Journal of conservative dentistry and endodontics最新文献

{"title":"Comparative evaluation of postoperative pain and healing following root canal obturation with calcium silicate and bioactive glass-based sealers to epoxy resin-based sealers: A systematic review and meta-analysis.","authors":"Vibha Rahul Hegde, Sanitra Rahul Hegde, Ushaina Eruch Fanibunda, Meghana Aditya Vartak","doi":"10.4103/JCDE.JCDE_8_25","DOIUrl":"https://doi.org/10.4103/JCDE.JCDE_8_25","url":null,"abstract":"<p><strong>Aim: </strong>To compare the postoperative pain and healing following obturation with calcium silicate and bioactive glass-based sealers to epoxy resin sealers.</p><p><strong>Materials and methods: </strong>A systematic search (2018-2024) was conducted using PubMed, Cochrane, and Google Scholar, following the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines (PRISMA). Risk of bias (RoB) was assessed using Cochrane RoB 2 tool and quality was evaluated using GRADE. Twenty-three studies were included for qualitative analysis and 11 for quantitative analysis, including meta-analysis for bioactive glass and epoxy resin-based sealers.</p><p><strong>Results: </strong>Meta-analysis revealed no significant difference in pain occurrence between groups at 24 h, 48 h, and 7 days. Similarly, for bioactive glass sealer, no significant difference in pain occurrence was observed at 24 h, 48 h, and 7 days.</p><p><strong>Conclusion: </strong>Calcium-silicate-based sealers showed comparable and satisfactory results to epoxy resin sealers regarding postoperative pain incidence and intensity. In addition, they facilitated improved healing of periapical tissues. Notably, bioactive glass-based sealer also demonstrated exceptional properties, offering enhanced benefits.</p>","PeriodicalId":516842,"journal":{"name":"Journal of conservative dentistry and endodontics","volume":"28 3","pages":"211-221"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12007741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of fracture resistance of endodontically treated teeth with wedge shaped non-carious cervical lesions using different types of esthetic post: An <i>in vitro</i> study.","authors":"Mousumi Biswas, Dibyendu Mazumdar, B Gengadharani, Kallol Kumar Saha, Binayak Saha, Debjani Saha","doi":"10.4103/JCDE.JCDE_46_25","DOIUrl":"https://doi.org/10.4103/JCDE.JCDE_46_25","url":null,"abstract":"<p><strong>Introduction: </strong>Background of the study: Conventionally, postcore and crown foundation systems have been employed for restoring endodontically treated teeth (ETT).</p><p><strong>Aim: </strong>The aim of this study was to evaluate and compare the fracture resistance of ETT with wedge-shaped noncarious cervical lesions (NCCLs) using different types of esthetic posts.</p><p><strong>Technique: </strong>Forty maxillary first premolars possessing two root canals have been randomly divided into four groups (<i>n</i> = 10). Thirty tooth specimens were used to generate buccal wedge-shaped NCCLs. Zirconia and prefabricated fiber posts have been cemented in Groups III and IV. In universal testing machine, the palatal cusp has been subjected to nonaxial compressive stress at 30° angle with crosshead speed of 0.5 mm/min till fracture occurred. (1) Group I - composite resin core (CRC), (2) Group II - NCCLs + CRC, (3) Group III - NCCLs + PFC + CRC, and (4) Group IV - NCCLs + custom-made zirconia post + CRC.</p><p><strong>Results: </strong>A one-way analysis of variance/Kruskal-Wallis test was employed to compare the outcome variables between the study groups, which showed Group III's fracture resistance was noticeably greater than Group I. Finally, there has been a substantial difference (<i>P</i> < 0.0001) between Group IV and all other groups.</p><p><strong>Conclusion: </strong>Maxillary premolars with NCCLs that were repaired endodontically utilizing PFCs showed higher fracture resistance than maxillary premolars without posts.</p>","PeriodicalId":516842,"journal":{"name":"Journal of conservative dentistry and endodontics","volume":"28 3","pages":"285-289"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12007747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of chitosan nanoparticle dentin pretreatment with different concentrations and application times to improve bonding at resin-dentin interface.","authors":"Rinki Meher, Rashmi Rekha Mallick, Priyanka Sarangi, Amit Jena, Shradha Suman, Gaurav Sharma","doi":"10.4103/JCDE.JCDE_850_24","DOIUrl":"https://doi.org/10.4103/JCDE.JCDE_850_24","url":null,"abstract":"<p><strong>Aim: </strong>The aim was to study the effect of various chitosan nanoparticles (CNPs) solution concentrations with different application times on the microtensile bond strength (µTBS) of resin composite to human demineralized dentin.</p><p><strong>Materials and methods: </strong>Flat dentin occlusal surfaces from 90 extracted premolar teeth were randomly divided into three pretreatment groups (<i>n</i> = 30) before adhesive application: Group I: 0.2% CNPs, Group II: 0.5% CNPs, and Group III: 1% CNPs. Further, samples were divided into three subgroups (<i>n</i> = 10) based on the different durations of application of CNPs (A: 30 s, B: 60 s, and C: 90 s) and prepared accordingly. Subsequently, after self-etch adhesive application, nanohybrid composite buildup was done. Bonded teeth were sectioned into resin-dentin sticks (0.9 mm²) for µTBS analysis. In addition, stereomicroscopic analysis (×25) was performed to evaluate the failure modes as cohesive, adhesive, or mixed. Data were analyzed using repeated measures of ANOVA along with Wilks' lambda test and Dunn-Bonferroni multiple comparison test (<i>P</i> < 0.05).</p><p><strong>Results: </strong>The highest and lowest values of µTBS were observed with 0.2% CNPs at 60 s and 1% CNPs at 90 s, respectively (<i>P</i> < 0.05). Stereomicroscopic fracture pattern analysis revealed 50-cohesive, 34-mixed, and only 6-adhesive failures.</p><p><strong>Conclusion: </strong>The 60 s application of 0.2% CNPs to demineralized dentin before dentin adhesive application enhanced the bond strength at the resin-dentin interface. Overall efficiency varied according to CNPs concentration and application time. Clinical significance: CNPs pretreatment improves bonding effectiveness. This approach creates new possibilities to form a functional bonding interface, thereby prolonging the longevity of restorations.</p>","PeriodicalId":516842,"journal":{"name":"Journal of conservative dentistry and endodontics","volume":"28 3","pages":"248-252"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12007738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy of sodium hypochlorite, silver nanoparticles, and chitosan nanoparticles on gutta-percha cone disinfection and topographical changes analyzed by atomic force microscopy: An <i>in vitro</i> study.","authors":"Tushar Raheja, Jagat Bhushan, Rajesh Kumar Joshi, Sonia Bhonchal Bhardwaj","doi":"10.4103/JCDE.JCDE_804_24","DOIUrl":"https://doi.org/10.4103/JCDE.JCDE_804_24","url":null,"abstract":"<p><strong>Context: </strong>Evaluation of newer nanoparticle-based disinfectants for the disinfection of contaminated gutta-percha cones and surface topographical changes induced by them.</p><p><strong>Aim: </strong>To evaluate the effectiveness of sodium hypochlorite (NaOCl), silver nanoparticles (AgNPs) solution, and chitosan nanoaparticles (ChNPs) solution for the disinfection of gutta-percha cones contaminated with <i>Bacillus subtilis</i> (MTCC 441) and <i>Candida albicans</i> (MTCC 227) and the topographical changes induced by them.</p><p><strong>Methods: </strong>Minimum inhibitory concentration and minimum bactericidal concentration of NaOCl, AgNPs, and ChNPs against <i>B. subtilis</i> and <i>C. albicans</i> were determined by the broth microdilution method and colony-forming unit assay, respectively. Gutta-percha cones were artificially contaminated with <i>B. subtilis</i> and <i>C. albicans</i>. Contaminated cones were immersed for 1, 3, and 5 min in 2.62% NaOCl, 5.25% NaOCl, 250 µg/ml AgNP's, and 625 µg/ml ChNPs solution, and the mean colony-forming units (CFUs) were evaluated after disinfection. Topographical changes induced by these agents at different time intervals were assessed by atomic force microscopy (AFM).</p><p><strong>Statistical analysis: </strong>The data were analyzed by a two-way analysis of variance and Bonferroni <i>post hoc</i> test performed using licensed GraphPad Prism (v5.0).</p><p><strong>Results: </strong>NaOCl was the most effective disinfectant, eliminating both microorganisms within 1 min of immersion time. AgNPs and ChNPs showed no CFU units at 5 min of immersion time against <i>B. subtilis</i> but were able to eliminate <i>C. albicans</i> within 1 min of immersion. AFM analysis showed that, with all disinfectants on increasing time of immersion, the topographical changes become significant in comparison to the control.</p><p><strong>Conclusion: </strong>NaOCl at both concentrations was the most effective disinfectant, causing minimal topographical alterations at 1 min of immersion time.</p>","PeriodicalId":516842,"journal":{"name":"Journal of conservative dentistry and endodontics","volume":"28 3","pages":"242-247"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12007733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing adhesive performance with N, N, N', N'-tetrakis (2-pyridyl methyl) ethylenediamine matrix metalloproteinase inhibitors: A comprehensive study of degree of conversion, microleakage, and micro-tensile bond strength in dental adhesives.","authors":"Arman Salehi, Mohammad Atai, Mahdi Aliomrani, Negar Salehi, Ramin Rahati","doi":"10.4103/JCDE.JCDE_743_24","DOIUrl":"https://doi.org/10.4103/JCDE.JCDE_743_24","url":null,"abstract":"<p><strong>Aim: </strong>Matrix metalloproteinases (MMPs) play a significant role in the degradation of dentin collagen within hybrid layers, affecting the longevity of resin-bonded restorations. The incorporation of MMP inhibitors into dental adhesives has been explored to address this issue. This study aimed to assess the impact of the MMP inhibitor, N, N, N', N'-Tetrakis (2-pyridyl methyl) ethylenediamine (TPEN), on key adhesive properties, including the degree of conversion (DC), microleakage, and micro-tensile bond strength, shedding light on their potential in enhancing bond durability.</p><p><strong>Subjects and methods: </strong>Microleakage evaluations were conducted on 24 premolar specimens, while micro-tensile bond strength measurements were performed on the buccal surface of dentin samples. The DC was determined using Fourier Transform Infrared spectroscopy (FTIR) spectroscopy.</p><p><strong>Results: </strong>The findings revealed no significant difference in DC between the adhesive with MMP inhibitors and the control group (<i>P</i> = 0.998). Remarkably, the adhesive containing the MMP inhibitor, TPEN, exhibited significantly higher micro-tensile bond strength than the control group (<i>P</i> = 0.008). However, there was no notable distinction between the two groups concerning microleakage (<i>P</i> = 0.085).</p><p><strong>Conclusion: </strong>The results suggest that including TPEN can effectively enhance micro-tensile bond strength in dental adhesives without compromising DC or exacerbating microleakage. This highlights the potential of MMP inhibitors in improving bond durability in restorative dentistry.</p>","PeriodicalId":516842,"journal":{"name":"Journal of conservative dentistry and endodontics","volume":"28 3","pages":"290-296"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12007739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new cleaning protocol in minimally invasive endodontic surgery: RUA (\"retro irrigant activation\").","authors":"Dina Abdellatif, Davide Mancino, Massimo Pisano, Sara De Fontaine, Alfredo Iandolo","doi":"10.4103/JCDE.JCDE_799_24","DOIUrl":"https://doi.org/10.4103/JCDE.JCDE_799_24","url":null,"abstract":"<p><p>Surgical endodontics refers to the branch of dentistry concerned with diagnosing and treating lesions of endodontic origin that do not respond to conventional orthograde treatment. This case report introduces a novel retrocleaning protocol applied during endodontic surgery. A 52-year-old female patient presented to our clinic with pain in tooth #2.2. A preoperative cone-beam computed tomography (CBCT) scan with high resolution (75 µ) revealed incomplete endodontic treatment and a large periapical radiolucency associated with tooth #2.2. The diagnosis was incomplete root canal treatment and symptomatic apical periodontitis. The CBCT showed complete calcification of the apical third of the tooth, and endodontic surgery was indicated as orthograde retreatment was not feasible. The patient's condition presented a complex case, as the calcification obstructed the endodontic space, making traditional orthograde retreatment useless. This situation necessitated the development and application of a new retrocleaning protocol. This case report demonstrates the successful healing of periapical disease achieved through the application of a novel three-dimensional retrocleaning technique in conservative endodontic surgery. This protocol's promising outcomes offer optimism and inspire further exploration of its potential to improve clinical success rates in endodontic surgery significantly.</p>","PeriodicalId":516842,"journal":{"name":"Journal of conservative dentistry and endodontics","volume":"28 3","pages":"297-301"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12007736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dentinal tubule penetration of a silicone-based endodontic sealer following N-acetyl cysteine intracanal medicament removal using ultrasonic agitation and laser activated irrigation - An <i>in vitro</i> study.","authors":"Pranjali S Narvekar, Sunita Shivanand, Sneha Patil, Sarvesh Raikar, Amrita Mallick, Preeti K Doddwad","doi":"10.4103/JCDE.JCDE_842_24","DOIUrl":"https://doi.org/10.4103/JCDE.JCDE_842_24","url":null,"abstract":"<p><strong>Context: </strong>The removal of intracanal medicament is essential for sealer penetration and the success of endodontic therapy.</p><p><strong>Aims: </strong>To evaluate and compare the dentinal tubule penetration of a silicone-based endodontic sealer following N-acetyl cysteine (NAC) intracanal medicament removal using ultrasonic agitation and laser-activated irrigation.</p><p><strong>Materials and methods: </strong>Eighty-one extracted single-rooted mandibular premolars were decoronated and prepared with ProTaper Universal rotary files up to MAF F3. To prepare medicament, NAC powder was mixed with propylene glycol in the ratio of 1:1, placed using a size #30 Lentulospiral, and specimens stored in an incubator for 14 days. The specimens were then instrumented with #30 Hedström and divided into three groups according to final irrigant activation techniques: Group I: Diode laser activation, Group II: Passive Ultrasonic agitation, Group III: No agitation (positive control). Canals were obturated with GuttaFlow bioseal sealer mixed with 0.1% Rhodamine B dye and gutta-percha cones and incubated for 7 days. The specimens were sectioned horizontally to obtain 1 mm thick sections from 2, 5, and 8 mm from the apex. Sections were examined under Confocal Laser Scanning Microscope to measure the depth of sealer penetration (in µm).</p><p><strong>Statistical analysis: </strong>One-way analysis of variance and Tukeys multiple <i>post hoc</i> test.</p><p><strong>Results: </strong>The highest mean depth of penetration of 728.52 µm was seen with Group I, followed by Group II and least was seen in Group III.</p><p><strong>Conclusions: </strong>Diode laser activation group was most effective in the removal of NAC intracanal medicament from all the three regions of the root canal.</p>","PeriodicalId":516842,"journal":{"name":"Journal of conservative dentistry and endodontics","volume":"28 3","pages":"231-236"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12007743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the antimicrobial effectiveness of endodontic sealers against oral pathogens associated with failed root canal treatments.","authors":"Ajay Chhabra, K P Ramya, B Saravana Prathap, Mallika Sengupta, Aditya Kundu, Priyanka Yadav, Sona J Parvathy","doi":"10.4103/JCDE.JCDE_841_24","DOIUrl":"https://doi.org/10.4103/JCDE.JCDE_841_24","url":null,"abstract":"<p><strong>Overview: </strong>Residual pathogens lead to treatment failure. Microbes like <i>Enterococcus faecalis</i>, <i>Candida albicans</i>, and <i>Actinomyces israelii</i> are often isolated after failed root canal therapy. Therefore, the antimicrobial efficacy of sealers is critical for treatment outcomes.</p><p><strong>Aim: </strong>To evaluate the antimicrobial efficacy of endodontic sealers against <i>E. faecalis</i> and <i>C. albicans</i>.</p><p><strong>Methodology: </strong>The agar diffusion test was used to evaluate the antibacterial efficacy of four sealers: MTA Fillapex, Bio-C-Sealer, Sealapex, and Seal-Pex. Each microorganism's bacterial suspension was added to agar plates separately. The sterile discs were then placed on the plates; later, a freshly mixed sealer was coated on the sterile discs. After 24 h of incubation, inhibition zones were measured.</p><p><strong>Results: </strong>The Kruskal-Wallis test was used to analyze the data, and the Mann-Whitney <i>U</i>-test was used for <i>post hoc</i> pairwise comparison. The results demonstrated that Seal-Pex has potent antibacterial activity against E. faecalis (P < 0.05). Against C. albicans, both MTA Fillapex and Seal-Pex were effective, with MTA Fillapex showing a statistically significant difference compared to Bio-C Sealer and Sealapex.</p><p><strong>Conclusion: </strong>Seal-Pex, an epoxy resin-based sealer, exhibited a significant antimicrobial efficacy against <i>E. faecalis</i>. Conversely, MTA Fillapex demonstrated notable antifungal activity against <i>C. albicans</i>, surpassing other tested sealers. These findings highlight the differential antimicrobial and antifungal properties of the sealers.</p>","PeriodicalId":516842,"journal":{"name":"Journal of conservative dentistry and endodontics","volume":"28 3","pages":"264-268"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12007748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the efficacy of sonic activation in root canal cleaning with an endocator adenosine triphosphate tester: An <i>in vitro</i> study.","authors":"Nagesh Bolla, Roopadevi Garlapati, Sayesh Vemuri, Ram Chowdary Basam, Lahari Bolla, Yedla Sahitya","doi":"10.4103/JCDE.JCDE_764_24","DOIUrl":"10.4103/JCDE.JCDE_764_24","url":null,"abstract":"<p><strong>Context: </strong>Evaluating the efficacy of sonic activation in root canal cleaning using an Endocator adenosine triphosphate (ATP) tester.</p><p><strong>Aim: </strong>The aim of this study was to assess the cleaning efficacy of needle irrigation and sonic activation by measuring ATP values and colony-forming units (CFUs) during root canal procedure.</p><p><strong>Settings and design: </strong>The design of the study is an <i>in vitro</i> study.</p><p><strong>Materials and methods: </strong>Eighty (<i>n</i> = 80) extracted mandibular molars were selected, and distal root canals were enlarged to F2 with ProTaper Gold rotary files. Canals were rinsed with 2 mL of 5.25% sodium hypochlorite (NaOCl), 2 mL of 17% ethylenediaminetetraacetic acid, and 2 mL of distilled water. Samples are sterilized, <i>Enterococcus faecalis</i> is inoculated and incubated at 37° for 4 weeks. Baseline ATP values and CFU are measured. Samples are divided into four groups of n = 20 and are irrigated. Group 1:2 mL of distilled water for 30 s. Group 2: 2 mL of distilled water activated with SmartLite Pro EndoActivator (SLP-EA) for 30 s. Group 3: 2 mL of 1% NaOCl for 30 s. Group 4: 2 mL of 1% NaOCl activated with SLP-EA for 30 s. The irrigation procedure was repeated for nine cycles. ATP values and CFU are recorded after each cycle. Friedman, Kruskal-Wallis, Wilcoxon, and Tukey's <i>post hoc</i> tests are used for statistical evaluation.</p><p><strong>Results: </strong>A significant decrease in ATP values and CFU from baseline to residual level is observed in all groups (<i>P</i> ≤ 0.05). Microbial load reduction is significant in Group 4, followed by Groups 2 and 3.</p><p><strong>Conclusions: </strong>1% NaOCl + SLP-EA showed better efficacy by recording lower ATP values and CFU.</p>","PeriodicalId":516842,"journal":{"name":"Journal of conservative dentistry and endodontics","volume":"28 2","pages":"175-181"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11878686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of root canal disinfection efficacy of three different endodontic irrigants using EndoVac: An <i>in vitro</i> bioluminescence-assisted study.","authors":"Sohail Yasin, D N Nirupama, Mohan Thomas Nainan, D N Naveen, R Vijay, Helen Thomas","doi":"10.4103/JCDE.JCDE_594_24","DOIUrl":"10.4103/JCDE.JCDE_594_24","url":null,"abstract":"<p><strong>Aim: </strong>To compare and evaluate root canal disinfection efficacy of three different endodontic irrigants 2.5% sodium hypochlorite (NaOCl), 2% chlorhexidine (CHX), and 2% alexidine (ALX) using negative pressure irrigation (NPI) system with EndoVac and syringe irrigation (SI) against <i>Enterococcus faecalis</i>.</p><p><strong>Materials and methods: </strong>Seventy single-rooted mandibular premolars were decoronated, enlarged up to F4, autoclaved, and inoculated with <i>E. faecalis</i> for 21 days. The samples were divided into seven groups (n = 10) according to the protocol of disinfection: G1: 2.5% NaOCl + NPI, G2: 2.5% NaOCl + SI, G3: 2% CHX + NPI, G4: 2% CHX + SI, G5: 2% ALX + NPI, G6: 2% ALX + SI, and G7: no irrigation (positive control group). Adenosine triphosphate Assay was performed using luminometer for relative luminescence units (RLU) before and after the irrigation protocol.</p><p><strong>Statistical analysis: </strong>One-way ANOVA test followed by Dunn's <i>post hoc</i> and Wilcoxon Signed-Rank Test analysis was performed (<i>P</i> < 0.05).</p><p><strong>Results and conclusion: </strong>G1 (7.90 ± 6.03) and G2 (2.90 ± 1.79) exhibited the least mean RLU values with no significant difference among them. It was noted that G5 (32.30 ± 7.92) performed better than G6 (14.20 ± 4.05) significantly (<i>P</i> < 0.008). G3 (27.70 ± 7.85) and G4 (28.50 ± 6.62) irrespective of irrigation protocols did not show significant differences in disinfection efficacy. Irrespective of irrigation protocol used, all the 3 irrigants exhibited a decrease in RLU values. In our study, EndoVac irrigation system did not improve the disinfection efficacy of the irrgiants.</p>","PeriodicalId":516842,"journal":{"name":"Journal of conservative dentistry and endodontics","volume":"28 2","pages":"132-137"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11878680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}