Biopsychosocial science and medicine最新文献

{"title":"When MICE and FIML Disagree: Investigating Inconsistencies in Missing Data Analysis.","authors":"Jiepeng Yuan, David Freire, Noelle M Hurd, Xin Tong","doi":"10.1097/PSY.0000000000001536","DOIUrl":"https://doi.org/10.1097/PSY.0000000000001536","url":null,"abstract":"<p><strong>Objective: </strong>Missing data are pervasive and pose a significant challenge in social, behavioral, and health research. Although Multivariate Imputation by Chained Equations (MICE) is widely used because of its flexibility and practical usefulness, recent empirical studies have shown that different MICE algorithms and full information maximum likelihood (FIML) estimation may produce inconsistent statistical conclusions. This study systematically compared the performance of FIML and commonly used MICE algorithms for handling missing data in linear regression models.</p><p><strong>Methods: </strong>Simulation studies were conducted to compare FIML with three commonly used MICE algorithms, including predictive mean matching (PMM), Bayesian linear regression (norm), and classification and regression trees (CART). Simulation conditions varied sample size, effect size, number of auxiliary variables, missing data mechanism, and missing data rate.</p><p><strong>Results: </strong>Results showed that although MICE is a powerful approach for handling missing data, some default settings of MICE algorithms produced biased model estimations under certain conditions. Performance also varied across the imputation algorithms and could depart from the FIML benchmark.</p><p><strong>Conclusions: </strong>Findings highlight the importance of carefully selecting and implementing MICE algorithms when handling missing data and provide practical guidance for choosing between MICE and FIML in applied research.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Partner Dyads to Promote Physical Activity among Women at Risk for CVD: Daily Perceptions of Communication and Associations with Physical Activity Outcomes.","authors":"Danielle Arigo, Amanda L Folk, Tess Thompson, Jacqueline A Mogle","doi":"10.1097/PSY.0000000000001535","DOIUrl":"https://doi.org/10.1097/PSY.0000000000001535","url":null,"abstract":"<p><strong>Objective: </strong>To examine day-to-day experiences of social support and peer partner influence during a tailored physical activity (PA) intervention.</p><p><strong>Methods: </strong>The parent intervention was designed for women in midlife (ages 40-65) with elevated risk for cardiovascular disease (CVD), for whom lack of social support is a barrier to cardioprotective levels of PA. Women in midlife with ≥1 CVD risk factor (e.g., hypertension; N=62, MAge=53, MBMI=32.6 kg/m2, 44% from underrepresented groups) enrolled in an 8-week PA intervention combining PA coaching with formation of partner dyads for between-session support (n=31).Women who enrolled were paired in partner dyads and did not have a relationship prior to enrolling. They wore a digital PA monitor and completed daily end-of-day surveys throughout the program (94% compliance). Multilevel models tested for within-person associations between daily satisfaction with partner support (individual and dyad levels), including preliminary tests of partner influence.</p><p><strong>Results: </strong>Partners communicated on 58% of days, primarily via texting (used on 92% of communication days). Perceived support varied within-person and within-dyad (ICCs=0.37-0.48); women reported greater PA motivation and took more steps on days when they experienced greater partner support (Ps<0.040, srs=0.19-0.32). Partners' daily PA motivation and steps showed weak correlations (rs=0.008-0.24); associations between partners' perceptions and each others' PA outcomes were slightly stronger (srs=0.20-0.28) and reflected different experiences of support.</p><p><strong>Conclusions: </strong>Among women with elevated risk for CVD, support in health-focused partnerships has potential to influence daily PA motivation and behavior. Additional investigation will improve partner-based PA intervention toward reduction in CVD risk for this group.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149198224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse Childhood Experiences, Allostatic Load, and Adult Health: The Mediating and Moderating Role of Personality in a Nationally Representative US Study.","authors":"Luke E Barry, Mina Habib, Roch A Nianogo, George M Slavich","doi":"10.1097/PSY.0000000000001534","DOIUrl":"https://doi.org/10.1097/PSY.0000000000001534","url":null,"abstract":"<p><strong>Objective: </strong>Adverse childhood experiences (ACEs) are strong risk factors for biological dysregulation, morbidity, and mortality over the lifespan. Although research has begun investigating potential risk and resilience processes that mediate and moderate these associations, little research has examined the unique role that personality plays in linking ACEs with biological and clinical health in adulthood.</p><p><strong>Method: </strong>To investigate, we used cross-sectional data from the 2006 and 2008 assessments of the nationally representative US Health and Retirement Study (n=9708). Exposures included any ACEs (before age 18) and specific ACEs (i.e., parental substance use, physical abuse, repeating a school year). Mediators were personality characteristics, measured using the top quartile (Yes/No) of Big Five personality characteristics (i.e., conscientiousness, agreeableness, neuroticism, openness, extraversion). Outcomes were allostatic load and the number of chronic diseases present in adulthood. We used causal mediation analysis to estimate the extent to which personality mediated and/or moderated the association of ACEs with each outcome.</p><p><strong>Results: </strong>Individuals with any ACEs had 5% higher allostatic load (Adjusted incidence rate ratio [aIR]: 1.05, 95% CI [1.01, 1.09]) and 9% more chronic diseases (aIR: 1.09, 95%CI [1.06, 1.12]) than those with no ACEs. There was a clear dose-response relationship, such that participants with the maximum of three ACEs had 20% higher allostatic load and 25% more chronic diseases in adulthood than those with no ACEs. Neuroticism mediated and moderated the association of any ACEs with chronic diseases, accounting for approximately 44% of this ACE-morbidity association.</p><p><strong>Conclusions: </strong>ACEs are associated with higher allostatic load and morbidity, with neuroticism both mediating and moderating the ACE-morbidity association. Research is needed to determine whether and, if so, when interventions targeting neuroticism may help mitigate the substantial burden of ACEs on lifespan health.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149140174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breathing Easy Together: How Positive Airway Pressure Adherence Benefits Both Patients and Partners.","authors":"Wendy M Troxel, Brian R W Baucom, Stevie Shock, Kelly Glazer Baron","doi":"10.1097/PSY.0000000000001475","DOIUrl":"https://doi.org/10.1097/PSY.0000000000001475","url":null,"abstract":"<p><strong>Objectives: </strong>Emerging research highlights the interdependence of sleep within couples and the impact of sleep disorders on couples' relationship quality; however, most sleep treatments are focused solely on the individual. WePAP is a dyadic, behavioral treatment to promote positive airway pressure (PAP) adherence in patients with obstructive sleep apnea (OSA) and sleep quality in both patients and partners. This analysis examines the impact of WePAP compared to Information Control (IC) on the couples' relationship quality. Across treatment conditions, we examined whether greater PAP adherence associates with better sleep and relationship quality, higher quality of life (QOL) and lower depression in both patients and partners.</p><p><strong>Methods: </strong>Patients who were diagnosed with OSA and prescribed PAP and their partners were randomly assigned to WePAP or information control (IC). Relationship quality (satisfaction and conflict), QOL, and depression were assessed in both partners via validated questionnaires at baseline and at 3-months. Sleep duration and efficiency were assessed via one-week of actigraphy in both partners. Primary analyses evaluated changes over time and between-group differences in relationship quality, from baseline to 3-month follow-up. Secondary analyses employed mixed models to assess whether greater patient PAP adherence predicts better relationship quality, mental health, and QoL, and greater sleep duration and efficiency.</p><p><strong>Results: </strong>The analytic sample included 32 midlife and older adult couples (age m=62.97; SD=9.04). There were no significant within-group or between-group changes in relationship satisfaction or conflict in patients or partners. Greater PAP adherence was associated with higher levels of relationship satisfaction and QOL and lower levels of relationship conflict and depressive symptoms, and shorter sleep duration for patients and partners.</p><p><strong>Conclusions: </strong>Identifying the dyadic effects of sleep apnea treatment on both partners' wellbeing may serve as a compelling motivator to encourage adherence to PAP therapy.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149130106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental Health, Type D Personality, Health Status, and Recurrent Health Care Utilization in Patients With Nonobstructive Coronary Artery Disease.","authors":"Paula M C Mommersteeg, Nina Kupper, Carmen Siebers, Jos Widdershoven, Paul Lodder","doi":"10.1097/PSY.0000000000001519","DOIUrl":"https://doi.org/10.1097/PSY.0000000000001519","url":null,"abstract":"<p><strong>Objective: </strong>Recurrent cardiac health care utilization (HCU) is common in patients with nonobstructive coronary artery disease (NOCAD), yet long-term mental health, personality, and health status contributing to repeated emergency department visits (ED) and diagnostic testing remain unclear. This study examined 10-year patterns and predictors of recurrent cardiac HCU in patients with NOCAD.</p><p><strong>Methods: </strong>In total 546 patients (52% women) were followed with ED visits or repeat diagnostic tests. Baseline assessments included anxiety, depressive symptoms, type D personality, fatigue, health status, and disease-specific quality of life. Negative binomial regression evaluated associations between baseline mental health and health status and total HCU, with adjustment for age, sex, education, obesity, diabetes, and major adverse cardiac events (MACE). Sex-stratified and MACE-stratified analyses were explored.</p><p><strong>Results: </strong>During follow-up, 24% of the patients experienced a single, and 26% multiple HCU. Higher anxiety, fatigue, poorer physical health, more frequent angina, and lower quality of life were associated with greater HCU, in age and sex-adjusted models. After full adjustment, lower baseline quality of life, diabetes, and subsequent MACE remained independent predictors. Sex-stratified analyses showed that baseline angina frequency and lower quality of life predicted HCU in women. Most patients with recurrent HCU did not develop MACE, suggesting that subjective symptom burden, rather than disease progression, was the main driver of long-term HCU.</p><p><strong>Conclusions: </strong>Recurrent HCU is frequent in NOCAD and is strongly influenced by baseline quality of life and cardiometabolic risk. These findings highlight the need to address symptom burden in NOCAD to reduce recurrent testing and improve long-term outcomes.</p><p><strong>Clinical trial registration: </strong>ClinicalTrials.gov (NCT01788241) https://clinicaltrials.gov/study/NCT01788241.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":"88 8","pages":"703-712"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149122507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Article Summaries for October 2026 Biopsychosocial Science and Medicine , Volume 88, Issue 8.","authors":"","doi":"10.1097/PSY.0000000000001529","DOIUrl":"https://doi.org/10.1097/PSY.0000000000001529","url":null,"abstract":"","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":"88 8","pages":"655"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149122480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Short-Term Psychological Intervention on Depression Dynamics in Aortic Stenosis Patients Undergoing Transcatheter Aortic Valve Implantation.","authors":"Laura Bäz, Claudia Lasch, Kristina Noeh, Jenny Rosendahl, Peter Schlattmann, P Christian Schulze, Bernhard Strauss, Gudrun Dannberg, Marcus Franz","doi":"10.1097/PSY.0000000000001513","DOIUrl":"10.1097/PSY.0000000000001513","url":null,"abstract":"<p><strong>Objective: </strong>Because depression has been identified as a relevant comorbidity in cardiovascular patients, we aimed to assess the impact of a brief expectation-focused psychological intervention on depression dynamics in aortic stenosis patients undergoing transcatheter aortic valve implantation (TAVI).</p><p><strong>Methods: </strong>From 82 TAVI patients showing a Hospital Anxiety and Depression Scale (HADS-D) score ≥8 points for depression, 74 patients underwent 1:1 randomization, with 38 assigned to the control (CON; treatment as usual) and 36 to the intervention (INT; psychological short-term intervention) group. The psychological intervention consisted of 2 individual sessions before and 2 booster sessions after TAVI. Per protocol, the HADS-D score for depression at 6 months was defined as the primary outcome and compared with baseline between the CON and the INT group by using analysis of covariance (ANCOVA).</p><p><strong>Results: </strong>Regarding the primary outcome measure, there was a mean HADS-D depression score of 10.76 (SD: 2.77) at baseline and 9.44 (SD: 4.56) at 6 months after TAVI in the CON group and of 9.86 (SD: 2.0) at baseline and 7.5 (SD: 3.15) at 6 months after TAVI in the INT group. ANCOVA did not show a significant effect of the psychological short-term interventions versus control (estimate=-1.67; 95% CI=-3.64 to -0.29) on depression dynamics 6 months after TAVI, adjusted for baseline HADS-D.</p><p><strong>Conclusions: </strong>An effect of a psychological intervention on depression dynamics could not be shown. However, there was an improvement in depression at 6 months after TAVI, which is probably due to a decline in heart failure symptoms.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"699-702"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148537969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Racial Group Differences in NREM Sleep Physiology Contribute to Memory Vulnerability.","authors":"Lauren N Whitehurst, Jillian R Silva-Jones, Andrew D Krystal, Wendy B Mendes, Aric A Prather","doi":"10.1097/PSY.0000000000001512","DOIUrl":"10.1097/PSY.0000000000001512","url":null,"abstract":"<p><strong>Objective: </strong>Racial sleep disparities may lead to long-term cognitive health consequences, with a specific impact on memory formation and maintenance. Few studies have examined the physiological sleep features, including nonrapid eye movement (NREM) stage 2 and 3 sleep and the corresponding electroencephalographic activity indicative of these stages (ie, delta oscillations 0.5 to 4 Hz), that are sensitive to racial stress and result in memory vulnerability, which is the goal of this investigation.</p><p><strong>Methods: </strong>We assessed self-report and polysomnographic indices of sleep, psychosocial outcomes, and memory performance in a sample of young, Black ( n =63) and White ( n =77) adults living in the United States.</p><p><strong>Results: </strong>Black participants self-reported more experiences of discrimination, lower incomes, perceived social status, and educational attainment, as well as worse subjective sleep quality. Racial group membership was associated with differential presleep memory profiles for both neutral and negatively valenced word pairs; however, memory disparities were attenuated after accounting for sociodemographic and psychosocial factors. Overnight sleep architectural differences emerged, with Black participants spending more time in stage 2 sleep, less time in stage 3 sleep, and having reduced NREM delta power when compared with White participants. NREM delta activity was a significant mediator of racial group membership and postsleep memory performance, especially for negative valenced word pairs.</p><p><strong>Conclusion: </strong>These findings suggest that known racial sleep disparities likely lead to daily, measurable deficits in memory for Black Americans and that NREM delta activity may be a uniquely sensitive biopsychosocial factor that can support cognitive resilience for those experiencing racialized contexts.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"677-688"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13623063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148581647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Depressive Symptoms With COVID-19 Hospitalization or Death: The C4R Study.","authors":"Elizabeth C Oelsner, Yifei Sun, Pallavi P Balte, Norrina B Allen, Howard Andrews, April P Carson, Yuni Choi, Shelley A Cole, Talea Cornelius, David Couper, Mary Cushman, Martha Daviglus, Mitchell S V Elkind, Linda C Gallo, Jose D Gutierrez, Virginia J Howard, Carmen R Isasi, Yiqun Jin, Suzanne E Judd, Alka M Kanaya, Namratha R Kandula, Robert C Kaplan, Gregory L Kinney, Anna M Kucharska-Newton, Daniel T Lackland, Joyce S Lee, Barry J Make, Yuan-I Min, Joanne M Murabito, Arnita F Norwood, Victor E Ortega, Kelley Pettee Gabriel, Bruce M Psaty, Elizabeth A Regan, Daniela Sotres-Alvarez, David Schwartz, James M Shikany, Bharat Thyagarajan, Jason G Umans, Vasan S Ramachandran, Tianyou Wang, Sally E Wenzel, Prescott G Woodruff, Chaoqi Wu, Vanessa Xanthakis, Ying Zhang, Wendy S Post, Ryan T Demmer","doi":"10.1097/PSY.0000000000001509","DOIUrl":"10.1097/PSY.0000000000001509","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the relationship between depressive symptoms and risk for COVID-19 hospitalization and death in a US general population-based sample.</p><p><strong>Methods: </strong>We studied participants enrolled in observational NIH-funded cohorts from 1971 to 2010 with ongoing follow-up through 2023. Prepandemic Centers for Epidemiologic Studies Depression (CES-D) 10-item scale scores ≥10 defined elevated depressive symptoms. Questionnaires, medical records, and death certificates classified incidents of COVID-19 as severe (hospitalized/fatal) or nonsevere from April 2020 through February 2023.</p><p><strong>Results: </strong>Of 33,565 participants, 633 (1.9%) had incident severe COVID-19 over a mean (SD) follow-up of 453 (207) days. Elevated prepandemic depressive symptoms were present in 4922 (16.3%) of participants. Elevated prepandemic depressive symptoms increased the hazard of severe COVID-19 in fully adjusted (aHR=1.27; 95% CI=1.03-1.57) models. In sex-stratified models ( p -interaction=.03), elevated depressive symptoms increased the hazard in women (aHR=1.49; 95% CI=1.17-1.90) but not in men (aHR=0.96; 95% CI=0.67-1.39).</p><p><strong>Conclusions: </strong>Prepandemic depressive symptoms were associated with increased risk of severe COVID-19 among women in a large US general population-based study of adults, and associations in men were neither confirmed nor ruled out. These results support current CDC recommendations that depression be considered an underlying medical condition associated with a higher risk for severe COVID-19 and suggest that increased clinical focus on risk mitigation for COVID-19 and other acute respiratory infections among patients with depressive symptoms is warranted.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"666-676"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148877150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular Stress Physiology and Interoceptive Pathways to Brain Aging and Health.","authors":"Peter J Gianaros","doi":"10.1097/PSY.0000000000001510","DOIUrl":"10.1097/PSY.0000000000001510","url":null,"abstract":"<p><strong>Objective: </strong>Individuals with a phenotypic tendency to react to acute psychological stressors with large and prolonged rises in blood pressure (stressor-evoked blood pressure reactivity) may be at risk for hypertension and adverse cardiovascular outcomes. The latter outcomes themselves drive cerebrovascular disease and later-life dementias. At issue here is the plausibility of whether stressor-evoked blood pressure reactivity could be considered as a form of cardiovascular stress physiology that relates to cerebrovascular disease and dementia vulnerability via \"bottom-up\" or interoceptive pathways of the brain-heart axis.</p><p><strong>Method: </strong>This Scientific Spotlight describes a heuristic Neurovascular Burden of Stress hypothesis on cardiovascular physiology and interoceptive pathways to aging-related pathology within the brain.</p><p><strong>Results: </strong>Some evidence in need of replication suggests that stressor-evoked blood pressure reactivity relates to white matter brain lesions; risk for ischemic strokes; and higher rates of vascular determinants of dementia.</p><p><strong>Conclusion: </strong>A new generation of research is needed to understand the interoceptive pathways by which cardiovascular stress physiology could predispose to cerebrovascular disease and dementia, as well as to identify biopsychosocial factors that could be modified to support healthy brain aging.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"656-665"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13623061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148475569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}