Biopsychosocial science and medicine最新文献

{"title":"Maternal Psychological Responses During Regional War: A Cross-sectional Study of Fear of Childbirth, Stress, and Intolerance of Uncertainty.","authors":"Haya Hebi, Nadir Ganem, Maya Frank Wolf, Lior Lowenstein, Rotem Kahalon, Liron Rozenkrantz, Inshirah Sgayer","doi":"10.1097/PSY.0000000000001444","DOIUrl":"10.1097/PSY.0000000000001444","url":null,"abstract":"<p><strong>Objective: </strong>Armed conflict may intensify psychological vulnerability during pregnancy. This cross-sectional study examined associations of perceived stress and intolerance of uncertainty during wartime, with fear of childbirth and maternal outcomes.</p><p><strong>Methods: </strong>During the 2024 Iron Swords War, 200 pregnant women beyond 32 weeks gestation were recruited at a tertiary hospital near Israel's northern border. Using questionnaires, we assessed perceived stress, intolerance of uncertainty, and fear of childbirth. Maternal and neonatal outcomes were extracted from medical records.</p><p><strong>Results: </strong>A regression analysis revealed that fear of childbirth was significantly predicted by higher perceived stress (β=0.31, p <.001), greater intolerance of uncertainty (β=0.23, p =.002), and nulliparity (β=0.13, p =.045). Together, these variables accounted for 25% of the variance in fear of childbirth ( R2 =0.25). In addition, perceived stress and intolerance of uncertainty were each significantly correlated with fear of childbirth in bivariate analyses ( r =0.42 and r =0.40, respectively). Logistic regression showed that fear of childbirth predicted emergent cesarean delivery (OR=2.63, 95% CI=1.07-5.04, p =.033).</p><p><strong>Conclusions: </strong>Exposure to war-related stress and uncertainty was linked to heightened fear of childbirth and may impact maternal outcomes. These results emphasize the importance of identifying and addressing psychological distress early in pregnancy, particularly in settings impacted by armed conflict.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"257-261"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145461152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biopsychosocial Science and Medicine, Volume 88, Issue 2.","authors":"","doi":"10.1097/PSY.0000000000001470","DOIUrl":"https://doi.org/10.1097/PSY.0000000000001470","url":null,"abstract":"","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146128965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Type D Personality on Coronary Artery Disease Severity in Acute Coronary Syndrome Patients: Sex Differences.","authors":"Di Wang, Chengqian Xu, Mengru Sun, Bingji Huang, Jiaxin Shi, Bo Yu, Yini Wang, Ping Lin","doi":"10.1097/PSY.0000000000001431","DOIUrl":"10.1097/PSY.0000000000001431","url":null,"abstract":"<p><strong>Objective: </strong>This cross-sectional study aimed to examine the association between type D personality and the severity of coronary artery disease in patients with acute coronary syndrome (ACS), with a specific focus on sex-stratified differences.</p><p><strong>Methods: </strong>ACS patients (n=9236) completed the Chinese Type D Personality Scale. The Gensini score assessed disease severity. Multivariate linear regression, adjusted for covariates, analyzed the relationship between type D personality and Gensini score, with a sex stratified analysis exploring the impact of sex.</p><p><strong>Results: </strong>In total, 20.1% (1853) of ACS patients had a type D personality. Type D personality was measured using standardized scores of negative affectivity (Z-NA) and social inhibition (Z-SI). Multivariate linear regression analysis showed that Z-NA (B=0.03, 95% CI=0.02-0.05, p <.001), Z-SI (B=0.05, 95% CI=0.04-0.07, p <.001), and their interaction term (B=0.02, 95% CI=0.01-0.03, p <.001) were all significantly associated with the Gensini score [Ln]. Further sex-stratified analyses revealed that, among male patients, Z-NA (B=0.04, 95% CI=0.03-0.06, p <.001), Z-SI (B=0.06, 95% CI=0.04-0.07, p <.001), and their interaction (B=0.03, 95% CI=0.02-0.04, p <.001) were all significantly associated with the Gensini score [Ln]. However, no statistically significant associations were observed in female patients.</p><p><strong>Conclusions: </strong>Sex differences significantly influence the relationship between type D personality and coronary disease severity in ACS patients, particularly in males, warranting targeted interventions.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"16-23"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145202769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex Differences in the Adverse Electromechanical Remodeling of the Heart After Repeated Witness Stress in Adult Rats: Relationship With a Specific miRNA Signature.","authors":"Margherita Barbetti, Iolanda Bilotti, Donald Ielpo, Rocchina Vilella, Caterina Frati, Valeria Naponelli, Diego Andolina, Luisa Lo Iacono, Andrea Sgoifo, Monia Savi, Luca Carnevali","doi":"10.1097/PSY.0000000000001406","DOIUrl":"10.1097/PSY.0000000000001406","url":null,"abstract":"<p><strong>Objective: </strong>Sex disparities in the association between psychosocial stress and cardiovascular risk have been reported, yet the extent to which social stress impacts cardiovascular function in a sex-specific manner remains unclear. The objectives of this study were to investigate sex differences in the electromechanical remodeling of the heart of socially stressed rats, and to explore potential epigenetic mechanisms (cardiac microRNAs).</p><p><strong>Methods: </strong>Adult wild-type Groningen rats of both sexes vicariously experienced the social defeat bout between 2 males for 9 consecutive days [\"witness stress\" (WS) paradigm] or were exposed to a control condition ( n =8/sex/group). After repeated WS exposure, arrhythmic vulnerability was evaluated via beta-adrenergic stimulation with isoproterenol in conscious rats, while cardiac contractile properties were assessed via hemodynamic analyses under anesthesia. Cardiac tissue was collected to measure expression levels of several miRNAs (including miR-22 and miR-34a) and their molecular targets (eg, SIRT1) involved in the regulation of cardiac electromechanical function.</p><p><strong>Results: </strong>An increased vulnerability to isoproterenol-induced arrhythmias was found in male, but not female, rats with a history of WS. Signs of contractile dysfunction were found in both sexes after WS, but to a greater extent in males. In addition, only male WS rats exhibited a significantly higher cardiac expression of miR-34a and miR-22, which were associated with a reduced expression of their common molecular target (SIRT-1).</p><p><strong>Conclusion: </strong>These findings suggest an epigenetic mechanism underlying the larger vulnerability to adverse cardiac electromechanical remodeling in socially stressed male rats, informing our understanding of the sex-specific impact of social stress on cardiac function.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"37-47"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12721695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Police-related Stress and Carotid Intima Media Thickness Among African American Women.","authors":"Lori S Hoggard, Raphiel J Murden, Nicole D Fields, Christy L Erving, Shivika Udaipuria, Reneé H Moore, Viola Vaccarino, Arshed A Quyyumi, Emma Barinas-Mitchell, Tené T Lewis","doi":"10.1097/PSY.0000000000001428","DOIUrl":"10.1097/PSY.0000000000001428","url":null,"abstract":"<p><strong>Objective: </strong>Anti-black police violence and harassment have been identified as public health issues. However, studies have primarily focused on direct and/or vicarious police encounters. A dearth of studies has also examined vigilance related to future police encounters, and to our knowledge, no studies have examined all 3 kinds of police-related stress among African American women.</p><p><strong>Methods: </strong>We employed a latent class analysis (LCA) approach to identify classes of African American women ( N = 422), aged 30 to 46, based on the patterning of various forms of self-reported police-related stress: direct, vicarious, police-related vigilance for self, and police-related vigilance for children. We then examined associations between latent class membership and carotid intima media thickness (IMT), a marker of cardiovascular risk.</p><p><strong>Results: </strong>We identified 3 latent classes of police-related stress: (1) high child vigilance-high personal exposure, (2) no child vigilance-high personal exposure, and (3) moderate child vigilance-low self vigilance-low personal exposure class. Findings from the fully adjusted model reveal that the no child vigilance-high personal exposure class had lower common carotid artery (CCA) IMT than the high child vigilance-high personal exposure and moderate child vigilance-low self vigilance-low personal exposure classes.</p><p><strong>Conclusions: </strong>Vigilance for children's future police encounters may be associated with increased cardiovascular risk in African American women. Agency, system, and policy-level solutions may be needed to reduce anti-black police violence and improve the cardiovascular health of this high-risk population.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"113-123"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13114687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144985813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feeling Blue and Trying Not to Lose Heart: Associations Between Mental Health and Cardiovascular Health Groups for Black Young Adult Women.","authors":"Vanessa V Volpe, Abbey N Collins","doi":"10.1097/PSY.0000000000001415","DOIUrl":"https://doi.org/10.1097/PSY.0000000000001415","url":null,"abstract":"<p><strong>Objective: </strong>Black women in the United States experience a high burden of incident cardiovascular (CV) disease, yet research often focuses on midlife and beyond. One psychological correlate of CV health for Black young adults is mental health. The current study fills a gap in existing CV health prevention knowledge by using an intersectional (ie, racially gendered age-specific) person-centered approach to investigate the CV health groups of Black young adult women and group differences in depression, anxiety, and stress symptoms.</p><p><strong>Methods: </strong>Data came from a non-probability sample of 482 Black young adult women (ages 18 to 35). Participants completed an online survey in which they self-reported depression, anxiety, and stress, 6 indicators of CV health, and sociodemographics using standardized measures. A latent class analysis was used to identify CV health classes and test differences in class membership by mental health symptoms.</p><p><strong>Results: </strong>Four classes of CV health were uncovered: moderate high CV health (36.93% of the sample), healthy fiber (12.67%), healthy BMI (17.01%), and moderately healthy physical activity (33.4%). Black young adult women in the moderate high CV health class had fewer depression, anxiety, and stress symptoms compared with all other classes (P<.005). Additional differences in symptoms between suboptimal CV health classes emerged.</p><p><strong>Conclusions: </strong>Groups with varied combinations of CV health indicators and associations with mental health emerged. These nuances might help tailor prevention efforts for Black young adult women based on the heterogeneity in cardiovascular health groups and mental health symptoms for this population.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":"88 1","pages":"100-112"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145859754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emotion Regulation and Favorable Cardiovascular Health Among Women.","authors":"Claudia Trudel-Fitzgerald, Laura Chen, Colleen B McGrath, Farah Qureshi, Tianyi Huang, Laura D Kubzansky","doi":"10.1097/PSY.0000000000001412","DOIUrl":"10.1097/PSY.0000000000001412","url":null,"abstract":"<p><strong>Objective: </strong>Emerging evidence suggests maladaptive (eg, suppression) versus adaptive (eg, reappraisal) emotion regulation strategies predict the risk of cardiovascular disease, which is the leading cause of death among women. Recognizing that health encompasses more than the absence of disease, we investigated whether reappraisal and suppression strategies are individually or jointly related to favorable cardiovascular health (CVH) over time among women.</p><p><strong>Methods: </strong>At baseline in 2017-2018, 28,759 postmenopausal women free of cardiovascular disease (age mean =63) from the Nurses' Health Study II cohort answered the validated Emotion Regulation Questionnaire assessing reappraisal and suppression strategies. Favorable CVH was defined at baseline and in 2019 based on self-reported diagnoses of hypertension, cholesterol, and diabetes, as well as body mass index and smoking status. Poisson regression models evaluated the relative risk (RR) and 95% CI of having favorable CVH in 2019 related to baseline use of each emotion regulation strategy and their interplay, considering relevant covariates.</p><p><strong>Results: </strong>In sociodemographic-adjusted models, greater reappraisal use was related to a higher likelihood of having favorable CVH (RR per 1-SD increase =1.07, 95% CI=1.06-1.09), while greater suppression use was related to a lower likelihood (RR per 1-SD increase =0.96, 95% CI=0.94-0.97). Relative to women reporting lower use of both strategies, those using both strategies frequently (RR=1.13, 95% CI=1.08-1.19) and those favoring reappraisal over suppression use (RR=1.21, 95% CI=1.14-1.27) had a higher likelihood of favorable CVH. Associations were attenuated, but most remained evident after adjusting for baseline CVH and health behaviors.</p><p><strong>Conclusions: </strong>Use of adaptive versus maladaptive emotion regulation strategies predicts the likelihood of having favorable CVH in expected directions.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"71-82"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Potentially Traumatic Perinatal Complications on Postpartum Psychological Distress and Cardiometabolic Risk: Implications for Women's Heart Health.","authors":"Yasmin B Kofman, Leah Cha, Christine Dunkel Schetter, Jennifer A Sumner","doi":"10.1097/PSY.0000000000001407","DOIUrl":"10.1097/PSY.0000000000001407","url":null,"abstract":"<p><strong>Objective: </strong>Perinatal complications are well-documented cardiovascular disease risk factors. However, the potential for these complications to be psychologically traumatic due to their life-threatening nature-and their association with postpartum psychological distress and cardiometabolic risk-remains underexplored. This gap is important, as perinatal complications, trauma and related distress, and cardiometabolic risk factors are independently linked to cardiovascular disease and may have a compounded impact when co-occurring.</p><p><strong>Methods: </strong>Data were analyzed from 2510 predominantly low-income, racially and ethnically diverse postpartum women. We reviewed medical charts and interviews at 1 month postpartum to identify potentially traumatic perinatal complications, defined as severe or life-threatening complications during pregnancy, labor, delivery, and the postnatal period (up to 2 weeks after birth) affecting the mother or newborn. Postpartum psychological distress, including symptoms of depression, anhedonia, and anxiety, was assessed at 1 and 6 months postpartum, with posttraumatic stress disorder symptoms assessed at 6 months postpartum. Composite indices of cardiometabolic risk were calculated at 6 and 12 months postpartum.</p><p><strong>Results: </strong>A range of potentially traumatic complications was identified, with 21% of women experiencing a life-threatening complication affecting mothers or newborns. The presence of complications was significantly positively associated with psychological distress, including depressive and anxiety symptoms, at 1 month postpartum. No significant associations were observed for distress at 6 months postpartum. The presence of complications was also significantly positively associated with cardiometabolic risk scores at 6 and 12 months postpartum.</p><p><strong>Conclusions: </strong>Potentially traumatic pregnancy complications are prevalent and correlate with postpartum psychological distress and cardiometabolic risk, with implications for maternal cardiovascular health.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"48-60"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex and Sociocultural Gender Norms Score Differences in Major Adverse Cardiac Events and Mortality Five Years Following Coronary Angioplasty.","authors":"Sophie C M van den Houdt, Frederique J Hafkamp, Paula M C Mommersteeg, Jos Widdershoven, Nina Kupper","doi":"10.1097/PSY.0000000000001440","DOIUrl":"10.1097/PSY.0000000000001440","url":null,"abstract":"<p><strong>Objective: </strong>Research on adverse outcomes following percutaneous coronary intervention (PCI) yields conflicting findings regarding sex-specific outcomes, suggesting that focusing solely on biological differences may be insufficient. Therefore, we explored the impact of both sex and a composite sociocultural gender norms score on major adverse cardiac events (MACE) among patients in the 5 years following PCI.</p><p><strong>Methods: </strong>Among 1571 participants (M age = 64.03 ± 10.99; 77.2% males), 13.1% experienced MACE and 7.8% faced mortality (39.3% cardiac-related) within the 5-year follow-up. A sociocultural gender norms score (higher: more feminine, lower: more masculine), derived from occupational status and type, educational status, and civil status, was constructed. Binary logistic regressions analyzed the main effects of sex and sociocultural gender norms, and their interaction, while adjusting for age and medical covariates.</p><p><strong>Results: </strong>No sex differences were observed. More feminine sociocultural gender norms scores were associated with cardiac outcomes [OR = 1.16 (95% CI = 1.03-1.32)] and all-cause mortality [OR = 1.62 (95% CI = 1.17-2.26)]. However, an intricate interplay between sociocultural gender norms and adverse outcomes appeared when adjusting for covariates: older age, cardiac history, and comorbid disorders were among the covariates, which correlated negatively with outcomes and with sociocultural gender norms.</p><p><strong>Conclusions: </strong>While the sociocultural gender norms score emerged as a better explanatory factor for outcomes than sex, its effects overlapped with multiple medical covariates and age, emphasizing the need for deeper exploration of this complex interplay. These findings mark the initial stage in a broader understanding of gender's role in outcomes.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"124-134"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145188205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Forms of Childhood Maltreatment and Vascular Function Indices in Black Men and Women.","authors":"Telisa A Spikes, Roland J Thorpe, Sandra B Dunbar, Vasiliki Michopoulos, Jordan Pelkmans, Whitney Wharton, Latesha K Harris, Puja K Mehta, Priscilla Pemu, Herman Taylor, Arshed Quyyumi","doi":"10.1097/PSY.0000000000001449","DOIUrl":"10.1097/PSY.0000000000001449","url":null,"abstract":"<p><strong>Objective: </strong>Examine the association between types of childhood maltreatment and surrogate markers of vascular function, and to test whether sex modifies these relationships.</p><p><strong>Methods: </strong>Childhood maltreatment and indices of vascular function were assessed in a cohort of healthy Black adults without known CVD (n=404). Maltreatment (physical, sexual, emotional, and general trauma) domains were assessed using the Early Trauma Inventory Short Form. A trauma severity index score was calculated by summing the indexes for each domain. Outcomes of central augmentation index (cAIx) corrected for a heart rate of 75 bpm, and carotid femoral pulse wave velocity were measured as indices of wave reflections and arterial stiffness, respectively, and central pulse pressure (CPP). Associations between each domain and outcomes were assessed using multivariate-adjusted (demographics, clinical, health behaviors, and depressive symptoms) and sex-stratified linear regression models.</p><p><strong>Results: </strong>The cohort had a mean age of 53±10.3 years, and 61% were women. After adjustments, emotional abuse (2.68 [95% CI: -4.78, -0.58, P =.013]) and physical abuse (-2.38 [-4.26, -0.50, P =<.001]) were associated with cAIx in the overall cohort. Significant sex interactions were identified for emotional ( P= .009) and physical abuse ( P= .001) with cAIx and for emotional abuse with CPP ( P =.021). Among women, physical abuse was associated with a higher cAIx (2.22 [95% CI: 0.70, 3.73, P =.004]), and among men, a lower cAIx (-2.59 [95% CI: -4.98, -0.19, P =.035]). Emotional abuse was also associated with higher CPP measures among women (1.31 [95% CI: 0.15, 2.46, P =.027]) with no associations identified in men.</p><p><strong>Conclusions: </strong>Physical and emotional abuse was associated with higher cAIx and CPP in women, but not men, suggesting sex-specific effects of early trauma on vascular function.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"61-70"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12721644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145644240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}