSF) biomarker concentrations in the three PPA variants, and to assess any agreement between CSF biomarkers and (18)F-florbetapir PET. A group of 10 PPA were retrospectively enrolled. Patients with logopenic variant (lvPPA) showed different levels of Aβ1-42 and p-tau compared to nonfluent/agrammatic and semantic variants (nfv/svPPA). All nfv/svPPA patients had negative amyloid PET. Among the lvPPA group, a negative amyloid PET was found only in one patient, who was also the only one to display a normal CSF. Thus, this small cohort appeared to display an excellent agreement between CSF and (18)F-florbetapir PET and suggest that these examinations may have the same validity in detecting in vivo evidence of AD pathology in PPA clinical variants.","PeriodicalId":520551,"journal":{"name":"Alzheimer disease and associated disorders","volume":" ","pages":"282-284"},"PeriodicalIF":2.1,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/WAD.0000000000000289","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36861640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Distinguishing Dementia With Lewy Bodies From Alzheimer Disease: What is the Influence of the GBA Genotype in Ashkenazi Jews? 区分路易体痴呆与阿尔茨海默病:GBA基因型对德系犹太人的影响?

IF 2.1

Alzheimer disease and associated disorders Pub Date : 2019-07-01 DOI: 10.1097/WAD.0000000000000283

Noa Bregman, Gitit Kavé, Anat Mirelman, Avner Thaler, Mali Gana Weisz, Anat Bar-Shira, Avi Orr-Urtreger, Nir Giladi, Tamara Shiner

{"title":"Distinguishing Dementia With Lewy Bodies From Alzheimer Disease: What is the Influence of the GBA Genotype in Ashkenazi Jews?","authors":"Noa Bregman, Gitit Kavé, Anat Mirelman, Avner Thaler, Mali Gana Weisz, Anat Bar-Shira, Avi Orr-Urtreger, Nir Giladi, Tamara Shiner","doi":"10.1097/WAD.0000000000000283","DOIUrl":"https://doi.org/10.1097/WAD.0000000000000283","url":null,"abstract":"Cognitive deficits beyond memory impairment, such as those affecting language production or executive functioning, can be useful in clinically distinguishing between dementia syndromes. We tested the hypothesis that Ashkenazi Jewish (AJ) patients who have dementia with Lewy bodies (DLB) and carry glucocerebrosidase (GBA) mutations will have verbal fluency deficits different from those found in Alzheimer disease (AD), whereas AJ patients with DLB who have no GBA mutations will have similar deficits in verbal fluency to those found in AD. We compared performance in phonemic and semantic verbal fluency tasks in 44 AJ patients with DLB and 20 patients with AD, matched for age, education, and age of immigration. All groups were found to have a deficit in semantic verbal fluency. On conducting the phonemic task, patients with DLB who carried GBA mutations scored more poorly than patients with AD, whereas DLB-noncarriers performed similarly to patients with AD. We suggest that verbal fluency tasks could serve as a possible clinical marker to subtype patients with DLB, with phonemic fluency being a marker for GBA-associated DLB.","PeriodicalId":520551,"journal":{"name":"Alzheimer disease and associated disorders","volume":" ","pages":"279-281"},"PeriodicalIF":2.1,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/WAD.0000000000000283","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36861643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Alzheimer Disease-associated Cortical Atrophy Does not Differ Between Chinese and Whites. 阿尔茨海默病相关的皮质萎缩在中国人和白人之间没有差异。

IF 2.1

Alzheimer disease and associated disorders Pub Date : 2019-07-01 DOI: 10.1097/WAD.0000000000000315

Jia Fan, Marian Tse, Jessie S Carr, Bruce L Miller, Joel H Kramer, Howard J Rosen, Luke W Bonham, Jennifer S Yokoyama

{"title":"Alzheimer Disease-associated Cortical Atrophy Does not Differ Between Chinese and Whites.","authors":"Jia Fan, Marian Tse, Jessie S Carr, Bruce L Miller, Joel H Kramer, Howard J Rosen, Luke W Bonham, Jennifer S Yokoyama","doi":"10.1097/WAD.0000000000000315","DOIUrl":"https://doi.org/10.1097/WAD.0000000000000315","url":null,"abstract":"Purpose: To assess whether there are differences in Alzheimer disease (AD)-associated atrophy regions in Chinese and white patients with AD versus cognitively normal older adults, and to test whether associations between clinical severity and gray matter volume are similar or different across these ethnic groups in a cross-sectional analysis.Materials and methods: Chinese and white patients with AD, individuals with mild cognitive impairment, and cognitively normal controls (46 white and 48 Chinese) were clinically evaluated at an academic center within 1 year of magnetic resonance imaging acquisition. Clinical severity was assessed using the Clinical Dementia Rating Sum of Boxes and cortical atrophy was measured using voxel-based morphometry as well as Freesurfer. Chinese and white cohorts were demographically matched for age, sex, and education.Results: Clinical severity by diagnosis was similar across ethnicities. Chinese and white patient groups showed similar amounts of atrophy in the regions most affected in AD after accounting for demographic variables and head size. There was no significant difference between ethnic groups when compared by atrophy and clinical severity.Conclusions: Our study suggests that Chinese and white patients with AD, when matched demographically, are clinically and neuroanatomically similar on normalized measures of cortical atrophy and clinical severity.","PeriodicalId":520551,"journal":{"name":"Alzheimer disease and associated disorders","volume":" ","pages":"186-193"},"PeriodicalIF":2.1,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/WAD.0000000000000315","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37243439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

IF 2.1

Alzheimer disease and associated disorders Pub Date : 2019-07-01 DOI: 10.1097/WAD.0000000000000324

Ali Ezzati, Andrea R Zammit, Mindy J Katz, Carol A Derby, Molly E Zimmerman, Richard B Lipton

{"title":"Health-related Quality of Life, Cognitive Performance, and Incident Dementia in a Community-based Elderly Cohort.","authors":"Ali Ezzati, Andrea R Zammit, Mindy J Katz, Carol A Derby, Molly E Zimmerman, Richard B Lipton","doi":"10.1097/WAD.0000000000000324","DOIUrl":"https://doi.org/10.1097/WAD.0000000000000324","url":null,"abstract":"Background: We hypothesized that higher quality of life would be associated with better cognitive function and a reduced risk of incident all cause dementia and Alzheimer disease (AD) in older adults.Materials and methods: Participants included 1183 older adults with an average age of 78.2 (SD=5.3) from Einstein Aging Study. The 36-Item Short-Form Health Survey was used to measure health-related quality of life (HRQoL). We investigated baseline associations between the cognitive domains of memory, executive function, and general fluid ability with 8 subscales of the 36-Item Short-Form Health Survey (physical functioning, role limitations due to physical problems, bodily pain, general health perceptions, social functioning, role limitations due to emotional problems, vitality, and general mental health) and the 2 component summary scores of physical component summary (PCS) and mental component summary (MCS). Next, we used Cox proportional hazard models to assess the predictive validity of HRQoL subscales for the onset of incident dementia and incident AD.Results: At baseline, higher scores (better HRQoL) on MCS and its 4 subscales (social functioning, role limitations due to emotional problems, vitality, and general mental health) were associated with higher performance on both memory and executive function domains. Higher scores in role limitation due to physical problems, role limitation due to emotional problems, and general mental health subscales were associated with reduced risk of incident dementia. Higher MCS, but not PCS, predicted a reduced incident of all-cause dementia and AD.Conclusions: These findings suggest that diminution of HRQoL precedes the onset of diagnosable dementia and may be useful in the prediction of dementia onset.","PeriodicalId":520551,"journal":{"name":"Alzheimer disease and associated disorders","volume":" ","pages":"240-245"},"PeriodicalIF":2.1,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/WAD.0000000000000324","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37283705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

The Relationship Between Caregiver Burden and Emotion Recognition Deficits in Persons With MCI and Early AD: The Mediating Role of Caregivers' Subjective Evaluations. 照顾者负担与轻度认知障碍及早期AD患者情绪识别缺陷的关系:照顾者主观评价的中介作用

IF 2.1

Alzheimer disease and associated disorders Pub Date : 2019-07-01 DOI: 10.1097/WAD.0000000000000323

Naama Spitzer, Tal Shafir, Yaffa Lerman, Perla Werner

{"title":"The Relationship Between Caregiver Burden and Emotion Recognition Deficits in Persons With MCI and Early AD: The Mediating Role of Caregivers' Subjective Evaluations.","authors":"Naama Spitzer, Tal Shafir, Yaffa Lerman, Perla Werner","doi":"10.1097/WAD.0000000000000323","DOIUrl":"https://doi.org/10.1097/WAD.0000000000000323","url":null,"abstract":"Objectives: Emotion recognition (ER) abilities change in people with early Alzheimer disease (AD) and mild cognitive impairment (MCI) and can influence their caregivers' lives and experiences. The aims of this study were: (1) to assess caregivers' awareness of ER deficits in care-receivers with early AD or MCI; (2) to examine the mediating role of caregivers' subjective evaluations on the relationship between caregiver burden and ER deficits in persons with MCI and early AD.Methods: Persons with MCI (N=29) and with early AD (N=26) performed an ER task (objective emotion recognition, OER) of watching short clips of dynamic bodily and dynamic facial expressions of 6 basic emotions. In addition, their family caregivers (N=55) were interviewed to measure their evaluation of their relatives' ER ability (subjective emotion recognition, SER) as well as their own experience of burden.Results: Two thirds of the caregivers either underestimated or overestimated the care-receivers' ER deficits. Regression results yielded a significant positive relationship between OER and SER, as well as a significant negative relationship between SER and caregiver burden. Moreover, SER was found to mediate the relationship between OER and caregiver burden.Conclusion: Caregivers' better awareness of ER deficits in people with MCI and early AD might mitigate the deleterious consequences of caregiving for persons with cognitive deterioration and might therefore allow better chances for people with dementia to age in a homecare setting.","PeriodicalId":520551,"journal":{"name":"Alzheimer disease and associated disorders","volume":" ","pages":"266-271"},"PeriodicalIF":2.1,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/WAD.0000000000000323","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37283707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10