Biopsychosocial science and medicine最新文献

{"title":"Longitudinal Study of Familism, Inflammation, and Metabolic Syndrome in Black Adolescents From Lower-Income Households.","authors":"Edith Chen, Kayla Park, Yin-Chun Lo, Talia Berger-White, Christina Vargas, Robin Hayen","doi":"10.1097/PSY.0000000000001499","DOIUrl":"10.1097/PSY.0000000000001499","url":null,"abstract":"<p><strong>Objective: </strong>This study examined longitudinal associations between familism (valuing the family unit more than the individual, feelings of obligation and responsibility toward the family), inflammation, and metabolic syndrome (MetS) in a sample of Black adolescents from lower-income households.</p><p><strong>Methods: </strong>Four hundred Black adolescents (ages 14 to 19) were recruited into this study. Adolescents and one parent independently completed a questionnaire measure of familism (expectations about the obligations adolescent have to the family) at baseline. As well, in adolescents, assessments of 6 markers of low-grade inflammation and MetS (counts of the number of MetS components above clinical cutoffs; composite z-scores of each MetS component) were taken at baseline. One year later, inflammation was re-assessed. Two years later, MetS was re-assessed. Discrepancies in familism (directional difference between parent and adolescent reports of familism; absolute difference between parent and adolescent familism scores) were calculated.</p><p><strong>Results: </strong>Adolescents who held higher familism beliefs than their parents had higher levels of low-grade inflammation one year later, b=0.032, SE=0.016, P <.05, which in turn predicted higher levels of MetS 2 years later (count: b=0.537, SE=0.077, P <.001; composite: b=0.294, SE=0.051, P <.001). The indirect effects were significant (for prospective associations, count: coefficient=0.016, 95%CI [0.002, 0.034]; composite: coefficient=0.009, 95%CI [0.001, 0.020]). No associations were found with absolute difference in familism scores.</p><p><strong>Conclusions: </strong>These findings suggest the importance of understanding family values from multiple perspectives (eg, parent, adolescent). Adolescents' perceptions about their families, particularly in relation to how their parents perceive the family, may have implications for the development of cardiovascular risk in young people over time.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"535-546"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147985026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrointestinal-specific Anxiety in IBD: Associations With Disease Activity, Psychological Symptoms, and Serotonergic Polymorphisms.","authors":"Konstantina Atanasova, Stefanie Mellein, Laura-Louise Knoedler, Vivianne Dorothee Niehaus, Hadil Mirkhan, Philipp Arthur Thomann, Stefanie Lis, Matthias Philip Alexander Ebert, Wolfgang Reindl, Anne Kerstin Thomann","doi":"10.1097/PSY.0000000000001493","DOIUrl":"10.1097/PSY.0000000000001493","url":null,"abstract":"<p><strong>Objective: </strong>Many people living with an inflammatory bowel disease (IBD) experience persistent abdominal symptoms even in the absence of active inflammation. These symptoms are referred to as irritable bowel syndrome (IBS)-like symptoms. Gastrointestinal-specific anxiety (GSA) is a common feature of disorders of gut-brain interaction and may also be relevant in patients with IBD experiencing IBS-like symptoms.</p><p><strong>Methods: </strong>This cross-sectional study examined the associations between psychological variables and GSA in individuals with IBD in different states of disease activity (n=308, age: 42.4±19.4; female: 183, male: 125). In two subsamples of 83 patients (age: 41.2±15.9; female: 37, male: 46) and 70 patients (age: 42.1±16.1; female: 32, male: 38), links to single-nucleotide polymorphisms (SNPs) in genes related to serotonin signaling and serum tryptophan metabolites, respectively, were explored.</p><p><strong>Results: </strong>Psychological variables including anxiety (β=.393, p <.001) and depression (β=.284, p <.001) predicted GSA levels. Genetic analyses revealed associations for serotonergic variants; however, none of these associations remained statistically significant after correction for multiple testing. While disease activity was linked to GSA (β=.171, p =.002), inflammatory biomarkers and tryptophan metabolites did not exhibit any significant associations.</p><p><strong>Conclusions: </strong>Our findings suggest that GSA as a specific type of anxiety is strongly related to psychological symptoms in IBD. Anxiety was the strongest predictor of GSA, contributing even more strongly to GSA than disease activity. Screening patients for GSA could help to detect disturbances in gut-brain interactions and improve individualized treatment.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"572-580"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148039062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Article Summaries for July-August 2026 Biopsychosocial Science and Medicine, Volume 88, Issue 6.","authors":"","doi":"10.1097/PSY.0000000000001503","DOIUrl":"https://doi.org/10.1097/PSY.0000000000001503","url":null,"abstract":"","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":"88 6","pages":"499"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148393254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Combined Impact of Type D Personality and Depressive Comorbidity on Post-PCI Major Adverse Cardiac Events: The Mediating Role of Heart Rate Variability.","authors":"Jiaxin Shi, Bingji Huang, Mengru Sun, Hui Tao, Wenpei Liu, Bo Yu, Yini Wang, Ping Lin","doi":"10.1097/PSY.0000000000001492","DOIUrl":"10.1097/PSY.0000000000001492","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to explore the impact of coexisting Type D personality and depression on the incidence of major adverse cardiac events (MACEs) following percutaneous coronary intervention (PCI), and to examine the mediating role of heart rate variability (HRV).</p><p><strong>Methods: </strong>This prospective cohort study included 990 patients with coronary artery disease who underwent PCI between May 2022 and May 2023. Type D personality, depressive symptoms, and HRV were assessed at baseline. Patients were followed for 2 years to monitor the occurrence of MACE.</p><p><strong>Results: </strong>During the follow-up period, 289 patients experienced MACE. HRV indices were lower in the comorbid group compared with the group without psychological conditions, particularly SDNN (82.50 vs. 94.33) and SDANN (71.32 vs. 80.95). In the \"NA×Depression\" interaction pathway, the indirect effects of SDNN and SDANN on MACE were statistically significant across low, moderate, and high depression levels, with the a × b effects being 0.676 and 0.688 at low depression, 0.604 and 0.618 at moderate depression, and 0.460 and 0.479 at high depression, respectively. Notably, the indirect effect estimates were slightly larger at low to moderate depression levels, and all values showed significant positive mediation effects. In the \"SI×Depression\" interaction pathway, the ab indirect effects of SDNN and SDANN were also statistically significant at low, moderate, and high depression levels, with the values being 0.377 and 0.411 at low depression, 0.309 and 0.342 at moderate depression, and 0.174 and 0.204 at high depression.</p><p><strong>Conclusions: </strong>Type D personality combined with depression elevates post-PCI MACE risk, with NA playing a core role. SDNN and SDANN (key HRV indices) mediate this association, supporting routine psychological and HRV screening plus targeted interventions to improve outcomes.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"555-563"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147871288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Mediating Role of Daily Affect Dynamics in Bidirectional and Longitudinal Associations Between Depressive Symptoms and Inflammation.","authors":"Sun Ah Lee, Jennifer E Graham-Engeland, Soomi Lee, David M Almeida","doi":"10.1097/PSY.0000000000001494","DOIUrl":"10.1097/PSY.0000000000001494","url":null,"abstract":"<p><strong>Objective: </strong>Extensive research has established relationships between depression and inflammation, yet greater attention is needed to elucidate mechanisms through which these processes unfold across multiple levels of analysis and time scales. This cohort panel study evaluated the role of daily affect dynamics in bidirectional and longitudinal associations between depressive symptoms and inflammation.</p><p><strong>Methods: </strong>Using data from the second and third waves of the Midlife in the United States (MIDUS) study, the sample included 563 adults (M age =52.4; 57% female; 84% White). During the Biomarker Project, depressive symptoms were assessed at a single time point using the CESD-20, and the inflammatory markers were collected, including CRP and 4 cytokines (IL-6, IL-8, TNFα, IL-10). During the Daily Diary Project, daily affect and stress were measured over 8 consecutive days. Two affect dynamics indicators were specified: affective variability and reactivity to daily stressors. Multilevel structural equation models simultaneously tested autoregressive and cross-lagged associations between depressive symptoms and inflammation at the person-level, and day-level mediated paths involving daily affect dynamics.</p><p><strong>Results: </strong>Results revealed that affective variability and reactivity mediated the autoregressive paths of depressive symptoms across 2 waves. Positive affective variability mediated the pathway from heightened baseline depressive symptoms to higher CRP levels at follow-up. Negative affective reactivity to daily stressors mediated the pathway from higher baseline CRP to subsequent depressive symptoms.</p><p><strong>Conclusions: </strong>Findings suggest daily affective processes as potential mechanisms linking depressive symptoms and inflammation, underscoring the significance of promoting affective stability and adaptive stress responses in everyday life.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"521-534"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13383811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147950573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative Analysis of Placebo Response Models to Optimize Clinical Trials in Premenstrual Disorders: A Model-Based Meta-analysis.","authors":"Xiao Yang, Yinghua Lv, Yuan Liu, Zihao Cai, Juan Yang, Qing-Shan Zheng, Lu-Jin Li","doi":"10.1097/PSY.0000000000001491","DOIUrl":"10.1097/PSY.0000000000001491","url":null,"abstract":"<p><strong>Objective: </strong>This study quantitatively analyze the evaluation indicators used in premenstrual disorder clinical trials, establishes a placebo response model, observes its influencing factors, and provides a basis for the design of future clinical trials.</p><p><strong>Methods: </strong>A comprehensive search was conducted in PubMed, EMBASE, Cochrane Library, and PsychINFO for randomized controlled trials (RCTs) related to premenstrual disorders. The time course of the placebo responses were modeled and analyzed for common evaluation indicators. Furthermore, the placebo response for each indicator under various conditions was simulated to provide an external control and inform sample size estimation.</p><p><strong>Results: </strong>In the 47 studies included in the analysis, it includes 5406 patients, 5 common evaluation indicators were identified: total symptom score, depression symptom score, anxiety symptom score, irritability symptom score, and physical symptom score. The maximum placebo response ranged from 20.9% to 38.4%, with the efficacy plateau being reached within 2 to 3 months. The total symptom score is recommended as the primary outcome due to its minimal placebo response size, rapid onset of action, and low intertrial variability. Using this model as an external control, the study suggests that the efficacy of natural S-equol was not significantly different from that of a placebo. Furthermore, the placebo response model was found to provide accurate effect sizes for sample size estimation under various conditions.</p><p><strong>Conclusion: </strong>The placebo response models of common evaluation indicators in clinical trials of drugs for premenstrual disorders have been established, providing an important basis for the optimized design and decision-making of subsequent clinical trials.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":"88 6","pages":"564-571"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148393236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitoception via the Metabokine GDF15 and Human Health.","authors":"Cynthia C Liu, Qiuhan Huang, Evan D Shaulson, Caroline Trumpff, Elissa Epel, Lisa Feldman Barrett, Daniel W Belsky, Maxwell Z Wilson, Alan A Cohen, Eugene Mosharov, Nirosha J Murugan, Tor D Wager, Martin Picard","doi":"10.1097/PSY.0000000000001498","DOIUrl":"10.1097/PSY.0000000000001498","url":null,"abstract":"<p><p>To survive and thrive, living organisms must monitor and regulate cell-level energy supply, demand, and transformation. Metabolic energy is monitored through a set of brain-directed interoceptive processes we refer to as metaboception. Here, we review evidence for a specific metaboceptive signaling cascade mediated by the cytokine/metabokine growth differentiation factor 15 (GDF15), which we refer to as mitoception. Mitoception involves an afferent signaling arm initiated by the integrative stress response within cells, and an efferent signaling arm that simultaneously promotes systemic energy conservation and fuel mobilization. Afferent mitoceptive signaling is mediated by GDF15 released when cells face energy demand in excess of their energy transformation capacity, creating an energy gap. The efferent arm of mitoceptive signaling arises when GDF15 receptors in the brainstem receive the signal and initiate psychological experiences including fatigue and anxiety, together with neuroendocrine stress responses. Mitoceptive outputs thus reprioritize systemic energy metabolism to promote efficient allostasis, survival, and long-term health. This article is an introduction to GDF15 psychobiology. We propose a GDF15-driven mitoception cascade that makes predictions about modifiable processes shaping fatigue and mood, mental health disorders, the healing process, well-being, and the rate of aging.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"500-520"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148207548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accentuating the Positive: Contribution of Positive Relations With Others and Daily Interpersonal Interactions to Longevity.","authors":"Melissa M Franks, Elliot M Friedman","doi":"10.1097/PSY.0000000000001502","DOIUrl":"https://doi.org/10.1097/PSY.0000000000001502","url":null,"abstract":"<p><strong>Objective: </strong>Social connection has well-established benefits for individual health and longevity. Positive Relations with Others, a distinct form of social connection, benefits health and longevity independent from more established forms, including social integration. Our primary aim is to investigate these forms of social connection as predictors of longevity. We also explore daily positive interpersonal interactions and daily interpersonal stressors as predictors of longevity beyond the contributions of social connection.</p><p><strong>Methods: </strong>Data for this study (N=1757) are from the national longitudinal Midlife in the United States study (MIDUS), the National Study of Daily Experiences (NSDE), and the National Death Index. Participants for the NSDE study were randomly selected from the MIDUS sample and completed short telephone interviews about daily experiences for 8 consecutive days.</p><p><strong>Results: </strong>Positive Relations with Others was significantly associated with a reduced mortality hazard (HR=0.88, P=.02). When daily interpersonal interactions were added, daily positive interpersonal interactions (HR=0.93, P=.001) predicted lower mortality hazard and reduced the association between Positive Relations with Others and mortality (HR=0.91, P=.067). Neither social integration nor daily interpersonal stressors were associated with mortality .</p><p><strong>Conclusions: </strong>Findings reveal the health benefits of cultivating social ties that are mutual and meaningful, and also of engaging in daily positive interpersonal interactions. Cultivating positive relations operates in conjunction with routine positive interpersonal interactions to promote health and longevity.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148255327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Article Summaries for June 2026 Biopsychosocial Science and Medicine, Volume 88, Issue 5.","authors":"","doi":"10.1097/PSY.0000000000001497","DOIUrl":"https://doi.org/10.1097/PSY.0000000000001497","url":null,"abstract":"","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":"88 5","pages":"421"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148160288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Causal Correlations Between Depression and Musculoskeletal Disorders: A Bidirectional Mendelian Randomization Study.","authors":"Jingyi Tong, Min Zhu, Weijia Tan, Jiajia Chen","doi":"10.1097/PSY.0000000000001474","DOIUrl":"10.1097/PSY.0000000000001474","url":null,"abstract":"<p><strong>Objective: </strong>Observational studies suggest a strong but poorly understood association between depression and musculoskeletal disorders (MSDs). This study aims to investigate the bidirectional causal relationships between depression and specific MSDs using Mendelian randomization (MR).</p><p><strong>Methods: </strong>Bidirectional MR used GWAS data from European (n=484,598) and East Asian (n=152,389) populations. Independent SNPs ( p <5×10 - ⁸; supplementary p <1×10 - ⁷; F>10) were IVs. Causal effects were estimated via inverse variance weighted (IVW), MR-RAPS, and other methods, with sensitivity tests (MR-PRESSO, stratified analysis) for pleiotropy/heterogeneity.</p><p><strong>Results: </strong>Genetically predicted depression was associated with increased risk of neck-shoulder pain (IVW OR 1.48, 95% CI 1.26-1.71, p =7.14×10 - ⁶), hip pain (OR 1.20, 95% CI = 1.05-1.37, p =.005), and knee pain (OR 1.29, 95% CI = 1.09-1.52, p =.002), but not back or low back pain. Reverse MR indicated significant effects of neck-shoulder pain (OR 1.08, 95% CI = 1.05-1.12, p =6.22×10 - ⁷), back pain (OR 1.00, 95% CI = 0.99-1.00, p =1.18×10 - ¹¹), hip pain (OR 1.06, 95% CI = 1.01-1.12, p =.014), and knee pain (OR 1.02, 95% CI = 1.00-1.05, p =.025) on depression risk. No significant heterogeneity or horizontal pleiotropy was detected in most analyses, though some reverse analyses showed evidence of these violations.</p><p><strong>Conclusions: </strong>Genetic prediction of depression correlates with increased neck-shoulder/hip/knee pain risk, with reverse associations for these MSDs and depression. Findings are preliminary and require clinical validation.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"475-482"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147825792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}