The National medical journal of India最新文献_第2页

Allergic angina (Kounis syndrome) following a multivitamin injection. 复合维生素注射后的过敏性心绞痛（库尼斯综合征）。

The National medical journal of India Pub Date : 2026-03-01 DOI: 10.25259/NMJI_517_2024

Sudhinder Murali, Savitha Manavalan, Sudha Vidyasagar, Bakul Raj

引用次数: 0

Increased indolamine 2,3-dioxygenase activity in people with type 2 diabetes and comorbid depression. 2型糖尿病合并抑郁症患者吲哚胺2,3-双加氧酶活性增高

The National medical journal of India Pub Date : 2026-03-01 DOI: 10.25259/NMJI_1101_2023

Proteesh Rana, Mina Chandra, Kalpana Chandra, Shrishti Dahuja, Bijo Varughese, Vandana Roy, Seema Kapoor, Murali Rao

{"title":"Increased indolamine 2,3-dioxygenase activity in people with type 2 diabetes and comorbid depression.","authors":"Proteesh Rana, Mina Chandra, Kalpana Chandra, Shrishti Dahuja, Bijo Varughese, Vandana Roy, Seema Kapoor, Murali Rao","doi":"10.25259/NMJI_1101_2023","DOIUrl":"10.25259/NMJI_1101_2023","url":null,"abstract":"Background Depression is a major psychiatric comorbid condition of type 2 diabetes mellitus (T2DM). Serotonin, the major neurotransmitter implicated in depression, is a tryptophan derivative. Tryptophan is chiefly metabolised through the kynurenine pathway with indolamine-2,3-dioxygenase (IDO) as the rate-limiting enzyme. Hence, serum tryptophan and kynurenine concentrations and their ratio (K/T ratio) as a measure of IDO activity are possible biomarkers of depression in T2DM. Methods Severity of depression in adults with T2DM attending a primary care facility in Delhi was rated using the Hamilton Depression Rating Scale (HAM-D 17 items). Baseline serum tryptophan and kynurenine concentrations, along with their ratio, were estimated. A follow-up HAM-D rating was done after 16 weeks of standard therapy and the quantum HAM-D score improvement was correlated with the K/T ratio. Results Of 106 people with T2DM screened for depression, 52 had syndromal depression and were recruited for the study. There was no significant association between age, sex, marital status, religion, serum tryptophan, and kynurenine levels with respect to the severity of depression, but the mean K/T ratio was significantly higher among those with severe depression (p<0.05). There was a significant correlation between serum kynurenine and HAM-D score improvement at 16 weeks. Conclusion K/T ratio, a measure of IDO activity, was found to be a severity marker for depression in T2DM, without any prognostic significance. Further studies are required to explore the K/T ratio as a state marker, severity marker, and prognostic biomarker of depression in people with T2DM.","PeriodicalId":519891,"journal":{"name":"The National medical journal of India","volume":"39 2","pages":"69-73"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147273846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Survival analysis of second-line chemotherapy in platinum-sensitive relapsed ovarian cancer patients. 铂敏感卵巢癌复发患者二线化疗的生存分析。

The National medical journal of India Pub Date : 2026-01-01 DOI: 10.25259/NMJI_449_2023

Vineet Talwar, Atika Dogra, Varun Goel, Vidya Krishna

{"title":"Survival analysis of second-line chemotherapy in platinum-sensitive relapsed ovarian cancer patients.","authors":"Vineet Talwar, Atika Dogra, Varun Goel, Vidya Krishna","doi":"10.25259/NMJI_449_2023","DOIUrl":"10.25259/NMJI_449_2023","url":null,"abstract":"Background Patients of ovarian cancer who respond to the initial chemotherapy (CT) regimen may respond again to the same drugs after relapse. We aimed to evaluate the survival of patients with recurrent ovarian cancer (ROC) treated with second-line CT drugs such as liposomal doxorubicin, paclitaxel/carboplatin, and/or bevacizumab. Methods Electronic medical records of ovarian cancer patients registered between January 2009 and December 2017 were reviewed to identify those with ROC. Data regarding demographics, clinical characteristics, treatment, recurrence, vital status at last contact, etc. were retrieved. The log-rank test was applied to compare the Kaplan-Meier curves for survival analysis. Results A total of 119 cases met the inclusion criteria. The median age at diagnosis and relapse was 49 and 51 years, respectively. The medians for progression-free survival (PFS) and post-relapse survival (PRS) were 19 (95% CI 10.34-21.66) months and 34 (95% CI 37.17-56.83) months, respectively. The PFS was significantly higher among premenopausal women (p=0.025). Patients treated with paclitaxel/carboplatin-based second-line CT had significantly higher PRS compared to those treated with liposomal doxorubicin/carboplatin (p<0.001). Overall survival was also significantly different between the stage groups (p=0.003). Conclusions The 5-year PFS rate in ROC treated with second-line CT is <20%. The rate of secondary recurrence is moderately high, leading to reduced survival. Paclitaxel/carboplatin-based second-line CT significantly increases PRS among ROC patients. The probability of mortality increases as the stage advances.","PeriodicalId":519891,"journal":{"name":"The National medical journal of India","volume":"39 1","pages":"6-12"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146128547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation of carotid artery intima-media thickness with parameters of mineral bone disorder in patients with chronic kidney disease. 慢性肾病患者颈动脉内膜-中膜厚度与矿物骨紊乱参数的相关性

The National medical journal of India Pub Date : 2026-01-01 DOI: 10.25259/NMJI_827_2022

Adhip Arora, Rashmi Chaudhary, Sahil Arora, Raisa Arora

{"title":"Correlation of carotid artery intima-media thickness with parameters of mineral bone disorder in patients with chronic kidney disease.","authors":"Adhip Arora, Rashmi Chaudhary, Sahil Arora, Raisa Arora","doi":"10.25259/NMJI_827_2022","DOIUrl":"10.25259/NMJI_827_2022","url":null,"abstract":"Background Chronic kidney disease (CKD) is associated with accelerated cardiovascular (CV) risk, particularly due to subclinical atherosclerosis. Carotid intima-media thickness (CIMT) is a non-invasive marker of early athero-sclerotic changes. Altered mineral metabolism in CKD, also known as CKD-mineral bone disorder (CKD-MBD), may contribute to vascular damage. We evaluated the association between CIMT and mineral metabolism markers in people with diabetes who had pre-dialysis CKD. Methods A cross-sectional observational study was done in 110 adults with diabetes and pre-dialysis CKD. Biochemical markers including serum phosphate, intact parathyroid hormone (iPTH), fibroblast growth factor (FGF)-23, and 24-hour urinary phosphate were analyzed. CIMT was measured using B-mode ultrasonography. Correlation and regression analyses were performed. Results CIMT showed significant positive correlations with serum phosphate, FGF-23, iPTH, and serum creatinine, and negative correlations with nephron index and urinary phosphate excretion. Serum phosphate >6 mg/dl strongly predicted CIMT >0.9 mm. Conclusion Mineral metabolism markers, particularly serum phosphate and FGF-23, are significantly associated with subclinical atherosclerosis in CKD. Monitoring these parameters may aid in assessment of early CV risk in patients with CKD.","PeriodicalId":519891,"journal":{"name":"The National medical journal of India","volume":"39 1","pages":"13-18"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146128406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author reply Re: Patil AB. Attitude of undergraduate medical students towards medical research: A cross-sectional study. AB.本科医学生对医学研究的态度：一项横断面研究。

The National medical journal of India Pub Date : 2026-01-01 DOI: 10.25259/NMJI_1805_2025

Aruna Bholenath Patil

引用次数: 0

Long-term outcomes of SCOT HEART trial: Coming of age for coronary CT angiography? 苏格兰心脏试验的长期结果：冠状动脉CT血管造影的成熟？

The National medical journal of India Pub Date : 2026-01-01 DOI: 10.25259/NMJI_175_2025

Mohsin Raj Mantoo, Ambuj Roy

引用次数: 0

Cutaneous tuberculosis: Epidemiology, pathogenesis, clinical features and investigations. 皮肤结核：流行病学、发病机制、临床特征和调查。

The National medical journal of India Pub Date : 2026-01-01 DOI: 10.25259/NMJI_1087_2024

Parul Verma, Geeti Khullar, Satyaki Ganguly, P Narsimha Rao, Pragya Nair, Anup Tiwary, Sudipta Roy, C R Revankar, Saurabh Raut, Aditi Jha

引用次数: 0

Incidence and predictors of long Covid-19 in hospitalized patients: A cohort study. 住院患者长期Covid-19的发病率和预测因素：一项队列研究

The National medical journal of India Pub Date : 2026-01-01 DOI: 10.25259/NMJI_222_2023

Pooja Vyas, Dinesh Joshi, Kewal Kanabar, Meena Parmar, Jaykumar Vadodariya, Krutika Patel, Bhavin Patel, Suketu Dave, Mumukshi Patel, Gunjan Modi

{"title":"Incidence and predictors of long Covid-19 in hospitalized patients: A cohort study.","authors":"Pooja Vyas, Dinesh Joshi, Kewal Kanabar, Meena Parmar, Jaykumar Vadodariya, Krutika Patel, Bhavin Patel, Suketu Dave, Mumukshi Patel, Gunjan Modi","doi":"10.25259/NMJI_222_2023","DOIUrl":"10.25259/NMJI_222_2023","url":null,"abstract":"Background Long-term Covid-19 symptoms have the potential to negatively impact health and quality of life. We evaluated the incidence and predictors of long Covid-19 among hospitalized patients. Methods We prospectively collected clinical data of 393 patients diagnosed as Covid-19 positive and admitted to our hospital. At 1-year follow-up, all vital parameters and laboratory investigations were recorded. A multiple logistic regression model was used to determine predictors of long Covid-19. Results Long Covid-19 was found in 34.4% of patients at 1-year follow-up. Most commonly reported symptoms were joint pain (40%), fatigue (33%), and dyspnoea (22.9%). Severity of disease at the time of admission (1.5; 95% Confidence Interval [CI] 1.09-2.2; p=0.01), high body-mass index (BMI) (1.1; 95% CI 1.03-1.13; p=0.003) and increased age (1.02; 95% CI 1.00-1.04; p=0.02) were independent predictors of long Covid-19 on follow-up. Conclusion Almost one-third of patients were diagnosed with long Covid-19 at 1-year follow-up. Severity of disease at the time of admission, increased BMI, and increased age were independent predictors of long Covid-19.","PeriodicalId":519891,"journal":{"name":"The National medical journal of India","volume":"39 1","pages":"19-22"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146128389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liquid Biopsy: A Timely Technology Waiting to be Taken Seriously. 液体活检：一项亟待重视的及时技术。

The National medical journal of India Pub Date : 2026-01-01 DOI: 10.25259/NMJI_2214_2025

Ram Hemant Datar

引用次数: 0

Clinical spectrum and intermediate outcomes of community and hospital-acquired acute kidney injury: A single centre study. 社区和医院获得性急性肾损伤的临床谱和中期结果：一项单中心研究

The National medical journal of India Pub Date : 2026-01-01 DOI: 10.25259/NMJI_295_2023

Naveen Kumar Mattewada, Dhanin Puthiyottil, Sreejith Parameswaran, P S Priyamvada

{"title":"Clinical spectrum and intermediate outcomes of community and hospital-acquired acute kidney injury: A single centre study.","authors":"Naveen Kumar Mattewada, Dhanin Puthiyottil, Sreejith Parameswaran, P S Priyamvada","doi":"10.25259/NMJI_295_2023","DOIUrl":"10.25259/NMJI_295_2023","url":null,"abstract":"Background There is minimal literature on the spectrum and long-term outcomes of acute kidney injury (AKI) from tropical countries. Methods Patients with AKI without underlying chronic kidney disease (CKD), were recruited from March 2017 to December 2018 to assess their outcomes. Survivors were followed for a year post-discharge. A linear model with fixed effects was created to compare the estimated glomerular filtration rate (eGFR) trajectories of patients with and without CKD at the end of follow-up. Results A total of 529 patients with AKI were recruited, of which 288 (54.4%) were hospital-acquired AKI. Infections and sepsis were the most common aetiologies for community-acquired AKI and hospital-acquired AKI. The overall mortality rate was 42.9% (n=227). The ICU stay (HR 1.78; 95% CI 1.08-2.93), mechanical ventilation (HR 1.98; 95% CI 1.09-3.54), and the requirement for inotropic support (HR 2.36; 95% CI 1.65-3.39) were independent risk factors of in-hospital mortality. Among 156 subjects with long-term follow-up, 70 (44.9%) developed CKD after a median follow-up of 12 months. Age (p<0.001) and hospital-acquired AKI (p=0.014) were significant predictors, whereas ICU stay and comorbid conditions did not influence the GFR trajectories. CKD patients showed a lower eGFR from the first follow-up (p<0.001). Conclusions AKI is associated with significant mortality. Even after an apparent recovery, around half the survivors progress to CKD at the end of 1 year.","PeriodicalId":519891,"journal":{"name":"The National medical journal of India","volume":"39 1","pages":"23-29"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146128448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0