Pediatric discovery最新文献_第9页

Nutritional strategies for childhood obesity treatment and prevention without counting calories-A narrative review. 在不计算卡路里的情况下治疗和预防儿童肥胖的营养策略。

Pediatric discovery Pub Date : 2025-01-10 eCollection Date: 2025-03-01 DOI: 10.1002/pdi3.2524

Karolina Kuźbicka

引用次数: 0

Advances in examination methods for adolescent idiopathic scoliosis. 青少年特发性脊柱侧凸检查方法研究进展。

Pediatric discovery Pub Date : 2025-01-09 eCollection Date: 2025-03-01 DOI: 10.1002/pdi3.2518

Di Li, Peikang Wang, Man Zhang, Xinkai Zhang, Hailun Yao, Xing Liu

{"title":"Advances in examination methods for adolescent idiopathic scoliosis.","authors":"Di Li, Peikang Wang, Man Zhang, Xinkai Zhang, Hailun Yao, Xing Liu","doi":"10.1002/pdi3.2518","DOIUrl":"10.1002/pdi3.2518","url":null,"abstract":"The purpose of this article is to provide an overview of techniques for evaluating patients with adolescent idiopathic scoliosis (AIS). It encompasses the history, clinical examinations, and diagnostic imaging methods for AIS. These methods include digital radiological examination, EOS® imaging, nuclear medicine, ultrasound, body surface topography techniques such as the Moiré pattern technique, raster stereophotography, and DIERS formetric 4D as well as computed tomography and magnetic resonance imaging (MRI). Traditionally, full-spine standing X-rays have been the standard for diagnosing AIS. High-quality clinical assessments may continue as a reference for assessing other spinal deformities. However, the new diagnostic imaging methods aim to reduce radiation exposure while maintaining image quality and practicality. Emerging technologies demonstrate strong reliability and effectiveness in diagnostic imaging of AlS. These techniques may be beneficial for diagnosing and monitoring AIS and its progression without requiring high levels of radiation exposure. The article is a search and summary of the PubMed electronic database to understand the current and future status of AIS imaging technology, which can not only help to introduce other researchers to the field but also serve as a valuable source for healthcare professionals to study existing methods, develop new ones, or select evaluation strategies.","PeriodicalId":520221,"journal":{"name":"Pediatric discovery","volume":"3 1","pages":"e2518"},"PeriodicalIF":0.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CXCL14 increase dendritic cell antigen presentation and promote asthma immune response. CXCL14增加树突状细胞抗原呈递，促进哮喘免疫应答。

Pediatric discovery Pub Date : 2025-01-05 eCollection Date: 2025-09-01 DOI: 10.1002/pdi3.2514

Wenjie Wu, Fengxia Ding, Yan Li, Zhou Fu

{"title":"CXCL14 increase dendritic cell antigen presentation and promote asthma immune response.","authors":"Wenjie Wu, Fengxia Ding, Yan Li, Zhou Fu","doi":"10.1002/pdi3.2514","DOIUrl":"10.1002/pdi3.2514","url":null,"abstract":"Asthma is a chronic airway inflammatory disease characterized by reversible airflow limitation and airway hyperresponsiveness, which requires long-term drug treatment and management. It is very important to study the etiology and pathogenesis of asthma for clinical asthma prevention and treatment. In this study, to understand the correlation between C-X-C motif chemokine ligand 14 (CXCL14) in bone marrow dendritic cells (BMDCs) and antigen presentation of asthma dendritic cells (DCs), an in vitro model of BMDCs was constructed for RNA sequencing (RNA-seq). The changes of CXCL14 in BMDCs after house dust mites (HDM) stimulation were evaluated. Finally, evaluated the inflammation of the lung tissue in mice, and the expression of costimulatory molecules on the DCs surface in the lung tissue was analyzed by flow cytometry. The results showed that CXCL14 was upregulated in BMDCs after HDM stimulation, and its function was related to signal molecule interaction and the immune system. The expression of CXCL14 was increased in the HDM-induced allergic asthma model. Knockdown of CXCL14 reduced the expression of costimulatory molecules CD86, CD80, and major histocompatibility complex II on the surface of DCs in the lung tissue of mice, induced immune tolerance, and reduced lung inflammatory cell infiltration and inflammatory factor levels, providing new ideas and theoretical basis for the clinical treatment of bronchial asthma.","PeriodicalId":520221,"journal":{"name":"Pediatric discovery","volume":"3 3","pages":"e2514"},"PeriodicalIF":0.0,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12483293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new prediction diagnosis model of incomplete Kawasaki disease based on data mining with big data. 基于大数据数据挖掘的不完全川崎病预测诊断新模型

Pediatric discovery Pub Date : 2024-12-23 eCollection Date: 2025-12-01 DOI: 10.1002/pdi3.2516

Zhen Yang, Bo Pan, Jia Liu, Haolin Wang, Jie Tian

{"title":"A new prediction diagnosis model of incomplete Kawasaki disease based on data mining with big data.","authors":"Zhen Yang, Bo Pan, Jia Liu, Haolin Wang, Jie Tian","doi":"10.1002/pdi3.2516","DOIUrl":"10.1002/pdi3.2516","url":null,"abstract":"Kawasaki disease (KD) is an acute, self-limited febrile illness occurring in children. In actual clinical situations, unlike complete Kawasaki disease (CKD), incomplete Kawasaki disease (IKD) lacks typical symptoms and is difficult to distinguish from many febrile illnesses, which poses a challenge to accurate diagnosis and misleading the treatment. Therefore, we investigated the independent risk factors for early prediction of IKD in children. In this research, 809 children suffering from IKD were recruited from the Children's Hospital of Chongqing Medical University from 2007 to 2017, as well as 2427 children were related to febrile diseases, divided into the IKD group and the other related febrile disease group. According to the results of univariate analysis, the study population was divided into three age groups to develop group-specific models that demonstrated more effective performance. Finally, the 0-24 months old group obtained eight independent risk factors: CRP, LDH, UA, TP, ALB, RDA, PLT, and HGB, with the ROC curve showing an AUC of 0.862 in the predictive model and 0.88 in the new dataset. Meanwhile, LDH, UA, ALB, PLT, and MCHC were in the 24-60 months old group, among which AUC was 0.83 in the predictive model and 0.82 in the new dataset; the older group obtained LDH, UA, MCHC, and PLT, with an AUC of 0.7 in the predictive model and 0.8 in the new dataset. Particularly, UA is a new independent risk factor of IKD. These findings offer valuable insights into guiding the personalized diagnosis of IKD in pediatric patients.","PeriodicalId":520221,"journal":{"name":"Pediatric discovery","volume":"3 4","pages":"e2516"},"PeriodicalIF":0.0,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12753023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145879685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploratory analysis of the key role of immune function changes in BPD. 免疫功能改变在BPD中关键作用的探索性分析。

Pediatric discovery Pub Date : 2024-12-21 eCollection Date: 2024-12-01 DOI: 10.1002/pdi3.2515

Tianyi Wu, Xingmeng Fu, Xiaoxia Gong, Jingyi You, Zhou Fu, Chang Shu

{"title":"Exploratory analysis of the key role of immune function changes in BPD.","authors":"Tianyi Wu, Xingmeng Fu, Xiaoxia Gong, Jingyi You, Zhou Fu, Chang Shu","doi":"10.1002/pdi3.2515","DOIUrl":"10.1002/pdi3.2515","url":null,"abstract":"Bronchopulmonary dysplasia (BPD) is one of the most prevalent and severe chronic lung diseases in premature infants. The objective of the current study was to screen for key BPD-associated genes and pathways by transcriptomic analysis from clinical patients and animal models. In our study, the differentially expressed genes were screened from 58 children with 14-day BPD and 40 normal children in the GSE32472 dataset of the Gene Expression Omnibus database. Then, we identified four hub genes (Cd3e, Cd3g, Cd247, and Itk) and a signaling pathway (T cell receptor signaling pathway) by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis and protein-protein interaction analysis. The differential expression of the relevant pathways and gene sets among the groups was verified via GSEA analysis. Subsequently, a rat model of BPD with hyperoxia-induced lung injury was established, and the transcriptome sequencing of the whole lung tissue was performed. A similar analysis was done on the sequencing data of the hub genes and associated pathway screening to verify the accuracy. Ultimately, quantitative polymerase chain reaction was performed to validate the transcriptomics data of core gene expression in the rat model. Our study revealed that the downregulation of the expression of the above four key genes in the course of BPD leads to a decrease in the function of T cell receptor signaling pathways, it causes immune dysfunction and increases the severity of lung inflammation as well as susceptibility to other respiratory infectious diseases.","PeriodicalId":520221,"journal":{"name":"Pediatric discovery","volume":"2 4","pages":"e2515"},"PeriodicalIF":0.0,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metronomic chemotherapy in pediatric neuroblastoma. 节律化疗治疗小儿神经母细胞瘤。

Pediatric discovery Pub Date : 2024-12-10 eCollection Date: 2024-12-01 DOI: 10.1002/pdi3.2512

Yi Jiang, Chengjun Xi, Chao Yang

{"title":"Metronomic chemotherapy in pediatric neuroblastoma.","authors":"Yi Jiang, Chengjun Xi, Chao Yang","doi":"10.1002/pdi3.2512","DOIUrl":"10.1002/pdi3.2512","url":null,"abstract":"Metronomic chemotherapy (MC) is an innovative therapeutic approach that involves the chronic administration of low doses of chemotherapy agents. This strategy aims to sustain prolonged and active plasma levels of drugs, which can result in favorable tolerability. MC has shown promise in the treatment of hematologic and solid tumors, including high-risk neuroblastoma and relapsed/refractory (R/R) neuroblastoma. In the contemporary management of neuroblastoma, MC stands as a viable maintenance therapy for newly diagnosed patients lacking access to autologous stem cell transplantation or immunotherapy, particularly in resource-constrained regions. Furthermore, it serves as a pragmatic alternative for individuals intolerant to intensified regimens or undergoing palliative care for R/R neuroblastoma. Nevertheless, the quest for the optimal MC regimen persists, necessitating comprehensive investigations to delineate standardized protocols. Moreover, the identification of potential biomarkers or prognostic indicators assumes paramount significance in refining MC strategies for future breakthroughs in this domain. This review embarks on a comprehensive exploration of MC in neuroblastoma, offering insights into its historical underpinnings, diverse applications, adverse effect and future prospects, endeavoring to enrich our understanding of MC role in neuroblastoma management.","PeriodicalId":520221,"journal":{"name":"Pediatric discovery","volume":"2 4","pages":"e2512"},"PeriodicalIF":0.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fostering innovation and advancement in evidence-based practice and guidelines within the field of pediatrics: The 2024 BRIGHT declaration. 促进儿科领域循证实践和指南的创新和进步：2024年光明宣言。

Pediatric discovery Pub Date : 2024-12-10 eCollection Date: 2024-12-01 DOI: 10.1002/pdi3.2513

Xu Wang, Hui Liu, Janne Estill, Fujian Song, Akihiko Ozaki, Juan V A Franco, Ivan D Florez, Etienne Ngeh, Nav Persaud, Liliya Eugenevna Ziganshina, Myeong Soo Lee, Lu Zhang, Yuan Chi, Yuting Duan, Enmei Liu, Yaolong Chen, Xiaodong Zhao

引用次数: 0

Mortality trends in suicide among pediatric and adolescent patients aged 15-24 years in Mississippi, 2012-2022. 2012-2022年密西西比州15-24岁儿童和青少年自杀死亡率趋势

Pediatric discovery Pub Date : 2024-12-05 eCollection Date: 2025-03-01 DOI: 10.1002/pdi3.2511

Elizabeth Jones

{"title":"Mortality trends in suicide among pediatric and adolescent patients aged 15-24 years in Mississippi, 2012-2022.","authors":"Elizabeth Jones","doi":"10.1002/pdi3.2511","DOIUrl":"10.1002/pdi3.2511","url":null,"abstract":"Due to the lack of studies examining suicide trends and its implications on pediatric populations, this study aimed to address the gap in research and to identify the magnitude and the impact of suicide by exploring trends in suicide among Mississippians from 2012 to 2022. The study uses data from the Mississippi Statistically Automated Health Resource System, which is an online database with data collected from vital statistics. Joinpoint regression models were used to calculate annual percentage change (APC) and average annual percentage change (AAPC) as an indicator of trends. The overall age-adjusted suicide rate increased from 9.4 deaths per 100,000 in 2012 to 10.8 deaths per 100,000 in 2022 for pediatric and adolescent patients aged 15-24 years (14.9% increase). There are upward trends for females (AAPC, 6.33%, 95% CI, -0.82%-16.82%), Blacks (AAPC, 7.72%, 95% CI, 2.19%-16.47%), and other races (AAPC, 7.59%, 95% CI, -0.83%-21.47%). Males had a downward trend from 2015 to 2022 (APC, -1.46%, 95 CI, -14.05%-1.35%). Whites also had a downward trend from 2017 to 2022 (APC, 4.74%, 95% CI, -15.42% to -0.96%). This study identified an overall increase in suicide. However, trends varied by gender, race, and age. Based on the findings, Mississippi needs more initiatives aimed toward equitable prevention of suicide among youth and the implementation of gun control policies. By implementing these measures, Mississippi could tremendously benefit and improve mental health outcomes and reduce suicide within the state.","PeriodicalId":520221,"journal":{"name":"Pediatric discovery","volume":"3 1","pages":"e2511"},"PeriodicalIF":0.0,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric postural orthostatic tachycardia syndrome: From mechanisms to individualized management. 儿童体位性心动过速综合征：从机制到个体化治疗。

Pediatric discovery Pub Date : 2024-11-24 eCollection Date: 2024-12-01 DOI: 10.1002/pdi3.2509

Wenrui Xu, Hongfang Jin, Ying Liao, Junbao Du

引用次数: 0

Pediatric endocardial temporary pacemaker implantation: Clinical characteristics and outcomes from a Chinese National Regional Health Center. 儿童心内膜临时起搏器植入：来自中国国家区域卫生中心的临床特征和结果。

Pediatric discovery Pub Date : 2024-11-18 eCollection Date: 2025-03-01 DOI: 10.1002/pdi3.2508

Zhongyuan Liu, Kaijun Zhang, Jun Ren, Penghui Yang, Mi Li, Ping Xiang

{"title":"Pediatric endocardial temporary pacemaker implantation: Clinical characteristics and outcomes from a Chinese National Regional Health Center.","authors":"Zhongyuan Liu, Kaijun Zhang, Jun Ren, Penghui Yang, Mi Li, Ping Xiang","doi":"10.1002/pdi3.2508","DOIUrl":"10.1002/pdi3.2508","url":null,"abstract":"Endocardial temporary pacemakers (TP) are widely used in the treatment of cardiovascular diseases in adults, but their application and clinical experience in the treatment of pediatric cardiovascular cases are relatively limited. This study aims to share the experience of using endocardial TP at a pediatric medical center in China. The study included patients who received their first endocardial TP implantation in the Department of Cardiology at Children's Hospital of Chongqing Medical University, China, from 2016 to 2022. A retrospective analysis of their clinical data was conducted. Our study involved 45 children who underwent endocardial TP implantation. Among these, 25 children (55.56%) converted to sinus rhythm after pacemaker parameter adjustment and the pacemaker was successfully removed; 13 children (28.89%) did not recover sinus rhythm and ultimately required a permanent pacemaker; in 4 cases, the family refused permanent pacemaker implantation; in 1 case, the treatment was abandoned by the family; and 2 children died during hospitalization. Notably, among the 20 children with fulminant myocarditis (FM), 16 children (80.00%) converted to sinus rhythm after pacemaker parameter adjustment and the pacemaker was successfully removed; 3 children (15.00%) ultimately received a permanent pacemaker; and 1 child died during hospitalization. Endocardial TP have shown remarkable efficacy in the treatment of critical heart disease, especially FM.","PeriodicalId":520221,"journal":{"name":"Pediatric discovery","volume":"3 1","pages":"e2508"},"PeriodicalIF":0.0,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0