Pediatric discovery最新文献

Protective Effects of the Ketogenic Diet on Cognitive Impairment Induced by Status Epilepticus in Rats: Modulation of Neuroinflammation Through the NF-κB Signaling Pathway. 生酮饮食对癫痫持续状态大鼠认知障碍的保护作用：通过NF-κB信号通路调节神经炎症。

Pediatric discovery Pub Date : 2025-06-23 eCollection Date: 2025-06-01 DOI: 10.1002/pdi3.70013

Wandi Wang, Lingman Wang, Chunxue Jiang, Shengxuan Zhang, Chen Tan, Liqiong Peng, Ran Ding, Bing Tian, Xiaojie Song, Li Jiang

{"title":"Protective Effects of the Ketogenic Diet on Cognitive Impairment Induced by Status Epilepticus in Rats: Modulation of Neuroinflammation Through the NF-κB Signaling Pathway.","authors":"Wandi Wang, Lingman Wang, Chunxue Jiang, Shengxuan Zhang, Chen Tan, Liqiong Peng, Ran Ding, Bing Tian, Xiaojie Song, Li Jiang","doi":"10.1002/pdi3.70013","DOIUrl":"10.1002/pdi3.70013","url":null,"abstract":"Epilepsy is a chronic neurological disorder characterized by abnormal synchronized neuronal discharges, leading to cognitive dysfunction. The ketogenic diet (KD) has shown promise as an effective treatment for drug-resistant epilepsy (DRE), reducing seizures and improving cognitive and behavioral outcomes in patients. However, the precise neuroprotective mechanisms are not fully understood. This study aimed to investigate the effects of KD on cognitive impairment and hippocampal neurocircuit damage in rats with status epilepticus (SE), with a focus on a nuclear factor-kappa B (NF-κB) signaling. SE was induced using pilocarpine, and rats were assigned to KD and control groups. After 7 and 20 days of KD treatment, cognitive function was assessed using the elevated plus-maze, Morris water maze, novel object recognition, and Y-maze tests. Hippocampal tissue was analyzed for structural damage of neurocircuit. NF-κB pathway activation was evaluated by western blot and immunofluorescence. Results indicated that KD significantly improved cognitive performance and reduced hippocampal damage. Additionally, KD inhibited NF-κB pathway activation, evidenced by decreased levels of NF-κB, p-IκB, and proinflammatory cytokines. These findings suggest that KD may alleviate cognitive deficits and hippocampal damage by modulating the NF-κB signaling, providing insights into its neuroprotective mechanisms and potential as an alternative treatment for epilepsy.","PeriodicalId":520221,"journal":{"name":"Pediatric discovery","volume":"3 2","pages":"e70013"},"PeriodicalIF":0.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute Genitourinary Pain and Swelling in a Child-Look Out for the Rashes! 儿童急性泌尿生殖系统疼痛和肿胀——小心皮疹！

Pediatric discovery Pub Date : 2025-06-21 eCollection Date: 2025-06-01 DOI: 10.1002/pdi3.70012

Frankel Lin, Jasmine Huang, Sudipta Roy Chowdhury

引用次数: 0

A Review of the Current State of Off-Label Therapies for Pediatric Inflammatory Bowel Disease. 儿童炎症性肠病说明书外治疗现状综述

Pediatric discovery Pub Date : 2025-06-17 eCollection Date: 2025-06-01 DOI: 10.1002/pdi3.70011

Yassin El-Najjar, Mary-Joe Touma, Shuai Tan, Xiaoqin Zhou, Qi Liu

引用次数: 0

SLEEP-WAKE: A Comprehensive Mnemonic for Systematic Screening of Sleep-Related Issues. 睡眠-觉醒：系统筛选睡眠相关问题的综合助记器。

Pediatric discovery Pub Date : 2025-06-14 eCollection Date: 2025-06-01 DOI: 10.1002/pdi3.70010

Karen Spruyt

引用次数: 0

Identification of Prognostic Biomarkers in Gene Expression Profile of Neuroblastoma Via Machine Learning. 通过机器学习识别神经母细胞瘤基因表达谱中的预后生物标志物。

Pediatric discovery Pub Date : 2025-05-27 eCollection Date: 2025-06-01 DOI: 10.1002/pdi3.70009

Shuxin Tang, Jinhua Fan, Yupeng Cun

{"title":"Identification of Prognostic Biomarkers in Gene Expression Profile of Neuroblastoma Via Machine Learning.","authors":"Shuxin Tang, Jinhua Fan, Yupeng Cun","doi":"10.1002/pdi3.70009","DOIUrl":"10.1002/pdi3.70009","url":null,"abstract":"Neuroblastoma (NB) is a common pediatric solid malignancy characterized by heterogeneous clinical outcomes. The identification of predictive and interpretable prognostic biomarkers is critical for advancing precision medicine in NB. We proposed an integrative network-based machine learning method for biomarker discovery, which employed a network smoothed t-statistic support vector machine to select prognostic related biomarkers, and then we performed network analysis on these biomarkers to find hub genes. Later, we conducted a comprehensive analysis to integrate bulk and single-cell RNA sequencing data to character the tumor microenvironment of prognostic state and correlated them to the discovered hub genes. This analysis identified 528 prognostic biomarkers associated with NB. Network-based analysis further refined this set to 11 hub prognostic biomarkers for NB: AURKA, BLM, BRCA1, BRCA2, CCNA2, CHEK1, E2F1, MAD2L1, PLK1, RAD51, and RFC3. Among these genes, high RFC3 expression was significantly associated with poor prognosis, highlighting its potential as a novel prognostic biomarker in NB. Additionally, our findings revealed that these biomarkers are correlated to chemotherapy drugs, such as vincristine and cyclophosphamide. Furthermore, drug sensitivity analyses identified several candidate drugs, such as dactinomycin, bortezomib, docetaxel, and sepantronium bromide, that may hold therapeutic potential for NB treatment. This study offers novel insights to underlying NB prognosis and therapeutic targets and provides a foundation for developing personalized treatment strategies to improve clinical outcomes.","PeriodicalId":520221,"journal":{"name":"Pediatric discovery","volume":"3 2","pages":"e70009"},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Authors' Reply to PDI-2024-0087: Letter to the Editor for "Metronomic Chemotherapy in Pediatric Neuroblastoma". 作者对PDI-2024-0087的回复：《节拍化疗在小儿神经母细胞瘤中的应用》

Pediatric discovery Pub Date : 2025-05-21 eCollection Date: 2025-06-01 DOI: 10.1002/pdi3.70008

Chao Yang

引用次数: 0

Risk Factors and Clinical Features of Deterioration in 739 COVID-19 Affected Children Aged Under 14 Years in Zhuhai, China: A Multicenter, Retrospective Study. 珠海市739例14岁以下感染COVID-19儿童病情恶化的危险因素和临床特征：一项多中心回顾性研究

Pediatric discovery Pub Date : 2025-05-19 eCollection Date: 2025-06-01 DOI: 10.1002/pdi3.70001

Ting Liu, Zhaojun Pan, Cheng Zhang, Fanlin Huang, Jundong Ding, Wenxiu Song, Yongwu Xie, Guang Lin

{"title":"Risk Factors and Clinical Features of Deterioration in 739 COVID-19 Affected Children Aged Under 14 Years in Zhuhai, China: A Multicenter, Retrospective Study.","authors":"Ting Liu, Zhaojun Pan, Cheng Zhang, Fanlin Huang, Jundong Ding, Wenxiu Song, Yongwu Xie, Guang Lin","doi":"10.1002/pdi3.70001","DOIUrl":"10.1002/pdi3.70001","url":null,"abstract":"To retrospectively analyze the clinical characteristics of children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, this study involved 739 children with SARS-CoV-2 infection who were admitted to multiple medical institutions in Zhuhai City from December 15, 2022 to January 24, 2023. Epidemiological and clinical data were collected and analyzed using statistical methods to understand the disease characteristics. The onset and progression of SARS-CoV-2 infection in children were significantly associated with age distribution, basic illness, vaccination status, exposure history, and family clustering. The most common clinical symptoms were fever (91.7%) and cough (81.6%). Laboratory findings indicated elevated neutrophil count, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, prothrombin time, and procalcitonin, creatine kinase, D-dimer, and IL-6 levels, along with decreased lymphocyte count, platelet count, and lymphocyte-to-monocyte ratio. Lung computed tomography (CT) showed imaging changes strongly linked to severe infection. After receiving anti-inflammatory, symptomatic, supportive, and antipathogen therapies, 74% of the children displayed clinical symptomatic relief, 26% of the children were cured and discharged, and there were no fatalities. In Zhuhai, children infected with SARS-CoV-2 commonly exhibit family-based transmission, with fever and cough as the predominant symptoms. Factors, such as young age, basic illness, specific laboratory markers, and patchy exudative changes on lung CT scans, served as critical indicators of severe infection. Early detection and monitoring of these factors, along with timely vaccination against novel coronavirus, can mitigate disease severity and prevent progression.","PeriodicalId":520221,"journal":{"name":"Pediatric discovery","volume":"3 2","pages":"e70001"},"PeriodicalIF":0.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Translating OMWaNA Trial Findings and Exploring Wider Implications for KMC in Neonatal Care. 翻译OMWaNA试验结果并探索新生儿护理中KMC的更广泛含义。

Pediatric discovery Pub Date : 2025-05-08 eCollection Date: 2025-06-01 DOI: 10.1002/pdi3.70006

Aditya Hemendra Bhatt, Somashekhar Marutirao Nimbalkar, Dipen Vasudev Patel, Reshma Kushal Pujara

引用次数: 0

Assessing the Impact of Screen Time on the Motor Development of Children: A Systematic Review. 评估屏幕时间对儿童运动发展的影响：一项系统综述。

Pediatric discovery Pub Date : 2025-04-30 eCollection Date: 2025-06-01 DOI: 10.1002/pdi3.70002

Danyal Bakht, Faiza Yousaf, Zainab Alvi, Muhammad Khan Buhadur Ali, Mirza Muhammad Hadeed Khawar, Luqman Munir, Syed Faqeer Hussain Bokhari, Muhammad Shoaib Qureshi, Mehnahil Raza, Ali Akram Qureshi

{"title":"Assessing the Impact of Screen Time on the Motor Development of Children: A Systematic Review.","authors":"Danyal Bakht, Faiza Yousaf, Zainab Alvi, Muhammad Khan Buhadur Ali, Mirza Muhammad Hadeed Khawar, Luqman Munir, Syed Faqeer Hussain Bokhari, Muhammad Shoaib Qureshi, Mehnahil Raza, Ali Akram Qureshi","doi":"10.1002/pdi3.70002","DOIUrl":"10.1002/pdi3.70002","url":null,"abstract":"Screen time, defined as the amount of time spent engaging with electronic screens, has become inevitable in modern life. The rise in screen time among children under 5 years old has raised concerns about its association with motor development including gross and fine motor skills. Conflicting evidence on the association of screen time requires more investigation and the planning of targeted interventions. This systematic review aims to explore the relationship between screen time and motor development in children aged 0-7 years, considering various influencing factors like screen type, exposure duration, and context. Following preferred reporting items for systematic reviews and meta-analyses (PRISMA) and assessing the methodological quality of systematic reviews (AMSTAR) guidelines, a literature search was conducted in May 2024 in databases including PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), and ScienceDirect. Eligible studies were observational or experimental, involved children aged 0-7 years, and assessed the outcomes between screen time and motor development. The quality of the included studies was assessed through Joanna Briggs Institute's (JBI) critical appraisal checklist. Out of 1490 records initially identified, 24 studies met the inclusion criteria for this review. Among these, 17 studies reported a significant negative correlation between screen time and motor development in children, while 5 studies found no statistically significant association. Two studies presented mixed findings, indicating both negative and positive associations between screen time and motor development. Excessive screen time in early childhood is mainly linked to negative effects on motor development. The association varies with screen content and environment, highlighting the need for balanced screen time and early interventions.","PeriodicalId":520221,"journal":{"name":"Pediatric discovery","volume":"3 2","pages":"e70002"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the Editor for "Metronomic Chemotherapy in Pediatric Neuroblastoma". 致“小儿神经母细胞瘤节律化疗”编辑的信。

Pediatric discovery Pub Date : 2025-04-17 eCollection Date: 2025-06-01 DOI: 10.1002/pdi3.70003

Ana Ivanovski, Dimitrije Nikolic, Ana Cirovic, Aleksandar Cirovic

引用次数: 0