Pediatric discovery最新文献_第3页

Median Effective Volume of 0.2% Ropivacaine for Ultrasound-Guided Axillary Brachial Plexus Block in Children Aged 6-10 Years: A Prospective Dose-Finding Study Using Up-and-Down Sequential Allocation. 超声引导下0.2%罗哌卡因用于6-10岁儿童腋窝臂丛阻滞的中位有效容积：一项使用上下顺序分配的前瞻性剂量研究。

Pediatric discovery Pub Date : 2026-06-11 eCollection Date: 2026-09-01 DOI: 10.1002/pdi3.70049

Tauseef Ahmad, Fei Yang, Yao Xu, Ying Yang, Huanjie Yun, Fei Xu, Yulin Xue, Yu Zhou, Zongke Shi, Yuan Shi, Shangyingying Li, Shengfen Tu

{"title":"Median Effective Volume of 0.2% Ropivacaine for Ultrasound-Guided Axillary Brachial Plexus Block in Children Aged 6-10 Years: A Prospective Dose-Finding Study Using Up-and-Down Sequential Allocation.","authors":"Tauseef Ahmad, Fei Yang, Yao Xu, Ying Yang, Huanjie Yun, Fei Xu, Yulin Xue, Yu Zhou, Zongke Shi, Yuan Shi, Shangyingying Li, Shengfen Tu","doi":"10.1002/pdi3.70049","DOIUrl":"10.1002/pdi3.70049","url":null,"abstract":"The optimal dose for ultrasound-guided axillary brachial plexus block (ABPB) in children remains poorly defined. This study aimed to find the median effective volume (EV50) of ropivacaine (0.2%) for ABPB in children aged 6-10 years. A prospective, double-blind, dose-finding trial using the Dixon up-and-down method was conducted. Pediatric patients (aged 6-10 years, ASA I-II) undergoing unilateral elbow or below-elbow surgery were enrolled. Ultrasound-guided ABPB was performed using a dual-injection technique with supplemental musculocutaneous nerve blockade. The initial volume of ropivacaine (0.2%) was 0.5 mL/kg, adjusted by 0.05 mL/kg based on the previous patient's response. The study continued until seven inflection points were observed from failure to success. EV50 and EV95 (95% effective volume) were calculated using isotonic regression and bootstrapping, with 95% confidence intervals (CIs). Patient demographics, postoperative pain scores, and adverse events were monitored. Twenty-nine patients were enrolled. The EV50 was 0.350 mL/kg (95% CI: 0.197-0.362 mL/kg), and the EV95 was 0.395 mL/kg (95% CI: 0.385-0.396 mL/kg). No adverse events were observed during the perioperative period. This study provides evidence-based dosing parameters for 0.2% ropivacaine in pediatric ABPB, aiding clinicians in optimizing efficacy and safety. The findings support age-specific precision in pediatric regional anesthesia.","PeriodicalId":520221,"journal":{"name":"Pediatric discovery","volume":" ","pages":"e70049"},"PeriodicalIF":0.0,"publicationDate":"2026-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13398711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gastric Lipoma in a 10-Year-Old Patient: A Case Report and Literature Review. 10岁患者胃脂肪瘤1例报告及文献复习。

Pediatric discovery Pub Date : 2026-06-11 eCollection Date: 2026-06-01 DOI: 10.1002/pdi3.70055

Yiwen Huang, Ting Li, Baisha Huang, Peng Li, Xiaochun Zhu, Wuping Ge, Chengwei Chai

引用次数: 0

The Airway Epithelial Barrier in Childhood Asthma: A Central Player in Glucocorticoid Therapy, Resistance, and Severe Asthma. 儿童哮喘的气道上皮屏障：糖皮质激素治疗、抵抗和严重哮喘的中心角色。

Pediatric discovery Pub Date : 2026-05-26 eCollection Date: 2026-06-01 DOI: 10.1002/pdi3.70056

Tangqiaochu Gan, Zhou Fu, Chao Niu

{"title":"The Airway Epithelial Barrier in Childhood Asthma: A Central Player in Glucocorticoid Therapy, Resistance, and Severe Asthma.","authors":"Tangqiaochu Gan, Zhou Fu, Chao Niu","doi":"10.1002/pdi3.70056","DOIUrl":"10.1002/pdi3.70056","url":null,"abstract":"Childhood asthma remains a global public health challenge with suboptimal control, despite the availability of inhaled corticosteroids (ICS) as first-line therapy. Glucocorticoids suppress inflammation and protect the airway epithelial barrier (AEB) via genomic and nongenomic pathways. However, a significant subset of patients, particularly those with severe asthma, exhibits glucocorticoid resistance. Emerging evidence reveals a dual role of glucocorticoids on the AEB: beyond protection, they may inadvertently compromise barrier integrity by inducing epithelial apoptosis and dysfunction. This review synthesizes current knowledge on glucocorticoid mechanisms in asthma, focusing on the AEB as a critical interface between therapeutic efficacy and treatment failure. We show that AEB impairment serves as one of the key mechanisms underpinning glucocorticoid resistance and the progression to severe asthma, with heightened relevance in children due to the unique vulnerability of their developing airways. Furthermore, we examine how infections, nutritional factors (e.g., vitamins A and D), and immune maturation intersect with AEB integrity and glucocorticoid responsiveness. By reframing the AEB as both a target and a determinant of glucocorticoid efficacy, this review highlights the urgent need for barrier-focused strategies to overcome resistance and improve outcomes in childhood asthma.","PeriodicalId":520221,"journal":{"name":"Pediatric discovery","volume":"4 2","pages":"e70056"},"PeriodicalIF":0.0,"publicationDate":"2026-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13320833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148371666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case Report: Management of Developmental Dysplasia With Cystic Lesions of the Left Hip Acetabular Bone With Pemberton Pelvis Osteotomy Planned With a 3D-Printed Model. 一例报告：管理发育不良伴囊性病变左髋臼骨与Pemberton骨盆截骨计划与3d打印模型。

Pediatric discovery Pub Date : 2026-05-26 eCollection Date: 2026-06-01 DOI: 10.1002/pdi3.70052

Ting Li, Ke Sun, Jianglong Xu, Yushu Liu, Shengping Tang

引用次数: 0

Comparing Fenton and INTERGROWTH-21st Growth Charts in Assessing Preterm Infant Growth Below 33 Weeks' Gestation. 比较Fenton和intergrowth -21生长图在评估妊娠33周以下早产儿生长中的作用。

Pediatric discovery Pub Date : 2026-04-28 eCollection Date: 2026-06-01 DOI: 10.1002/pdi3.70051

Vitor Dos Santos Andrade, Juliana Dantas de Araújo Santos Camargo, Sávio Ferreira Camargo, Amanda Karoline da Costa Bezerra, Raionara Cristina de Araújo Santos, Cijara Leonice de Freitas, Camiliane Azevedo Ferreira, Ricardo Ney Cobucci, Claudia Rodrigues Souza Maia

引用次数: 0

A Comprehensive Review of the Genetic Etiology and Management of Orofacial Clefts. 口腔面裂的遗传病因及治疗综述。

Pediatric discovery Pub Date : 2026-04-16 eCollection Date: 2026-06-01 DOI: 10.1002/pdi3.70037

Emily Kim, Rebeka Dejenie, Caroline Kim, Russell Reid

引用次数: 0

Exploring the Reproductive Toxicity of Bisphenol S Through a Network Toxicology and Molecular Docking Analysis. 通过网络毒理学和分子对接分析探索双酚S的生殖毒性。

Pediatric discovery Pub Date : 2026-04-12 DOI: 10.1002/pdi3.70036

Siyuan Wang, Yan Fu, Xu Huang, Qitong Guo, Xiangqin Zheng, Shengde Wu, Lianju Shen, Guanghui Wei

{"title":"Exploring the Reproductive Toxicity of Bisphenol S Through a Network Toxicology and Molecular Docking Analysis.","authors":"Siyuan Wang, Yan Fu, Xu Huang, Qitong Guo, Xiangqin Zheng, Shengde Wu, Lianju Shen, Guanghui Wei","doi":"10.1002/pdi3.70036","DOIUrl":"10.1002/pdi3.70036","url":null,"abstract":"The aim of this study was to investigate the potential reproductive toxicity of bisphenol S (BPS) and the related molecular mechanisms through a network toxicology approach. By utilizing various databases, including the Comparative Toxicogenomics Database (CTD), GeneCards, Online Mendelian Inheritance in Man (OMIM), the Pharmacogenomics Knowledgebase (PharmGKB), and the Therapeutics Target Database (TTD), and limiting the species to Homo sapiens, we confirmed 45 potential targets related to both BPS exposure and reproductive injury. Additional analysis via STRING and Cytoscape pinpointed 4 key targets: AKT serine/threonine kinase 1 (AKT1), interleukin-6 (IL-6), interleukin-1-beta (IL-1β), and tumor necrosis factor α (TNFα). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses indicated that the principal targets of BPS-mediated reproductive damage are mainly involved in oxidative stress signaling and cell secretion pathways. Because PI3K/AKT regulates the secretion of IL-6, IL-1β, and TNFα, we focus on AKT1 in the molecular docking experiments. Unexpectedly, we found a strong interaction between BPS and AKT1. Furthermore, the results suggested that women may be more susceptible to BPS-mediated reproductive toxicity than men. This study provides a theoretical framework for understanding the molecular mechanisms through which BPS causes reproductive toxicity and lays the foundation for preventing and treating reproductive disorders related to BPS exposure. In addition, our network toxicology-based method can accelerate the discovery of pathways involved in the toxic effects of environmental chemicals that are currently unknown.","PeriodicalId":520221,"journal":{"name":"Pediatric discovery","volume":" ","pages":"e70036"},"PeriodicalIF":0.0,"publicationDate":"2026-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13398782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Jervell and Lange-Nielsen Syndrome Related Clinical Genetics and Experimental Models. Jervell和Lange-Nielsen综合征相关临床遗传学和实验模型。

Pediatric discovery Pub Date : 2026-04-08 eCollection Date: 2026-06-01 DOI: 10.1002/pdi3.70047

Yafei Zhou, Christopher L-H Huang, Ying Yang, Yanmin Zhang

引用次数: 0

The Median Effective Concentration of Sevoflurane for I-Gel Laryngeal Mask Insertion in Unpremedicated Children Aged 1-10 Years: A Prospective Concentration-Finding Study. 1-10岁未用药儿童I-Gel喉罩插入七氟醚的中位有效浓度：一项前瞻性浓度发现研究

Pediatric discovery Pub Date : 2026-03-29 eCollection Date: 2026-03-01 DOI: 10.1002/pdi3.70039

Zhengwei Gan, Shangyingying Li, Shun Yang, Ling Liu, Qianyu Deng, Yaqiong Tian, Li Yang, Fei Yang, Shengfen Tu

{"title":"The Median Effective Concentration of Sevoflurane for I-Gel Laryngeal Mask Insertion in Unpremedicated Children Aged 1-10 Years: A Prospective Concentration-Finding Study.","authors":"Zhengwei Gan, Shangyingying Li, Shun Yang, Ling Liu, Qianyu Deng, Yaqiong Tian, Li Yang, Fei Yang, Shengfen Tu","doi":"10.1002/pdi3.70039","DOIUrl":"10.1002/pdi3.70039","url":null,"abstract":"The minimum alveolar concentration of sevoflurane varies with age in children, and the median effective concentration (EC50) of sevoflurane for I-gel insertion in children of different ages has not been reported. The aim of this study was to determine the EC50 of end-tidal sevoflurane maintained for 2.5 min for I-gel insertion in children aged 1-10 years and also to estimate the 95% effective concentration (EC95). This study aimed to recruit children who were scheduled to undergo laparoscopic high ligation of the inguinal hernia sac or laparoscopic high ligature of the sheath process. Children were stratified into three age groups. We employed Dixon's up-and-down method in this study. The target end-tidal sevoflurane concentration was then maintained at 2% for 2.5 min for the first child. The concentration for the subsequent patient was determined based on the response of the previous patient, with adjustments of 0.2%. This study was terminated when seven crossover points were reached. In the 1-3-year-old group including 3-year-old, EC50 was 1.75% (95% confidence interval [CI], 1.72%-2.03%), and EC95 was 2.17% (95% CI, 1.96%-2.18%). In the 3-6-year-old group including 6-year-old, EC50 was 1.60% (95% CI, 1.35%-1.83%), and EC95 was 1.96% (95% CI, 1.77%-1.98%). In the 6-10-year-old group, EC50 was 0.96% (95% CI, 0.93%-2.20%) and EC95 was 2.36% (95% CI, 2.15%-2.38%). Our study determined the EC50 of end-tidal sevoflurane required for I-gel insertion in unpremedicated children aged 1-10 years and the results demonstrate to be both safe and effective for pediatric patients.","PeriodicalId":520221,"journal":{"name":"Pediatric discovery","volume":"4 1","pages":"e70039"},"PeriodicalIF":0.0,"publicationDate":"2026-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13097571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147794739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhibition of GATA4 and MEF2C Induced by Hypo-Acetylation of Histone H3 Partly Reverse Heart Failure in Mice. 组蛋白H3低乙酰化诱导的GATA4和MEF2C抑制部分逆转小鼠心力衰竭

Pediatric discovery Pub Date : 2026-03-27 eCollection Date: 2026-03-01 DOI: 10.1002/pdi3.70045

Xinru Gan, Bo Pan, Lingjuan Liu, Mi Li, Huichao Sun

{"title":"Inhibition of GATA4 and MEF2C Induced by Hypo-Acetylation of Histone H3 Partly Reverse Heart Failure in Mice.","authors":"Xinru Gan, Bo Pan, Lingjuan Liu, Mi Li, Huichao Sun","doi":"10.1002/pdi3.70045","DOIUrl":"10.1002/pdi3.70045","url":null,"abstract":"The pathogenesis of heart failure involves a highly intricate process regulated by diverse epigenetic factors, transcription factors, noncoding RNAs, and cyclins. Notably, the reexpression of embryonic cardiac transcription factors, including GATA, MEF2, and Nkx2.5, is considered to exert critical influence in the initiation and advancement of heart failure. Nevertheless, the precise mechanisms through which epigenetic modifications drive this reprogramming of gene expression remain poorly defined. This investigation aims to clarify the role of histone acetylation in regulating the reexpression of embryonic cardiac transcription factors during heart failure. Our research indicates that during heart failure of mice, there are distinct histone acetylation modifications associated with the reexpression of these factors. Notably, GATA4 and MEF2C show significant increases, whereas Nkx2.5 shows a decrease compared to normal groups during heart failure progression. These findings imply that embryonic GATA4 and MEF2C may promote the development of heart failure, whereas Nkx2.5 does not appear to participate in disease progression. Furthermore, treatment with curcumin, a known inhibitor of histone acetylation, reduces acetylation levels at H3K4, H3K9, and H3K27 within the promoter regions of GATA4 and MEF2 C in a murine model of heart failure, leading to downregulation of these genes and subsequent enhancement of cardiac performance. In summary, our study demonstrates that p300 exerts site-specific regulatory effects on various transcription factors via histone modifications, and low acetylation status at specific sites can inhibit reactivation of GATA4 and MEF2C during the myocardial dysfunction period thereby improving cardiac performance of mice.","PeriodicalId":520221,"journal":{"name":"Pediatric discovery","volume":"4 1","pages":"e70045"},"PeriodicalIF":0.0,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13097322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147794679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0