Biopsychosocial science and medicine最新文献

{"title":"Cognitive-Behavioral Sleep and Nutritional Intervention Enhances Recovery and Survival in Rectal Cancer Patients Undergoing Abdominoperineal Resection: A Randomized Controlled Trial.","authors":"Gang Wang, Shengjie Pan","doi":"10.1097/PSY.0000000000001468","DOIUrl":"10.1097/PSY.0000000000001468","url":null,"abstract":"<p><strong>Objective: </strong>Patients with rectal cancer undergoing abdominoperineal resection (APR) frequently experience perioperative sleep disturbance and nutritional decline, both linked to impaired recovery, heightened inflammation, and poorer survival. Evidence for combined behavioral sleep and nutritional interventions in this high-risk population is limited.</p><p><strong>Methods: </strong>In this single-center randomized controlled trial, 186 stage I-III rectal cancer patients scheduled for APR were assigned (1:1) to receive standard enhanced recovery after surgery (ERAS) or ERAS plus a structured cognitive-behavioral sleep intervention (CBSI) with individualized nutritional support. Initiated 2 weeks preoperatively and continued for 6 months postoperatively, the program included cognitive restructuring, stimulus control, sleep restriction, relaxation training, relapse prevention, and tailored nutrition plans. The primary outcome was the change in the Pittsburgh Sleep Quality Index (PSQI) at 6 months. Secondary outcomes were Hospital Anxiety and Depression Scale (HADS) scores, inflammatory markers (IL-6, CRP), and 2-year disease-free survival (DFS) and overall survival (OS).</p><p><strong>Results: </strong>Compared with controls, the intervention group showed greater PSQI improvement at 6 months (-3.8, 95% CI=-4.5 to -3.1, p <.001), with benefits sustained at 12 months. Reductions in HADS-anxiety (-2.1, p <.001) and HADS-depression (-2.3, p <.001) were observed, along with lower IL-6 and CRP at 3 months. Two-year DFS (88.2% vs. 74.2%, p =.018) and OS (92.5% vs. 80.6%, p =.024) were higher in the intervention group.</p><p><strong>Conclusions: </strong>Integrating CBSI with nutritional support significantly improved sleep, psychological well-being, inflammation, and survival in rectal cancer patients undergoing APR, supporting its inclusion in perioperative oncology care.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"264-273"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146129056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Major Lifetime Discrimination Exposure Accelerates Brain Microstructural Aging: Diffusion MRI Evidence From MIDUS.","authors":"Ajay Kumar Nair, Nagesh Adluru, Anna J Finley, Lauren K Gresham, Sarah E Skinner, Steven R Kecskemeti, Andrew L Alexander, Richard J Davidson, David R Williams, Carol D Ryff, Stacey M Schaefer","doi":"10.1097/PSY.0000000000001467","DOIUrl":"10.1097/PSY.0000000000001467","url":null,"abstract":"<p><strong>Objective: </strong>Experiencing discrimination is associated with faster biological aging, as reflected in telomere shortening and DNA methylation. However, the impact of discrimination on brain aging processes remains unclear. Here, we tested whether individuals who reported at least one major lifetime discrimination event would exhibit steeper age-related associations in microstructural metrics within whole-brain white matter and the hippocampus, consistent with accelerated brain microstructural aging, compared with those with no such experiences.</p><p><strong>Methods: </strong>We analyzed multi-shell diffusion-weighted MRI data from the Midlife in the United States (MIDUS) cohort ( n =147, mean age=65 years, range: 48 to 95 years) to assess brain microstructure using complementary statistical and biophysical diffusion models. Diffusion kurtosis imaging representation was used to derive diffusion tensor imaging (DTI) and white matter tract integrity (WMTI) measures. Additional microstructural health indices were derived using the neurite orientation dispersion and density imaging (NODDI) model. Permutation analyses of linear models were run within the whole-brain white matter and bilateral hippocampi, adjusting for sex, race, and education.</p><p><strong>Results: </strong>Participants who reported at least one major discriminatory experience during their lifetime exhibited accelerated age-associated changes in white matter microstructural measures, including higher mean and radial diffusivities, extra-axonal radial diffusivity, and free water fraction compared with those with no such experiences.</p><p><strong>Conclusions: </strong>These converging findings from complementary measures of brain microstructure suggest that major discrimination experiences may contribute to accelerated brain microstructural aging.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"297-309"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13003999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146129021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular and Circulatory Responses to Acute Mental Stress Among Individuals With Ischemic Cardiomyopathy.","authors":"Kasra Moazzami, Maggie Wang, Alireza Rahbar, Brad D Pearce, Amit J Shah, Yan V Sun, Yi-An Ko, Paolo Raggi, J Douglas Bremner, Viola Vaccarino, Arshed A Quyyumi","doi":"10.1097/PSY.0000000000001464","DOIUrl":"10.1097/PSY.0000000000001464","url":null,"abstract":"<p><strong>Objective: </strong>We studied responses to acute mental stress in individuals with stable coronary artery disease (CAD) with and without heart failure with reduced ejection fraction (HFrEF).</p><p><strong>Methods: </strong>Individuals with stable CAD ( N = 313, 45 with HFrEF) underwent a laboratory-based mental stress. HFrEF was defined as an ejection fraction of <40%. Hemodynamic reactivity and vasoconstriction during mental stress were evaluated using changes in systolic blood pressure and peripheral arterial tonometry, respectively. Immune function was assessed by measuring changes in interleukin-6 (IL-6) and circulating progenitor cell counts enumerated using flow cytometry of CD34-expressing mononuclear cells before and 90 minutes after mental stress.</p><p><strong>Results: </strong>During the mental stress testing, patients in the HFrEF exhibited a smaller (blunted) increase in systolic blood pressure compared with the non HFrEF group (30.4 ± 14.1 vs 41.9 ± 16.1 mm Hg, p < .001), greater vasoconstriction (PAT ratio 0.69 ± 0.30 vs 0.83 ± 0.40, p = .02), a larger increase in IL-6 levels (0.91 ± 0.11 vs 0.42 ± 0.14 pg/mL, p = .01), and larger increases in circulating progenitor cell counts (0.68 ± 0.12 vs 0.22 ± 0.11 cell/L, p = .009). After adjustment for demographic and traditional risk factors, each of these 4 maladaptive stress responses remained independently associated with the presence of HFrEF.</p><p><strong>Conclusions: </strong>Among individuals with stable CAD, the presence of HFrEF was independently associated with a blunted systolic blood pressure response, greater vasoconstriction, increased inflammation, and enhanced progenitor cell mobilization with mental stress, a response that is associated with adverse long-term outcomes.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"334-340"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Pilot Study of the Real-World Impact of Digital Cognitive Behavioral Therapy for Inflammatory Bowel Disease (COMPASS-IBD) on Inflammation, Disease Activity, and Healthcare Use.","authors":"Natasha Seaton, Sophie Harding, Annie S K Jones, Tsz Wai Chow, Valeria Mondelli, Joanna L Hudson, Rona Moss-Morris","doi":"10.1097/PSY.0000000000001457","DOIUrl":"10.1097/PSY.0000000000001457","url":null,"abstract":"<p><strong>Objective: </strong>Inflammatory bowel disease (IBD) is commonly accompanied by psychological distress, which may worsen disease activity through gut-brain axis mechanisms. Psychological interventions including cognitive behavioral therapy (CBT) seem to reduce distress and inflammation in IBD. However, accessibility to psychological care remains limited. COMPASS-IBD, a digital CBT intervention tailored to IBD, aims to address these gaps.This nested exploratory, real-world study (NCT05330299) assessed the effectiveness of COMPASS-IBD in reducing inflammation, disease activity, and health care use in IBD patients. In addition, it examined relationships between changes in psychological distress and disease indicators.</p><p><strong>Methods: </strong>Adults with IBD experiencing psychological distress were recruited from a large gastroenterology service, and enrolled in COMPASS-IBD. Disease-related primary outcomes were faecal calprotectin (FCP), C-reactive protein (CRP), and self-reported disease activity (SRDA). Secondary outcomes included other inflammatory biomarkers (neutrophils, monocytes, lymphocytes, white blood cells (WBC), ferritin, flare frequency, and health care usage. The Patient Health Questionnaire-Anxiety and Depression Scale (PHQ-ADS) measured distress. Mixed-effects models evaluated outcomes at baseline, 12 weeks, and 6 months.</p><p><strong>Results: </strong>Sixty-five participants were included. There were significant reductions in CRP ( d range: -0.47 to -0.53, P <.01), but not FCP ( d range: -0.38 to -0.44, P <.10) or SRDA ( d =-0.28, P =.08). Significant improvements were observed in WBC and neutrophil counts ( P <.05), flare frequency ( P <.01), and psychological distress ( P <.001). Some types of health care usage were reduced ( P <.05). Associations between distress and primary outcomes were nonsignificant.</p><p><strong>Conclusions: </strong>This pilot suggests COMPASS-IBD may reduce inflammation levels, health care use, and psychological distress. However, analyses were underpowered. Larger randomized trials are needed to confirm findings, establish cost-effectiveness, and explore underlying gut-brain mechanisms.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"274-286"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13043230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145807209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimentally Induced Post-Event Rumination Alters Biological Stress Response Patterns to Repeated Stress.","authors":"Johanna Janson-Schmitt, Jesaja Haessner, Reimar Moeller, Nicolas Rohleder","doi":"10.1097/PSY.0000000000001458","DOIUrl":"10.1097/PSY.0000000000001458","url":null,"abstract":"<p><strong>Objective: </strong>Rumination-the repetitive negative thinking about stressful events-impairs biological stress system activity. However, its impact on the habituation of stress responses, particularly of the sympathetic nervous system (SNS) and hypothalamus-pituitary-adrenal (HPA) axis, remains understudied. This study examined how post-event rumination affects the habituation of biological responses to repeated stress.</p><p><strong>Methods: </strong>In this randomized experimental study, 47 participants were assigned to a rumination or control condition and exposed to two consecutive stress tasks. After the first stress exposure, the rumination group engaged in guided post-event rumination, while the control group reflected on a neutral everyday topic. Biological markers of HPA axis (cortisol) and SNS activity (salivary alpha-amylase, sAA), as well as psychological variables (positive and negative affect, state rumination), were assessed before and after each stressor.</p><p><strong>Results: </strong>Compared with the control group, participants in the rumination condition showed reduced habituation of HPA axis activity ( t(45) =-2.01, p =.025) and increased SNS activation over time, as indicated by rising sAA levels ( t(45) =-2.03, p =.024). No significant group differences were observed in self-reported affect or state rumination.</p><p><strong>Conclusions: </strong>Post-event rumination impairs biological habituation to repeated stress. These findings suggest that rumination disrupts physiological stress adaptation, which may contribute to prolonged stress responses and increased risk for stress-related health problems. Interventions targeting rumination may support more adaptive stress regulation and promote better health outcomes.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"322-333"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147350108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut Microbiota and Psychological Distress in Fibromyalgia: A Systematic Review.","authors":"Roberta Lanzara, Chiara Conti, Luigia Zito, Federico Anaclerio, Gianna Pia Affaitati, Maria Adele Giamberardino, Liborio Stuppia, Piero Porcelli","doi":"10.1097/PSY.0000000000001463","DOIUrl":"10.1097/PSY.0000000000001463","url":null,"abstract":"<p><strong>Objective: </strong>This systematic review aimed to summarize the recent evidence of the relationship between gut microbiota and psychological distress in patients with fibromyalgia (FM).</p><p><strong>Methods: </strong>According to PRISMA guidelines, we conducted a systematic search of the literature on PubMed, Scopus, EBSCO, Web of Science, and Cochrane. The records were selected using multiple combinations of relevant search terms involving microbiota, psychological distress, and FM. Articles in English with human participants were reviewed.</p><p><strong>Results: </strong>The initial search identified 135 records, excluding duplicates, of which 10 research reports met the predefined inclusion criteria and were analyzed. Most studies ( n = 7) were case-control, 2 were randomized controlled trials, and 1 was observational. Most studies found an imbalance in the gut microbial communities of FM patients and a significant difference between FM patients and HC in microbiome composition/diversity or gut permeability. Intestinal dysbiosis and gut permeability were also associated with high psychological distress (emotional, cognitive, and somatic symptoms).</p><p><strong>Conclusions: </strong>Alterations in the gut microbiota of FM patients seem to support the hypothesis that gut-brain axis regulation is impaired in stress-related pain conditions. Although the results are promising, further studies are needed to clarify the role of the microbiota-gut-brain axis in the pathophysiological mechanisms underlying FM.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"287-296"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145937337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Article Summaries for April 2026 Biopsychosocial Science and Medicine, Volume 88, Issue 3.","authors":"","doi":"10.1097/PSY.0000000000001480","DOIUrl":"https://doi.org/10.1097/PSY.0000000000001480","url":null,"abstract":"","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147597397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Interventions to Promote Physical Health: A Fresh Look with an Emphasis on Primary Prevention in the Early Family Environment.","authors":"Bert N Uchino","doi":"10.1097/PSY.0000000000001471","DOIUrl":"https://doi.org/10.1097/PSY.0000000000001471","url":null,"abstract":"<p><strong>Objective: </strong>Relationship processes such as social support have been reliably related to physical health outcomes and the focus of intense intervention efforts. This paper emphasizes the potential of early family primary prevention efforts to improve physical health outcomes across the lifespan.</p><p><strong>Method: </strong>Selective narrative review of the literature.</p><p><strong>Results: </strong>Primary prevention efforts can capitalize on lifespan models that highlight the importance of the early family environment. Preliminary studies are consistent with the promise of such approaches in altering health-relevant biological pathways in the child.</p><p><strong>Conclusions: </strong>Relationship and health interventions that focus on primary prevention are underutilized and should receive greater attention given its potential long-term impacts on psychosocial processes, biological function, and physical health.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148335596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Article Summaries for February-March 2026 Biopsychosocial Science and Medicine, Volume 88, Issue 2.","authors":"","doi":"10.1097/PSY.0000000000001470","DOIUrl":"https://doi.org/10.1097/PSY.0000000000001470","url":null,"abstract":"","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":"88 2","pages":"135-136"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146129060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Immediate Effects of a Resonant Breathing Exercise on Adolescents' Stress Responses: A Randomized Trial.","authors":"Nathalie Michels, Marie-Anne Vanderhasselt, Jolien Braet, Janne Vreye, Riet Vergauwe, Jente Depoorter, Matteo Giletta","doi":"10.1097/PSY.0000000000001448","DOIUrl":"10.1097/PSY.0000000000001448","url":null,"abstract":"<p><strong>Objective: </strong>This single-blind randomized controlled laboratory experiment investigated the impact of resonant breathing on adolescents' autonomic nervous system (ANS) and affective responses to a standardized acute stressor.</p><p><strong>Methods: </strong>Adolescents ( n = 150, aged 12 to 13 years, 40% boys) were randomized into 2 conditions: resonant breathing (RB condition) or spontaneous breathing (active control condition), both with visual guidance. In this registered report ( https://osf.io/8swdp ), mixed-effects models compared conditions on cardiac ANS (heart rate variability RMSSD, preejection period PEP) and affective responses (positive and negative affect) to the trier social stress test, across reactivity and recovery phases. In addition, conditions were compared on rumination and reappraisal use.</p><p><strong>Results: </strong>The determined resonant rate showed a narrow interquartile range (6.2 to 6.7 breaths/min) and proved difficult to sustain during the 10-minute exercise. The RB intervention significantly reduced breathing rate (Cohen d = -4.69) and increased RMSSD during the breathing phase ( d = 1.68). Compared with the control condition, PEP reactivity to the stressor was attenuated in the RB condition ( d = 0.32), supporting a protective effect. Unexpectedly, RMSSD stress reactivity was more pronounced in the RB condition ( d = -1.37), though this effect diminished in sensitivity analyses, suggesting regression to the mean. Exploratory analyses indicated that among adolescents with lower trait stress-related symptoms, RB reduced RMSSD stress reactivity relative to baseline ( d = 0.75). No differences between conditions were found in affective responses, emotion regulation, or stress recovery.</p><p><strong>Conclusions: </strong>The findings only partially support the hypothesis that RB buffers physiological stress reactivity, with no observed effects on affect or recovery. Repeated training may be essential for achieving the resonant rate and potentially enhancing stress-buffering capacity.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"166-178"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145553076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}