Eye and Brain最新文献

Differences and Similarities Between Primary Open Angle Glaucoma and Primary Angle-Closure Glaucoma. 原发性开角型青光眼与原发性闭角型青光眼的异同。

IF 3.1

Eye and Brain Pub Date : 2024-09-17 eCollection Date: 2024-01-01 DOI: 10.2147/EB.S472920

Yiwei Wang, Yanzhi Guo, Yang Zhang, Shouyue Huang, Yisheng Zhong

{"title":"Differences and Similarities Between Primary Open Angle Glaucoma and Primary Angle-Closure Glaucoma.","authors":"Yiwei Wang, Yanzhi Guo, Yang Zhang, Shouyue Huang, Yisheng Zhong","doi":"10.2147/EB.S472920","DOIUrl":"https://doi.org/10.2147/EB.S472920","url":null,"abstract":"Glaucoma is the leading cause of irreversible blindness worldwide. It is an ocular disease characterized by an increase in intraocular pressure or, in some cases, normal intraocular pressure, which leads to optic nerve damage and progressive constriction of the visual field (VF). Primary Open-Angle Glaucoma (POAG) and Primary Angle-Closure Glaucoma (PACG) represent the predominant forms of glaucoma. Numerous hypotheses have been posited to elucidate the pathogenic mechanisms underlying these conditions. There is an emerging understanding of the distinct pathological processes that differentiate the various types of glaucoma. While some similarities in the mechanisms between PACG and POAG have been suggested, evidence indicates that there are also significant differences between the two. This review synthesizes the similarities and differences in the etiology of optic neuropathy caused by POAG and PACG, considering their respective pathophysiological mechanisms, the morphology of the optic disc and surrounding tissues, genetic characteristics, optical coherence tomography angiography, optical coherence tomography, and structural and functional features from VF examinations. These characteristics may contribute to a deeper comprehension of the underlying pathogenesis of glaucoma and enhance the management of different types of this ocular condition.","PeriodicalId":51844,"journal":{"name":"Eye and Brain","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11416111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142300582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retina-Brain Homology: The Correlation Between Ophthalmic or Retinal Artery Occlusion and Ischemic Stroke. 视网膜-大脑同源性：眼部或视网膜动脉闭塞与缺血性中风之间的相关性。

IF 3.1

Eye and Brain Pub Date : 2024-08-12 eCollection Date: 2024-01-01 DOI: 10.2147/EB.S454977

Yufeng Yao, Qiyuan Song, Jingnan Zhang, Yingying Wen, Xiaoyan Dou

{"title":"Retina-Brain Homology: The Correlation Between Ophthalmic or Retinal Artery Occlusion and Ischemic Stroke.","authors":"Yufeng Yao, Qiyuan Song, Jingnan Zhang, Yingying Wen, Xiaoyan Dou","doi":"10.2147/EB.S454977","DOIUrl":"10.2147/EB.S454977","url":null,"abstract":"The retina's similar structure and function to the brain make it a unique visual \"window\" for studying cerebral disorders. Ophthalmic artery occlusion (OAO) or retinal artery occlusion (RAO) is a severe ophthalmic emergency that significantly affects visual acuity. Studies have demonstrated that patients with OAO or RAO face a notably higher risk of future acute ischemic stroke (AIS). However, ophthalmologists often overlook multidisciplinary approach involving the neurologist, to evaluate the risk of AIS and devise clinical treatment strategies for patients with OAO or RAO. Unlike the successful use of thrombolysis in AIS, the application of thrombolysis for OAO or RAO remains limited and controversial due to insufficient reliable evidence. In this review, we aim to summarize the anatomical and functional connections between the retina and the brain, and the clinical connection between OAO or RAO and AIS, compare and review recent advances in the effectiveness and safety of intravenous and intra-arterial thrombolysis therapy in patients with OAO or RAO, and discuss future research directions for OAO or RAO. Our goal is to advance the development of multidisciplinary diagnosis and treatment strategies for the disease, as well as to establish expedited pathways or thrombolysis guidelines for vascular intervention.","PeriodicalId":51844,"journal":{"name":"Eye and Brain","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11328846/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142001306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Comprehensive Review of Leber Hereditary Optic Neuropathy and Its Association with Multiple Sclerosis-Like Phenotypes Known as Harding's Disease. 全面回顾勒伯遗传性视神经病变及其与被称为哈丁氏病的多发性硬化症相似表型的关联。

IF 3.1

Eye and Brain Pub Date : 2024-07-29 eCollection Date: 2024-01-01 DOI: 10.2147/EB.S470184

Jehad Alorainy, Yara Alorfi, Rustum Karanjia, Nooran Badeeb

{"title":"A Comprehensive Review of Leber Hereditary Optic Neuropathy and Its Association with Multiple Sclerosis-Like Phenotypes Known as Harding's Disease.","authors":"Jehad Alorainy, Yara Alorfi, Rustum Karanjia, Nooran Badeeb","doi":"10.2147/EB.S470184","DOIUrl":"10.2147/EB.S470184","url":null,"abstract":"Leber Hereditary Optic Neuropathy (LHON) stands as a distinctive maternally inherited mitochondrial disorder marked by painless, subacute central vision loss, primarily affecting young males. This review covers the possible relationship between LHON and multiple sclerosis (MS), covering genetic mutations, clinical presentations, imaging findings, and treatment options. LHON is associated with mutations in mitochondrial DNA (mtDNA), notably m.11778G>A, m.3460G>A, and m.14484T>C, affecting complex I subunits. Beyond ocular manifestations, LHON can go beyond the eye into a multi-systemic disorder, showcasing extraocular abnormalities. Clinical presentations, varying in gender prevalence and outcomes, underscore the nature of mitochondrial optic neuropathies. Hypotheses exploring the connection between LHON and MS encompass mitochondrial DNA mutations triggering neurological diseases, immunologically mediated responses inducing demyelination, and the possibility of coincidental diseases. The research on mtDNA mutations among MS patients sheds light on potential associations with specific clinical subgroups, offering a unique perspective into the broader landscape of MS. Imaging findings, ranging from white matter alterations to cerebrospinal fluid biomarkers, further emphasize shared pathological processes between LHON-MS and classical MS. This comprehensive review contributes to the understanding of the complex relationship between LHON and MS.","PeriodicalId":51844,"journal":{"name":"Eye and Brain","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11296356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141890880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detecting Abnormal Eye Movements in Patients with Neurodegenerative Diseases – Current Insights 检测神经退行性疾病患者的异常眼球运动 - 最新见解

IF 4.4

Eye and Brain Pub Date : 2024-04-01 DOI: 10.2147/EB.S384769

Akila Sekar, Muriel Panouillères, Diego Kaski

{"title":"Detecting Abnormal Eye Movements in Patients with Neurodegenerative Diseases – Current Insights","authors":"Akila Sekar, Muriel Panouillères, Diego Kaski","doi":"10.2147/EB.S384769","DOIUrl":"https://doi.org/10.2147/EB.S384769","url":null,"abstract":"Abstract This review delineates the ocular motor disturbances across a spectrum of neurodegenerative disorders, including Alzheimer’s Disease (AD) and related disorders (ADRD), Parkinson’s Disease (PD), atypical parkinsonism, and others, leveraging advancements in eye-tracking technology for enhanced diagnostic precision. We delve into the different classes of eye movements, their clinical assessment, and specific abnormalities manifesting in these diseases, highlighting the nuanced differences and shared patterns. For instance, AD and ADRD are characterized by increased saccadic latencies and instability in fixation, while PD features saccadic hypometria and mild smooth pursuit impairments. Atypical parkinsonism, notably Progressive Supranuclear Palsy (PSP) and Corticobasal Syndrome (CBS), presents with distinct ocular motor signatures such as vertical supranuclear gaze palsy and saccadic apraxia, respectively. Our review underscores the diagnostic value of eye movement analysis in differentiating between these disorders and also posits the existence of underlying common pathological mechanisms. We discuss how eye movements have potential as biomarkers for neurodegenerative diseases but also some of the existing limitations.","PeriodicalId":51844,"journal":{"name":"Eye and Brain","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140794384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Fond Farewell. 依依惜别

IF 4.4

Eye and Brain Pub Date : 2024-02-01 eCollection Date: 2024-01-01 DOI: 10.2147/EB.S461359

Margaret Wong-Riley

引用次数: 0

Spotlight on Trans-Synaptic Degeneration in the Visual Pathway in Multiple Sclerosis. 聚焦多发性硬化症视觉通路的跨突触退化

IF 4.4

Eye and Brain Pub Date : 2023-12-29 eCollection Date: 2023-01-01 DOI: 10.2147/EB.S389632

Angeliki G Filippatou, Peter A Calabresi, Shiv Saidha, Olwen C Murphy

引用次数: 0

GGT1 Suppresses the Development of Ferroptosis and Autophagy in Mouse Retinal Ganglion Cell Through Targeting GCLC. GGT1通过靶向GCLC抑制小鼠视网膜神经节细胞铁下垂和自噬的发生。

IF 4.4

Eye and Brain Pub Date : 2023-11-21 eCollection Date: 2023-01-01 DOI: 10.2147/EB.S434280

Guihua Xu, Juanjuan Wang, Yiting Zhang, Zilin Chen, Ruidong Deng

{"title":"GGT1 Suppresses the Development of Ferroptosis and Autophagy in Mouse Retinal Ganglion Cell Through Targeting GCLC.","authors":"Guihua Xu, Juanjuan Wang, Yiting Zhang, Zilin Chen, Ruidong Deng","doi":"10.2147/EB.S434280","DOIUrl":"https://doi.org/10.2147/EB.S434280","url":null,"abstract":"Background: Glaucoma is a neurodegenerative disorder characterized with optic nerve injury and the loss of retinal ganglion cells (RGCs). Ferroptosis has been proved to be associated with the degradation of RGCs. The aim of this study is to elucidate the relationship between ferroptosis and glaucoma pathogenesis, and unveil the underlying mechanism.Methods: Methyl thiazolyl tetrazolium (MTT) assay was used to evaluate the proliferation of RGCs. The accumulation of cellular iron was measured by Iron assay kit, and the level of reactive oxygen species (ROS) was detected by fluorescence probe. The mitochondrial morphology and autophagosomes were analysed by using transmission electron microscopy (TEM). The contents of glutathione (GSH) and malondialdehyde (MDA) were tested by a GSH assay kit and an MDA detection kit, respectively. The expression of autophagy-related proteins was detected by Western blotting.Results: A serious cell damage, aberrant iron homeostasis, and oxidative stress was shown in RGC-5 after oxygen-glucose deprivation/reoxygenation (OGD/R) treatment and gamma-Glutamyl transpeptidase 1 (GGT1) knockdown, but these effects were significantly alleviated by overexpression of GGT1 or ferroptosis inhibitors. The TEM and immunofluorescent results indicated that mitochondria impairment and autophagosome accumulation in OGD/R-treated cells was improved after GGT1 overexpression, while the phenomenon in GGT1-silenced cells was aggravated. Furthermore, we found that GGT1 can interact with glutamate cysteine ligase catalytic subunit (GCLC) to inhibit autophagy and ferroptosis in RGC-5 cells.Conclusion: GGT1 represses autophagy in RGC-5 cells by targeting GCLC, which further restrains the development of ferroptosis in cells.","PeriodicalId":51844,"journal":{"name":"Eye and Brain","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10676118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138464252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuromodulation: Actions of Dopamine, Retinoic Acid, Nitric Oxide, and Other Substances on Retinal Horizontal Cells. 神经调控：多巴胺、视黄酸、一氧化氮和其他物质对视网膜水平细胞的作用。

IF 4.4

Eye and Brain Pub Date : 2023-10-31 eCollection Date: 2023-01-01 DOI: 10.2147/EB.S420050

Douglas G McMahon, John E Dowling

{"title":"Neuromodulation: Actions of Dopamine, Retinoic Acid, Nitric Oxide, and Other Substances on Retinal Horizontal Cells.","authors":"Douglas G McMahon, John E Dowling","doi":"10.2147/EB.S420050","DOIUrl":"10.2147/EB.S420050","url":null,"abstract":"Whereas excitation and inhibition of neurons are well understood, it is clear that neuromodulatory influences on neurons and their synapses play a major role in shaping neural activity in the brain. Memory and learning, emotional and other complex behaviors, as well as cognitive disorders have all been related to neuromodulatory mechanisms. A number of neuroactive substances including monoamines such as dopamine and neuropeptides have been shown to act as neuromodulators, but other substances thought to play very different roles in the body and brain act as neuromodulators, such as retinoic acid. We still understand little about how neuromodulatory substances exert their effects, and the present review focuses on how two such substances, dopamine and retinoic acid, exert their effects. The emphasis is on the underlying neuromodulatory mechanisms down to the molecular level that allow the second order bipolar cells and the output neurons of the retina, the ganglion cells, to respond to different environmental (ie lighting) conditions. The modulation described affects a simple circuit in the outer retina, involves several neuroactive substances and is surprisingly complex and not fully understood.","PeriodicalId":51844,"journal":{"name":"Eye and Brain","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10625386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71488810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Neuro-Ophthalmologist's Guide to Advances in Intracranial Pressure Measurements. 神经眼科医师颅内压测量进展指南。

IF 4.4

Eye and Brain Pub Date : 2023-09-27 eCollection Date: 2023-01-01 DOI: 10.2147/EB.S404642

Susan P Mollan, Sehrish N A Momin, Pavan S Khatkar, Olivia Grech, Alex J Sinclair, Georgios Tsermoulas

引用次数: 1

Monitoring Eye Movement in Patients with Parkinson's Disease: What Can It Tell Us? 监测帕金森病患者的眼动:它能告诉我们什么?

IF 3.1

Eye and Brain Pub Date : 2023-07-24 eCollection Date: 2023-01-01 DOI: 10.2147/EB.S384763

Yue Ran Sun, Sinem B Beylergil, Palak Gupta, Fatema F Ghasia, Aasef G Shaikh

引用次数: 0