Pediatric discovery最新文献_第8页

Age-Dependent Correlation of Pulmonary Function Impairment and Aortic Arch Stiffness in Mice. 小鼠肺功能损伤与主动脉弓硬度的年龄相关性。

Pediatric discovery Pub Date : 2025-04-02 eCollection Date: 2026-03-01 DOI: 10.1002/pdi3.2525

Ayman Isbatan, Samuel M Lee, Ali Imran Sarwar, Yuxing Yuan, Sunny Chen, Maricela Castellon, Dan A Marian, Richard D Minshall, Jie Tian, Irena Levitan, Jiwang Chen

{"title":"Age-Dependent Correlation of Pulmonary Function Impairment and Aortic Arch Stiffness in Mice.","authors":"Ayman Isbatan, Samuel M Lee, Ali Imran Sarwar, Yuxing Yuan, Sunny Chen, Maricela Castellon, Dan A Marian, Richard D Minshall, Jie Tian, Irena Levitan, Jiwang Chen","doi":"10.1002/pdi3.2525","DOIUrl":"10.1002/pdi3.2525","url":null,"abstract":"Progressive aging is known to negatively affect cardiopulmonary function, which increases the risk of developing cardiac/respiratory diseases. However, the relationship between the decline in pulmonary function and aortic arch stiffness in aging is not well understood. This study investigated the correlation between lung function impairment and aortic arch stiffness in male and female C57BL/6 mice from 2 to 52 weeks of age. Lung function was assessed using forced oscillation ventilation and aortic arch stiffness was measured through echocardiography. Our results show a progressive decline in lung function markers such as respiratory system resistance (Rrs) and tissue elastance (H) with age, alongside an increase in inspiratory capacity (IC) and compliance of the respiratory system (Crs). Aortic arch stiffness significantly increased with age, particularly during early adulthood, and was found to be a strong predictor of lung function impairment in both sexes. While linear regression models indicated that body weight was a more accurate predictor of lung function variability, aortic arch stiffness emerged as a reliable marker for the decline in pulmonary function. These findings suggest that aortic arch stiffness can serve as an early indicator of declining lung function and therefore provide a noninvasive method to assess cardiopulmonary health in aging populations. Future studies should explore the molecular mechanisms underlying these changes and extend the investigation to older mice to fully understand the long-term impacts of aging on cardiopulmonary function.","PeriodicalId":520221,"journal":{"name":"Pediatric discovery","volume":"4 1","pages":"e2525"},"PeriodicalIF":0.0,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13098100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147794714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progress in the treatment of subarterial ventricular septal defect. 动脉下室间隔缺损的治疗进展。

Pediatric discovery Pub Date : 2025-03-14 eCollection Date: 2025-03-01 DOI: 10.1002/pdi3.2519

Chunqiu Fan, Zhengxia Pan, Chun Wu, Yonggang Li, Hongbo Li, Yong An, Gang Wang, Jiangtao Dai

引用次数: 0

Salmonella meningitis bacteremia in two-week neonate: A rare and devastating disease. 两周新生儿沙门氏菌脑膜炎菌血症：一种罕见的毁灭性疾病。

Pediatric discovery Pub Date : 2025-03-12 eCollection Date: 2025-03-01 DOI: 10.1002/pdi3.2510

James S Bassett, Jerrin George, Michelle Cherian

引用次数: 0

Tibial tubercle avulsion fractures in children and adolescents. 儿童和青少年胫骨结节撕脱性骨折。

Pediatric discovery Pub Date : 2025-03-12 eCollection Date: 2025-03-01 DOI: 10.1002/pdi3.2521

Hailun Yao, Yuanlin He, Xiang Li, Mingyan Shi, Peikang Wang, Man Zhang, Xinkai Zhang, Xing Liu

{"title":"Tibial tubercle avulsion fractures in children and adolescents.","authors":"Hailun Yao, Yuanlin He, Xiang Li, Mingyan Shi, Peikang Wang, Man Zhang, Xinkai Zhang, Xing Liu","doi":"10.1002/pdi3.2521","DOIUrl":"10.1002/pdi3.2521","url":null,"abstract":"Tibial tubercle avulsion fractures (TTAFs) are uncommon injuries in the pediatric population, predominantly affecting children and adolescents who are approaching skeletal maturity and frequently engage in high-energy activities. Despite of their rarity, TTAFs can significantly impact the lives of young individuals involved in sports and other strenuous activities. The mechanism of TTAFs occurrence involves forceful quadriceps contraction against resistance or rapid knee flexion with contracted quadriceps. TTAFs may coincide with other related injuries due to their mechanism of occurrence and commonly present with an abrupt onset of pain, focal soft-tissue swelling and tenderness on palpation. Predisposing factors such as a history of Osgood-Schlatter disease and an extreme body mass index (BMI) could contribute to TTAFs susceptibility. Diagnosis of TTAFs typically relies on X-rays, complemented by computed tomography (CT) and magnetic resonance imaging (MRI) for screening associated injuries and preoperative assessment. While a well-established classification system exists, with the Ogden classification being the most commonly employed, intriguingly, a direct correlation between fracture type and treatment method, as well as the choice of surgical fixation modality, remains elusive. The management of TTAFs encompasses both conservative and surgical approaches, with open reduction internal fixation (ORIF) being the predominant surgical method and the prognosis for this condition is generally favorable. By synthesizing existing knowledge and presenting potential areas of uncertainty, this review aims to offer valuable insights to orthopedic practitioners when they are confronted with this infrequent injury.","PeriodicalId":520221,"journal":{"name":"Pediatric discovery","volume":"3 1","pages":"e2521"},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to High Infection Rates and Risk-Adapted Prevention Strategies in Contemporary Pediatric Allogeneic Hematopoietic Stem Cell Transplantation. 纠正当代儿童同种异体造血干细胞移植的高感染率和风险适应预防策略。

Pediatric discovery Pub Date : 2025-03-05 eCollection Date: 2025-03-01 DOI: 10.1002/pdi3.2527

引用次数: 0

An Analysis of Child Abuse Detected by Skeletal Surveys Before and During the COVID-19 Pandemic. COVID-19大流行之前和期间骨骼调查发现的虐待儿童情况分析

Pediatric discovery Pub Date : 2025-02-26 eCollection Date: 2025-03-01 DOI: 10.1002/pdi3.2526

Vincent R Li, Trevor A Pickering, Karen Kay Imagawa, Joseph M Rich, Amit S Sura

{"title":"An Analysis of Child Abuse Detected by Skeletal Surveys Before and During the COVID-19 Pandemic.","authors":"Vincent R Li, Trevor A Pickering, Karen Kay Imagawa, Joseph M Rich, Amit S Sura","doi":"10.1002/pdi3.2526","DOIUrl":"10.1002/pdi3.2526","url":null,"abstract":"The COVID-19 pandemic and the stay-at-home order may have impacted the risk of child physical abuse (CPA). Analyzing injury types in suspected CPA cases before and during the pandemic can provide valuable insights. The objective of this study is to compare the incidences and types of injuries detected by skeletal surveys in suspected CPA cases at a large academic children's hospital before and during the COVID-19 pandemic. The study compared the incidences and proportion of specific injury sites, types of traumas, and demographic characteristics before and during the pandemic using Pearson's chi-squared and Fisher's exact tests. A total of 479 patients who underwent skeletal surveys were included, with 306 patients sampled before the pandemic (63.8%) and 173 patients sampled during the pandemic (36.1%). There were no significant differences in age, gender, or ethnicity between the two groups. Highly suspicious CPA incidences were similar before (0.87/month) and during (0.81/month) the pandemic, reflecting 10.5% and 11.6% of all patients who underwent skeletal surveys, respectively. There were no significant demographic differences between the groups. However, the proportion of patients with intracranial or retinal hemorrhage significantly decreased (p < 0.05) during the pandemic, with no significant differences in types of skeletal fractures. In conclusion, the overall incidence of CPA remained similar before and during the pandemic. The significant decrease in intracranial and retinal hemorrhages suggests a potential change in injury patterns or reporting. Further research is needed to understand the factors contributing to these findings.Clinical trial registration: This study is a retrospective clinical trial and therefore not subject to clinical trial registration requirements.","PeriodicalId":520221,"journal":{"name":"Pediatric discovery","volume":"3 1","pages":"e2526"},"PeriodicalIF":0.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical characteristics and risk factors of severe bocavirus-positive pneumonia in children and a literature review. 儿童重症博卡病毒阳性肺炎的临床特点、危险因素及文献回顾

Pediatric discovery Pub Date : 2025-02-06 eCollection Date: 2025-12-01 DOI: 10.1002/pdi3.2523

Jing Liao, Zhongying Yang, Yu He, Jianhua Wei, Luo Ren, Enmei Liu, Na Zang

{"title":"Clinical characteristics and risk factors of severe bocavirus-positive pneumonia in children and a literature review.","authors":"Jing Liao, Zhongying Yang, Yu He, Jianhua Wei, Luo Ren, Enmei Liu, Na Zang","doi":"10.1002/pdi3.2523","DOIUrl":"10.1002/pdi3.2523","url":null,"abstract":"Increasing evidence suggests that human bocavirus (HBoV) is associated with respiratory symptoms in the absence of other identifiable pathogens and may even precipitate severe lower respiratory tract infections. However, only a few studies of severe human bocavirus infections in pediatric patients have been reported. The aim of the current study was to collect and analyze clinical data from children diagnosed with mild pneumonia and severe pneumonia, with an emphasis on those testing positive for HBoV from June 2009 to June 2019. Among the 799 HBoV-positive children included in the study, approximately 5.88% experienced severe pneumonia. Results revealed no significant differences between co-detection and single detection of HBoV-positive pneumonia in the severe and mild groups, supporting the pathogenicity of HBoV. A higher incidence of severe cases was observed in children lacking Bacillus Calmette-Guérin (BCG) vaccination, or with congenital airway or bronchopulmonary dysplasia (P = 0.046, P = 0.017). Overall, these findings indicate that HBoV can be identified in respiratory samples from children with severe pneumonia, denoting its role as a viral pathogen in hospitalized children with this condition. Preterm birth, wheezing history of previous infection, pulmonary underlying diseases such as airway dysplasia or bronchopulmonary dysplasia, and viremia may be the risk factors for severe pneumonia with HBoV positive.","PeriodicalId":520221,"journal":{"name":"Pediatric discovery","volume":"3 4","pages":"e2523"},"PeriodicalIF":0.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12753018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145879712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improving the neonatal mask ventilation skills of non-airway experts using the "Five Breath Method": A simulation study. 运用“五呼吸法”提高非气道专家新生儿口罩通气技能的模拟研究

Pediatric discovery Pub Date : 2025-02-04 eCollection Date: 2025-09-01 DOI: 10.1002/pdi3.2520

Anna Clebone

{"title":"Improving the neonatal mask ventilation skills of non-airway experts using the \"Five Breath Method\": A simulation study.","authors":"Anna Clebone","doi":"10.1002/pdi3.2520","DOIUrl":"10.1002/pdi3.2520","url":null,"abstract":"Trainees in several medical disciplines are expected to achieve competence in neonatal resuscitation. Managing the neonatal airway requires faculties in mask ventilation. Many trainees, however, have limited clinical experience with this skill. An algorithmic method incorporating the steps an airway expert would use for neonatal mask ventilation was designed. The goal of teaching this system, the \"Five Breath Method,\" is to assist trainees with learning and incorporating the steps of neonatal mask ventilation into clinical practice. We hypothesized that for pediatric residents, participating in a teaching session on the Five Breath Method would significantly decrease the time to achieve ventilation (\"air entry\") in a resuscitation scenario. A pilot study was completed on the Five Breath Method with 23 pediatric residents as subjects. Training in the Five Breath Method reduced the time required to achieve air entry using a neonatal simulator. Subjects required 57 [29-149 and 13-180] seconds (median [interquartile range and minimum-maximum]) before the teaching session and 16 [10-35 and 8-60] seconds after learning the Five Breath Method; Z = -4.11, and P < 0.001. For the 14 of the original subjects who were able to participate in the follow-up study 2-5 months later, 24 [22-38 and 12-69] seconds (median [interquartile range and minimum-maximum]) were required to achieve air entry in the identical experimental scenario. This showed an improvement in time to air entry when compared to that before training; Z = -2.42, and P = 0.01552. This study showed that as little as 10 min of training could drastically improve skills. Learning the Five Breath Method also led to retention of skills over time.","PeriodicalId":520221,"journal":{"name":"Pediatric discovery","volume":"3 3","pages":"e2520"},"PeriodicalIF":0.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12483298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145209003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spina bifida as a multifactorial birth defect: Risk factors and genetic underpinnings. 脊柱裂是一种多因素先天缺陷：危险因素和遗传基础。

Pediatric discovery Pub Date : 2025-01-25 eCollection Date: 2025-06-01 DOI: 10.1002/pdi3.2517

Ethan S Wong, Daniel A Hu, Lily Zhang, Rachel Qi, Cindy Xu, Ou Mei, Guowei Shen, Wulin You, Changqi Luo, Tong-Chuan He, Russell R Reid, Lewis S Shi, Michael J Lee, Yi Zhu

{"title":"Spina bifida as a multifactorial birth defect: Risk factors and genetic underpinnings.","authors":"Ethan S Wong, Daniel A Hu, Lily Zhang, Rachel Qi, Cindy Xu, Ou Mei, Guowei Shen, Wulin You, Changqi Luo, Tong-Chuan He, Russell R Reid, Lewis S Shi, Michael J Lee, Yi Zhu","doi":"10.1002/pdi3.2517","DOIUrl":"10.1002/pdi3.2517","url":null,"abstract":"Spina bifida is a birth defect resulting from abnormal embryonic development of the neural tube. Though spina bifida is divided into several subtypes, myelomeningocele-the most severe form of spina bifida often associated with a markedly diminished quality of life-accounts for a significant portion of cases. A broad range of genetic and environmental factors, many of which are still unknown, influence spina bifida, making it difficult to provide a comprehensive etiology for the disorder. Folic acid supplementation aided by the mandatory fortification of food is preventive; still, spina bifida persists due to numerous other confounding factors that affect risk. This article reviews the latest studies pertaining to the risk factors and genetics involved in spina bifida in an attempt to elucidate the complex background of the congenital malformation. Additionally, this review highlights the significant impact of environmental pollutants, adverse medication effects, and maternal health conditions such as diabetes and obesity on the prevalence of spina bifida. Emerging research on gene-environment interactions provides insight into how specific genetic variants may influence susceptibility to these environmental factors. We also discuss new technologies in genetic sequencing that show promise for the large-scale discovery of genes associated with spina bifida risk. Understanding these intricate interactions is crucial for developing effective prevention and intervention strategies.","PeriodicalId":520221,"journal":{"name":"Pediatric discovery","volume":"3 2","pages":"e2517"},"PeriodicalIF":0.0,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical characteristics of children with septic arthritis caused by different pathogenic bacteria. 不同致病菌所致儿童脓毒性关节炎的临床特点。

Pediatric discovery Pub Date : 2025-01-10 eCollection Date: 2025-03-01 DOI: 10.1002/pdi3.2522

Ziyu Li, Gefang Li, Jun Wu, Bo He, Qun Zhang

{"title":"Clinical characteristics of children with septic arthritis caused by different pathogenic bacteria.","authors":"Ziyu Li, Gefang Li, Jun Wu, Bo He, Qun Zhang","doi":"10.1002/pdi3.2522","DOIUrl":"10.1002/pdi3.2522","url":null,"abstract":"Septic arthritis is a serious infectious disease in children. In this study, we retrospectively analyzed the relationship between demographics, laboratory values at presentation, reported symptoms at presentation, joint involvement, and distribution characteristics of pathogenic bacteria in 171 patients during the period of 2012-2022. The results showed that a total of 77 pathogen-positive patients were detected in the 171 patients (culture-positive rate of 45.0%), 15 categories of pathogenic bacteria, and the highest detection rates were 52 cases of Staphylococcus aureus (67.5%), Streptococcus pyogenes in 7 cases (9.1%), and Streptococcus pneumoniae in 5 cases (6.5%). Comparison of these three pathogens revealed that the age of the Staphylococcus aureus and Streptococcus pyogenes groups was significantly older than that of the Streptococcus pneumoniae group (p < 0.05), and that the white blood cell count (WBC) of the Streptococcus pyogenes group was significantly higher than that of the Staphylococcus aureus group (p < 0.05), and that the Streptococcus pyogenes group had a significantly higher procalcitonin (PCT), which was significantly higher in the Streptococcus pneumoniae group (p < 0.05). The results suggest that the pathogenic bacteria of septic arthritis in children are mainly Staphylococcus aureus, Streptococcus pneumoniae infection occurred more commonly in the infant stage, and Staphylococcus aureus and Streptococcus pyogenes were detected frequently in school-age children. Streptococcus pyogenes was found to be more pathogenic than Staphylococcus aureus and Streptococcus pneumoniae.","PeriodicalId":520221,"journal":{"name":"Pediatric discovery","volume":"3 1","pages":"e2522"},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0