Alzheimer disease and associated disorders最新文献_第2页

GAD65 Autoimmune Encephalitis: A Cause of Rapidly Evolving Frontotemporal Atrophy. 自身免疫性脑炎:快速发展的额颞叶萎缩的一个原因。

IF 2.1

Alzheimer disease and associated disorders Pub Date : 2022-01-01 DOI: 10.1097/WAD.0000000000000463

Alexander Vanhoorne, Tim Van Langenhove, Marijke Miatton, Guy Laureys

引用次数: 1

Beliefs, Understanding, and Barriers Related to Dementia Research Participation Among Older African Americans. 老年非裔美国人参与痴呆症研究的信念、理解和障碍。

IF 2.1

Alzheimer disease and associated disorders Pub Date : 2022-01-01 DOI: 10.1097/WAD.0000000000000476

Erika Pugh, Joshua Stewart, Leah Carter, Matthew Calamia, Owen Carmichael, Robert L Newton

{"title":"Beliefs, Understanding, and Barriers Related to Dementia Research Participation Among Older African Americans.","authors":"Erika Pugh, Joshua Stewart, Leah Carter, Matthew Calamia, Owen Carmichael, Robert L Newton","doi":"10.1097/WAD.0000000000000476","DOIUrl":"https://doi.org/10.1097/WAD.0000000000000476","url":null,"abstract":"Background: United States Census Bureau projects African Americans (AAs) will be one of the fastest growing populations over the next 30 years. Research suggests they are at higher risk for developing dementia. It is important to know about AA adults' beliefs about, and knowledge of, dementia; and how these beliefs and knowledge impact participation in dementia research.Methods: Four focus groups were completed with 51 older AA adults (76.5% female; mean age=68) in Baton Rouge, Louisiana to examine understanding of dementia and barriers influencing willingness to participate in a clinical trial on dementia risk reduction.Findings: Participants exhibited awareness of several risk and protective factors related to dementia, including family history of dementia, lack of cognitive engagement, and sedentary lifestyles. They were willing to participate in interventions to lower the risk of developing dementia. Barriers to participation included invasive procedures, pharmaceutical interventions, mistrust of investigators, inadequate compensation, and long study duration.Discussion: Given the high relevance of dementia research to older AAs, their knowledge of dementia, and their willingness to participate in dementia research once barriers are addressed, it is imperative to continue to identify and remediate factors contributing to the poor representation of AAs in dementia research.","PeriodicalId":520551,"journal":{"name":"Alzheimer disease and associated disorders","volume":" ","pages":"52-57"},"PeriodicalIF":2.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39384708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Comment on "Comparison of the Accuracy of Short Cognitive Screens Among Adults With Cognitive Complaints in Turkey". 对“土耳其认知疾患成人短认知屏幕准确性比较”的评论。

IF 2.1

Alzheimer disease and associated disorders Pub Date : 2021-04-01 DOI: 10.1097/WAD.0000000000000448

Ahmet Turan Isik, Pinar Soysal

引用次数: 0

Response to "Comment on Comparison of the Accuracy of Short Cognitive Screens Among Adults With Cognitive Complaints in Turkey". 对“土耳其认知疾患成人短认知屏幕准确性比较评论”的回应。

IF 2.1

Alzheimer disease and associated disorders Pub Date : 2021-04-01 DOI: 10.1097/WAD.0000000000000449

Hacer D Varan, Rónán O'Caoimh, David W Molloy, Burcu B Yavuz

引用次数: 0

Impact of Disturbed Rest-activity Rhythms on Activities of Daily Living in Moderate and Severe Dementia Patients. 休息-活动节律紊乱对中重度痴呆患者日常生活活动的影响

IF 2.1

Alzheimer disease and associated disorders Pub Date : 2021-04-01 DOI: 10.1097/WAD.0000000000000423

Daiki Ishimaru, Hiroyuki Tanaka, Yuma Nagata, Yasuhiro Ogawa, Keita Fukuhara, Shinichi Takabatake, Takashi Nishikawa

{"title":"Impact of Disturbed Rest-activity Rhythms on Activities of Daily Living in Moderate and Severe Dementia Patients.","authors":"Daiki Ishimaru, Hiroyuki Tanaka, Yuma Nagata, Yasuhiro Ogawa, Keita Fukuhara, Shinichi Takabatake, Takashi Nishikawa","doi":"10.1097/WAD.0000000000000423","DOIUrl":"https://doi.org/10.1097/WAD.0000000000000423","url":null,"abstract":"Purpose: People with dementia exhibit disturbed rest-activity rhythms and extended sleep duration issues throughout their disease. Little is known about the effects of these issues on clinical problems for those with moderate and severe dementia. This cross-sectional study aimed to examine the associations of disturbed rest-activity rhythms and extended sleep duration with activities of daily living (ADL).Methods: Sleep parameters were measured using an actigraphy device. Cognitive function was assessed using the Mini-Mental State Examination and Cognitive Test for Severe Dementia, the Hyogo Activities of Daily Living Scale was used to assess ADL, and behavioral and psychological symptoms of dementia were assessed using the Neuropsychiatric Inventory-Nursing Home scale. Associations among rest-activity rhythms, sleep duration, and other clinical variables were analyzed with multiple linear regression. Clinical variables were compared between 2 groups categorized by onset timing of rest peak.Patients: Sixty-four participants with moderate and severe dementia were assessed.Results: In the correlation analysis, unstable daily rest-activity rhythm was associated with lower ADL. In the multiple linear regression analysis, low intradaily variability, and long daytime sleep duration were associated with low ADL. Aberrant rest peak timing showed lower ADL compared with nonaberrant timing.Conclusions: Abnormal rest-activity rhythm and sleep duration in persons with moderate and severe dementia may affect ADL.","PeriodicalId":520551,"journal":{"name":"Alzheimer disease and associated disorders","volume":" ","pages":"135-140"},"PeriodicalIF":2.1,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38714660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Polymorphism in the MAGI2 Gene Modifies the Effect of Amyloid β on Neurodegeneration. MAGI2基因多态性改变β淀粉样蛋白对神经变性的影响

IF 2.1

Alzheimer disease and associated disorders Pub Date : 2021-04-01 DOI: 10.1097/WAD.0000000000000422

Hang-Rai Kim, Taeyeop Lee, Jung K Choi, Yong Jeong

{"title":"Polymorphism in the MAGI2 Gene Modifies the Effect of Amyloid β on Neurodegeneration.","authors":"Hang-Rai Kim, Taeyeop Lee, Jung K Choi, Yong Jeong","doi":"10.1097/WAD.0000000000000422","DOIUrl":"https://doi.org/10.1097/WAD.0000000000000422","url":null,"abstract":"Introduction: A weak association between amyloid β (Aβ) deposition and neurodegeneration biomarkers, such as brain atrophy, has been repeatedly reported in a subset of patients with Alzheimer disease, suggesting individual differences in response to Aβ deposition.Methods: Here, we performed a genome-wide interaction study to identify single-nucleotide polymorphism (SNP) that modify the effect of Aβ (measured by 18F-florbetapir positron emission tomography) on brain atrophy (measured by cortical thickness using magnetic resonance imaging). We used magnetic resonance imaging, positron emission tomography, cerebrospinal fluid, and genetic data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database [discovery cohort, ADNI-GO/2 (n=723) and replication cohort, ADNI-1 (n=129)].Results: We identified a genome-wide suggestive interaction of rs3807779 SNP (β=-0.14, SE=0.029, P=9.08×10-7) in the discovery cohort. The greater dosage of rs3807779 SNP increased the detrimental effect of Aβ deposition on cortical thickness. In replication analyses, the congruent results were replicated to confirm our findings. Furthermore, rs3807779 SNP augmented the detrimental effect of Aβ deposition on cognitive function. Genetic profiling showed that rs3807779 has chromatin interactions with the promoter region of MAGI2 gene, suggesting its association with MAGI2 expression.Conclusions: These findings demonstrate that subjects carrying the rs3807779 SNP are more susceptible to Aβ-related neurodegeneration.","PeriodicalId":520551,"journal":{"name":"Alzheimer disease and associated disorders","volume":" ","pages":"114-120"},"PeriodicalIF":2.1,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38716071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Primary Endpoints in Current Phase II/III Trials for Alzheimer Disease: A Systematic Survey of Trials Registered at ClinicalTrials.gov. 当前阿尔茨海默病II/III期试验的主要终点:ClinicalTrials.gov注册试验的系统调查

IF 2.1

Alzheimer disease and associated disorders Pub Date : 2020-01-01 DOI: 10.1097/WAD.0000000000000297

Nozomi Takeshima, Keita Ishiwata, Takashi Sozu, Toshi A Furukawa

引用次数: 6

Capgras Syndrome in the Young: Schizophrenia or Alzheimer Disease? 年轻人的Capgras综合征:精神分裂症还是阿尔茨海默病?

IF 2.1

Alzheimer disease and associated disorders Pub Date : 2020-01-01 DOI: 10.1097/WAD.0000000000000360

Kok Pin Ng, Benjamin Wong, Wanying Xie, Nagaendran Kandiah

{"title":"Capgras Syndrome in the Young: Schizophrenia or Alzheimer Disease?","authors":"Kok Pin Ng, Benjamin Wong, Wanying Xie, Nagaendran Kandiah","doi":"10.1097/WAD.0000000000000360","DOIUrl":"https://doi.org/10.1097/WAD.0000000000000360","url":null,"abstract":"This is a case report of an atypical presentation of early onset Alzheimer disease (EOAD) in a young patient with Capgras syndrome and cognitive impairment. The concurrent onset of psychiatric and cognitive symptoms prompted a detailed evaluation for a neurodegenerative disease. A 50-year-old male lawyer presented with low mood, apathy, delusions, and auditory hallucinations over 18 months. He considered his wife as an imposter and would require her text message to confirm her identity. He became more forgetful and had to give up his law practice. His neuropsychological assessment was impaired in all domains. Genetic testing revealed homozygosity for APOEe4 alleles. His magnetic resonance imaging showed predominant parietal and medial temporal atrophy, [18F]Fluorodeoxyglucose positron emission tomography showed frontal, parietal and posterior temporal hypometabolism and [18F]Flutemetamol positron emission tomography was positive for amyloid deposition, leading to the diagnosis of EOAD. This case highlights EOAD as a differential diagnosis in young patients who present with Capgras syndrome.","PeriodicalId":520551,"journal":{"name":"Alzheimer disease and associated disorders","volume":" ","pages":"94-96"},"PeriodicalIF":2.1,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/WAD.0000000000000360","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37522468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Thermal Injury Deaths of Community-dwelling Older People With Dementia. 居住在社区的老年痴呆症患者的热伤死亡

IF 2.1

Alzheimer disease and associated disorders Pub Date : 2020-01-01 DOI: 10.1097/WAD.0000000000000290

Ross Bicknell, Briohny Kennedy, Tony Pham, Lyndal Bugeja, Joseph E Ibrahim

引用次数: 0

The Diagnostic Pathway From Cognitive Impairment to Dementia in Japan: Quantification Using Real-World Data. 日本从认知障碍到痴呆的诊断途径:使用真实世界数据进行量化。

IF 2.1

Alzheimer disease and associated disorders Pub Date : 2019-10-01 DOI: 10.1097/WAD.0000000000000322

Christopher M Black, Baishali M Ambegaonkar, James Pike, Eddie Jones, Joseph Husbands, Rezaul K Khandker

{"title":"The Diagnostic Pathway From Cognitive Impairment to Dementia in Japan: Quantification Using Real-World Data.","authors":"Christopher M Black, Baishali M Ambegaonkar, James Pike, Eddie Jones, Joseph Husbands, Rezaul K Khandker","doi":"10.1097/WAD.0000000000000322","DOIUrl":"https://doi.org/10.1097/WAD.0000000000000322","url":null,"abstract":"Objective: This study aimed to quantify the diagnostic pathway from cognitive impairment (CI) to dementia in Japan.Methods: This was a real-world, cross-sectional survey of patients with CI and their physicians.Results: Data for 1107 patients were provided by 106 physicians. Mean time from initial symptoms to the first consultation was 7.4±6.9 months; 42% of patients had moderate/severe CI at first consultation. Mean time from the first consultation to formal diagnosis was 2.9±11.0 months (1.9±8.8 mo if not referred to a secondary physician, and 5.1±14.6 mo if referred). Time from the first consultation to diagnosis was shorter with more severe CI at first consultation (P=0.0072). The highest proportion of patients were diagnosed by neurologists (45.8%). Tests or scales were used to aid diagnosis in 81.2% of patients. There was no association of disease severity and referral to a secondary physician; 30.9% of patients were referred, the majority (57.7%) to a neurologist.Conclusions: A substantial proportion of patients with dementia in Japan experience CI for some time before consulting a physician. Government policy to increase public understanding and awareness of dementia, and a proposed dementia screening system, should increase the proportion of individuals consulting physicians before disease progression.","PeriodicalId":520551,"journal":{"name":"Alzheimer disease and associated disorders","volume":" ","pages":"346-353"},"PeriodicalIF":2.1,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/WAD.0000000000000322","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37003891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6