Biopsychosocial science and medicine最新文献_第2页

Posttraumatic Stress Disorder, Obesity, and Epigenetic Aging: A Replication Study in 1828 Veterans. 创伤后应激障碍、肥胖和表观遗传衰老：1828名退伍军人的重复研究。

Biopsychosocial science and medicine Pub Date : 2025-07-01 Epub Date: 2025-05-07 DOI: 10.1097/PSY.0000000000001397

Kyle J Bourassa, Melanie E Garrett, Allison E Ashley-Koch, Jean C Beckham, Nathan A Kimbrel

{"title":"Posttraumatic Stress Disorder, Obesity, and Epigenetic Aging: A Replication Study in 1828 Veterans.","authors":"Kyle J Bourassa, Melanie E Garrett, Allison E Ashley-Koch, Jean C Beckham, Nathan A Kimbrel","doi":"10.1097/PSY.0000000000001397","DOIUrl":"10.1097/PSY.0000000000001397","url":null,"abstract":"Objective: Posttraumatic stress disorder (PTSD) is associated with poor health, and prior research suggests that accelerated epigenetic aging could help explain this association. A recent study found that veterans with both PTSD and obesity had greater risk for accelerated epigenetic aging compared with those with either PTSD or obesity individually, or neither condition. The objective of this study was to conduct a replication and extension of this prior work.Methods: This study included models approximating the recent study's analytic approach in a sample of 1828 post-9/11 veterans. Our extension also included additional aging measures (PC-GrimAge and DunedinPACE), a more diverse sample, additional covariates (chronological age, smoking), and use of continuous measures of PTSD, obesity, and accelerated aging.Results: In contrast with the original report, we did not find evidence that obesity moderated the association of PTSD and aging, indicating that veterans with both conditions had greater risk for accelerated aging. Although several significant interactions were observed, they were in the opposite direction of the original study findings (ie, PTSD was more strongly associated with aging scores among veterans with less body mass). Our results instead demonstrated that PTSD was associated with accelerated aging across all continuously measured aging scores (0.08 ≤all βs ≤0.10), and that obesity was associated with faster DunedinPACE aging scores [β=0.36, 95% CI (0.28, 0.44)].Conclusions: Our findings provide additional evidence that PTSD and obesity may be useful targets for interventions aiming to slow aging and improve health.","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"355-361"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144311173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Personality Traits and the Risk of Osteoporosis in 3 Longitudinal Samples. 三个纵向样本的人格特征与骨质疏松风险。

Biopsychosocial science and medicine Pub Date : 2025-07-01 Epub Date: 2025-05-20 DOI: 10.1097/PSY.0000000000001404

Yannick Stephan, Angelina R Sutin, Brice Canada, Antonio Terracciano

{"title":"Personality Traits and the Risk of Osteoporosis in 3 Longitudinal Samples.","authors":"Yannick Stephan, Angelina R Sutin, Brice Canada, Antonio Terracciano","doi":"10.1097/PSY.0000000000001404","DOIUrl":"10.1097/PSY.0000000000001404","url":null,"abstract":"Objective: Osteoporosis is a prevalent age-related condition with significant individual and economic costs. Identifying factors implicated in the risk of osteoporosis is thus critical to designing effective preventive actions and interventions. This study examined the cross-sectional and prospective associations between the 5 major personality traits and the risk of osteoporosis.Methods: Participants were older adults aged 50 to 104 years ( N >20,000) from the Health and Retirement Study, the English Longitudinal Study of Ageing, and the National Health and Aging Trends Study. Baseline measures of personality traits, demographic, clinical, and behavioral factors were obtained in the 3 samples. Data on osteoporosis diagnosis were reported at baseline and up to 10 years later.Results: Random effect meta-analyses indicated that higher neuroticism was related to a higher risk of concurrent [odds ratios (OR)= 1.16, 95% CI: 1.11-1.21] and incident [hazard ratios (HR)= 1.18, 95% CI: 1.13-1.24] osteoporosis, whereas higher extraversion and higher conscientiousness were associated with a lower risk of concurrent (OR: 0.91, 95% CI: 0.85-0.97 and OR: 0.93, 95% CI: 0.89-0.98, respectively) and incident (HR: 0.92, 95% CI: 0.85-1.00 and HR: 0.91, 95% CI: 0.84-0.98, respectively) osteoporosis. Openness and agreeableness were unrelated to osteoporosis. Chronic conditions, BMI, physical activity, and smoking partly explained these associations. There was little replicable evidence for moderation by age and sex.Conclusions: Consistent with other chronic conditions, this multicohort study provides novel evidence that higher neuroticism is a vulnerability factor for osteoporosis, whereas extraversion and conscientiousness are protective.","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"372-379"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute Active, but not Passive, Psychological Stress Increases non-classical Monocyte Proportions. 急性主动，而非被动，心理应激增加非经典单核细胞比例。

Biopsychosocial science and medicine Pub Date : 2025-06-20 DOI: 10.1097/PSY.0000000000001416

Victoria G Linsley, Nicolette C Bishop, Matthew J Roberts, Nicola J Paine

{"title":"Acute Active, but not Passive, Psychological Stress Increases non-classical Monocyte Proportions.","authors":"Victoria G Linsley, Nicolette C Bishop, Matthew J Roberts, Nicola J Paine","doi":"10.1097/PSY.0000000000001416","DOIUrl":"https://doi.org/10.1097/PSY.0000000000001416","url":null,"abstract":"Objective: Psychological stress exposure is a modifiable risk factor for cardiovascular disease (CVD), possibly through promoting a heightened inflammatory milieu. Under psychological stress, changes in monocyte subsets from classical (CM) to intermediate (IM) and non-classical (NCM) could indicate a more pro-inflammatory environment. We investigated the impact of acute psychological stress (active and passive) on monocyte subsets and leukocyte count ratios.Methods: Twenty-four participants completed a 20-min baseline period, followed by a passive (International Affective Picture System: IAPS) and active stress task (socially evaluative Paced Auditory Serial Addition Test: PASAT) with 90-min recovery after each task. Blood samples were collected to determine changes in: CM, IM and NCM count/proportions, systemic inflammation response index (SIRI) and neutrophil:lymphocyte ratio (NLR).Results: CM proportions decreased (89.4% to 87.0%; P=0.007) and NCM proportions increased (6.8% to 2.1%; P=0.035) from baseline to immediately post-PASAT. There were no differences in monocyte subsets from baseline to post-IAPS (CM% P>0.99; IM% P=>0.99; NCM% P>0.99). NLR and SIRI did not differ from baseline in response to either the PASAT or IAPS (P>0.05).Conclusion: Acute active, but not passive, psychological stress promoted a transition in monocyte subsets towards a more pro-inflammatory environment, which may be an important advancement in markers used to assess the inflammatory response to acute psychological stress.","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144562577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Additive Contributions of Polygenic Risk Scores and Interpersonal Stressors to Adolescent Body Mass Index. 多基因风险评分和人际压力因素对青少年体重指数的加性贡献。

Biopsychosocial science and medicine Pub Date : 2025-06-17 DOI: 10.1097/PSY.0000000000001414

Krista M Ekberg, Giorgia Michelini, Kristin L Schneider, Anna R Docherty, Andrey A Shabalin, Greg Perlman, Roman Kotov, Daniel N Klein, Monika A Waszczuk

{"title":"Additive Contributions of Polygenic Risk Scores and Interpersonal Stressors to Adolescent Body Mass Index.","authors":"Krista M Ekberg, Giorgia Michelini, Kristin L Schneider, Anna R Docherty, Andrey A Shabalin, Greg Perlman, Roman Kotov, Daniel N Klein, Monika A Waszczuk","doi":"10.1097/PSY.0000000000001414","DOIUrl":"https://doi.org/10.1097/PSY.0000000000001414","url":null,"abstract":"Objective: Genetics contribute to elevated body mass index (BMI) in youth. Adolescents experiencing interpersonal stressors (e.g., peer victimization or parental criticism) may additionally be at a heightened risk for developing high BMI. However, few studies have examined additive contributions of genetic factors and interpersonal stressors to BMI. The current study aimed to address this gap by analyzing associations of BMI with polygenic risk scores (PRS) for BMI and an inflammatory C-reactive protein (CRP), and a range of interpersonal stressors, in a community-based adolescent sample.Methods: 827 adolescents (Mage=13.63, SD=1.01, 76% girls of European ancestry) completed self-report measures of peer victimization and parental criticism at baseline. BMI was assessed on average 2 years after baseline. PRS were calculated using summary statistics from the largest genome-wide association studies of BMI and CRP. Analyses consisted of linear regressions, adjusting for population stratification and demographic characteristics.Results: BMI-PRS and CRP-PRS were independently and significantly associated with BMI (β=0.20 and β=0.10, P<0.05, respectively). Additionally, greater father criticism at baseline was independently associated with higher phenotypic BMI at follow-up (β=0.12, P<0.05). Peer victimization and maternal criticism were not associated with BMI.Conclusions: Genetic vulnerabilities to high BMI and inflammation, as well as father criticism, were significantly and uniquely associated with BMI in adolescents. The results are consistent with models of additive contributions of genetics and interpersonal stress to health outcomes.","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144311172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Creating Somatic Symptoms in the Lab: Stability and Preditive Validity of Symptoms in the Affect and Symptom Paradigm in a Sample from the General Population Over 18 Months. 在实验室中创造躯体症状：18个月以上的普通人群样本中情感和症状范式中症状的稳定性和预测有效性。

Biopsychosocial science and medicine Pub Date : 2025-06-11 DOI: 10.1097/PSY.0000000000001413

Tara M Petzke, Ferenc Köteles, Omer Van den Bergh, Michael Witthöft

{"title":"Creating Somatic Symptoms in the Lab: Stability and Preditive Validity of Symptoms in the Affect and Symptom Paradigm in a Sample from the General Population Over 18 Months.","authors":"Tara M Petzke, Ferenc Köteles, Omer Van den Bergh, Michael Witthöft","doi":"10.1097/PSY.0000000000001413","DOIUrl":"10.1097/PSY.0000000000001413","url":null,"abstract":"Objective: The Affect and Symptom Paradigm (ASP) is an experimental setup that can reliably provoke somatic symptoms in a laboratory setting through the mere presentation of negative pictures. People with persistent somatic symptoms show characteristic effects in this paradigm, including elevated symptom reports and differential brain pattern activation, which suggests that the ASP might be a valuable diagnostic tool. In this cohort study, we tested the temporal stability and ability of the ASP to predict somatic symptom distress over a longer period of time.Methods: We assessed N =91 participants from the general population (69% female) over two timepoints which were 18 months apart. Participants completed the ASP as well as a questionnaire on somatic symptom distress (PHQ-15). Correlation analyses (Bayesian and frequentist) as well as cross-lagged-panel models (CLPMs) were used to test the temporal stability and cross-lagged associations.Results: In the CLPMs, somatic symptom distress (PHQ-15) at T 1 significantly predicted ASP symptom provocation at T 2 (β=0.22, P =0.029) while controlling for the ASP at T 1 . Moreover, ASP symptom provocation at T 1 significantly predicted cardiorespiratory symptoms (but not overall symptoms) in the PHQ-15 at T 2 (β=0.275, P =0.019). The autoregressive paths indicated moderate-to-high temporal stability (all β>0.27, all P <0.050).Conclusions: The outcome of experimental somatic symptom provocation using the ASP appears stable over time and can significantly predict variability in the experience of cardiorespiratory symptoms (in the PHQ-15) 1.5 years later. Large cohort and intervention studies on chronic somatic symptoms and functional disorders may benefit from including experimental measures such as the ASP.","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144288107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Roles of Gender and Patient versus Caregiver Status in Cardiovascular and Affective Responses to an Induced Stress. 性别和患者与照顾者状态在诱导应激的心血管和情感反应中的作用。

Biopsychosocial science and medicine Pub Date : 2025-06-11 DOI: 10.1097/PSY.0000000000001408

Youngmee Kim, Thomas C Tsai, David Spiegel, Charles S Carver

{"title":"The Roles of Gender and Patient versus Caregiver Status in Cardiovascular and Affective Responses to an Induced Stress.","authors":"Youngmee Kim, Thomas C Tsai, David Spiegel, Charles S Carver","doi":"10.1097/PSY.0000000000001408","DOIUrl":"https://doi.org/10.1097/PSY.0000000000001408","url":null,"abstract":"Objective: Adults with cancer and their family caregivers have displayed compromised cardiovascular functioning and elevated psychological distress, yet the independent and synergistic roles of gender and patient-versus-caregiver status in their cardiovascular and affective stress responses are yet to be elucidated.Methods: Patients newly diagnosed with colorectal cancer (n=118, 56 y old, 36% female, 62% Hispanic, 6.5 mo post-diagnosis) and their spousal caregivers (n=118, 55 y old, 70% female) underwent a stress induction task that is relevant to close relationship and health issues. Cardiovascular-Root Mean Square of the Successive Differences (RMSSD), heart rate (HR), and systolic and diastolic blood pressure (SBP and DBP)- and affective (positive and negative affect, and stress) responses were assessed for its resting, stress reactivity, and recovery patterns.Results: Stress induction was successful noted in both cardiovascular and affective markers. General linear modeling for repeated measures revealed that the synergistic effects of gender and patient-versus-caregiver status in RMSSD, HR, DBP, and positive affect responses (4.180≤F≤8.185, P<0.043), with female caregivers showing the most heightened responses. Caregivers reported greater stress reactivity in negative affect than patients (F=28.046, P<0.001).Conclusions: Findings highlight the independent and synergistic effects of gender and patient-versus-caregiver roles in cardiovascular stress regulation. Findings also suggest the different ways in which gender shapes cardiovascular and affective phenotypes in stress situations, which may impact the etiology and progression of premature morbidities in this vulnerable population.","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144288110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Article Summaries for June 2025 Biopsychosocial Science and Medicine, Volume 87, Issue 5. 《生物心理社会科学与医学》，第87卷，第5期。

Biopsychosocial science and medicine Pub Date : 2025-06-01 Epub Date: 2025-05-20 DOI: 10.1097/PSY.0000000000001409

引用次数: 0

Child Maltreatment and Whole-person Health: Investigation of Psychosocial Buffers Using Structural Equation Modeling. 儿童虐待与全人健康：使用结构方程模型的社会心理缓冲调查。

Biopsychosocial science and medicine Pub Date : 2025-06-01 Epub Date: 2025-04-07 DOI: 10.1097/PSY.0000000000001390

Yanping Jiang, Emily A Brinck, Sarah Ascienzo, Angela Groves, Kathy Trang, Charlotte V Farewell

{"title":"Child Maltreatment and Whole-person Health: Investigation of Psychosocial Buffers Using Structural Equation Modeling.","authors":"Yanping Jiang, Emily A Brinck, Sarah Ascienzo, Angela Groves, Kathy Trang, Charlotte V Farewell","doi":"10.1097/PSY.0000000000001390","DOIUrl":"10.1097/PSY.0000000000001390","url":null,"abstract":"Objective: The purpose of this study was to investigate psychosocial factors that may modify associations between child maltreatment and whole-person health (ie, depressive symptoms, chronic health conditions, psychological well-being, and inflammation).Methods: Data were drawn from a subsample ( N = 1255) of Midlife in the United States study, a national longitudinal study of health and well-being. Structural equation modeling was applied to test hypotheses.Results: Child maltreatment was associated with more depressive symptoms (standardized β = 0.29, p < .001), more chronic health conditions ( β = 0.24, p < .001), poorer psychological well-being ( β = -0.25, p < .001), and elevated C-reactive protein (β = 0.06, p = .041), but not with interleukin-6 (IL-6; β = 0.06, p = .055). There were significant interaction effects between child maltreatment and psychological resources on depressive symptoms (unstandardized b = -0.009, SE = 0.005, p = .045) and IL-6 ( b = -0.001, SE = 0.000, p = .042). Specifically, there were stronger relationships between child maltreatment and more depressive symptoms and elevated IL-6 at low levels of psychological resources than at high levels of psychological resources. There were no statistically significant interaction effects between child maltreatment and social resources on any health outcomes.Conclusions: High levels of psychological resources significantly mitigate the long-term effects of child maltreatment on depressive symptoms and inflammation among middle-aged and older adults.","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"338-348"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Residence in Communities With Higher Violent Crimes Associated With Lower Reward-related Brain Function. 居住在暴力犯罪率较高的社区与较低的奖励相关脑功能有关。

Biopsychosocial science and medicine Pub Date : 2025-06-01 Epub Date: 2025-04-11 DOI: 10.1097/PSY.0000000000001389

Zoe V Adogli, Iris Ka-Yi Chat, Andrew A Gepty, Ann L Carroll, Katherine S F Damme, Carly Flaig, Robin Nusslock, Lauren B Alloy

{"title":"Residence in Communities With Higher Violent Crimes Associated With Lower Reward-related Brain Function.","authors":"Zoe V Adogli, Iris Ka-Yi Chat, Andrew A Gepty, Ann L Carroll, Katherine S F Damme, Carly Flaig, Robin Nusslock, Lauren B Alloy","doi":"10.1097/PSY.0000000000001389","DOIUrl":"10.1097/PSY.0000000000001389","url":null,"abstract":"Objective: A growing body of research suggests that exposure to adversities shapes neural development and function that guide approach motivation and decision-making. Residing in communities with high violent crime is considered a form of adversity. However, its link to brain function is not adequately understood. Furthermore, most of the adversity literature examines individual-level exposure (eg, crime victimization), whereas efforts to consider neighborhood-level factors (eg, neighborhood safety) are sparse. This study examined the hypothesis that late adolescents and emerging adults who lived in a community with higher violent crime rates would exhibit altered reward-related neural activation.Methods: Adolescents ( N = 101; 55% females) participated in the fMRI monetary incentive delay task. Participants' hometown violent crime statistics were extracted from the Federal Bureau of Investigation's Uniform Crime Reports. Multiple regressions examined the association of crime rates with nucleus accumbens (NAc) and orbitofrontal cortex (OFC) activation to reward anticipation or outcome.Results: Living in high-crime communities was associated with lower NAc activation during reward anticipation ( B = -0.041, SE = 0.015, t = -2.695, P = 0.008, adjusted P = 0.032; ΔR2 = 0.061), and not with OFC activation during anticipation, or NAc and OFC activation during outcome.Conclusions: Residence in neighborhoods with high levels of environmental threat, characteristic of high-crime communities, may be linked with blunted NAc reward anticipation. Although living in a high-crime community is a passive form of exposure to adversity, these findings indicate that it may be sufficient to observe distinct individual differences in reward-related brain function.","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"305-315"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Exercise Withdrawal on Stress Reactivity to Repeated Mental and Physical Challenge Tasks. 运动退出对重复精神和身体挑战任务应激反应的影响。

Biopsychosocial science and medicine Pub Date : 2025-06-01 Epub Date: 2025-03-27 DOI: 10.1097/PSY.0000000000001388

Ali A Weinstein, Jenna R Krall, Duua Qureshi, Krish Seth, Ananya Seth, Willem J Kop

{"title":"Effect of Exercise Withdrawal on Stress Reactivity to Repeated Mental and Physical Challenge Tasks.","authors":"Ali A Weinstein, Jenna R Krall, Duua Qureshi, Krish Seth, Ananya Seth, Willem J Kop","doi":"10.1097/PSY.0000000000001388","DOIUrl":"10.1097/PSY.0000000000001388","url":null,"abstract":"Objective: Cessation of exercise has adverse consequences for health. There is a critical gap in the literature on the potential risks of dysregulated reactivity to stressors during periods of inactivity. This study examines experimentally controlled exercise withdrawal (EW) on reactivity to repeated exposure to mental and physical challenge tasks.Methods: Regular exercisers (mean age ± SD: 31 ± 8 y; 55% females) were randomly assigned to either withdraw ( n = 20) or continue ( n = 20) their usual exercise for 2 weeks. Participants took part in 3 study visits during which they performed a mental challenge task (Stroop color-word test: Stroop) and a physical challenge task (cold pressor). Systolic blood pressure (SBP), diastolic blood pressure, and heart rate responses were measured at each visit. Change scores from baseline to peak levels were used to measure reactivity and a linear mixed-effect model was used to estimate the reactivity attenuation over time between the EW and control groups.Results: In response to the Stroop, the magnitude of attenuation over time was larger in the control group than in the EW group across all outcomes and time points. There were statistically significant attenuations in SBP (-8.46 mmHg; CI = -14.5, -2.5), diastolic blood pressure (-5.3 mmHg; CI = -9.5, -1.2), and heart rate (-9.1 bpm; CI = 15.36, -2.92) for the control group compared with only significant attenuations in SBP (-6.9 mmHg; CI = 12.9, -0.9) for the EW group in response to the Stroop. In response to the cold pressor, there were no statistically significant attenuations.Conclusions: This investigation provides evidence that EW interferes with the attenuation of physiological responses to repeated mental challenge tasks.","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"332-337"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143757672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0