Biopsychosocial science and medicine最新文献

{"title":"Associations Between Growth Differentiation Factor 15 and Anxiety and Depression in the General Population: The Akershus Cardiac Examination 1950 Study.","authors":"Ragnhild Dypvik, Katrine Kveli Fjukstad, Stian Lydersen, Trygve Berge, Arnljot Tveit, Helge Røsjø, Torbjørn Omland, Gunnar Einvik, Magnus Nakrem Lyngbakken","doi":"10.1097/PSY.0000000000001365","DOIUrl":"https://doi.org/10.1097/PSY.0000000000001365","url":null,"abstract":"<p><strong>Objective: </strong>Several studies suggest a bidirectional association between inflammation, and anxiety and depression. Elevated inflammatory cytokines generate and aggravate neuroinflammation, which may play a part in developing psychological symptoms. Growth differentiation factor 15 (GDF-15) is a novel biomarker possibly reflecting fibrosis and inflammation. The aim of the current study was to investigate the associations between levels of GDF-15 and symptoms of anxiety and depression in the general population.</p><p><strong>Methods: </strong>We measured GDF-15 in middle-aged persons participating in the Akershus Cardiac Examination 1950 Study. Symptoms of anxiety and depression were assessed using the Hospital Anxiety and Depression Scale (HADS), with HADS ≥8 denoting significant symptoms. We used multivariable regression analysis to assess the associations between GDF-15 and HADS, adjusting for levels of C-reactive protein (CRP), demographics, and comorbidities.</p><p><strong>Results: </strong>A total of 3638 participants had valid assessment of HADS and measurements of GDF-15 and CRP. The mean age was 63.9 (SD 0.65) years, and 48.8% were women. In adjusted models, levels of GDF-15 were associated with the continuous HADS-D score (β = 0.27, 95% confidence interval [CI] = 0.12 to 0.43) and HADS-D score ≥8 (odds ratio = 1.41, 95% CI = 1.12 to 1.78), but not with the continuous HADS-A score (β = 0.06, 95% CI = -0.12 to 0.24) or HADS-A score ≥8 (odds ratio = 1.06, 95% CI = 0.88 to 1.27).</p><p><strong>Conclusions: </strong>Levels of GDF-15 are independently associated with symptoms of depression in the general population. Our results reinforce the notion that inflammation may be a contributing factor for the development of clinical depression.</p><p><strong>Registration: </strong>ClinicalTrials.gov identifier NCT01555411 (Akershus Cardiac Examination [ACE] 1950 Study), https://clinicaltrials.gov/study/NCT01555411.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":"87 2","pages":"153-159"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resting-State Functional Connectivity Does Not Predict Individual Differences in Perceived Psychological Stress Among Midlife Adults: Evidence From a Preregistered Cross-Validation Study.","authors":"Chrystal Spencer, Javier Rasero, Rebecca G Reed, Timothy D Verstynen, Peter J Gianaros","doi":"10.1097/PSY.0000000000001358","DOIUrl":"https://doi.org/10.1097/PSY.0000000000001358","url":null,"abstract":"<p><strong>Objective: </strong>It is theorized that appraisals of perceived psychological stress are represented in the brain. However, a neural signature that reliably predicts perceived stress has yet to be fully characterized. Accordingly, the present preregistered study tested whether whole-brain resting-state functional connectivity patterns predict individual differences in perceived stress.</p><p><strong>Methods: </strong>Participants (N = 417; 53% female; 24.2% non-White; aged 30-54 years) completed the 10-item Perceived Stress Scale and underwent a 5-minute resting-state functional magnetic resonance imaging scan. Functional connectivity (FC) was computed between areas distributed across the brain. In total, 19,900 functional connections (edges) were retained for analyses. Cross-validated and multivariate machine learning methods were implemented. Using this approach, two penalized regression models with cross-validation-elastic net and ridge-were conducted to predict perceived stress from the edges.</p><p><strong>Results: </strong>Across the elastic net and ridge regression models, whole-brain resting-state FC patterns failed to predict individual differences in perceived stress. However, in exploratory analyses, they successfully generalized in cross-validation to predict age for both models (elastic net: r = 0.193, p < .0001, 95% CI = 0.099-0.284, RMSE = 6.661, MAE = 5.715, R2 = 0.037; ridge: r = 0.197, p < .0001, 95% CI = 0.103-0.287), RMSE = 6.613, MAE = 5.8140, R2 = 0.039).</p><p><strong>Conclusion: </strong>These results suggest that resting-state FC patterns may not reliably predict individual differences in self-reported perceived stress among midlife adults.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":"87 2","pages":"138-145"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Table of Contents.","authors":"","doi":"10.1097/01.psy.0001106024.70286.61","DOIUrl":"https://doi.org/10.1097/01.psy.0001106024.70286.61","url":null,"abstract":"","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":"87 2","pages":"i"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Article Summaries for February-March 2025 Biopsychosocial Science and Medicine, Volume 87, Issue 2.","authors":"","doi":"10.1097/PSY.0000000000001371","DOIUrl":"https://doi.org/10.1097/PSY.0000000000001371","url":null,"abstract":"","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":"87 2","pages":"95"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory and Cardiovascular Responses to Active and Passive Acute Psychological Stress.","authors":"Victoria G Linsley, Nicolette C Bishop, Matthew J Roberts, Malik Hamrouni, Mayada Demashkieh, Nicola J Paine","doi":"10.1097/PSY.0000000000001367","DOIUrl":"https://doi.org/10.1097/PSY.0000000000001367","url":null,"abstract":"<p><strong>Objective: </strong>Acute psychological stress is a risk factor for cardiovascular disease (CVD), possibly through promoting a heightened inflammatory profile. Active stressors are commonly used to investigate cardiovascular and immune reactivity; however, this response may not translate to other stress modalities. We aimed to decipher potential differences in immune responses to passive and active stressors.</p><p><strong>Methods: </strong>Eighty-eight participants completed this study. After a baseline period, a passive (International Affective Picture System [IAPS]) and active stress task (Paced Auditory Serial Addition Test [PASAT]) were completed in a randomized order, with 45-minute rest post-tasks. Cardiovascular measures (including SBP, DBP, HR) were collected continuously. Blood samples were collected after each time point determining inflammatory responses, including circulating and stimulated interleukin-6 (IL-6), systemic inflammation response index (SIRI), neutrophil/lymphocyte ratio (NLR), TNF-α, and P- and E-selectin.</p><p><strong>Results: </strong>Cardiovascular measures were higher during the PASAT than IAPS (p < .001). Circulating IL-6 levels increased from baseline to 45-minutes after both tasks (p ≤ .001), with no difference between 45-minute post-PASAT and 45-minute post-IAPS (p > .05). SIRI increased from baseline to post-IAPS (p = .013), 45-minute post-IAPS (p = .004), and 45-minute post-PASAT (p < .001). No difference in SIRI between 45-minute post-PASAT and 45-minute post-IAPS existed. NLR increased from baseline to 45-minute post-PASAT (p = .008). There were no significant time effects for TNF-α, P-selectin, or E-selectin (all p > .05).</p><p><strong>Conclusion: </strong>Both stressors increased circulating IL-6 levels and SIRI. Cardiovascular measures were higher during the active task, but the magnitude of inflammatory responses did not significantly differ between tasks. Regardless of stress modality, an immune response ensues, potentially increasing the risk of CVD over time.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":"87 2","pages":"107-117"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Impacts of Depression and Inflammatory Factors in Pancreatic Cancer Patients.","authors":"Po See Chen, Yang-Chen Shen, Cheng-Feng Lin, Ping-Yen Liu, Peng-Chan Lin, Pei-Fang Su, Chia-Jui Yen, Yan-Shen Shan","doi":"10.1097/PSY.0000000000001368","DOIUrl":"https://doi.org/10.1097/PSY.0000000000001368","url":null,"abstract":"<p><strong>Objective: </strong>This study explores the potential connections between clinical depression, inflammation, and cancer progression in pancreatic cancer patients.</p><p><strong>Methods: </strong>Conducted from May 2021 to May 2023 at the National Cheng Kung University Hospital Clinical Data Warehouse, this prospective study involved 279 pancreatic cancer patients. The nine-item self-reported Patient Health Questionnaire (PHQ-9) was used to assess depressive symptoms. The study focused on the correlation between clinically significant depression (PHQ-9 scores >10), levels of inflammatory factors, and patient survival rates.</p><p><strong>Results: </strong>At the time of diagnosis, 34.0% of the patients exhibited clinically significant depression. Analysis using Fixed Effects in Generalized Linear Mixed Models (GLMM) revealed a notable link between log-transformed C-reactive protein (ln CRP) levels with occurrence of depression (odds ratio [OR] = 1.274, p = .010). Furthermore, a univariate Cox proportional hazard model with time-varying covariates indicated a correlation between clinically significant depression and decreased overall survival (hazard ratio [HR] = 6.245, p < .001). A multivariate Cox model also showed significant associations of both ln CRP levels (HR = 1.966, p = .030) and clinically significant depression (HR = 3.611, p = .028) with survival outcomes.</p><p><strong>Conclusions: </strong>The findings highlight a complex interplay between inflammation, depression, and survival in pancreatic cancer patients. However, the study is limited by the lack of control over all potential confounders, such as chronic conditions, which could independently influence both depression and inflammatory biomarkers.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":"87 2","pages":"146-152"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse Childhood Experiences Influence Longitudinal Changes in Leptin But Not Adiponectin.","authors":"Sara Matovic, Christoph Rummel, Elena Neumann, Jennifer McGrath, Jean-Philippe Gouin","doi":"10.1097/PSY.0000000000001366","DOIUrl":"https://doi.org/10.1097/PSY.0000000000001366","url":null,"abstract":"<p><strong>Objective: </strong>Adverse childhood experiences (ACEs) are associated with a greater risk of obesity and cardiometabolic disease. Adipokines, including leptin and adiponectin, play vital roles in biological processes linked to obesity and cardiometabolic risk. The adiponectin/leptin ratio may represent a marker of impaired hormonal regulation of adipose tissue. Prior cross-sectional studies suggest patterns of higher plasma leptin and lower adiponectin among adults who have experienced ACEs. This study addresses whether ACEs influence longitudinal changes in leptin, adiponectin, and the adiponectin/leptin ratio, after accounting for current chronic stress and adiposity.</p><p><strong>Methods: </strong>This longitudinal study included 192 middle-aged mothers (mean age = 46.78 years) experiencing higher (n = 108) and lower (n = 84) chronic caregiving stress. Adipokines and adiposity were measured at three timepoints: T1 (baseline), T2 (15 months later), and T3 (30 months after T1). ACEs were assessed retrospectively using the Childhood Trauma Questionnaire.</p><p><strong>Results: </strong>Mixed-effect models showed that leptin and adiponectin increased over time. Greater ACEs exposure was associated with larger increases in leptin over time, but it was not related to adiponectin or the adiponectin/leptin ratio. Current caregiving stress was not related to leptin and adiponectin levels and did not interact with ACEs in predicting adipokine levels. Mediation analyses revealed that increases in waist circumference partially mediated the association between ACEs and increases in leptin over time.</p><p><strong>Conclusions: </strong>ACEs may increase vulnerability to cardiometabolic risk in midlife caregiving mothers through its influence on longitudinal changes in leptin and central adiposity.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":"87 2","pages":"118-128"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cover.","authors":"","doi":"10.1097/01.psy.0001106016.81493.b8","DOIUrl":"https://doi.org/10.1097/01.psy.0001106016.81493.b8","url":null,"abstract":"","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":"87 2","pages":"i"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review and Meta-Analysis of the Association Between Pain-Related Fear and Pain Intensity in Experimental Pain Models.","authors":"Lindsay A Kutash, MacKenzie A Sayer, Douglas L Delahanty","doi":"10.1097/PSY.0000000000001359","DOIUrl":"https://doi.org/10.1097/PSY.0000000000001359","url":null,"abstract":"<p><strong>Objective: </strong>Pain is a multifaceted experience influenced by sensory and affective factors, with significant variability in perception among individuals that affects pain management and recovery. Pain-related fear (PRF) has been linked to a number of adverse outcomes in clinical pain populations, including pain intensity. Experimental studies offer unique insight into the direction and magnitude of the PRF-pain intensity relationship; however, results of relevant studies are mixed. The present meta-analysis aimed to synthesize findings of laboratory studies investigating PRF and pain intensity in order to estimate the pooled effect of this relationship as well as to evaluate potential moderators and competing variables contributing to between-study variability (preregistration ID: CRD42023432110).</p><p><strong>Methods: </strong>Searches in PubMed, PsychINFO, and Cochrane Library yielded 27 independent samples, totaling 1633 participants, that reported correlations between PRF and pain intensity in healthy, pain-free individuals.</p><p><strong>Results: </strong>Results revealed a pooled effect size that was positive and significant (r = 0.22, p < .001), with the magnitude of the relationship varying by PRF measurement tool (Q = 8.48, p = .004). Specifically, studies that used the Fear of Pain Questionnaire (McNeil and Rainwater, 1998) reported more robust effect sizes than alternative PRF measurement tools. Although competing psychological variables were related to both PRF and pain intensity, PRF predicted pain intensity over and above these factors.</p><p><strong>Conclusion: </strong>The present results indicate a unique positive effect of PRF, as measured in the absence of an ongoing pain experience, on later perceptions of pain intensity. The implications for future experimental pain studies and clinical translation are discussed.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":"87 2","pages":"96-106"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"All Issue Ads.","authors":"","doi":"10.1097/01.psy.0001106028.34900.a4","DOIUrl":"https://doi.org/10.1097/01.psy.0001106028.34900.a4","url":null,"abstract":"","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":"87 2","pages":"i"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}