Biopsychosocial science and medicine最新文献

{"title":"The Association Between Cytomegalovirus Infection and Daily Stress Processes in Early Adulthood.","authors":"Elana M Gloger, Aaron A Miller, Thomas W McDade, Suzanne C Segerstrom","doi":"10.1097/PSY.0000000000001472","DOIUrl":"10.1097/PSY.0000000000001472","url":null,"abstract":"<p><strong>Objective: </strong>Cytomegalovirus (CMV), a common, asymptomatic, latent virus, may contribute to individual differences in daily psychological stress processes and ensuing poor health. Though mechanisms linking CMV to daily stress are poorly understood, CMV has been associated with self-regulatory deficits in older adults that, in turn, may affect daily stress processes. We examined this model in young adults who may still be able to modify CMV-related interference on daily life.</p><p><strong>Methods: </strong>Participants ( N =108, M age =19.8, 83.3% female, 72% White) completed a lab visit and a 14-day daily diary (90.2% response rate; Brief Self-Control Scale, Behavioral Inhibition/Behavioral Activation Scale, Difficulties in Emotion Regulation Scale, Daily Inventory of Stressful Events, PROMIS Emotional Distress-Depression and Anxiety). CMV IgG was assayed from finger stick dried blood spot samples via ELISA. Gaussian and Poisson multilevel models tested the effects of CMV serostatus and IgG antibodies.</p><p><strong>Results: </strong>CMV seropositivity associated with lower daily stress exposure at higher levels of BAS-Drive (λ=-0.098, p =.047) and with lower daily stress severity at higher levels of BAS-total and BAS-drive (γ=-0.011, p =.011; γ=-0.018, p =.020). Higher CMV IgG associated with lower daily stress severity at higher levels of BAS-fun seeking and BAS-total (γ=-0.013, p =.043; γ=-0.008, p =.024).</p><p><strong>Conclusions: </strong>CMV interacted with motivation to affect daily stress processes in young adults. However, CMV may just be epiphenomenal to an untested factor that relates to self-regulation and stress. Findings represent vital work in understanding contributions to healthspan, or years of healthy living, early in life. Future research should continue examining CMV latency effects from younger to older adulthood.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"452-463"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147871284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between Childhood Adversity and Pain in Breast Cancer Survivors.","authors":"Enya M Daang, Patricia A Ganz, Julienne E Bower","doi":"10.1097/PSY.0000000000001487","DOIUrl":"10.1097/PSY.0000000000001487","url":null,"abstract":"<p><strong>Objective: </strong>Pain is a prominent symptom in breast cancer survivors, but associated factors are still under investigation. Childhood adversity has been linked to pain in adulthood through emotional and biological pathways but has been relatively unexplored in the context of breast cancer. The current study examines the association between childhood adversity and pain in breast cancer survivors and meditation by ambivalence over emotional expression (hereinafter referred to as emotional ambivalence) and inflammation. We hypothesize a positive association between childhood adversity and pain, mediated by greater emotional ambivalence and higher levels of inflammation.</p><p><strong>Methods: </strong>Women diagnosed with stage 0 to IIIA breast cancer ( N =175) completed assessments 1 year after the completion of primary treatment, including questionnaires assessing childhood adversity (Risky Families), emotional ambivalence (ambivalence towards emotional expressivity), and pain (SF-36). Blood samples were collected to measure plasma markers of inflammation (IL-1ra, IL-6, CRP, and sTNFR-II).</p><p><strong>Results: </strong>Childhood adversity was significantly associated with greater pain, B =0.36, p =.008, which was significantly mediated by emotional ambivalence, B =0.09, 95% CI [0.02, 0.18]. There were no significant indirect effects through any of the inflammatory markers. We also explored the associations between dimensions of childhood adversity and pain. Similar linear regression and mediation results were found for threat and neglect, whereas there were no significant findings in models examining household chaos.</p><p><strong>Conclusions: </strong>Findings highlight the relevance of childhood adversity as a contributor to persistent pain in breast cancer survivors and identify emotional ambivalence as a key pathway and potential target for intervention.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"444-451"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13648670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147794774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consultation-Liaison Psychiatry Interventions: The Sooner, The Better.","authors":"Alice Demesmaeker, Thomas Fovet, Ali Amad, Fabien D'Hondt, Mathilde Horn","doi":"10.1097/PSY.0000000000001484","DOIUrl":"10.1097/PSY.0000000000001484","url":null,"abstract":"<p><strong>Objective: </strong>Psychiatric disorders are common among general hospital patients. A large study conducted previously showed that timely contact with a consultation-liaison psychiatry (CLP) service is associated with a shorter length of stay (LOS). The aim of this work was to replicate this study with recent data covering the pandemic period to confirm the impact of timely contact with CLP on LOS.</p><p><strong>Methods: </strong>We retrospectively included 2070 patients referred to CLP between 2018 and 2022 at the University Hospital of Lille. General linear models were used to assess associations between the timing of CLP interventions and LOS and to identify predictors of the timing of CLP interventions (eg, age, sex, type of ward, psychiatric diagnosis, and year of admission).</p><p><strong>Results: </strong>The timing of CLP interventions was significantly positively associated with LOS. Referral time (ie, log(days before consultation)/log(LOS)) was significantly associated with log-transformed LOS (model 1: β=0.11, p <.001), and this association remained consistent after adjustment for covariates (model 2: β=0.13, p <.001). Admissions in 2020 and 2021 were associated with shorter times before CLP interventions (Model 3: β =-0.06, p =.020 and β =-0.06, p =.022, respectively), whereas surgical and intensive care admissions were associated with longer times to consultation (model 3: β =0.04, p =.036 and β =0.08, p <.001, respectively).</p><p><strong>Conclusions: </strong>The present study confirms that earlier CLP intervention is associated with shorter LOS in general hospitals. The COVID health emergency provided an opportunity to demonstrate the benefits of early psychiatric consultation to reduce LOS.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"493-497"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147680065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy Hormones and Offspring Psychiatric Problems: Testing Associations Between Placental Corticotropin-Releasing Hormone and Children's Age 8 Internalizing Outcomes.","authors":"Alexandra D W Sullivan, Emily S Barrett, Alexis Sullivan, Michael Coccia, Amanda Noroña-Zhou, Brent Collett, Karen Derefinko, Danielle S Roubinov, Kecia N Carroll, Ruby Nguyen, Roger Smith, Qi Zhao, Kaja Z LeWinn, Nicole R Bush","doi":"10.1097/PSY.0000000000001478","DOIUrl":"10.1097/PSY.0000000000001478","url":null,"abstract":"<p><strong>Objective: </strong>Placental corticotropin-releasing hormone (pCRH) is a peptide essential for fetal development and birth timing. Prenatal programming frameworks position maternal pCRH as a primary neuroendocrine mediator underlying the intergenerational transmission of stress, but empirical evidence is sparse. Using rigorous methodology, we conducted the first investigation of associations between pCRH and multi-informant indicators of offspring internalizing psychopathology during middle childhood.</p><p><strong>Methods: </strong>This study used the Conditions Affecting Neurocognitive Development and Learning in Early Childhood (CANDLE) sample of socioeconomically diverse mother-child dyads ( n =838) followed prospectively from pregnancy. We estimated pCRH rate of rise and level at delivery using maternal second and third trimester blood plasma. We operationalized child internalizing psychopathology and related behavioral phenotypes at age 8 with maternal report of internalizing problems, child report of depression and anxiety, and task-based indicators of threat sensitivity. Covariate-adjusted regression models estimated associations between pCRH and offspring outcomes and whether fetal sex moderated associations.</p><p><strong>Results: </strong>Neither rate of rise nor cumulative exposure was associated with any of the 6 multi-method, multi-informant child outcomes tested (eg, child-reported depression and anxiety symptoms, maternal-reported internalizing problems, task-based indicators of threat sensitivity) ( p s range from .16-.83). Fetal sex did not moderate associations.</p><p><strong>Conclusions: </strong>Contrasting theory and findings in smaller samples at younger ages, evidence from this study did not support pCRH as a plausible maternal neuroendocrine mediator for the intergenerational transmission of stress effects on offspring internalizing psychopathology during middle childhood. Future research exploring potential for waning associations across early childhood or other potential mechanisms is warranted.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"422-433"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147597433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence for the Absence of Attentional Biases Towards Stigma-Related and Disease-Related Information in Atopic Dermatitis.","authors":"Henning Holle, Chloe North, Antoinette I M van Laarhoven, Shernaz Walton","doi":"10.1097/PSY.0000000000001479","DOIUrl":"10.1097/PSY.0000000000001479","url":null,"abstract":"<p><strong>Objective: </strong>The attentional hypothesis of psychological distress suggests that people with visible dermatological conditions may display an attentional preference for disease-related or stigma-related cues. Although this idea has been tested in psoriasis, the current work is the first to examine it in the context of atopic dermatitis.</p><p><strong>Methods: </strong>We conducted 4 preregistered online experiments in which individuals with atopic dermatitis ( N =133) and matched healthy controls completed an emotional spatial cueing task. Reaction times to stigma-related and disease-related threat words, compared with neutral words, were used as indicators of attentional bias.</p><p><strong>Results: </strong>Across all 4 studies, participants with atopic dermatitis did not show enhanced attention toward threat-related stimuli. Frequentist analyses revealed no significant attentional bias differences between groups either at shorter stimulus onset asynchronies (300 ms, reflecting disengagement processes) or at longer ones (1300 ms, reflecting sustained attention under strategic control). Bayes Factors provided additional support for the null in 3 experiments (BF10<1/3) and inconclusive evidence in one (BF10=0.4).</p><p><strong>Conclusions: </strong>Contrary to the attentional hypothesis, individuals with atopic dermatitis did not preferentially allocate attention to disease-related or stigma-related cues. By combining preregistration, frequentist statistics, and Bayesian inference, this work provides robust evidence that is incompatible with the assumption of attentional hypervigilance in atopic dermatitis.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"483-492"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147794780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cortisol Recovery Differs Among Sexual and Gender Diverse Couples Compared With Cisgender Heterosexual Couples.","authors":"Silke Jacmin-Park, Sophie Bergeron, Robert-Paul Juster","doi":"10.1097/PSY.0000000000001485","DOIUrl":"10.1097/PSY.0000000000001485","url":null,"abstract":"<p><strong>Objective: </strong>Positive romantic relationships are linked to physical health through stress buffering. A growing number of studies have used the Trier Social Stress Test (TSST) to examine cortisol reactivity and recovery among couples. To date, research has focused on stress-exposed individuals' cortisol output, often neglecting support-providing partners' responses and their contribution to the couple's recovery. Further, beyond documented sex differences in reactive cortisol, gender and sexual orientation have been related to variability in stress reactivity. Yet, sexual and gender diverse (SGD) couples have received little attention among these studies.</p><p><strong>Methods: </strong>One hundred one couples ( N= 202), including 42 SGD couples, took part in a 2-hour laboratory protocol. One partner underwent the TSST and the other acted as a support during filmed discussions before and after the task. Both partners provided 7 saliva samples and completed anxiety and sociodemographic measures.</p><p><strong>Results: </strong>Male sex was predictive of stronger cortisol reactivity among stress-exposed participants ( β s=0.04 to 0.06; p s=.005 to .045), whereas female sex was predictive of higher cortisol secretion among supporting partners ( β s=0.06 to 0.08; p s=.009 to .027). Among stress-exposed participants, no difference in total cortisol output was found when comparing gender and sexual orientation subgroups ( p s > .14). Notably, SGD couples presented lower cortisol secretion after the TSST than cisgender heterosexual couples ( β s=-0.03 to -0.05; p s=.026 to .035).</p><p><strong>Conclusions: </strong>Sex differences were observed among stress-exposed individuals and supporting partners. Critically, SGD couples may uniquely benefit from partner support in recovering from stress when compared with cisgender heterosexual couples.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"434-443"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147794842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosocial and Clinical Correlates of Somatic Symptom Disorder in Patients With and Without Somatic Comorbidities: Cross-Sectional Findings From the SOMA.SSD Study.","authors":"Henrike Wittenbecher, Stefanie Hahn, Yvonne Nestoriuc, Kristina Blankenburg, André Strahl, Franz Pauls, Kerstin Maehder, Bernd Löwe, Anne Toussaint","doi":"10.1097/PSY.0000000000001483","DOIUrl":"10.1097/PSY.0000000000001483","url":null,"abstract":"<p><strong>Objective: </strong>Somatic symptom disorder (SSD) is characterized by persistent physical symptoms causing significant distress. Unlike earlier criteria, SSD does not require the absence of other medical conditions, resulting in a heterogeneous patient population. Few studies have systematically compared SSD patients with and without somatic comorbidities. This study examined the frequency of somatic comorbidities in SSD and their associations with psychosocial characteristics and disorder severity.</p><p><strong>Methods: </strong>Cross-sectional data from the SOMA.SSD study were analyzed. SSD was diagnosed through the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5). Somatic comorbidity was assessed with the physician-rated Cumulative Illness Rating Scale (CIRS). Patients with and without somatic comorbidity were compared on psychosocial and clinical variables. Ordinal logistic regression identified factors associated with SSD severity.</p><p><strong>Results: </strong>A total of 241 SSD patients were included from a psychosomatic outpatient clinic (mean age: 44.5 y, SD 13.7; 66.8% female). SSD severity was mild in 35.7%, moderate in 38.6%, and severe in 25.7%. Mean CIRS score was 4.4 (SD: 3.18; range: 0 to 52), with 61.0% of patients having at least one somatic comorbidity. Patients with somatic comorbidity were older and reported lower physical but higher mental health-related quality of life. Higher health anxiety was associated with greater SSD severity ( β =0.287, p <.001), whereas somatic comorbidity was not linked to severity or psychosocial measures.</p><p><strong>Conclusions: </strong>Somatic comorbidities were common in SSD but did not influence severity or psychosocial profile, supporting the validity of the diagnosis independent of physical disease. Health anxiety emerged as a key correlate of severity, highlighting its relevance as a treatment target.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"464-474"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13220931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147680116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attachment Insecurity and Well-Being in Dementia Spousal Caregivers: The Moderating Role of Marital Satisfaction.","authors":"Vincent D Lai, Daniel L Argueta, Kelly N Brice, Bryan T Denny, Charles Green, Luis D Medina, Jensine Paoletti-Hatcher, Paul E Schulz, Jennifer M Stinson, E Lydia Wu-Chung, Cobi J Heijnen, Christopher P Fagundes","doi":"10.1097/PSY.0000000000001466","DOIUrl":"10.1097/PSY.0000000000001466","url":null,"abstract":"<p><strong>Objective: </strong>Caregivers for spouses with Alzheimer disease and related dementias (AD/ADRD) who exhibit insecure attachment orientations-specifically, greater attachment anxiety and/or avoidance-are at risk for poorer physical and mental well-being. Marital satisfaction, or caregivers' general evaluations of their relationship with their spouses, may buffer this risk. We tested marital satisfaction as a potential buffer of the associations between attachment orientation and psychological and physiological indices of well-being.</p><p><strong>Methods: </strong>A cross-sectional sample of 264 AD/ADRD spousal caregivers completed self-report measures of attachment orientation, marital satisfaction, and depressive symptoms and provided blood samples. We conducted multiple regression models to test study hypotheses.</p><p><strong>Results: </strong>Greater attachment avoidance was associated with more depressive symptoms ( P = .002) and higher lipopolysaccharide (LPS)-stimulated cytokine production ( P = .001). The associations between attachment avoidance and depressive symptoms ( P = .045) or LPS-stimulated cytokine production ( P = .028) were weaker at higher levels of marital satisfaction. Greater attachment anxiety was associated with more depressive symptoms ( P < .001), and, unexpectedly, this association was stronger as caregivers reported higher levels of marital satisfaction ( P = .028). Marital satisfaction did not moderate the association between attachment anxiety and LPS-stimulated cytokine production ( P = .20).</p><p><strong>Conclusions: </strong>Our work contributes to the body of research examining psychosocial factors that shape well-being among caregivers. Our findings may inform future interventions focusing on the marital relationship to improve caregiver well-being; although these interventions may benefit avoidantly attached caregivers, anxiously attached caregivers may benefit most from intervention approaches tailored to their specific attachment orientation.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"408-420"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13340580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146128997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Somatic Symptom Distress, Health Anxiety, Alexithymia, and Emotion Generation: Results of an Evidence Accumulation Model.","authors":"Karoline Sophie Sauer, Ann-Kathrin Mohr, Michael Witthöft","doi":"10.1097/PSY.0000000000001459","DOIUrl":"10.1097/PSY.0000000000001459","url":null,"abstract":"<p><strong>Objective: </strong>High levels of somatic symptom distress and health anxiety have been linked to difficulties in emotion generation, identification, and regulation. However, these findings stem largely from correlational studies using questionnaires. Mechanistic experimental evidence is scarce and inconclusive.</p><p><strong>Methods: </strong>The present study investigated associations between somatic symptom distress (SSS-8), health anxiety (MK-HAI), alexithymia (TAS-20), and experimental indicators of emotion generation in N = 78 participants (age: M = 23.12, SD = 3.50; sex: 80.8% females, 19.2% males). An innovative experimental paradigm of emotion generation by Givon and colleagues (2023) was used, which assesses emotional responses to normed negative or positive pictures. It allows the calculation of evidence accumulation parameters that reflect emotion processing efficiency (drift-rate) and response bias in emotion reporting (threshold), based on a linear ballistic accumulator model.</p><p><strong>Results: </strong>Somatic symptom distress was not associated with emotion processing efficiency (drift-rate) for negative emotions (BF inclusion = 0.49). There was anecdotal evidence for an effect of health anxiety (BF inclusion = 2.53), but the effect was small and inconclusive [ b = -0.01, SD = 0.004, 95% CI (-0.01, <0.001)], thus failing to support a strong association. Experimental indicators of emotion generation were also unrelated to self-reported alexithymia (0.14 < BF 10 < 0.18).</p><p><strong>Conclusions: </strong>The study did not provide evidence that somatic symptom distress or health anxiety are linked to a markedly reduced efficiency in processing of negative emotions. As this was a convenience sample with predominantly nonclinical symptom levels, future studies should test the generalizability of these findings to clinical samples.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"350-359"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146121670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Negative Affect and Plasma Aldosterone in Working Adults.","authors":"William D Eckerle, Bethany Barone-Gibbs, Thomas Kamarck, Subashan Perera, Matthew F Muldoon","doi":"10.1097/PSY.0000000000001477","DOIUrl":"10.1097/PSY.0000000000001477","url":null,"abstract":"<p><strong>Objective: </strong>Previous research suggests that psychological stress and its correlates, such as heightened negative affect, are associated with increased risk for cardiovascular disease. It has been suggested that activity of the renin-angiotensin-aldosterone system (RAAS) may be a mechanism linking stress and negative affect to risk for cardiovascular disease, but evidence in support of an association between negative affect and RAAS activity is inconsistent. The present study sought to test the hypothesis that individuals who report greater levels of negative affect would have heightened plasma aldosterone concentrations.</p><p><strong>Methods: </strong>Using preintervention baseline data from the RESET-BP trial, we examined the association between negative affect, measured by the Profile of Mood States and Short-Form 36 questionnaires, and plasma aldosterone in 193 adult men and women (aged 24 to 65 years, 55% females).</p><p><strong>Results: </strong>Correlational and linear regression analyses showed no evidence of an association between aldosterone and negative affect, with or without controlling for sex, age, BMI, education, and race.</p><p><strong>Conclusions: </strong>Negative affect may not be related to concentrations of aldosterone, and additional research is required to understand the psychological mediators of previously observed associations between mood-related psychopathology and aldosterone.</p>","PeriodicalId":520402,"journal":{"name":"Biopsychosocial science and medicine","volume":" ","pages":"399-407"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147477556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}