Biopsychosocial science and medicine最新文献

{"title":"A Pilot Study of the Real-World Impact of Digital Cognitive Behavioral Therapy for Inflammatory Bowel Disease (COMPASS-IBD) on Inflammation, Disease Activity, and Healthcare Use.","authors":"Natasha Seaton, Sophie Harding, Annie S K Jones, Tsz Wai Chow, Valeria Mondelli, Joanna L Hudson, Rona Moss-Morris","doi":"10.1097/PSY.0000000000001457","DOIUrl":"10.1097/PSY.0000000000001457","url":null,"abstract":"<p><strong>Objective: </strong>Inflammatory bowel disease (IBD) is commonly accompanied by psychological distress, which may worsen disease activity through gut-brain axis mechanisms. Psychological interventions including cognitive behavioral therapy (CBT) seem to reduce distress and inflammation in IBD. However, accessibility to psychological care remains limited. COMPASS-IBD, a digital CBT intervention tailored to IBD, aims to address these gaps.This nested exploratory, real-world study (NCT05330299) assessed the effectiveness of COMPASS-IBD in reducing inflammation, disease activity, and health care use in IBD patients. In addition, it examined relationships between changes in psychological distress and disease indicators.</p><p><strong>Methods: </strong>Adults with IBD experiencing psychological distress were recruited from a large gastroenterology service, and enrolled in COMPASS-IBD. Disease-related primary outcomes were faecal calprotectin (FCP), C-reactive protein (CRP), and self-reported disease activity (SRDA). Secondary outcomes included other inflammatory biomarkers (neutrophils, monocytes, lymphocytes, white blood cells (WBC), ferritin, flare frequency, and health care usage. The Patient Health Questionnaire-Anxiety and Depression Scale (PHQ-ADS) measured distress. Mixed-effects models evaluated outcomes at baseline, 12 weeks, and 6 months.</p><p><strong>Results: </strong>Sixty-five participants were included. There were significant reductions in CRP ( d range: -0.47 to -0.53, P <.01), but not FCP ( d range: -0.38 to -0.44, P <.10) or SRDA ( d =-0.28, P =.08). Significant improvements were observed in WBC and neutrophil counts ( P <.05), flare frequency ( P <.01), and psychological distress ( P <.001). Some types of health care usage were reduced ( P <.05). Associations between distress and primary outcomes were nonsignificant.</p><p><strong>Conclusions: </strong>This pilot suggests COMPASS-IBD may reduce inflammation levels, health care use, and psychological distress. However, analyses were underpowered. Larger randomized trials are needed to confirm findings, establish cost-effectiveness, and explore underlying gut-brain mechanisms.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"274-286"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13043230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145807209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimentally Induced Post-Event Rumination Alters Biological Stress Response Patterns to Repeated Stress.","authors":"Johanna Janson-Schmitt, Jesaja Haessner, Reimar Moeller, Nicolas Rohleder","doi":"10.1097/PSY.0000000000001458","DOIUrl":"10.1097/PSY.0000000000001458","url":null,"abstract":"<p><strong>Objective: </strong>Rumination-the repetitive negative thinking about stressful events-impairs biological stress system activity. However, its impact on the habituation of stress responses, particularly of the sympathetic nervous system (SNS) and hypothalamus-pituitary-adrenal (HPA) axis, remains understudied. This study examined how post-event rumination affects the habituation of biological responses to repeated stress.</p><p><strong>Methods: </strong>In this randomized experimental study, 47 participants were assigned to a rumination or control condition and exposed to two consecutive stress tasks. After the first stress exposure, the rumination group engaged in guided post-event rumination, while the control group reflected on a neutral everyday topic. Biological markers of HPA axis (cortisol) and SNS activity (salivary alpha-amylase, sAA), as well as psychological variables (positive and negative affect, state rumination), were assessed before and after each stressor.</p><p><strong>Results: </strong>Compared with the control group, participants in the rumination condition showed reduced habituation of HPA axis activity ( t(45) =-2.01, p =.025) and increased SNS activation over time, as indicated by rising sAA levels ( t(45) =-2.03, p =.024). No significant group differences were observed in self-reported affect or state rumination.</p><p><strong>Conclusions: </strong>Post-event rumination impairs biological habituation to repeated stress. These findings suggest that rumination disrupts physiological stress adaptation, which may contribute to prolonged stress responses and increased risk for stress-related health problems. Interventions targeting rumination may support more adaptive stress regulation and promote better health outcomes.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"322-333"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147350108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut Microbiota and Psychological Distress in Fibromyalgia: A Systematic Review.","authors":"Roberta Lanzara, Chiara Conti, Luigia Zito, Federico Anaclerio, Gianna Pia Affaitati, Maria Adele Giamberardino, Liborio Stuppia, Piero Porcelli","doi":"10.1097/PSY.0000000000001463","DOIUrl":"10.1097/PSY.0000000000001463","url":null,"abstract":"<p><strong>Objective: </strong>This systematic review aimed to summarize the recent evidence of the relationship between gut microbiota and psychological distress in patients with fibromyalgia (FM).</p><p><strong>Methods: </strong>According to PRISMA guidelines, we conducted a systematic search of the literature on PubMed, Scopus, EBSCO, Web of Science, and Cochrane. The records were selected using multiple combinations of relevant search terms involving microbiota, psychological distress, and FM. Articles in English with human participants were reviewed.</p><p><strong>Results: </strong>The initial search identified 135 records, excluding duplicates, of which 10 research reports met the predefined inclusion criteria and were analyzed. Most studies ( n = 7) were case-control, 2 were randomized controlled trials, and 1 was observational. Most studies found an imbalance in the gut microbial communities of FM patients and a significant difference between FM patients and HC in microbiome composition/diversity or gut permeability. Intestinal dysbiosis and gut permeability were also associated with high psychological distress (emotional, cognitive, and somatic symptoms).</p><p><strong>Conclusions: </strong>Alterations in the gut microbiota of FM patients seem to support the hypothesis that gut-brain axis regulation is impaired in stress-related pain conditions. Although the results are promising, further studies are needed to clarify the role of the microbiota-gut-brain axis in the pathophysiological mechanisms underlying FM.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"287-296"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145937337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy Hormones and Offspring Psychiatric Problems: Testing Associations Between Placental Corticotropin Releasing Hormone and Children's Age 8 Internalizing Outcomes.","authors":"Alexandra D W Sullivan, Emily S Barrett, Alexis Sullivan, Michael Coccia, Amanda Noroña-Zhou, Brent Collett, Karen Derefinko, Danielle Roubinov, Kecia N Carroll, Ruby Nguyen, Roger Smith, Qi Zhao, Kaja Z LeWinn, Nicole R Bush","doi":"10.1097/PSY.0000000000001478","DOIUrl":"https://doi.org/10.1097/PSY.0000000000001478","url":null,"abstract":"<p><strong>Objective: </strong>Placental corticotropin-releasing hormone (pCRH) is a peptide essential for fetal development and birth timing. Prenatal programming frameworks position maternal pCRH as a primary neuroendocrine mediator underlying the intergenerational transmission of stress, but empirical evidence is sparse. Using rigorous methodology, we conducted the first investigation of associations between pCRH and multi-informant indicators of offspring internalizing psychopathology during middle childhood.</p><p><strong>Methods: </strong>This study used the Conditions Affecting Neurocognitive Development and Learning in Early Childhood (CANDLE) sample of socioeconomically diverse mother-child dyads (n=838) followed prospectively from pregnancy. We estimated pCRH rate of rise and level at delivery using maternal 2nd and 3rd trimester blood plasma. We operationalized child internalizing psychopathology and related behavioral phenotypes at age eight with maternal report of internalizing problems, child report of depression and anxiety, and task-based indicators of threat sensitivity. Covariate-adjusted regression models estimated associations between pCRH and offspring outcomes and whether fetal sex moderated associations.</p><p><strong>Results: </strong>Neither rate of rise nor cumulative exposure were associated with any of the six multi-method, multi-informant child outcomes tested (e.g., child-reported depression and anxiety symptoms, maternal-reported internalizing problems, task-based indicators of threat sensitivity (ps range from .16-.83). Fetal sex did not moderate associations.</p><p><strong>Conclusions: </strong>Contrasting theory and findings in smaller samples at younger ages, evidence from this study did not support pCRH as a plausible maternal neuroendocrine mediator for the intergenerational transmission of stress effects on offspring internalizing psychopathology during middle childhood. Future research exploring potential for waning associations across early childhood or other potential mechanisms is warranted.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147597433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Article Summaries for April 2026 Biopsychosocial Science and Medicine, Volume 88, Issue 3.","authors":"","doi":"10.1097/PSY.0000000000001480","DOIUrl":"https://doi.org/10.1097/PSY.0000000000001480","url":null,"abstract":"","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147597397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Article Summaries for February-March 2026 Biopsychosocial Science and Medicine, Volume 88, Issue 2.","authors":"","doi":"10.1097/PSY.0000000000001470","DOIUrl":"https://doi.org/10.1097/PSY.0000000000001470","url":null,"abstract":"","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":"88 2","pages":"135-136"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146129060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Immediate Effects of a Resonant Breathing Exercise on Adolescents' Stress Responses: A Randomized Trial.","authors":"Nathalie Michels, Marie-Anne Vanderhasselt, Jolien Braet, Janne Vreye, Riet Vergauwe, Jente Depoorter, Matteo Giletta","doi":"10.1097/PSY.0000000000001448","DOIUrl":"10.1097/PSY.0000000000001448","url":null,"abstract":"<p><strong>Objective: </strong>This single-blind randomized controlled laboratory experiment investigated the impact of resonant breathing on adolescents' autonomic nervous system (ANS) and affective responses to a standardized acute stressor.</p><p><strong>Methods: </strong>Adolescents ( n = 150, aged 12 to 13 years, 40% boys) were randomized into 2 conditions: resonant breathing (RB condition) or spontaneous breathing (active control condition), both with visual guidance. In this registered report ( https://osf.io/8swdp ), mixed-effects models compared conditions on cardiac ANS (heart rate variability RMSSD, preejection period PEP) and affective responses (positive and negative affect) to the trier social stress test, across reactivity and recovery phases. In addition, conditions were compared on rumination and reappraisal use.</p><p><strong>Results: </strong>The determined resonant rate showed a narrow interquartile range (6.2 to 6.7 breaths/min) and proved difficult to sustain during the 10-minute exercise. The RB intervention significantly reduced breathing rate (Cohen d = -4.69) and increased RMSSD during the breathing phase ( d = 1.68). Compared with the control condition, PEP reactivity to the stressor was attenuated in the RB condition ( d = 0.32), supporting a protective effect. Unexpectedly, RMSSD stress reactivity was more pronounced in the RB condition ( d = -1.37), though this effect diminished in sensitivity analyses, suggesting regression to the mean. Exploratory analyses indicated that among adolescents with lower trait stress-related symptoms, RB reduced RMSSD stress reactivity relative to baseline ( d = 0.75). No differences between conditions were found in affective responses, emotion regulation, or stress recovery.</p><p><strong>Conclusions: </strong>The findings only partially support the hypothesis that RB buffers physiological stress reactivity, with no observed effects on affect or recovery. Repeated training may be essential for achieving the resonant rate and potentially enhancing stress-buffering capacity.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"166-178"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145553076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceived Discrimination and Immunological Aging: A Systematic Review of Cellular and Molecular Markers.","authors":"Adolfo G Cuevas, Emiko Kranz, Mariana Rodrigues, Ariel Binns, Gabrielle Martin, Natalie Herz, Alisha A Crump, Jemar R Bather, Steven W Cole","doi":"10.1097/PSY.0000000000001452","DOIUrl":"10.1097/PSY.0000000000001452","url":null,"abstract":"<p><strong>Objective: </strong>Perceived discrimination is a chronic social stressor that increases the risk of disease. While prior research has linked discrimination to adverse biological health outcomes, the cellular and molecular mechanisms underlying these associations remain understudied.</p><p><strong>Methods: </strong>We conducted a systematic review and identified 32 empirical studies that met the inclusion criteria examining the relationship between self-reported discrimination experiences and markers of immunological aging, focusing on telomere length, gene expression profiles, and immune cell composition.</p><p><strong>Results: </strong>Findings consistently showed discrimination to be associated with accelerated telomere shortening; altered transcriptional activity, particularly within proinflammatory and antiviral pathways aligned with the Conserved Transcriptional Response to Adversity; and shifts in immune cell populations indicative of immune aging and heightened inflammatory activity. Despite this growing evidence, the dominance of cross-sectional designs, limited racial/ethnic diversity in study populations, and narrow focus on select immune markers restrict generalizability and mechanistic clarity.</p><p><strong>Conclusion: </strong>We emphasize the need for longitudinal research, broader immune phenotyping, and rigorous modeling of behavioral and physiological mediators to elucidate how discrimination drives chronic immune dysregulation. Advancing this field is essential for understanding the biopsychosocial pathways linking discrimination to disease.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"137-155"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13134768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145553054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Marital Status With All-cause and Cause-specific Mortality in Women and Men From the Moli-sani Study Cohort.","authors":"Anwal Ghulam, Augusto Di Castelnuovo, Simona Costanzo, Francesco Gianfagna, Amalia De Curtis, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Licia Iacoviello, Marialaura Bonaccio","doi":"10.1097/PSY.0000000000001454","DOIUrl":"10.1097/PSY.0000000000001454","url":null,"abstract":"<p><strong>Objective: </strong>To study the relationship between marital status and all-cause and cause-specific mortality in Italian women and men, and to further analyse the role of potential mediating factors such as socioeconomic (eg, number of cohabitants, education, housing), behavioural (eg, smoking, leisure time physical activity, BMI), and physiological factors (eg, blood glucose, lipid levels).</p><p><strong>Methods: </strong>We conducted longitudinal analyses on 12,139 women and 11,166 men from the Moli-sani study: exposure and mediation variables were collected only at baseline (2005-2010), while participants were followed up for vital status for 14.5 years (IQR: 12.2 to 17.3; median). Marital status was categorized as married/cohabiting, divorced/separated, single/unmarried, or widowed. Mortality outcomes included all-cause, cardiovascular, cancer, and other causes. Mediation analyses examined explanatory mechanisms, and subgroup analyses evaluated generational differences.</p><p><strong>Results: </strong>Compared with married/cohabiting, single women showed elevated rates for all-cause and cancer mortality (HR = 1.33; 95% CI = 1.04-1.69 and HR = 1.92; 95% CI = 1.32-2.79, respectively). All men in unmarried categories faced higher mortality rates for all-cause mortality as compared with married/cohabiting (HR = 2.03; 95% CI = 1.51-2.72, HR = 1.40; 95% CI = 1.09-1.81, HR = 1.32; 95% CI = 1.11-1.56), for divorced/separated, single, and widowed, respectively. Mediation analyses revealed that smoking, cystatin C levels, and heart rate were relevant mediating factors for single women, divorced/separated men, and single men. While behavioural factors like leisure time, physical activity, diet quality, and heart rate played significant role in widowed men.</p><p><strong>Conclusions: </strong>Single women and all unmarried categories in men face significantly elevated rates of mortality. Part of these associations was explained by behavioural and physiological factors.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":"88 2","pages":"229-244"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146121676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parental Resilience Resources and Gestational Length: A Test of Prenatal Maternal Inflammatory Mediation.","authors":"Kavya Swaminathan, Christine Guardino, Haiyan Liu, Christine Dunkel Schetter, Jennifer Hahn-Holbrook","doi":"10.1097/PSY.0000000000001445","DOIUrl":"10.1097/PSY.0000000000001445","url":null,"abstract":"<p><strong>Objective: </strong>Adverse birth outcomes such as preterm birth and low birthweight can engender long-term developmental consequences for the health and well-being of offspring. Prior research demonstrates that chronic inflammation during pregnancy in women increases the risk of both birth and developmental adversities. However, little research has investigated whether protective factors like psychological resilience resources predict lower maternal inflammation in pregnancy and decrease the risk of preterm birth and infant low birth weight.</p><p><strong>Methods: </strong>In this study, we tested whether resilience resources measured in mothers and fathers predicted longer gestational length and higher birthweight through lower levels of systemic inflammation operationalized as C-reactive protein (CRP) in a sample of 217 parent dyads from the Community Child Health Network (CCHN) study. We also explored whether these effects varied by parental marital status. Resilience resources were conceptualized as a latent factor composed of social support, self-esteem, mastery, and optimism. We then tested a 2-stage latent moderated-mediation model followed by a multigroup structural equation model.</p><p><strong>Results: </strong>We found that paternal resilience resources predicted lower prenatal maternal CRP ( β =-0.39 , p =.009, SE=0.05), which in turn predicted a longer gestational length in married ( β =-0.41, p =.042, SE=0.53) but not unmarried parents, whether cohabiting or not. Maternal resilience resources did not directly predict CRP or birth outcomes.</p><p><strong>Conclusions: </strong>This research suggests that a combination of 4 resilience resources among fathers in married couples may be protective for maternal health.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"245-256"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12704204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145461136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}