Biopsychosocial science and medicine最新文献

{"title":"Cortisol Recovery Differs Among Sexual and Gender Diverse Couples Compared with Cisgender Heterosexual Couples.","authors":"Silke Jacmin-Park, Sophie Bergeron, Robert-Paul Juster","doi":"10.1097/PSY.0000000000001485","DOIUrl":"https://doi.org/10.1097/PSY.0000000000001485","url":null,"abstract":"<p><strong>Objective: </strong>Positive romantic relationships are linked to physical health via stress buffering. A growing number of studies have used the Trier Social Stress Test (TSST) to examine cortisol reactivity and recovery among couples. To date, research has focused on stress-exposed individuals' cortisol output, often neglecting support-providing partners' responses and their contribution to the couple's recovery. Further, beyond documented sex differences in reactive cortisol, gender and sexual orientation have been related to variability in stress reactivity. Yet, sexual and gender diverse (SGD) couples have received little attention among these studies.</p><p><strong>Methods: </strong>One hundred one couples (N=202), including 42 SGD couples, took part in a two-hour laboratory protocol. One partner underwent the TSST and the other acted as a support during filmed discussions before and after the task. Both partners provided seven saliva samples and completed anxiety and sociodemographic measures.</p><p><strong>Results: </strong>Male sex was predictive of stronger cortisol reactivity among stress-exposed participants (βs=.04-.06; ps=.005-.045), whereas female sex was predictive of higher cortisol secretion among supporting partners (βs=.06-.08; ps=.009-.027). Among stress-exposed participants, no difference in total cortisol output was found when comparing gender and sexual orientation subgroups (ps > .14). Notably, SGD couples presented lower cortisol secretion following the TSST than cisgender heterosexual couples (βs=-.03 to -.05; ps=.026-.035).</p><p><strong>Conclusion: </strong>Sex differences were observed among stress-exposed individuals and supporting partners. Critically, SGD couples may uniquely benefit from partner support in recovering from stress when compared with cisgender heterosexual couples.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147794842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between Childhood Adversity and Pain in Breast Cancer Survivors.","authors":"Enya M Daang, Patricia A Ganz, Julienne E Bower","doi":"10.1097/PSY.0000000000001487","DOIUrl":"https://doi.org/10.1097/PSY.0000000000001487","url":null,"abstract":"<p><strong>Objective: </strong>Pain is a prominent symptom in breast cancer survivors, but associated factors are still under investigation. Childhood adversity has been linked to pain in adulthood through emotional and biological pathways but has been relatively unexplored in the context of breast cancer. The current study examines the association between childhood adversity and pain in breast cancer survivors and meditation by ambivalence over emotional expression (hereinafter referred to as emotional ambivalence) and inflammation. We hypothesize a positive association between childhood adversity and pain, mediated by greater emotional ambivalence and higher levels of inflammation.</p><p><strong>Methods: </strong>Women diagnosed with stage 0-IIIA breast cancer completed assessments one year after the completion of primary treatment, including questionnaires assessing childhood adversity (Risky Families), emotional ambivalence (Ambivalence Towards Emotional Expressivity), and pain (SF-36). Blood samples were collected to measure plasma markers of inflammation (IL-1ra, IL-6, CRP, and sTNF-RII).</p><p><strong>Results: </strong>Childhood adversity was significantly associated with greater pain, B=0.36, P=.008, which was significantly mediated by emotional ambivalence, B=0.09, 95%CI [0.02, 0.18]. There were no significant indirect effects through any of the inflammatory markers. We also explored the associations between dimensions of childhood adversity and pain. Similar linear regression and mediation results were found for threat and neglect while there were no significant findings in models examining household chaos.</p><p><strong>Conclusions: </strong>Findings highlight the relevance of childhood adversity as a contributor to persistent pain in breast cancer survivors and identify emotional ambivalence as a key pathway and potential target for intervention.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147794774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Life Witnessing Community Violence and Susceptibility to the Common Cold in Adulthood.","authors":"Yeon Sik Jang, Jessica Chiang","doi":"10.1097/PSY.0000000000001482","DOIUrl":"https://doi.org/10.1097/PSY.0000000000001482","url":null,"abstract":"<p><strong>Objective: </strong>The current study investigated the relationship between witnessing community violence in youth and susceptibility to the common cold in adulthood, using Common Cold Project data.</p><p><strong>Methods: </strong>212 adults (42% female, aged 18 to 55) recalled witnessing community violence in childhood (ages 5, 10, 15) retrospectively, completed other demographic and psychosocial measures, and were then subsequently exposed to a virus that causes the common cold. After exposure, if participants displayed both infection and signs of illness, they were diagnosed with the common cold.</p><p><strong>Results: </strong>Multiple logistic regression analyses showed that witnessing community violence in youth was related to greater susceptibility to the common cold in adulthood, (b(SE)=.75(.30), OR=2.11, 95% CI=1.18, 3.83, P=.012), even when controlling for current socioeconomic status, early socioeconomic status, pre-challenge serostatus, race/ethnicity, age, and sex, as well as other potential confounds (i.e., BMI and season of viral challenge, current health, health behaviors, perceived stress, and early physical, social, and safety of neighborhood environments and stressful home settings).</p><p><strong>Conclusions: </strong>Early witnessing of community violence may be an important variable to consider for determining adult common cold diagnosis.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147680104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosocial and Clinical Correlates of Somatic Symptom Disorder in Patients With and Without Somatic Comorbidities: Cross-sectional Findings from the SOMA.SSD Study.","authors":"Henrike Wittenbecher, Stefanie Hahn, Yvonne Nestoriuc, Kristina Blankenburg, André Strahl, Franz Pauls, Kerstin Maehder, Bernd Löwe, Anne Toussaint","doi":"10.1097/PSY.0000000000001483","DOIUrl":"https://doi.org/10.1097/PSY.0000000000001483","url":null,"abstract":"<p><strong>Objective: </strong>Somatic Symptom Disorder (SSD) is characterized by persistent physical symptoms causing significant distress. Unlike earlier criteria, SSD does not require the absence of other medical conditions, resulting in a heterogeneous patient population. Few studies have systematically compared SSD patients with and without somatic comorbidities. This study examined the frequency of somatic comorbidities in SSD and their associations with psychosocial characteristics and disorder severity.</p><p><strong>Methods: </strong>Cross-sectional data from the SOMA.SSD study were analyzed. SSD was diagnosed via Structured Clinical Interview for The Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5). Somatic comorbidity was assessed with the physician-rated Cumulative Illness Rating Scale (CIRS). Patients with and without somatic comorbidity were compared on psychosocial and clinical variables. Ordinal logistic regression identified factors associated with SSD severity.</p><p><strong>Results: </strong>A total of 241 SSD patients were included from a psychosomatic outpatient clinic (mean age 44.5 y, SD 13.7; 66.8% female). SSD severity was mild in 35.7%, moderate in 38.6%, and severe in 25.7%. Mean CIRS score was 4.4 (SD 3.18; range 0-52), with 61.0% of patients having at least one somatic comorbidity. Patients with somatic comorbidity were older and reported lower physical but higher mental health-related quality of life. Higher health anxiety was associated with greater SSD severity (β=0.287, P<.001), whereas somatic comorbidity was not linked to severity or psychosocial measures.</p><p><strong>Conclusion: </strong>Somatic comorbidities were common in SSD but did not influence severity or psychosocial profile, supporting the validity of the diagnosis independent of physical disease. Health anxiety emerged as a key correlate of severity, highlighting its relevance as treatment target.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147680116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consultation-liaison Psychiatry Interventions: The Sooner, the Better.","authors":"Alice Demesmeaker, Thomas Fovet, Ali Amad, Fabien D'Hondt, Mathilde Horn","doi":"10.1097/PSY.0000000000001484","DOIUrl":"https://doi.org/10.1097/PSY.0000000000001484","url":null,"abstract":"<p><strong>Objective: </strong>Psychiatric disorders are common among general hospital patients. A large study conducted previously showed that timely contact with a consultation-liaison psychiatry (CLP) service is associated with a shorter length of stay (LOS). The aim of this work was to replicate this study with recent data covering the pandemic period to confirm the impact of timely contact with CLP on LOS.</p><p><strong>Methods: </strong>We retrospectively included 2070 patients referred to CLP between 2018 and 2022 at the University Hospital of Lille. General linear models were used to assess associations between the timing of CLP interventions and LOS and to identify predictors of the timing of CLP interventions (e.g., age, sex, type of ward, psychiatric diagnosis, and year of admission).</p><p><strong>Results: </strong>The timing of CLP interventions was significantly positively associated with LOS. Referral time (i.e. log(days before consultation)/log(LOS)) was significantly associated with log-transformed LOS (Model 1: β=0.11, P<.001), and this association remained consistent after adjustment for covariates (Model 2: β=0.13, P<.001). Admissions in 2020 and 2021 were associated with shorter times before CLP interventions (Model 3: β=-0.06, P=.020 and β=-0.06, P=.022, respectively), whereas surgical and intensive care admissions were associated with longer times to consultation (Model 3: β=0.04, P=.036 and β=0.08, P<.001, respectively).</p><p><strong>Conclusions: </strong>The present study confirms that earlier CLP intervention is associated with shorter LOS in general hospitals. Given the current health emergency, it is an opportunity to demonstrate the benefits of early psychiatric consultation to reduce LOS.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147680065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Joint Associations of Type D Personality and Allostatic Load With Coronary Artery Disease in Type 2 Diabetes: Evaluating the Role of Allostatic Load.","authors":"Lin Liu, Ting Han, Qingfang Ye, Yini Wang, Ping Lin","doi":"10.1097/PSY.0000000000001456","DOIUrl":"10.1097/PSY.0000000000001456","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to (1) evaluate and compare the independent associations and predictive strength of type D personality and allostatic load (AL) against traditional risk factors for coronary artery disease (CAD) in patients with type 2 diabetes (T2DM), (2) explore the potential mediating role of AL in the association between type D personality and CAD, and (3) investigate their joint effect on CAD risk.</p><p><strong>Methods: </strong>This cross-sectional study included 1089 patients with diabetes (aged 45 years or more). Type D personality was assessed using the type D scale-14. The AL index comprised 10 biomarkers from cardiovascular, metabolic, and immune systems, selected based on established criteria.</p><p><strong>Results: </strong>Among 1089 patients, 305 (28.0%) had CAD. The XGBoost machine learning model identified both AL and type D personality as factors exhibiting stronger associations with CAD prevalence than most traditional cardiovascular risk factors. Furthermore, mediation analysis revealed a significant indirect effect, suggesting that AL accounted for 16.67% of the observed association between type D personality and CAD. Regarding their combined impact, compared with the reference group (non-type D+low AL), adjusted odds ratios for CAD were 1.68 (95% CI = 1.12-2.52) for type D alone, 1.87 (95% CI = 1.33-2.63) for high AL alone, and 2.74 (95% CI = 1.77-4.25) for both factors combined.</p><p><strong>Conclusions: </strong>AL partially explained the type D-CAD association, and their co-occurrence conferred the highest CAD risk, suggesting potential utility for combined risk stratification.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"341-348"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145656694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social Isolation and Loneliness Elevating Osteoporosis and Fracture Morbidity, Mediated by Frailty and Systemic Inflammation.","authors":"Xin Wang, Xiaowen Ma, Haolong Zhou, Shuo Zheng, Shujie Zhao, Yingxi Wei, Qi Wang","doi":"10.1097/PSY.0000000000001461","DOIUrl":"10.1097/PSY.0000000000001461","url":null,"abstract":"<p><strong>Objective: </strong>Osteoporosis (OP) and fractures impose an increasingly heavy burden on aging populations. The social isolation and loneliness commonly experienced by older adults may influence skeletal health through multiple pathways. Therefore, we aim to examine the associations of social isolation and loneliness with the risk of OP and fractures.</p><p><strong>Methods: </strong>We included 432,635 participants from the UK Biobank cohort, with 14,810 OP and 21,758 fracture incident cases during a 14.8-year (median) follow-up. Associations between social isolation and loneliness with incident OP and fracture risks were analyzed by using Cox regression models. With polygenetic risk scores constructed by genome-wide significant genetic variants, we analyzed joint and interaction effects of social isolation and loneliness and genetic predisposed OP and fracture risk. Mediation effects of frailty and systemic inflammation were also explored.</p><p><strong>Results: </strong>Social isolation and loneliness were associated with increased hazards of OP [hazard ratio (HR)=1.12 (95% CI=1.07-1.19) and 1.19 (1.11-1.28), respectively] and fractures [1.11 (1.07-1.17) and 1.18 (1.12-1.26), respectively]. Genetic predispositions did not modify the associations. Frailty and systemic inflammation mediated their effects with 0.68% to 36.87% of total effects for social isolation, loneliness, and OP, and 0.45% to 23.17% of total effects for social isolation, loneliness, and fractures. Subgroup and sensitivity analyses confirmed the robustness of these findings.</p><p><strong>Conclusion: </strong>Social isolation and loneliness contribute to OP and fracture incidence, partially mediated by frailty and systemic inflammation. Our findings implicated the importance of strengthening social connection and target intervention of against frailty in OP and fracture prevention.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"310-321"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145822401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive-Behavioral Sleep and Nutritional Intervention Enhances Recovery and Survival in Rectal Cancer Patients Undergoing Abdominoperineal Resection: A Randomized Controlled Trial.","authors":"Gang Wang, Shengjie Pan","doi":"10.1097/PSY.0000000000001468","DOIUrl":"10.1097/PSY.0000000000001468","url":null,"abstract":"<p><strong>Objective: </strong>Patients with rectal cancer undergoing abdominoperineal resection (APR) frequently experience perioperative sleep disturbance and nutritional decline, both linked to impaired recovery, heightened inflammation, and poorer survival. Evidence for combined behavioral sleep and nutritional interventions in this high-risk population is limited.</p><p><strong>Methods: </strong>In this single-center randomized controlled trial, 186 stage I-III rectal cancer patients scheduled for APR were assigned (1:1) to receive standard enhanced recovery after surgery (ERAS) or ERAS plus a structured cognitive-behavioral sleep intervention (CBSI) with individualized nutritional support. Initiated 2 weeks preoperatively and continued for 6 months postoperatively, the program included cognitive restructuring, stimulus control, sleep restriction, relaxation training, relapse prevention, and tailored nutrition plans. The primary outcome was the change in the Pittsburgh Sleep Quality Index (PSQI) at 6 months. Secondary outcomes were Hospital Anxiety and Depression Scale (HADS) scores, inflammatory markers (IL-6, CRP), and 2-year disease-free survival (DFS) and overall survival (OS).</p><p><strong>Results: </strong>Compared with controls, the intervention group showed greater PSQI improvement at 6 months (-3.8, 95% CI=-4.5 to -3.1, p <.001), with benefits sustained at 12 months. Reductions in HADS-anxiety (-2.1, p <.001) and HADS-depression (-2.3, p <.001) were observed, along with lower IL-6 and CRP at 3 months. Two-year DFS (88.2% vs. 74.2%, p =.018) and OS (92.5% vs. 80.6%, p =.024) were higher in the intervention group.</p><p><strong>Conclusions: </strong>Integrating CBSI with nutritional support significantly improved sleep, psychological well-being, inflammation, and survival in rectal cancer patients undergoing APR, supporting its inclusion in perioperative oncology care.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"264-273"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146129056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Major Lifetime Discrimination Exposure Accelerates Brain Microstructural Aging: Diffusion MRI Evidence From MIDUS.","authors":"Ajay Kumar Nair, Nagesh Adluru, Anna J Finley, Lauren K Gresham, Sarah E Skinner, Steven R Kecskemeti, Andrew L Alexander, Richard J Davidson, David R Williams, Carol D Ryff, Stacey M Schaefer","doi":"10.1097/PSY.0000000000001467","DOIUrl":"10.1097/PSY.0000000000001467","url":null,"abstract":"<p><strong>Objective: </strong>Experiencing discrimination is associated with faster biological aging, as reflected in telomere shortening and DNA methylation. However, the impact of discrimination on brain aging processes remains unclear. Here, we tested whether individuals who reported at least one major lifetime discrimination event would exhibit steeper age-related associations in microstructural metrics within whole-brain white matter and the hippocampus, consistent with accelerated brain microstructural aging, compared with those with no such experiences.</p><p><strong>Methods: </strong>We analyzed multi-shell diffusion-weighted MRI data from the Midlife in the United States (MIDUS) cohort ( n =147, mean age=65 years, range: 48 to 95 years) to assess brain microstructure using complementary statistical and biophysical diffusion models. Diffusion kurtosis imaging representation was used to derive diffusion tensor imaging (DTI) and white matter tract integrity (WMTI) measures. Additional microstructural health indices were derived using the neurite orientation dispersion and density imaging (NODDI) model. Permutation analyses of linear models were run within the whole-brain white matter and bilateral hippocampi, adjusting for sex, race, and education.</p><p><strong>Results: </strong>Participants who reported at least one major discriminatory experience during their lifetime exhibited accelerated age-associated changes in white matter microstructural measures, including higher mean and radial diffusivities, extra-axonal radial diffusivity, and free water fraction compared with those with no such experiences.</p><p><strong>Conclusions: </strong>These converging findings from complementary measures of brain microstructure suggest that major discrimination experiences may contribute to accelerated brain microstructural aging.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"297-309"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13003999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146129021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular and Circulatory Responses to Acute Mental Stress Among Individuals With Ischemic Cardiomyopathy.","authors":"Kasra Moazzami, Maggie Wang, Alireza Rahbar, Brad D Pearce, Amit J Shah, Yan V Sun, Yi-An Ko, Paolo Raggi, J Douglas Bremner, Viola Vaccarino, Arshed A Quyyumi","doi":"10.1097/PSY.0000000000001464","DOIUrl":"10.1097/PSY.0000000000001464","url":null,"abstract":"<p><strong>Objective: </strong>We studied responses to acute mental stress in individuals with stable coronary artery disease (CAD) with and without heart failure with reduced ejection fraction (HFrEF).</p><p><strong>Methods: </strong>Individuals with stable CAD ( N = 313, 45 with HFrEF) underwent a laboratory-based mental stress. HFrEF was defined as an ejection fraction of <40%. Hemodynamic reactivity and vasoconstriction during mental stress were evaluated using changes in systolic blood pressure and peripheral arterial tonometry, respectively. Immune function was assessed by measuring changes in interleukin-6 (IL-6) and circulating progenitor cell counts enumerated using flow cytometry of CD34-expressing mononuclear cells before and 90 minutes after mental stress.</p><p><strong>Results: </strong>During the mental stress testing, patients in the HFrEF exhibited a smaller (blunted) increase in systolic blood pressure compared with the non HFrEF group (30.4 ± 14.1 vs 41.9 ± 16.1 mm Hg, p < .001), greater vasoconstriction (PAT ratio 0.69 ± 0.30 vs 0.83 ± 0.40, p = .02), a larger increase in IL-6 levels (0.91 ± 0.11 vs 0.42 ± 0.14 pg/mL, p = .01), and larger increases in circulating progenitor cell counts (0.68 ± 0.12 vs 0.22 ± 0.11 cell/L, p = .009). After adjustment for demographic and traditional risk factors, each of these 4 maladaptive stress responses remained independently associated with the presence of HFrEF.</p><p><strong>Conclusions: </strong>Among individuals with stable CAD, the presence of HFrEF was independently associated with a blunted systolic blood pressure response, greater vasoconstriction, increased inflammation, and enhanced progenitor cell mobilization with mental stress, a response that is associated with adverse long-term outcomes.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"334-340"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}