Pediatric discovery最新文献_第4页

Exploratory analysis of the key role of immune function changes in BPD. 免疫功能改变在BPD中关键作用的探索性分析。

Pediatric discovery Pub Date : 2024-12-21 eCollection Date: 2024-12-01 DOI: 10.1002/pdi3.2515

Tianyi Wu, Xingmeng Fu, Xiaoxia Gong, Jingyi You, Zhou Fu, Chang Shu

{"title":"Exploratory analysis of the key role of immune function changes in BPD.","authors":"Tianyi Wu, Xingmeng Fu, Xiaoxia Gong, Jingyi You, Zhou Fu, Chang Shu","doi":"10.1002/pdi3.2515","DOIUrl":"10.1002/pdi3.2515","url":null,"abstract":"Bronchopulmonary dysplasia (BPD) is one of the most prevalent and severe chronic lung diseases in premature infants. The objective of the current study was to screen for key BPD-associated genes and pathways by transcriptomic analysis from clinical patients and animal models. In our study, the differentially expressed genes were screened from 58 children with 14-day BPD and 40 normal children in the GSE32472 dataset of the Gene Expression Omnibus database. Then, we identified four hub genes (Cd3e, Cd3g, Cd247, and Itk) and a signaling pathway (T cell receptor signaling pathway) by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis and protein-protein interaction analysis. The differential expression of the relevant pathways and gene sets among the groups was verified via GSEA analysis. Subsequently, a rat model of BPD with hyperoxia-induced lung injury was established, and the transcriptome sequencing of the whole lung tissue was performed. A similar analysis was done on the sequencing data of the hub genes and associated pathway screening to verify the accuracy. Ultimately, quantitative polymerase chain reaction was performed to validate the transcriptomics data of core gene expression in the rat model. Our study revealed that the downregulation of the expression of the above four key genes in the course of BPD leads to a decrease in the function of T cell receptor signaling pathways, it causes immune dysfunction and increases the severity of lung inflammation as well as susceptibility to other respiratory infectious diseases.","PeriodicalId":520221,"journal":{"name":"Pediatric discovery","volume":"2 4","pages":"e2515"},"PeriodicalIF":0.0,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metronomic chemotherapy in pediatric neuroblastoma. 节律化疗治疗小儿神经母细胞瘤。

Pediatric discovery Pub Date : 2024-12-10 eCollection Date: 2024-12-01 DOI: 10.1002/pdi3.2512

Yi Jiang, Chengjun Xi, Chao Yang

{"title":"Metronomic chemotherapy in pediatric neuroblastoma.","authors":"Yi Jiang, Chengjun Xi, Chao Yang","doi":"10.1002/pdi3.2512","DOIUrl":"10.1002/pdi3.2512","url":null,"abstract":"Metronomic chemotherapy (MC) is an innovative therapeutic approach that involves the chronic administration of low doses of chemotherapy agents. This strategy aims to sustain prolonged and active plasma levels of drugs, which can result in favorable tolerability. MC has shown promise in the treatment of hematologic and solid tumors, including high-risk neuroblastoma and relapsed/refractory (R/R) neuroblastoma. In the contemporary management of neuroblastoma, MC stands as a viable maintenance therapy for newly diagnosed patients lacking access to autologous stem cell transplantation or immunotherapy, particularly in resource-constrained regions. Furthermore, it serves as a pragmatic alternative for individuals intolerant to intensified regimens or undergoing palliative care for R/R neuroblastoma. Nevertheless, the quest for the optimal MC regimen persists, necessitating comprehensive investigations to delineate standardized protocols. Moreover, the identification of potential biomarkers or prognostic indicators assumes paramount significance in refining MC strategies for future breakthroughs in this domain. This review embarks on a comprehensive exploration of MC in neuroblastoma, offering insights into its historical underpinnings, diverse applications, adverse effect and future prospects, endeavoring to enrich our understanding of MC role in neuroblastoma management.","PeriodicalId":520221,"journal":{"name":"Pediatric discovery","volume":"2 4","pages":"e2512"},"PeriodicalIF":0.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fostering innovation and advancement in evidence-based practice and guidelines within the field of pediatrics: The 2024 BRIGHT declaration. 促进儿科领域循证实践和指南的创新和进步：2024年光明宣言。

Pediatric discovery Pub Date : 2024-12-10 eCollection Date: 2024-12-01 DOI: 10.1002/pdi3.2513

Xu Wang, Hui Liu, Janne Estill, Fujian Song, Akihiko Ozaki, Juan V A Franco, Ivan D Florez, Etienne Ngeh, Nav Persaud, Liliya Eugenevna Ziganshina, Myeong Soo Lee, Lu Zhang, Yuan Chi, Yuting Duan, Enmei Liu, Yaolong Chen, Xiaodong Zhao

引用次数: 0

Mortality trends in suicide among pediatric and adolescent patients aged 15-24 years in Mississippi, 2012-2022. 2012-2022年密西西比州15-24岁儿童和青少年自杀死亡率趋势

Pediatric discovery Pub Date : 2024-12-05 eCollection Date: 2025-03-01 DOI: 10.1002/pdi3.2511

Elizabeth Jones

{"title":"Mortality trends in suicide among pediatric and adolescent patients aged 15-24 years in Mississippi, 2012-2022.","authors":"Elizabeth Jones","doi":"10.1002/pdi3.2511","DOIUrl":"10.1002/pdi3.2511","url":null,"abstract":"Due to the lack of studies examining suicide trends and its implications on pediatric populations, this study aimed to address the gap in research and to identify the magnitude and the impact of suicide by exploring trends in suicide among Mississippians from 2012 to 2022. The study uses data from the Mississippi Statistically Automated Health Resource System, which is an online database with data collected from vital statistics. Joinpoint regression models were used to calculate annual percentage change (APC) and average annual percentage change (AAPC) as an indicator of trends. The overall age-adjusted suicide rate increased from 9.4 deaths per 100,000 in 2012 to 10.8 deaths per 100,000 in 2022 for pediatric and adolescent patients aged 15-24 years (14.9% increase). There are upward trends for females (AAPC, 6.33%, 95% CI, -0.82%-16.82%), Blacks (AAPC, 7.72%, 95% CI, 2.19%-16.47%), and other races (AAPC, 7.59%, 95% CI, -0.83%-21.47%). Males had a downward trend from 2015 to 2022 (APC, -1.46%, 95 CI, -14.05%-1.35%). Whites also had a downward trend from 2017 to 2022 (APC, 4.74%, 95% CI, -15.42% to -0.96%). This study identified an overall increase in suicide. However, trends varied by gender, race, and age. Based on the findings, Mississippi needs more initiatives aimed toward equitable prevention of suicide among youth and the implementation of gun control policies. By implementing these measures, Mississippi could tremendously benefit and improve mental health outcomes and reduce suicide within the state.","PeriodicalId":520221,"journal":{"name":"Pediatric discovery","volume":"3 1","pages":"e2511"},"PeriodicalIF":0.0,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric postural orthostatic tachycardia syndrome: From mechanisms to individualized management. 儿童体位性心动过速综合征：从机制到个体化治疗。

Pediatric discovery Pub Date : 2024-11-24 eCollection Date: 2024-12-01 DOI: 10.1002/pdi3.2509

Wenrui Xu, Hongfang Jin, Ying Liao, Junbao Du

引用次数: 0

Pediatric endocardial temporary pacemaker implantation: Clinical characteristics and outcomes from a Chinese National Regional Health Center. 儿童心内膜临时起搏器植入：来自中国国家区域卫生中心的临床特征和结果。

Pediatric discovery Pub Date : 2024-11-18 eCollection Date: 2025-03-01 DOI: 10.1002/pdi3.2508

Zhongyuan Liu, Kaijun Zhang, Jun Ren, Penghui Yang, Mi Li, Ping Xiang

{"title":"Pediatric endocardial temporary pacemaker implantation: Clinical characteristics and outcomes from a Chinese National Regional Health Center.","authors":"Zhongyuan Liu, Kaijun Zhang, Jun Ren, Penghui Yang, Mi Li, Ping Xiang","doi":"10.1002/pdi3.2508","DOIUrl":"10.1002/pdi3.2508","url":null,"abstract":"Endocardial temporary pacemakers (TP) are widely used in the treatment of cardiovascular diseases in adults, but their application and clinical experience in the treatment of pediatric cardiovascular cases are relatively limited. This study aims to share the experience of using endocardial TP at a pediatric medical center in China. The study included patients who received their first endocardial TP implantation in the Department of Cardiology at Children's Hospital of Chongqing Medical University, China, from 2016 to 2022. A retrospective analysis of their clinical data was conducted. Our study involved 45 children who underwent endocardial TP implantation. Among these, 25 children (55.56%) converted to sinus rhythm after pacemaker parameter adjustment and the pacemaker was successfully removed; 13 children (28.89%) did not recover sinus rhythm and ultimately required a permanent pacemaker; in 4 cases, the family refused permanent pacemaker implantation; in 1 case, the treatment was abandoned by the family; and 2 children died during hospitalization. Notably, among the 20 children with fulminant myocarditis (FM), 16 children (80.00%) converted to sinus rhythm after pacemaker parameter adjustment and the pacemaker was successfully removed; 3 children (15.00%) ultimately received a permanent pacemaker; and 1 child died during hospitalization. Endocardial TP have shown remarkable efficacy in the treatment of critical heart disease, especially FM.","PeriodicalId":520221,"journal":{"name":"Pediatric discovery","volume":"3 1","pages":"e2508"},"PeriodicalIF":0.0,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Continuous positive airway pressure in delivery room in extremely preterm infants: A single-center retrospective study in China. 中国极早产儿产房持续气道正压通气的单中心回顾性研究

Pediatric discovery Pub Date : 2024-10-25 eCollection Date: 2025-06-01 DOI: 10.1002/pdi3.2507

Xiaoting Zhang, Long Chen, Xiaoyun Zhong, Jiangfeng Ou, Yuan Shi

{"title":"Continuous positive airway pressure in delivery room in extremely preterm infants: A single-center retrospective study in China.","authors":"Xiaoting Zhang, Long Chen, Xiaoyun Zhong, Jiangfeng Ou, Yuan Shi","doi":"10.1002/pdi3.2507","DOIUrl":"10.1002/pdi3.2507","url":null,"abstract":"To assess the beneficial effects of delivery room continuous positive airway pressure (DRCPAP) in extremely preterm infants, a single-center retrospective study was performed at the Women and Children's Hospital of Chongqing Medical University in China. Infants born between January 2016 and December 2018 were regarded as the control group, and those born between January 2019 and August 2022 were considered as the observation group (DRCPAP group). The primary outcome was tracheal intubation within 72 h after birth. Six hundred and seven patients were included in the study (control: 232; DRCPAP: 375). Compared with the control group, DRCPAP reduced the intubation rate (56.8% vs. 62.9%, OR 0.57, 95% CI 0.34-0.96, p = 0.035), including <28 weeks gestational age (GA) subgroup (61.5% vs. 84.7%, OR 0.12, 95% CI 0.02-0.78, p = 0.027). One-to-one propensity score matching (195:195) was used to match the baseline characteristics of patients in DRCPAP and control group. After matching, no significant differences were observed in intubation rate within 72 h between the two groups (20.5% [40 of 195] vs. 22.1% [43 of 195]; p = 0.711). Whether DRCPAP can reduce intubation rate within 72 h requires further investigation.","PeriodicalId":520221,"journal":{"name":"Pediatric discovery","volume":"3 2","pages":"e2507"},"PeriodicalIF":0.0,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Waardenburg-Shah syndrome: A case of neonatal palliative care. Waardenburg-Shah综合征：新生儿姑息治疗一例。

Pediatric discovery Pub Date : 2024-09-24 eCollection Date: 2024-12-01 DOI: 10.1002/pdi3.2506

Michael Colpani, Maria Del Carmen Rodriguez Perez, Bruno Angelo Drera, Francesco Maria Risso

引用次数: 0

Perioperative hemodynamic parameters monitored by three noninvasive technologies in children with congenital heart disease: A prospective study. 三种无创技术监测先天性心脏病患儿围手术期血流动力学参数：一项前瞻性研究

Pediatric discovery Pub Date : 2024-09-12 eCollection Date: 2025-06-01 DOI: 10.1002/pdi3.2505

Xiaoyu Xiong, Feng Xu, Wei Qiu, Shaojun Li, Chengjun Liu

{"title":"Perioperative hemodynamic parameters monitored by three noninvasive technologies in children with congenital heart disease: A prospective study.","authors":"Xiaoyu Xiong, Feng Xu, Wei Qiu, Shaojun Li, Chengjun Liu","doi":"10.1002/pdi3.2505","DOIUrl":"10.1002/pdi3.2505","url":null,"abstract":"This study aims to compare the efficiencies of three noninvasive technologies in monitoring the perioperative hemodynamics of children with congenital heart disease (CHD) including ventricular septal defects with or without atrial septal defects. Three noninvasive technologies included transthoracic echocardiography (TTE), electrical cardiometry (EC), and vasoactive inotropic score (VIS). Parameters included left ventricular ejection fraction (LVEF) and cardiac index (cardiac index monitored by ultrasound, uCI) in TTE, cardiac index (cardiac index monitored by electrical cardiometry, eCI) and systemic vascular resistance index (SVRI) in EC, and VIS. Seventy-four children were eligible. Three types of adverse events (AEs) related to disease activity and prognosis were observed, including cardio-pulmonary resuscitation in five cases (5/74, 6.76%), hypoxic-ischemic brain damage in four cases (4/74, 5.41%) and hemopurification in four cases (4/74, 5.41%). Except for LVEF, eight parameters (VISmax [maximum VIS], VISmea [mean VIS], uCImea [mean uCI], uCImin [minimum uCI], eCImea [mean eCI], eCImin [minimum eCI], SVRImea [mean SVRI], and SVRImin [minimum SVRI]) showed predictive value for any AE (p < 0.05). VISmea, uCImea, and eCImea demonstrated the highest accuracy and linear associations (AUROC > 0.9, p = 0.00). Linear associations also existed between the three groups of parameters and the duration of mechanical ventilation (MV) and the length of stay (LOS) in the intensive care unit (ICU). The duration of MV and the LOS in the ICU increased as VISmea rose, or uCImea and eCImea fell (p < 0.05). LVEF in TTE could not predict any AE (p > 0.05) and not fully reflect the cardiovascular function. Therefore, most parameters obtained in TTE, EC, and VIS can reflect the perioperative hemodynamics of children with CHD, with VISmea, uCImea, and eCImea being most accurate.","PeriodicalId":520221,"journal":{"name":"Pediatric discovery","volume":"3 2","pages":"e2505"},"PeriodicalIF":0.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiomyocyte proliferation and regeneration in congenital heart disease. 先天性心脏病的心肌细胞增殖与再生

Pediatric discovery Pub Date : 2024-09-01 Epub Date: 2024-08-12 DOI: 10.1002/pdi3.2501

Jialiang Liang, Xingyu He, Yigang Wang

{"title":"Cardiomyocyte proliferation and regeneration in congenital heart disease.","authors":"Jialiang Liang, Xingyu He, Yigang Wang","doi":"10.1002/pdi3.2501","DOIUrl":"10.1002/pdi3.2501","url":null,"abstract":"Despite advances in prenatal screening and a notable decrease in mortality rates, congenital heart disease (CHD) remains the most prevalent congenital disorder in newborns globally. Current therapeutic surgical approaches face challenges due to the significant rise in complications and disabilities. Emerging cardiac regenerative therapies offer promising adjuncts for CHD treatment. One novel avenue involves investigating methods to stimulate cardiomyocyte proliferation. However, the mechanism of altered cardiomyocyte proliferation in CHD is not fully understood, and there are few feasible approaches to stimulate cardiomyocyte cell cycling for optimal healing in CHD patients. In this review, we explore recent progress in understanding genetic and epigenetic mechanisms underlying defective cardiomyocyte proliferation in CHD from development through birth. Targeting cell cycle pathways shows promise for enhancing cardiomyocyte cytokinesis, division, and regeneration to repair heart defects. Advancements in human disease modeling techniques, CRISPR-based genome and epigenome editing, and next-generation sequencing technologies will expedite the exploration of abnormal machinery governing cardiomyocyte differentiation, proliferation, and maturation across diverse genetic backgrounds of CHD. Ongoing studies on screening drugs that regulate cell cycling are poised to translate this nascent technology of enhancing cardiomyocyte proliferation into a new therapeutic paradigm for CHD surgical interventions.","PeriodicalId":520221,"journal":{"name":"Pediatric discovery","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11412308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142306178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0