Alzheimer disease and associated disorders最新文献

Risk of Alzheimer Disease and Other Dementias in Patients With Parkinson Disease: A Nationwide Cohort Study. 帕金森病患者阿尔茨海默病和其他痴呆的风险：一项全国性队列研究

Alzheimer disease and associated disorders Pub Date : 2026-05-06 DOI: 10.1097/WAD.0000000000000722

Youngoh Bae, Minseo Kim, Sang Ryong Jeon, Seung Won Lee, Hohyun Jung

{"title":"Risk of Alzheimer Disease and Other Dementias in Patients With Parkinson Disease: A Nationwide Cohort Study.","authors":"Youngoh Bae, Minseo Kim, Sang Ryong Jeon, Seung Won Lee, Hohyun Jung","doi":"10.1097/WAD.0000000000000722","DOIUrl":"https://doi.org/10.1097/WAD.0000000000000722","url":null,"abstract":"Introduction: Dementia is a major nonmotor complication of Parkinson disease (PD), yet its subtype-specific and time-dependent risk remains incompletely characterized.Methods: We conducted a nationwide retrospective cohort study using Korean National Health Insurance claims and health screening data. Newly diagnosed PD patients (ICD-10: G20) and propensity score-matched controls were followed after a 3-year washout period. Dementia outcomes were defined using ICD-10 codes and classified as Alzheimer disease dementia (F00, G30), other dementias (F01-F03), and overall dementia. Incidence rate ratios (IRRs) and adjusted hazard ratios (aHRs) were estimated using Cox models.Results: PD was associated with higher dementia incidence across all subtypes. IRRs were 3.38 (95% CI: 3.12-3.67) for Alzheimer disease dementia, 4.67 (95% CI: 4.16-5.23) for other dementias, and 3.60 (95% CI: 3.33-3.90) for overall dementia. Elevated risks persisted after multivariable adjustment and were more pronounced in younger patients and men, with variation by dementia subtype and time since diagnosis.Conclusions: PD was associated with an increased risk of dementia in this nationwide cohort. The heterogeneity observed by subtype, age, and follow-up period suggests that dementia risk may emerge early in specific subgroups, supporting early cognitive monitoring without implying causality.","PeriodicalId":520551,"journal":{"name":"Alzheimer disease and associated disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147848893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Survey of Mobile Phone Usage Among Patients With Cognitive Impairment. 认知障碍患者手机使用情况调查。

Alzheimer disease and associated disorders Pub Date : 2026-04-13 DOI: 10.1097/WAD.0000000000000721

Shota Suzumura, Megumi Suzuki, Akiko Maeda, Keisuke Okaniwa, Yuki Okochi, Hikaru Kondo, Shigeo Tanabe, Hajime Takechi, Yohei Otaka

{"title":"Survey of Mobile Phone Usage Among Patients With Cognitive Impairment.","authors":"Shota Suzumura, Megumi Suzuki, Akiko Maeda, Keisuke Okaniwa, Yuki Okochi, Hikaru Kondo, Shigeo Tanabe, Hajime Takechi, Yohei Otaka","doi":"10.1097/WAD.0000000000000721","DOIUrl":"https://doi.org/10.1097/WAD.0000000000000721","url":null,"abstract":"Mobile phones are increasingly being proposed as tools to support daily life among older adults with cognitive impairment; however, empirical data on their actual ownership and use in clinical settings remain limited. This study aimed to clarify mobile phone ownership and usage patterns among older adults with cognitive impairment attending memory clinics. Eighty-two older adults with cognitive impairment (mean age: 80.4 y; mean Mini-Mental State Examination score: 18.1 points) were included. Data were collected using caregiver-administered questionnaires and analyzed descriptively. Among the participants, 65 (79.3%) owned a mobile phone, with an almost equal distribution of smartphones (n=33) and featured phones (n=32). Fifteen phone owners did not use their devices. Reported use was largely limited to basic communication functions. These findings indicate limited mobile phone ownership and functional use among older adults with cognitive impairment and underscore the need to consider cognitive limitations when implementing mobile technologies.","PeriodicalId":520551,"journal":{"name":"Alzheimer disease and associated disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147680056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Engagement and Agitation in Dementia: Clinical and Environmental Factors in Nonpharmacological Therapy. 痴呆患者参与与躁动之间的关系：非药物治疗中的临床和环境因素。

Alzheimer disease and associated disorders Pub Date : 2026-03-30 DOI: 10.1097/WAD.0000000000000720

Arisa Nishitani, Hiroyuki Tanaka

{"title":"Association Between Engagement and Agitation in Dementia: Clinical and Environmental Factors in Nonpharmacological Therapy.","authors":"Arisa Nishitani, Hiroyuki Tanaka","doi":"10.1097/WAD.0000000000000720","DOIUrl":"10.1097/WAD.0000000000000720","url":null,"abstract":"Introduction: Agitation is a common behavioral symptom in dementia that increases caregiver burden and contributes to hospitalization or institutionalization. Nonpharmacological interventions are essential to manage agitation; however, their effectiveness has been inconsistent. A potential explanation is that engagement-defined as patients' attitudes and behaviors during therapy-has rarely been incorporated into the evaluation of these interventions. This study aimed to clarify the association between engagement and agitation and to identify related clinical and environmental factors.Methods: This cross-sectional study included 66 hospitalized individuals with dementia (mean age 81.4±6.9 y). Assessments comprised demographics, cognitive function, activities of daily living, behavioral and psychological symptoms, environmental parameters, comorbidities, pain, and engagement. Correlation and multiple regression analyses were conducted to explore factors associated with engagement.Results: Engagement was positively correlated with cognitive function and daily living abilities, and negatively correlated with dementia severity, pain, agitation, depression, visual impairment, and humidity. Multiple regression analysis showed engagement was independently associated with pain, dementia severity, visual impairment, and agitation.Conclusions: Engagement in dementia was influenced by pain, dementia severity, visual impairment, and agitation. Attention to these factors, particularly pain management, may optimize nonpharmacological interventions, enhance engagement, and help reduce agitation in dementia.","PeriodicalId":520551,"journal":{"name":"Alzheimer disease and associated disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147577487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Joint Associations of Physical Activity and Sleep Quality With Cognitive Function Among Older Adults in China. 中国老年人身体活动和睡眠质量与认知功能的联合关系

Alzheimer disease and associated disorders Pub Date : 2026-01-01 Epub Date: 2026-02-09 DOI: 10.1097/WAD.0000000000000713

Shiyi Li, Xianlan Li, Chan Yong, Yingchao Xiong, Wennuo Liu, Zhaowei Yue, Nanyan Li, Yufei Wang, Junmin Zhou

{"title":"Joint Associations of Physical Activity and Sleep Quality With Cognitive Function Among Older Adults in China.","authors":"Shiyi Li, Xianlan Li, Chan Yong, Yingchao Xiong, Wennuo Liu, Zhaowei Yue, Nanyan Li, Yufei Wang, Junmin Zhou","doi":"10.1097/WAD.0000000000000713","DOIUrl":"10.1097/WAD.0000000000000713","url":null,"abstract":"Introduction: The joint associations of physical activity (PA) and sleep quality with cognitive function remain unclear.Methods: The study was an observational analysis of an 8-week clustered randomized controlled trial with a 24-month follow-up in rural older Chinese. The trial took place from May 2021 to May 2023, in Sichuan, China. The participants' cognitive function was evaluated using the Telephone Interview for Cognitive Status. Linear mixed effects models and stratified analysis were performed.Results: The study population comprised a total of 498 older adults. The average age was 70.96, and 55.4% were female. The interaction between PA and sleep quality was significant on global cognition ( P =0.04) and memory ( P =0.04). Compared with the low-PA and poor sleep quality group, any category of PA combined with sleep quality had better global cognition function, and the high-PA and good sleep quality group had the best global cognition function ( β =0.58, 95% CI: 0.29-0.92) and memory ( β =0.43, 95% CI: 0.23-0.64).Conclusion: Both higher levels of PA and better sleep quality are important for cognitive health, supporting the need for dual-behavior interventions in aging populations.","PeriodicalId":520551,"journal":{"name":"Alzheimer disease and associated disorders","volume":" ","pages":"38-45"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146145779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Behavioral Variant Frontotemporal Dementia With C9orf72 Intermediate Repeat Expansion : A case report. 行为变异性额颞叶痴呆伴C9orf72中间重复扩增1例报告。

Alzheimer disease and associated disorders Pub Date : 2026-01-01 Epub Date: 2026-02-10 DOI: 10.1097/WAD.0000000000000718

Sufen Huang, Yuzhang Bei, Qingxiang Zhang, Haitian Nan, Junjie Li

引用次数: 0

Associations of Immigrant Generation with Level and Change in Self-Reported Everyday Cognition and Objectively Measured Cognition. 移民一代与自我报告日常认知和客观测量认知水平和变化的关系。

Alzheimer disease and associated disorders Pub Date : 2026-01-01 Epub Date: 2026-02-24 DOI: 10.1097/WAD.0000000000000716

Shelli Vodovozov, Anna M Pederson, Oanh L Meyer, Adina Zeki Al Hazzouri, Rachel L Peterson, Claire C Meunier, Rachel A Whitmer, Chelsea Kuiper, Maria M Glymour

{"title":"Associations of Immigrant Generation with Level and Change in Self-Reported Everyday Cognition and Objectively Measured Cognition.","authors":"Shelli Vodovozov, Anna M Pederson, Oanh L Meyer, Adina Zeki Al Hazzouri, Rachel L Peterson, Claire C Meunier, Rachel A Whitmer, Chelsea Kuiper, Maria M Glymour","doi":"10.1097/WAD.0000000000000716","DOIUrl":"10.1097/WAD.0000000000000716","url":null,"abstract":"Introduction: Evidence on cognitive aging differences across immigrant generations is limited.Methods: Kaiser Healthy Aging and Different Life Experiences (KHANDLE) participants reported immigrant generation, categorized as adulthood immigrants (immigrated ≥18 y of age, n=294, 14.51%), childhood immigrants (immigrated <18, n=105, 5.18%), second-generation (US-born with ≥1 foreign-born parent, n=553, 27.29%), and third-generation or later (reference, n=1074, 53.01%). Verbal episodic memory (VEM), executive function (EF), and everyday cognition (12-item Ecog) were assessed up to 4 times. Level and change in cognition were modeled with linear mixed-effects regressions.Results: Compared with third-generation participants, adulthood immigrants had worse VEM [(β = -0.19; 95% CI: -0.30, -0.08); EF (β = -0.61; -0.72, -0.50); and Ecog (β = 0.29; 0.19, 0.40)]; childhood immigrants had lower EF [β = -0.21 (-0.36, -0.05)]; and second-generation participants had worse VEM [β = -0.11 (-0.20, -0.02)], EF [β = -0.10 (-0.19, -0.01)], and Ecog [β = 0.10 (0.009, 0.18)]. Cognitive change did not differ by immigrant generation.Conclusions: Individuals who immigrated in adulthood averaged worse cognitive scores and self-reported everyday cognition.","PeriodicalId":520551,"journal":{"name":"Alzheimer disease and associated disorders","volume":"40 1","pages":"8-13"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12955959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147346167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends and Disparities in Alzheimer Disease-Related Mortality in the United States From 1999 to 2020: A CDC WONDER Analysis. 1999年至2020年美国阿尔茨海默病相关死亡率的趋势和差异：CDC WONDER分析

Alzheimer disease and associated disorders Pub Date : 2026-01-01 Epub Date: 2026-02-24 DOI: 10.1097/WAD.0000000000000712

Sophia Ahmed, Muhammad H Shoaib, Hanzala A Farooqi, Muhammad A Nadir, Muhammad M Sajid, Hooria W Saeed, Mahrukh Iqbal, Muhammad Sohaib, Vivek Barun, Sheetal Goyal

{"title":"Trends and Disparities in Alzheimer Disease-Related Mortality in the United States From 1999 to 2020: A CDC WONDER Analysis.","authors":"Sophia Ahmed, Muhammad H Shoaib, Hanzala A Farooqi, Muhammad A Nadir, Muhammad M Sajid, Hooria W Saeed, Mahrukh Iqbal, Muhammad Sohaib, Vivek Barun, Sheetal Goyal","doi":"10.1097/WAD.0000000000000712","DOIUrl":"10.1097/WAD.0000000000000712","url":null,"abstract":"Background: Alzheimer disease (AD) is a leading cause of mortality in the United States; yet, population-level mortality trends and disparities remain underexplored.Objective: This study aimed to evaluate AD-related mortality trends from 1999 to 2020 and assess disparities by demographic and geographic factors.Methods: Data were obtained from the CDC WONDER database. Deaths were identified using ICD-10 codes for AD (F01, F03, G30, G31.1) among individuals aged 45 years and older. Crude mortality rates (CMRs) and age-adjusted mortality rates (AAMRs) per 100,000 population were calculated. Joinpoint regression analysis was used to assess trends, and disparities were analyzed by sex, race/ethnicity, age, urbanization, census region, and state.Results: From 1999 to 2020, 6,697,209 deaths were attributed to AD (AAMR: 90.727). Mortality rates increased significantly (AAPC: 3.18). Females had higher AAMRs (94.31) than males (83.23). Non-Hispanic Black individuals had the highest AAMR (94.53), followed by non-Hispanic White (93.73), non-Hispanic American Indian (66.80), Hispanic (66.33), and non-Hispanic Asian individuals (46.16). Individuals aged 85 years and older had the highest CMR (3574.928). Rural areas had higher AAMRs (95.080) than urban areas (89.772). The Midwest had the highest AAMR (96.131), whereas the Northeast had the lowest (78.564). States such as South Carolina (119.789) and Tennessee (113.624) had higher AAMRs compared with New York (64.16) and Florida (68.677).Conclusions: Significant disparities exist in AD-related mortality across demographic and geographic groups. These findings highlight the need for targeted public health interventions, improved health care access, and early diagnostic efforts.","PeriodicalId":520551,"journal":{"name":"Alzheimer disease and associated disorders","volume":"40 1","pages":"30-37"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147346179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing Language Impairments Across the Neurodegeneration Continuum: Diagnostic Utility of the BECLA-TR in MCI and Alzheimer Disease. 评估神经变性连续体中的语言障碍：BECLA-TR在MCI和阿尔茨海默病中的诊断效用

Alzheimer disease and associated disorders Pub Date : 2026-01-01 Epub Date: 2026-02-24 DOI: 10.1097/WAD.0000000000000715

Samet Tosun, Fenise Selin Karali, Elif İkbal Eskioğlu, Nilgün Çinar, Joël Macoir

{"title":"Assessing Language Impairments Across the Neurodegeneration Continuum: Diagnostic Utility of the BECLA-TR in MCI and Alzheimer Disease.","authors":"Samet Tosun, Fenise Selin Karali, Elif İkbal Eskioğlu, Nilgün Çinar, Joël Macoir","doi":"10.1097/WAD.0000000000000715","DOIUrl":"10.1097/WAD.0000000000000715","url":null,"abstract":"Background: As the global population ages, the prevalence of major neurocognitive disorders (MND), particularly Alzheimer disease (AD), continues to rise. Mild Cognitive Impairment (MCI) is considered a prodromal stage of AD, yet differentiating MCI from early-stage AD remains a clinical challenge, especially regarding language impairments.Objective: This study aimed to examine the diagnostic utility of the Turkish adaptation of the Batterie d'Évaluation Cognitive du Langage (BECLA-Tr) and to determine its effectiveness as one of the first multidimensional language assessments standardized for Turkish speakers.Methods: Ninety participants (30 MCI, 30 AD, and 30 healthy controls) completed the BECLA-Tr in addition to general cognitive and language screening tests. The BECLA-Tr assesses 4 domains: recognition of spoken and written words, semantic processing, spoken production, and written language.Results: AD participants showed significant impairments across nearly all BECLA-Tr domains compared with both MCI and controls. MCI participants exhibited selective deficits in semantic processing while maintaining comparable performance to controls in spoken and written production.Conclusion: The BECLA-Tr demonstrated strong diagnostic sensitivity for detecting language impairments across the neurodegeneration continuum, supporting its clinical use for early detection and intervention in MCI and AD.","PeriodicalId":520551,"journal":{"name":"Alzheimer disease and associated disorders","volume":"40 1","pages":"52-58"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147346170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum Expression of miR-106b-3p and Its Diagnostic Significance in Alzheimer Disease. miR-106b-3p在阿尔茨海默病中的血清表达及其诊断意义

Alzheimer disease and associated disorders Pub Date : 2026-01-01 Epub Date: 2026-02-17 DOI: 10.1097/WAD.0000000000000710

Dan Hou, Zhiyong Hou, Hong Qu, Ming Sun, Liping Wang

{"title":"Serum Expression of miR-106b-3p and Its Diagnostic Significance in Alzheimer Disease.","authors":"Dan Hou, Zhiyong Hou, Hong Qu, Ming Sun, Liping Wang","doi":"10.1097/WAD.0000000000000710","DOIUrl":"10.1097/WAD.0000000000000710","url":null,"abstract":"Background: MicroRNAs, as key regulators in gene expression, may hold the key to understanding Alzheimer disease (AD) pathogenesis and diagnosis.Aims: To explore the expression level of miR-106b-3p in the serum of AD patients, and evaluate its diagnostic value for AD.Methods: A total of 250 AD patients and 200 healthy controls were enrolled. Real-time quantitative PCR with fluorescence detection was used to determine the relative expression level of miR-106b-3p. Correlation was analyzed by the Pearson linear correlation analysis. The receiver operating characteristic was used to evaluate the diagnostic efficacy of serum miR-106b-3p for AD. In vitro AD cellular models were established to explore the potential mechanism of miR-106b-3p in AD.Results: The expression of miR-106b-3p in the serum of AD patients is significantly elevated, and its level is negatively correlated with the MMSE score. ROC curve analysis shows that it has certain diagnostic value. miR-106b-3p is a risk factor associated with AD. In addition, miR-106b-3p targets BDNF, affects the functions of SH-SY5Y cells, and promotes the occurrence and development of AD.Conclusion: Serum miR-106b-3p is significantly elevated in AD and may serve as a diagnostic biomarker. Preliminary evidence suggests it promotes AD progression by targeting BDNF, highlighting its potential as a therapeutic target for early intervention.","PeriodicalId":520551,"journal":{"name":"Alzheimer disease and associated disorders","volume":"40 1","pages":"23-29"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147346203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural Brain Correlates With Appetite and Eating Disturbances Across the Alzheimer Disease Spectrum. 在阿尔茨海默病谱系中，大脑结构与食欲和饮食障碍相关。

Alzheimer disease and associated disorders Pub Date : 2026-01-01 Epub Date: 2026-02-17 DOI: 10.1097/WAD.0000000000000719

Truelove Ejiofor, Olajugba Oluwafunmilayo J, Arushi Kala, Archibong D Ephraim, Obed O Apochi

{"title":"Structural Brain Correlates With Appetite and Eating Disturbances Across the Alzheimer Disease Spectrum.","authors":"Truelove Ejiofor, Olajugba Oluwafunmilayo J, Arushi Kala, Archibong D Ephraim, Obed O Apochi","doi":"10.1097/WAD.0000000000000719","DOIUrl":"10.1097/WAD.0000000000000719","url":null,"abstract":"Introduction: Neuropsychiatric symptoms are integral features of Alzheimer disease (AD) and may precede cognitive impairment. Appetite and eating disturbances are common across the AD spectrum.Methods: We analyzed 7223 participants from the National Alzheimer Coordinating Center with Uniform Data Set assessments and MRI. Appetite and eating disturbances were assessed using the Neuropsychiatric Inventory Questionnaire. Cross-sectional associations with brain volumes were examined using multivariable regression. Longitudinal analyses among participants without baseline appetite disturbance used discrete-time survival models.Results: Appetite disturbances were present in 9.4% of participants and were associated with greater neuropsychiatric burden and disease severity. Cross-sectionally, lower global gray matter volume showed the most robust association, while regional effects were attenuated after neuropsychiatric adjustment. Longitudinally, baseline brain structure predicted incident appetite disturbance only among cognitively normal participants (OR per SD decrease=0.87).Discussion: Appetite disturbances may reflect diffuse neurodegenerative vulnerability and represent early behavioral markers of Alzheimer-related brain aging.","PeriodicalId":520551,"journal":{"name":"Alzheimer disease and associated disorders","volume":" ","pages":"14-22"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146215518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0