Pediatric discovery最新文献_第2页

Progress in the treatment of subarterial ventricular septal defect. 动脉下室间隔缺损的治疗进展。

Pediatric discovery Pub Date : 2025-03-14 eCollection Date: 2025-03-01 DOI: 10.1002/pdi3.2519

Chunqiu Fan, Zhengxia Pan, Chun Wu, Yonggang Li, Hongbo Li, Yong An, Gang Wang, Jiangtao Dai

引用次数: 0

Salmonella meningitis bacteremia in two-week neonate: A rare and devastating disease. 两周新生儿沙门氏菌脑膜炎菌血症：一种罕见的毁灭性疾病。

Pediatric discovery Pub Date : 2025-03-12 eCollection Date: 2025-03-01 DOI: 10.1002/pdi3.2510

James S Bassett, Jerrin George, Michelle Cherian

引用次数: 0

Tibial tubercle avulsion fractures in children and adolescents. 儿童和青少年胫骨结节撕脱性骨折。

Pediatric discovery Pub Date : 2025-03-12 eCollection Date: 2025-03-01 DOI: 10.1002/pdi3.2521

Hailun Yao, Yuanlin He, Xiang Li, Mingyan Shi, Peikang Wang, Man Zhang, Xinkai Zhang, Xing Liu

{"title":"Tibial tubercle avulsion fractures in children and adolescents.","authors":"Hailun Yao, Yuanlin He, Xiang Li, Mingyan Shi, Peikang Wang, Man Zhang, Xinkai Zhang, Xing Liu","doi":"10.1002/pdi3.2521","DOIUrl":"10.1002/pdi3.2521","url":null,"abstract":"Tibial tubercle avulsion fractures (TTAFs) are uncommon injuries in the pediatric population, predominantly affecting children and adolescents who are approaching skeletal maturity and frequently engage in high-energy activities. Despite of their rarity, TTAFs can significantly impact the lives of young individuals involved in sports and other strenuous activities. The mechanism of TTAFs occurrence involves forceful quadriceps contraction against resistance or rapid knee flexion with contracted quadriceps. TTAFs may coincide with other related injuries due to their mechanism of occurrence and commonly present with an abrupt onset of pain, focal soft-tissue swelling and tenderness on palpation. Predisposing factors such as a history of Osgood-Schlatter disease and an extreme body mass index (BMI) could contribute to TTAFs susceptibility. Diagnosis of TTAFs typically relies on X-rays, complemented by computed tomography (CT) and magnetic resonance imaging (MRI) for screening associated injuries and preoperative assessment. While a well-established classification system exists, with the Ogden classification being the most commonly employed, intriguingly, a direct correlation between fracture type and treatment method, as well as the choice of surgical fixation modality, remains elusive. The management of TTAFs encompasses both conservative and surgical approaches, with open reduction internal fixation (ORIF) being the predominant surgical method and the prognosis for this condition is generally favorable. By synthesizing existing knowledge and presenting potential areas of uncertainty, this review aims to offer valuable insights to orthopedic practitioners when they are confronted with this infrequent injury.","PeriodicalId":520221,"journal":{"name":"Pediatric discovery","volume":"3 1","pages":"e2521"},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to High Infection Rates and Risk-Adapted Prevention Strategies in Contemporary Pediatric Allogeneic Hematopoietic Stem Cell Transplantation. 纠正当代儿童同种异体造血干细胞移植的高感染率和风险适应预防策略。

Pediatric discovery Pub Date : 2025-03-05 eCollection Date: 2025-03-01 DOI: 10.1002/pdi3.2527

引用次数: 0

An Analysis of Child Abuse Detected by Skeletal Surveys Before and During the COVID-19 Pandemic. COVID-19大流行之前和期间骨骼调查发现的虐待儿童情况分析

Pediatric discovery Pub Date : 2025-02-26 eCollection Date: 2025-03-01 DOI: 10.1002/pdi3.2526

Vincent R Li, Trevor A Pickering, Karen Kay Imagawa, Joseph M Rich, Amit S Sura

{"title":"An Analysis of Child Abuse Detected by Skeletal Surveys Before and During the COVID-19 Pandemic.","authors":"Vincent R Li, Trevor A Pickering, Karen Kay Imagawa, Joseph M Rich, Amit S Sura","doi":"10.1002/pdi3.2526","DOIUrl":"10.1002/pdi3.2526","url":null,"abstract":"The COVID-19 pandemic and the stay-at-home order may have impacted the risk of child physical abuse (CPA). Analyzing injury types in suspected CPA cases before and during the pandemic can provide valuable insights. The objective of this study is to compare the incidences and types of injuries detected by skeletal surveys in suspected CPA cases at a large academic children's hospital before and during the COVID-19 pandemic. The study compared the incidences and proportion of specific injury sites, types of traumas, and demographic characteristics before and during the pandemic using Pearson's chi-squared and Fisher's exact tests. A total of 479 patients who underwent skeletal surveys were included, with 306 patients sampled before the pandemic (63.8%) and 173 patients sampled during the pandemic (36.1%). There were no significant differences in age, gender, or ethnicity between the two groups. Highly suspicious CPA incidences were similar before (0.87/month) and during (0.81/month) the pandemic, reflecting 10.5% and 11.6% of all patients who underwent skeletal surveys, respectively. There were no significant demographic differences between the groups. However, the proportion of patients with intracranial or retinal hemorrhage significantly decreased (p < 0.05) during the pandemic, with no significant differences in types of skeletal fractures. In conclusion, the overall incidence of CPA remained similar before and during the pandemic. The significant decrease in intracranial and retinal hemorrhages suggests a potential change in injury patterns or reporting. Further research is needed to understand the factors contributing to these findings.Clinical trial registration: This study is a retrospective clinical trial and therefore not subject to clinical trial registration requirements.","PeriodicalId":520221,"journal":{"name":"Pediatric discovery","volume":"3 1","pages":"e2526"},"PeriodicalIF":0.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spina bifida as a multifactorial birth defect: Risk factors and genetic underpinnings. 脊柱裂是一种多因素先天缺陷：危险因素和遗传基础。

Pediatric discovery Pub Date : 2025-01-25 eCollection Date: 2025-06-01 DOI: 10.1002/pdi3.2517

Ethan S Wong, Daniel A Hu, Lily Zhang, Rachel Qi, Cindy Xu, Ou Mei, Guowei Shen, Wulin You, Changqi Luo, Tong-Chuan He, Russell R Reid, Lewis S Shi, Michael J Lee, Yi Zhu

{"title":"Spina bifida as a multifactorial birth defect: Risk factors and genetic underpinnings.","authors":"Ethan S Wong, Daniel A Hu, Lily Zhang, Rachel Qi, Cindy Xu, Ou Mei, Guowei Shen, Wulin You, Changqi Luo, Tong-Chuan He, Russell R Reid, Lewis S Shi, Michael J Lee, Yi Zhu","doi":"10.1002/pdi3.2517","DOIUrl":"10.1002/pdi3.2517","url":null,"abstract":"Spina bifida is a birth defect resulting from abnormal embryonic development of the neural tube. Though spina bifida is divided into several subtypes, myelomeningocele-the most severe form of spina bifida often associated with a markedly diminished quality of life-accounts for a significant portion of cases. A broad range of genetic and environmental factors, many of which are still unknown, influence spina bifida, making it difficult to provide a comprehensive etiology for the disorder. Folic acid supplementation aided by the mandatory fortification of food is preventive; still, spina bifida persists due to numerous other confounding factors that affect risk. This article reviews the latest studies pertaining to the risk factors and genetics involved in spina bifida in an attempt to elucidate the complex background of the congenital malformation. Additionally, this review highlights the significant impact of environmental pollutants, adverse medication effects, and maternal health conditions such as diabetes and obesity on the prevalence of spina bifida. Emerging research on gene-environment interactions provides insight into how specific genetic variants may influence susceptibility to these environmental factors. We also discuss new technologies in genetic sequencing that show promise for the large-scale discovery of genes associated with spina bifida risk. Understanding these intricate interactions is crucial for developing effective prevention and intervention strategies.","PeriodicalId":520221,"journal":{"name":"Pediatric discovery","volume":"3 2","pages":"e2517"},"PeriodicalIF":0.0,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical characteristics of children with septic arthritis caused by different pathogenic bacteria. 不同致病菌所致儿童脓毒性关节炎的临床特点。

Pediatric discovery Pub Date : 2025-01-10 eCollection Date: 2025-03-01 DOI: 10.1002/pdi3.2522

Ziyu Li, Gefang Li, Jun Wu, Bo He, Qun Zhang

{"title":"Clinical characteristics of children with septic arthritis caused by different pathogenic bacteria.","authors":"Ziyu Li, Gefang Li, Jun Wu, Bo He, Qun Zhang","doi":"10.1002/pdi3.2522","DOIUrl":"10.1002/pdi3.2522","url":null,"abstract":"Septic arthritis is a serious infectious disease in children. In this study, we retrospectively analyzed the relationship between demographics, laboratory values at presentation, reported symptoms at presentation, joint involvement, and distribution characteristics of pathogenic bacteria in 171 patients during the period of 2012-2022. The results showed that a total of 77 pathogen-positive patients were detected in the 171 patients (culture-positive rate of 45.0%), 15 categories of pathogenic bacteria, and the highest detection rates were 52 cases of Staphylococcus aureus (67.5%), Streptococcus pyogenes in 7 cases (9.1%), and Streptococcus pneumoniae in 5 cases (6.5%). Comparison of these three pathogens revealed that the age of the Staphylococcus aureus and Streptococcus pyogenes groups was significantly older than that of the Streptococcus pneumoniae group (p < 0.05), and that the white blood cell count (WBC) of the Streptococcus pyogenes group was significantly higher than that of the Staphylococcus aureus group (p < 0.05), and that the Streptococcus pyogenes group had a significantly higher procalcitonin (PCT), which was significantly higher in the Streptococcus pneumoniae group (p < 0.05). The results suggest that the pathogenic bacteria of septic arthritis in children are mainly Staphylococcus aureus, Streptococcus pneumoniae infection occurred more commonly in the infant stage, and Staphylococcus aureus and Streptococcus pyogenes were detected frequently in school-age children. Streptococcus pyogenes was found to be more pathogenic than Staphylococcus aureus and Streptococcus pneumoniae.","PeriodicalId":520221,"journal":{"name":"Pediatric discovery","volume":"3 1","pages":"e2522"},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutritional strategies for childhood obesity treatment and prevention without counting calories-A narrative review. 在不计算卡路里的情况下治疗和预防儿童肥胖的营养策略。

Pediatric discovery Pub Date : 2025-01-10 eCollection Date: 2025-03-01 DOI: 10.1002/pdi3.2524

Karolina Kuźbicka

引用次数: 0

Advances in examination methods for adolescent idiopathic scoliosis. 青少年特发性脊柱侧凸检查方法研究进展。

Pediatric discovery Pub Date : 2025-01-09 eCollection Date: 2025-03-01 DOI: 10.1002/pdi3.2518

Di Li, Peikang Wang, Man Zhang, Xinkai Zhang, Hailun Yao, Xing Liu

{"title":"Advances in examination methods for adolescent idiopathic scoliosis.","authors":"Di Li, Peikang Wang, Man Zhang, Xinkai Zhang, Hailun Yao, Xing Liu","doi":"10.1002/pdi3.2518","DOIUrl":"10.1002/pdi3.2518","url":null,"abstract":"The purpose of this article is to provide an overview of techniques for evaluating patients with adolescent idiopathic scoliosis (AIS). It encompasses the history, clinical examinations, and diagnostic imaging methods for AIS. These methods include digital radiological examination, EOS® imaging, nuclear medicine, ultrasound, body surface topography techniques such as the Moiré pattern technique, raster stereophotography, and DIERS formetric 4D as well as computed tomography and magnetic resonance imaging (MRI). Traditionally, full-spine standing X-rays have been the standard for diagnosing AIS. High-quality clinical assessments may continue as a reference for assessing other spinal deformities. However, the new diagnostic imaging methods aim to reduce radiation exposure while maintaining image quality and practicality. Emerging technologies demonstrate strong reliability and effectiveness in diagnostic imaging of AlS. These techniques may be beneficial for diagnosing and monitoring AIS and its progression without requiring high levels of radiation exposure. The article is a search and summary of the PubMed electronic database to understand the current and future status of AIS imaging technology, which can not only help to introduce other researchers to the field but also serve as a valuable source for healthcare professionals to study existing methods, develop new ones, or select evaluation strategies.","PeriodicalId":520221,"journal":{"name":"Pediatric discovery","volume":"3 1","pages":"e2518"},"PeriodicalIF":0.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploratory analysis of the key role of immune function changes in BPD. 免疫功能改变在BPD中关键作用的探索性分析。

Pediatric discovery Pub Date : 2024-12-21 eCollection Date: 2024-12-01 DOI: 10.1002/pdi3.2515

Tianyi Wu, Xingmeng Fu, Xiaoxia Gong, Jingyi You, Zhou Fu, Chang Shu

{"title":"Exploratory analysis of the key role of immune function changes in BPD.","authors":"Tianyi Wu, Xingmeng Fu, Xiaoxia Gong, Jingyi You, Zhou Fu, Chang Shu","doi":"10.1002/pdi3.2515","DOIUrl":"10.1002/pdi3.2515","url":null,"abstract":"Bronchopulmonary dysplasia (BPD) is one of the most prevalent and severe chronic lung diseases in premature infants. The objective of the current study was to screen for key BPD-associated genes and pathways by transcriptomic analysis from clinical patients and animal models. In our study, the differentially expressed genes were screened from 58 children with 14-day BPD and 40 normal children in the GSE32472 dataset of the Gene Expression Omnibus database. Then, we identified four hub genes (Cd3e, Cd3g, Cd247, and Itk) and a signaling pathway (T cell receptor signaling pathway) by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis and protein-protein interaction analysis. The differential expression of the relevant pathways and gene sets among the groups was verified via GSEA analysis. Subsequently, a rat model of BPD with hyperoxia-induced lung injury was established, and the transcriptome sequencing of the whole lung tissue was performed. A similar analysis was done on the sequencing data of the hub genes and associated pathway screening to verify the accuracy. Ultimately, quantitative polymerase chain reaction was performed to validate the transcriptomics data of core gene expression in the rat model. Our study revealed that the downregulation of the expression of the above four key genes in the course of BPD leads to a decrease in the function of T cell receptor signaling pathways, it causes immune dysfunction and increases the severity of lung inflammation as well as susceptibility to other respiratory infectious diseases.","PeriodicalId":520221,"journal":{"name":"Pediatric discovery","volume":"2 4","pages":"e2515"},"PeriodicalIF":0.0,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0