Biopsychosocial science and medicine最新文献

{"title":"Ecologically Assessed Sleep Duration and Pulse Wave Velocity in Young Adult African Americans.","authors":"Paul P Sheriff, Kevin Boyd, Pewu Lavela, Ishaan Sandhu, Thomas A Mellman","doi":"10.1097/PSY.0000000000001455","DOIUrl":"10.1097/PSY.0000000000001455","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the association between arterial stiffness and sleep duration in young African American adults in an ecologically valid context.</p><p><strong>Methods: </strong>This study included 68 young adults (ages 18 to 35) who identified as African American. The average age of the sample was 28.4.±4.3 years and 38 (53.5%) were men. The average body mass index was in the healthy range and average insomnia severity was mild. Sleep was measured using actigraphy, and the time of lights out and awakenings were assessed using digital devices in participants' habitual environments. Pulse wave velocity (PWV) and central systolic pressure (CSP) were measured using the SphygmoCor CVO system in participants' homes in the morning, close to awakening from the last assessed sleep period.</p><p><strong>Results: </strong>PWV was significantly negatively correlated with total sleep time ( r =-0.26, p =.04); whereas CSP was correlated with age ( r =0.33, p =.003) and BMI ( r =0.28, p =.01) but not with any sleep measures. The results of a regression model indicated that the effect of total sleep time on PWV was accounted for by the males in the sample.</p><p><strong>Conclusion: </strong>Our results are consistent with a recent finding utilizing central augmentation indices during sleep regarding a relationship between sleep duration and arterial elasticity; however, we found the opposite relationship to gender. Replication and extension of these findings would add to the support for recognizing sleep duration as a modifiable risk factor for improving CV health.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"200-205"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145893562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Community Socioeconomic Disadvantage Relates to White Matter Hyperintensity Burden in Mid-to-Late Life Adults.","authors":"Anna L Marsland, Minjie Wu, Mia K DeCataldo, Howard J Aizenstein, Jinghang Li, Tamer S Ibrahim, Stephen B Manuck, Peter J Gianaros","doi":"10.1097/PSY.0000000000001453","DOIUrl":"10.1097/PSY.0000000000001453","url":null,"abstract":"<p><strong>Objective: </strong>Residing in communities characterized by socioeconomic disadvantage may confer risk for neurodegenerative brain changes and future neuropathology. Based on prior evidence, this study tested the hypotheses that (1) community-level disadvantage would relate independently of individual-level socioeconomic position to white matter hyperintensities (WMHs), which reflect subclinical brain pathology that may presage later dementia; and (2) this association would be partly explained by blood pressure, cardiometabolic risk, and/or systemic levels of inflammation. These hypotheses were examined among otherwise healthy middle-aged and older adults without clinical dementia at testing.</p><p><strong>Methods: </strong>Participants were 388 adults aged 40 to 72 years (53% female; 12% non-White) whose street addresses were entered into the Neighborhood Atlas to compute Area Deprivation Index scores by census block. Participants also underwent high-resolution (7 T) brain imaging to assess total WMH volume normalized for intracranial volume, and assessment of blood pressure, cardiometabolic (adiposity, lipids, glucose and insulin), and inflammatory (interleukin-6 and C-reactive protein) risk factors.</p><p><strong>Results: </strong>Linear regression models showed that higher community deprivation on the ADI was associated with greater WMH volume, independently of age, sex, years of education, smoking, and time between study visits (beta=0.11, p =.028). This association was largely independent of blood pressure, cardiometabolic risk, and systemic inflammation.</p><p><strong>Conclusions: </strong>The present novel findings add to growing evidence that community disadvantage relates to preclinical neurodegenerative changes, which may contribute to accelerated brain and cognitive aging. Future work is warranted to better understand pathways that link residential environments to brain health and to identify targets for community and public policy interventions.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"156-165"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12875623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145553073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential Effects of Body Posture on Biological and Psychological Responses in the Trier Social Stress Test.","authors":"Miriam Kurz, Luca Abel, Felicitas Burkhardt, Robert Richer, Veronika Ringgold, Lena Schindler-Gmelch, Bjoern M Eskofier, Nicolas Rohleder","doi":"10.1097/PSY.0000000000001450","DOIUrl":"10.1097/PSY.0000000000001450","url":null,"abstract":"<p><strong>Objective: </strong>Acute stress protocols are important tools for laboratory research on acute stress mechanisms. Several reasons necessitate varying body posture. However, the effect of such variations has not been systematically studied. We therefore examined the impact of body posture (sitting vs. standing) on biological and psychological stress responses induced by the Trier Social Stress Test (TSST) and its control condition (friendly TSST; f-TSST).</p><p><strong>Methods: </strong>One hundred four participants (57.69% female, mean age: 22.28, SD = 3.44) were randomly assigned to the sitting versus standing group and underwent the TSST and f-TSST on 2 separate days in randomized order. Stress responses were measured through salivary cortisol and alpha-amylase, HR, HRV, and self-reports.</p><p><strong>Results: </strong>Biological stress responses were higher in the TSST condition and the standing group (eg, maximum cortisol increase: p = .004). Psychological stress response was higher in the stress condition (eg, negative affect : p < .001), but was not different between posture groups (eg, negative affect : p = .819). No differences were observed in any markers after adjusting the stress-response measures for the non-stress condition (smallest p = .173).</p><p><strong>Conclusions: </strong>Although biological, but not psychological stress responses were affected by body posture overall, these effects did not persist when responses in the stress condition were adjusted by subtracting the non-stress values from the f-TSST. This implies that the effect of body posture can be neglected in studies with a non-stress control condition, but that its effects should be taken into account in studies with only the stress protocol.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"179-190"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12875627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145553107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posttraumatic Stress Disorder and Increased Incidence of Cardiovascular Disease: Independent Effects and Moderation of Risk by Comorbidities, Sex, and Age.","authors":"David S Krantz, Frances H Gabbay, Elizabeth A Belleau, Pablo A Aliaga, Gary H Wynn, Murray B Stein, Robert J Ursano, James A Naifeh","doi":"10.1097/PSY.0000000000001442","DOIUrl":"10.1097/PSY.0000000000001442","url":null,"abstract":"<p><strong>Objective: </strong>Posttraumatic stress disorder (PTSD) is associated with increased risk of cardiovascular disease (CVD) and multiple comorbidities. We evaluated whether comorbidities, sex, or age modify PTSD-related risk of hypertension or atherosclerotic CVD (ASCVD).</p><p><strong>Methods: </strong>Associations of PTSD, comorbidities (metabolic and behavioral risk factors, depression, and sleep disorders), sex, and age (<40 vs ≥40 years) with incident hypertension and ASCVD were assessed in a large sample of US Army soldiers (86.2% male; 93.7% age <40). Discrete-time survival analyses of medical record ICD codes compared all person-months with initial hypertension diagnosis ( n = 49,656 cases) to an equal-probability sample of control person-months. Parallel analyses were conducted for ASCVD (CAD, MI, stroke, heart failure; n = 2427 person-months).</p><p><strong>Results: </strong>In univariate models, PTSD predicted subsequent hypertension [OR = 3.0 (95% CI = 2.9-3.1)] and ASCVD [OR = 2.7 (95% CI = 2.2-3.3)]. Associations remained significant adjusting for comorbidities and sociodemographic/service-related variables [hypertension: OR = 1.9 (95% CI = 1.8-2.0); ASCVD: OR = 1.4 (95% CI = 1.2-1.8)]. Sex, age, and each comorbidity independently predicted hypertension, and PTSD interacted with sex, age, metabolic risk factors, depression, and sleep disorders. Stratification indicated stronger PTSD-hypertension associations among men, and among those: aged younger than 40, without metabolic risk factors, without depression, and without sleep disorders. Standardized risk estimates for hypertension were higher among those with versus without PTSD, with versus without each comorbidity, among men, and among those aged 40 years or older. Comorbidities and age independently predicted ASCVD, but did not modify PTSD-ASCVD associations.</p><p><strong>Conclusions: </strong>PTSD and comorbidities independently predict hypertension and ASCVD, and sex, age, and comorbidities modify PTSD-hypertension relationships, thus suggesting that preventive interventions address both PTSD and comorbidities.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"206-216"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12549015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145202803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emotion Regulation and Well-Being in Adults With Congenital Heart Disease.","authors":"Anna-Lena Ehmann, Paul C Helm, Ulrike M Bauer, Sven Barnow, Luise Pruessner","doi":"10.1097/PSY.0000000000001451","DOIUrl":"10.1097/PSY.0000000000001451","url":null,"abstract":"<p><strong>Objective: </strong>Congenital heart disease (CHD) is associated with daily stressors, including medical and physical limitations, as well as reduced social participation, necessitating psychological adjustment. Emotion regulation may be a key factor in this process and could explain variability in life satisfaction among individuals with CHD. However, emotion regulation has not been systematically investigated in this population.</p><p><strong>Methods: </strong>A total of 1187 adults (aged 18 to 85; 60.2% female) from the German National Register for Congenital Heart Defects were classified into simple, moderate, or complex CHD severity groups and completed self-report measures of emotion regulation, mental and general health, and life satisfaction.</p><p><strong>Results: </strong>Rumination, suppression, and avoidance were negatively associated with life satisfaction, mental health, and general health, whereas reappraisal, acceptance, problem solving, and social support showed positive associations (life satisfaction: r =-0.20 to 0.34, p <.001; mental health: r =-0.38 to 0.28, p =.19 to<.001; general health: r =-0.10 to 0.16, p =.19 to<.001). Simple slope analyses indicated that rumination predicted poorer general health at simple and moderate, but not complex, severity levels, when controlling for age, sex, relationship, and employment status. Suppression ability was linked to better general health only in complex CHD.</p><p><strong>Conclusions: </strong>Emotion regulation seems to be a critical factor in well-being outcomes among individuals with CHD. Findings highlight the importance of addressing emotion regulation skills in psychological interventions for this population.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":"88 2","pages":"217-228"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146121700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Testing the Daily Bidirectional Relationships Between Stress and Sleep Using Bivariate Multilevel Autoregressive Modeling.","authors":"Connor Nicholls, Kimberley Shoaf, Tanya Halliday, Aric A Prather, Brian R W Baucom, Kelly Glazer Baron","doi":"10.1097/PSY.0000000000001446","DOIUrl":"10.1097/PSY.0000000000001446","url":null,"abstract":"<p><strong>Objective: </strong>Previous studies have demonstrated that stress and sleep are bidirectional and perseverative cognition (ie, worry and rumination) is a key cognitive mechanism in this relationship. The goal of our study was to examine the relationships between stress and sleep, and test whether physical activity moderates the stress-sleep link.</p><p><strong>Methods: </strong>Participants aged 18 and above were recruited from May 2020 to November 2021 and completed questionnaires and 7 days of twice daily text-based surveys, morning and evening. Morning text-based surveys assessed evening/overnight perseverative cognition and sleep, and evening surveys assessed daily stress ratings. Habitual physical activity was measured by the International Physical Activity Questionnaire. Analyses were conducted using bivariate multilevel autoregressive modeling (ML-VAR), a discrete-time structural equation model (SEM), to test relationships between repeated daily measures of sleep (duration/efficiency), stress, and preservative cognition, which were adjusted for age, sex, and race/ethnicity.</p><p><strong>Results: </strong>We obtained data from 155 participants (age M =42, SD=15, 82 f) over 1009 days. In the models, 95% credibility intervals for both stress (95% CI=-0.7, -0.1) and perseverative cognition (95% CI=-13.3, -6) showed they predicted shorter sleep duration during the corresponding night. Perseverative cognition had a stronger relationship with sleep duration than stress, but did not mediate its relationship. Participants with higher habitual MVPA had a weaker relationship between stress and sleep duration (95% CI=<0.001, 0.015). Perseverative cognition also predicted lower sleep efficiency that night (95% CI=-0.024, -0.006). There were no significant mediators or moderators in models of sleep efficiency.</p><p><strong>Conclusions: </strong>Results demonstrated that stress and perseverative cognition had a stronger impact on sleep at night than the opposite direction. In addition, results highlight the importance of physical activity in mitigating the deleterious effects of stress.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"191-199"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145461144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal Psychological Responses During Regional War: A Cross-sectional Study of Fear of Childbirth, Stress, and Intolerance of Uncertainty.","authors":"Haya Hebi, Nadir Ganem, Maya Frank Wolf, Lior Lowenstein, Rotem Kahalon, Liron Rozenkrantz, Inshirah Sgayer","doi":"10.1097/PSY.0000000000001444","DOIUrl":"10.1097/PSY.0000000000001444","url":null,"abstract":"<p><strong>Objective: </strong>Armed conflict may intensify psychological vulnerability during pregnancy. This cross-sectional study examined associations of perceived stress and intolerance of uncertainty during wartime, with fear of childbirth and maternal outcomes.</p><p><strong>Methods: </strong>During the 2024 Iron Swords War, 200 pregnant women beyond 32 weeks gestation were recruited at a tertiary hospital near Israel's northern border. Using questionnaires, we assessed perceived stress, intolerance of uncertainty, and fear of childbirth. Maternal and neonatal outcomes were extracted from medical records.</p><p><strong>Results: </strong>A regression analysis revealed that fear of childbirth was significantly predicted by higher perceived stress (β=0.31, p <.001), greater intolerance of uncertainty (β=0.23, p =.002), and nulliparity (β=0.13, p =.045). Together, these variables accounted for 25% of the variance in fear of childbirth ( R2 =0.25). In addition, perceived stress and intolerance of uncertainty were each significantly correlated with fear of childbirth in bivariate analyses ( r =0.42 and r =0.40, respectively). Logistic regression showed that fear of childbirth predicted emergent cesarean delivery (OR=2.63, 95% CI=1.07-5.04, p =.033).</p><p><strong>Conclusions: </strong>Exposure to war-related stress and uncertainty was linked to heightened fear of childbirth and may impact maternal outcomes. These results emphasize the importance of identifying and addressing psychological distress early in pregnancy, particularly in settings impacted by armed conflict.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"257-261"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145461152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biopsychosocial Science and Medicine, Volume 88, Issue 2.","authors":"","doi":"10.1097/PSY.0000000000001470","DOIUrl":"https://doi.org/10.1097/PSY.0000000000001470","url":null,"abstract":"","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146128965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Type D Personality on Coronary Artery Disease Severity in Acute Coronary Syndrome Patients: Sex Differences.","authors":"Di Wang, Chengqian Xu, Mengru Sun, Bingji Huang, Jiaxin Shi, Bo Yu, Yini Wang, Ping Lin","doi":"10.1097/PSY.0000000000001431","DOIUrl":"10.1097/PSY.0000000000001431","url":null,"abstract":"<p><strong>Objective: </strong>This cross-sectional study aimed to examine the association between type D personality and the severity of coronary artery disease in patients with acute coronary syndrome (ACS), with a specific focus on sex-stratified differences.</p><p><strong>Methods: </strong>ACS patients (n=9236) completed the Chinese Type D Personality Scale. The Gensini score assessed disease severity. Multivariate linear regression, adjusted for covariates, analyzed the relationship between type D personality and Gensini score, with a sex stratified analysis exploring the impact of sex.</p><p><strong>Results: </strong>In total, 20.1% (1853) of ACS patients had a type D personality. Type D personality was measured using standardized scores of negative affectivity (Z-NA) and social inhibition (Z-SI). Multivariate linear regression analysis showed that Z-NA (B=0.03, 95% CI=0.02-0.05, p <.001), Z-SI (B=0.05, 95% CI=0.04-0.07, p <.001), and their interaction term (B=0.02, 95% CI=0.01-0.03, p <.001) were all significantly associated with the Gensini score [Ln]. Further sex-stratified analyses revealed that, among male patients, Z-NA (B=0.04, 95% CI=0.03-0.06, p <.001), Z-SI (B=0.06, 95% CI=0.04-0.07, p <.001), and their interaction (B=0.03, 95% CI=0.02-0.04, p <.001) were all significantly associated with the Gensini score [Ln]. However, no statistically significant associations were observed in female patients.</p><p><strong>Conclusions: </strong>Sex differences significantly influence the relationship between type D personality and coronary disease severity in ACS patients, particularly in males, warranting targeted interventions.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"16-23"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145202769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex Differences in the Adverse Electromechanical Remodeling of the Heart After Repeated Witness Stress in Adult Rats: Relationship With a Specific miRNA Signature.","authors":"Margherita Barbetti, Iolanda Bilotti, Donald Ielpo, Rocchina Vilella, Caterina Frati, Valeria Naponelli, Diego Andolina, Luisa Lo Iacono, Andrea Sgoifo, Monia Savi, Luca Carnevali","doi":"10.1097/PSY.0000000000001406","DOIUrl":"10.1097/PSY.0000000000001406","url":null,"abstract":"<p><strong>Objective: </strong>Sex disparities in the association between psychosocial stress and cardiovascular risk have been reported, yet the extent to which social stress impacts cardiovascular function in a sex-specific manner remains unclear. The objectives of this study were to investigate sex differences in the electromechanical remodeling of the heart of socially stressed rats, and to explore potential epigenetic mechanisms (cardiac microRNAs).</p><p><strong>Methods: </strong>Adult wild-type Groningen rats of both sexes vicariously experienced the social defeat bout between 2 males for 9 consecutive days [\"witness stress\" (WS) paradigm] or were exposed to a control condition ( n =8/sex/group). After repeated WS exposure, arrhythmic vulnerability was evaluated via beta-adrenergic stimulation with isoproterenol in conscious rats, while cardiac contractile properties were assessed via hemodynamic analyses under anesthesia. Cardiac tissue was collected to measure expression levels of several miRNAs (including miR-22 and miR-34a) and their molecular targets (eg, SIRT1) involved in the regulation of cardiac electromechanical function.</p><p><strong>Results: </strong>An increased vulnerability to isoproterenol-induced arrhythmias was found in male, but not female, rats with a history of WS. Signs of contractile dysfunction were found in both sexes after WS, but to a greater extent in males. In addition, only male WS rats exhibited a significantly higher cardiac expression of miR-34a and miR-22, which were associated with a reduced expression of their common molecular target (SIRT-1).</p><p><strong>Conclusion: </strong>These findings suggest an epigenetic mechanism underlying the larger vulnerability to adverse cardiac electromechanical remodeling in socially stressed male rats, informing our understanding of the sex-specific impact of social stress on cardiac function.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"37-47"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12721695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}