Retinal Vessel Oxygen Saturation in Patients with Unilateral Edema of the Optic Nerve Head: A Pilot Study.

IF 2.4 Q1 OPHTHALMOLOGY

Eye and Brain Pub Date : 2025-07-08 eCollection Date: 2025-01-01 DOI:10.2147/EB.S524274

Michal Březík, Veronika Matušková, Daniela Vysloužilová, Martin Šín, Veronika Chovancová, Kristína Sičová, Natália Jankaničová, Oldřich Chrapek

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Abstract

Purpose: Evaluate whether optic disc edema results in changes in retinal microcirculation.

Patients and methods: The study group consisted of 11 patients with unilateral optic disc edema (papilledema). The control group consisted of the healthy eyes of the same 11 patients. Patients underwent non-invasive photo-spectrometric retinal oximetry using Oxymap T1 retinal oximeter (Oxymap, Reykjavik, Iceland). In the eyes of these 11 patients, we examined the diameter of the retinal arteries and veins, arterial and venous blood oxygen saturation, and the difference in oxygen saturation between arterioles and venules (A-V difference).

Results: In the papilledema group, the decrease in the retinal arterial diameter was statistically significant (p=0.001). The median diameter of the retinal artery was 11.70 px (IQR 1.47) or after conversion 109.00 µm (IQR 14.00) in the papilledema group and 13.75 px (IQR 1.61) or 128.00 µm (IQR 15.00) in the control group. The increase in the diameter of the retinal veins in the papilledema group was statistically significant (p=0.012), where the median diameter in the papilledema group was 20.88 px (IQR 3.72) or 194.00 µm (IQR 35.00), and in the control group was 18.18 px (IQR 3.60) or 169 µm (IQR 33.00). There was a statistically significant decrease (p<0.001) in the venous saturation in the papilledema group with a median value of 53.16% (IQR 17.38) and 60.02% (IQR 11.98) in the control group. The median of the A-V difference was 51.92 (IQR 15.96) in the papilledema group, resp. 38.49 (IQR 9.75) in the control group and a significant increase in the papilledema group (p<0.001) was reported.

Conclusion: Automatic retinal oximetry demonstrated changes in the retinal microcirculation in patients with optic disc edema.

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单侧视神经头水肿患者视网膜血管氧饱和度：一项初步研究。

目的：评价视盘水肿是否引起视网膜微循环的改变。患者和方法：研究对象为11例单侧视盘水肿（视神经乳头水肿）患者。对照组由同样11例患者的健康眼睛组成。患者使用Oxymap T1视网膜血氧仪（Oxymap, Reykjavik, Iceland）进行无创光光谱视网膜血氧测定。在这11例患者的眼睛中，我们检查了视网膜动静脉直径，动静脉血氧饱和度，以及小动脉和小静脉之间的血氧饱和度差异（A-V差）。结果：乳头水肿组视网膜动脉直径减小，差异有统计学意义（p=0.001）。乳头水肿组视网膜动脉中位直径为11.70 px （IQR 1.47）或转换后109.00µm (IQR 14.00)，对照组为13.75 px （IQR 1.61）或128.00µm （IQR 15.00）。视神经乳头水肿组视网膜静脉直径增加有统计学意义（p=0.012），其中视神经乳头水肿组视网膜静脉直径中位数为20.88 px （IQR 3.72）或194.00µm (IQR 35.00)，对照组为18.18 px （IQR 3.60）或169µm （IQR 33.00）。结论：自动视网膜血氧仪显示视盘水肿患者视网膜微循环发生改变。

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来源期刊

Eye and Brain OPHTHALMOLOGY-

CiteScore

7.90

自引率

2.30%

发文量

审稿时长

16 weeks

期刊介绍： Eye and Brain is an international, peer-reviewed, open access journal focusing on basic research, clinical findings, and expert reviews in the field of visual science and neuro-ophthalmology. The journal’s unique focus is the link between two well-known visual centres, the eye and the brain, with an emphasis on the importance of such connections. All aspects of clinical and especially basic research on the visual system are addressed within the journal as well as significant future directions in vision research and therapeutic measures. This unique journal focuses on neurological aspects of vision – both physiological and pathological. The scope of the journal spans from the cornea to the associational visual cortex and all the visual centers in between. Topics range from basic biological mechanisms to therapeutic treatment, from simple organisms to humans, and utilizing techniques from molecular biology to behavior. The journal especially welcomes primary research articles or review papers that make the connection between the eye and the brain. Specific areas covered in the journal include: Physiology and pathophysiology of visual centers, Eye movement disorders and strabismus, Cellular, biochemical, and molecular features of the visual system, Structural and functional organization of the eye and of the visual cortex, Metabolic demands of the visual system, Diseases and disorders with neuro-ophthalmic manifestations, Clinical and experimental neuro-ophthalmology and visual system pathologies, Epidemiological studies.