Journal of conservative dentistry and endodontics最新文献

{"title":"Exosome-loaded human amniotic membrane hydrogel modulates regenerative responses of human dental pulp stem cells.","authors":"Hesti Witasari Jos Erry, Anggraini Margono, Dini Asrianti Bagio, Dewi Fatma Suniarti, Indra Kusuma, Hendrik Setia Budi, Rachmat Mauludin, Dodi Valentino Tambun, Normalina Sandora, Thanaphum Osathanon, Lisa Rinanda Amir","doi":"10.4103/JCDE.JCDE_576_26","DOIUrl":"10.4103/JCDE.JCDE_576_26","url":null,"abstract":"<p><strong>Context: </strong>Human dental pulp stem cell (hDPSC)-derived exosomes may support dentin-pulp regeneration, but free exosomes have limited local retention. Human amniotic membrane hydrogel may serve as a scaffold for exosome delivery.</p><p><strong>Aim: </strong>This study evaluated the effect of exosome-loaded human amniotic membrane (hAM-Exo) hydrogel on hDPSC responses compared with free exosomes under basal and lipopolysaccharide (LPS)-stimulated conditions.</p><p><strong>Materials and methods: </strong>hDPSCs were treated with free exosomes or hAM-Exo at 0.5%, 1%, and 5%, with or without LPS. Viability, cytocompatibility, migration, vascular endothelial growth factor-A (VEGF-A) secretion, and dentin sialophosphoprotein (DSPP) expression were evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, live/dead, scratch, and enzyme-linked immunosorbent assay (ELISA) assays. Data were analyzed using two-way analysis of variance and <i>post hoc</i> tests.</p><p><strong>Results: </strong>hAM-Exo was cytocompatible in all groups and showed a more stable metabolic profile than free exosomes at 96 h. hAM-Exo 1% significantly increased VEGF-A secretion under basal conditions at 48 h. Under LPS stimulation, hAM-Exo better preserved VEGF-A secretion than free exosomes, while hAM-Exo at all concentrations significantly enhanced DSPP expression on days 7 and 14.</p><p><strong>Conclusions: </strong>hAM-Exo modulated regenerative-related hDPSC responses under basal and inflammatory conditions compared with free exosomes, supporting scaffold-assisted exosome delivery for cell-free regenerative endodontics.</p>","PeriodicalId":516842,"journal":{"name":"Journal of conservative dentistry and endodontics","volume":"29 9","pages":"993-998"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13600708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149043157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Profilometric analysis of OptraPol^®, OptraGloss^®, and Sof-Lex^® polishing systems on surface roughness of Endure Nano composite: An <i>in vitro</i> study.","authors":"Divya Kunam, Tirunagari Chandana, Swetha Yadatha, Chnv Murali Krishna","doi":"10.4103/JCDE.JCDE_486_26","DOIUrl":"10.4103/JCDE.JCDE_486_26","url":null,"abstract":"<p><strong>Aim: </strong>The aim of this study was to evaluate the efficacy of commercially available polishing systems, 3M Sof-Lex^® Diamond Polishing Spiral, Ivoclar Vivadent OptraPol^®, and Ivoclar Vivadent OptraGloss^®, on the surface roughness (<i>R</i> _a) of Septodont Endure Nano composite using a profilometer.</p><p><strong>Materials and methods: </strong>Thirty-six disc-shaped specimens (8 mm diameter and 4 mm thickness) of Endure Nano composite were fabricated using a custom-made mold and polymerized with an LED light-curing unit. All specimens were sequentially finished under running water with 400-, 600-, and 1000-grit silicon carbide abrasive papers to standardize surface texture and then stored in saline at 37°C for 24 h. The samples were randomly divided into three groups (<i>n</i> = 12): Group I - Sof-Lex^® Diamond Polishing Spiral (3M ESPE, St Paul, MN, USA), Group II - OptraGloss^® (Ivoclar Vivadent AG, Schaan, Liechtenstein) Composite Kit Restoration Polisher and Group III - Optra Pól^® (Ivoclar Vivadent AG, Schaan, Liechtenstein) Composite Restoration Polisher; the polishing procedure for all three polishing systems was performed according to manufacturer instructions. Surface roughness (<i>R</i> _a) was measured at three points per specimen using a profilometer, and mean values were calculated.</p><p><strong>Results: </strong>A statistically significant difference was found among the groups (<i>P</i> < 0.005). OptraGloss^® (<i>R</i> _a = 0.2163 µm) demonstrated the lowest surface roughness, indicating the smoothest finish, followed by OptraPol^® (<i>R</i> _a = 0.4080 µm). In contrast, 3M Sof-Lex^® (<i>R</i> _a = 0.5086 µm) exhibited the highest surface roughness.</p><p><strong>Conclusions: </strong>OptraGloss^® was the most effective polishing system, producing a smoother surface compared to both OptraPol^® and 3M Sof-Lex^®.</p>","PeriodicalId":516842,"journal":{"name":"Journal of conservative dentistry and endodontics","volume":"29 9","pages":"1043-1047"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13600715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149043216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of dimethyl sulfoxide on microtensile bond strength and surface morphology of tribochemically repaired nanohybrid composite: An <i>in vitro</i> study.","authors":"D Sravya Sree, B Sai Krishna, Kommula Apoorva, Nalla Manasa, Puchakayala Samskruthi, Shreya Pabbati","doi":"10.4103/JCDE.JCDE_546_26","DOIUrl":"10.4103/JCDE.JCDE_546_26","url":null,"abstract":"<p><strong>Background: </strong>The emphasis on minimally invasive dentistry has increased the use of resin composites, but these restorations remain prone to secondary caries, fracture, and interface degradation, often requiring repair or replacement. Repairing rather than replacing can preserve tooth structure and shorten treatment. This study assessed how 50% dimethyl sulfoxide (DMSO) affected the surface topography and microtensile bond strength (µTBS) of a nanohybrid composite that had undergone tribochemical repair.</p><p><strong>Materials and methods: </strong>Aged nanohybrid composite blocks were assigned to three groups: Group C (control), Group CS (CoJet sandblasting), and Group CD (CoJet sandblasting +50% DMSO). All specimens received silane and universal adhesive, followed by repair with fresh nanohybrid composite. After thermocycling, µTBS was measured using the microtensile test. The surface morphology of additional specimens was assessed using scanning electron microscopy (SEM). Tukey's <i>post hoc</i> test (α = 0.05) and one-way analysis of variance were used to examine the data.</p><p><strong>Results: </strong>µTBS differed significantly among the three groups (<i>P</i> < 0.05). Mean µTBS values were 69.92 ± 9.45 MPa (Group C), 106.97 ± 9.55 MPa (Group CS), and 123.86 ± 8.64 MPa (Group CD), with Group CD showing the highest bond strength. SEM revealed a relatively smooth surface in the control group, distinct microretentive features after CoJet treatment, and a more irregular, cleaner surface when DMSO was applied after tribochemical conditioning.</p><p><strong>Conclusion: </strong>Within the parameters of this <i>in vitro</i> investigation, the use of 50% DMSO following tribochemical surface treatment considerably enhanced the bond strength and surface properties of the repaired nanohybrid composite, thereby supporting its usage as a simple additional step in composite repair procedures.</p>","PeriodicalId":516842,"journal":{"name":"Journal of conservative dentistry and endodontics","volume":"29 9","pages":"999-1004"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13600711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149043225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracanal medicament removal revisited: A volumetric cone beam computed tomography analysis of four techniques.","authors":"Tejaswini, K C Ponnappa, Salin Nanjappa, T N Girish","doi":"10.4103/JCDE.JCDE_513_26","DOIUrl":"10.4103/JCDE.JCDE_513_26","url":null,"abstract":"<p><strong>Context: </strong>Microorganisms in the root canal are the primary cause of pulpal and periapical disease. Although chemomechanical preparation reduces microbial load, complex canal anatomy hinders complete disinfection, necessitating intracanal medicaments like calcium hydroxide. However, residual medicament can compromise sealer penetration, dentin bonding, and increase apical microleakage, making its complete removal crucial. Techniques such as needle irrigation, sonic activation, passive ultrasonic irrigation, and XP-Endo Finisher have been proposed to improve their removal, while cone beam computed tomography (CBCT) enables accurate 3D assessment of residual materials.</p><p><strong>Aims: </strong>The aim of this study was to evaluate and compare the effectiveness of these four techniques in removing calcium hydroxide from root canals, using CBCT for volumetric analysis.</p><p><strong>Materials and methods: </strong>Sixty-four extracted human single-rooted premolars were collected and stored according to OSHA guidelines. The teeth were decoronated, and canals were prepared using a standardized chemomechanical protocol. Calcium hydroxide paste was placed as an intracanal medicament, and the samples were stored at 37°C and 100% relative humidity for 1 week. A pre-retrieval CBCT scan was obtained to assess the initial medicament volume. Specimens were randomly divided into four groups (<i>n</i> = 16) based on the removal technique: sonic activation, XP-Endo Finisher, passive ultrasonic irrigation and conventional needle irrigation. Following medicament removal using these four techniques, postretrieval CBCT scans were performed, and volumetric analysis was conducted using imaging software to quantify residual calcium hydroxide.</p><p><strong>Statistical analysis used: </strong>Data were analyzed using IBM SPSS; intergroup comparisons used analysis of variance/Kruskal-Wallis and pre-post changes used paired tests, with significance set at <i>P</i> < 0.05.</p><p><strong>Results: </strong>XP-Endo Finisher showed the highest reduction (95.3%), followed by passive ultrasonic irrigation (92.4%) and sonic activation (88.6%), with no significant differences (<i>P</i> > 0.05). Needle irrigation was least effective (74.6%), leaving significantly more residual Ca (OH) ₂ (<i>P</i> < 0.001).</p><p><strong>Conclusions: </strong>All techniques reduced calcium hydroxide, with the XP- Endo-finisher being the most effective, while needle irrigation was the least effective.</p>","PeriodicalId":516842,"journal":{"name":"Journal of conservative dentistry and endodontics","volume":"29 9","pages":"1048-1053"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13600707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149043199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative diagnostic accuracy of a You Only Look Once-11s deep learning model and human observers for detection of periapical lesions on intraoral periapical radiographs.","authors":"Rajinder Kumar Bansal, Ashtha Arya, Birmohan Singh, Mamta Singla, Jatinder Pal Singh, Marut Kumar","doi":"10.4103/JCDE.JCDE_522_26","DOIUrl":"10.4103/JCDE.JCDE_522_26","url":null,"abstract":"<p><strong>Context: </strong>Interpretation of intraoral periapical radiographs (IOPAs) is influenced by image quality and observer-related factors. This study evaluated a lightweight You Only Look Once (YOLO)-11s model for automated detection of periapical lesions and compared its output with that of a human observer.</p><p><strong>Aim: </strong>The study aimed to assess and compare the accuracy and diagnostic performance of YOLO-11s and human observers for detecting periapical lesions on IOPAs.</p><p><strong>Materials and methods: </strong>Radiographic records from 500 patients were reviewed retrospectively, yielding 1330 annotated tooth-level images. The dataset was divided into training (80%), validation (10%), and test (10%) subsets. Images were normalized, contrast-enhanced, and resized to 640 × 640 pixels. YOLO-11s was trained for up to 200 epochs. Performance was assessed using precision, sensitivity (recall), F1-score, mean average precision (mAP), confusion matrix analysis, precision-recall curves, and inference time. Cohen's kappa was used to assess interobserver agreement.</p><p><strong>Results: </strong>The YOLO-11s model demonstrated high diagnostic performance for periapical lesion detection, with a sensitivity of 89.4%, precision of 88.0%, and an F1-score of 88.4%. Out of 133 true tooth-level targets, 121 were detected, and 106 were correctly predicted as the periapical lesion (PLA) or healthy (PRA), giving an overall accuracy of 79.7%. The mAP50 and mAP50-95 values were 0.85 and 0.48, respectively, indicating good detection ability but moderate localization precision. However, no background region was correctly identified.</p><p><strong>Conclusion: </strong>The YOLO-11s model demonstrated high sensitivity for automated detection of periapical lesions on IOPAs and may serve as a valuable adjunctive diagnostic tool in endodontic practice.</p>","PeriodicalId":516842,"journal":{"name":"Journal of conservative dentistry and endodontics","volume":"29 9","pages":"1025-1032"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13600713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149042645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Before the split: Early intervention as the key to surviving the cracked tooth epidemic.","authors":"Shishir Singh","doi":"10.4103/JCDE.JCDE_902_26","DOIUrl":"10.4103/JCDE.JCDE_902_26","url":null,"abstract":"","PeriodicalId":516842,"journal":{"name":"Journal of conservative dentistry and endodontics","volume":"29 9","pages":"939-940"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13600705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149042678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of photosensitizers nitrogen-doped graphene quantum dots and indocyanine green against <i>Enterococcus faecalis</i> - An <i>in vitro</i> microbiological study.","authors":"N Kiran Kumar, Andria Dsouza, R S Mohan Kumar, Savitha B Naik, S Ansha Jasmin, K S Vaishnavi","doi":"10.4103/JCDE.JCDE_492_26","DOIUrl":"10.4103/JCDE.JCDE_492_26","url":null,"abstract":"<p><strong>Background: </strong>The persistent endodontic infections are commonly allied with <i>Enterococcus faecalis</i>, a microorganism capable of forming resistant biofilms that compromise root canal disinfection. Nitrogen-doped graphene quantum dots (N-GQDs) have recently arose as promising photosensitizers for antimicrobial photodynamic therapy (aPDT). The present study equated the antibacterial efficacy of N-GQD-mediated aPDT, indocyanine green (ICG)-mediated aPDT, and diode laser-activated sodium hypochlorite (NaOCl) in contrast to mature <i>E. faecalis</i> biofilms.</p><p><strong>Materials and methods: </strong>Thirty extracted human lower arch premolars were prepared and inoculated with <i>E. faecalis</i> for 14 days. Specimens were arbitrarily allocated to three groups (<i>n</i> = 10): Group I, N-GQDs (100 µg/mL) activated with a 670 nm diode laser; Group II, 0.05% ICG activated with an 810 nm diode laser; and Group III, 3% NaOCl activated with an 810 nm diode laser. Bacterial samples were collected before the treatment and after the treatment, cultured, and quantified by the colony-forming unit (CFU) analysis. Statistical assessments were executed using one-way ANOVA and Bonferroni <i>post hoc</i> tests.</p><p><strong>Results: </strong>All the treatment modalities reduced the bacterial counts; however, N-GQD-mediated aPDT demonstrated the greatest antibacterial effect. It showed a 99.27% reduction in CFUs, which was significantly higher than ICG-mediated aPDT (82.05%) and laser-activated NaOCl (62.03%) (<i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>N-GQD-mediated aPDT showed superior antibacterial activity against mature <i>E. faecalis</i> biofilms and can serve as an effective adjunctive approach for enhanced root canal disinfection.</p>","PeriodicalId":516842,"journal":{"name":"Journal of conservative dentistry and endodontics","volume":"29 9","pages":"1054-1060"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13600712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149042757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of biotene and xerostom on salivary function, biomarkers, and caries risk in radiation-induced xerostomia: A randomized controlled trial.","authors":"Anam Alam, Sonali Taneja, Anshuman Kumar, Akriti Dheer","doi":"10.4103/JCDE.JCDE_29_26","DOIUrl":"10.4103/JCDE.JCDE_29_26","url":null,"abstract":"<p><strong>Background: </strong>Radiation-induced xerostomia is a common complication in head and neck cancer (HNC) patients, significantly impairing oral health, nutrition, and quality of life. Salivary substitutes such as Biotene and Xerostom have been developed to manage symptoms, but clinical evidence comparing their effectiveness is limited.</p><p><strong>Aim: </strong>The aim is to evaluate and compare the efficacy of Biotene and Xerostom salivary systems in improving salivary properties and reducing caries susceptibility in postradiotherapy (RT) HNC patients.</p><p><strong>Methods: </strong>Sixty-six patients with radiation-induced xerostomia were randomly assigned to three groups: Biotene (<i>n</i> = 22), Xerostom (<i>n</i> = 22), and placebo (<i>n</i> = 22). Interventions were used for 28 days. Salivary flow rate, pH, buffering capacity, mucin-7 (MUC7), β-defensin-2, <i>Streptococcus mutans</i> count, and oral mucositis (OM) were assessed at baseline, 1, 3, and 6 months. Data were analyzed using repeated measures analysis of variance and Chi-square tests.</p><p><strong>Results: </strong>Both Biotene and Xerostom significantly improved salivary flow (Biotene: 1.26 ± 0.22 mL/min; Xerostom: 1.00 ± 0.25 mL/min) compared to placebo (0.76 ± 0.27 mL/min) at 6 months. pH and buffering capacity also improved in both intervention groups. MUC7 levels were higher in Biotene (77.71 ± 9.38 ng/mL) and Xerostom (74.92 ± 6.76 ng/mL) compared to placebo (61.48 ± 4.96 ng/mL), indicating enhanced mucosal protection. β-defensin-2 levels were lower in treatment groups, suggesting balanced immune activity. <i>S. mutans</i> counts were significantly reduced in Biotene (9.20 ± 8.50 CFU/mL) and Xerostom (12.5 ± 12.82 CFU/mL) versus placebo (118.75 ± 60.61 CFU/mL), reflecting reduced caries risk. OM severity was also lower in treated groups.</p><p><strong>Conclusion: </strong>Both Biotene and Xerostom improved salivary function, reduced microbial load, and enhanced oral mucosal protection in HNC patients with radiation-induced xerostomia. Biotene demonstrated marginally superior outcomes. These systems may serve as effective interventions for xerostomia management post-RT.</p>","PeriodicalId":516842,"journal":{"name":"Journal of conservative dentistry and endodontics","volume":"29 9","pages":"979-984"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13600718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149042834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physicochemical characterization of a drug-loaded nanosponge for endodontic regeneration.","authors":"Anu Elsa Swaroop, Sylvia Mathew, Shruthi Nagaraja, Mounica Veggalam, Poornima Ramesh, Deveswaran Rajamanickam","doi":"10.4103/JCDE.JCDE_562_26","DOIUrl":"10.4103/JCDE.JCDE_562_26","url":null,"abstract":"<p><strong>Background: </strong>Regenerative endodontics requires drug delivery systems that are both antimicrobial and bioactive to achieve favorable clinical outcomes.</p><p><strong>Aim: </strong>The aim of the study was to develop and characterize a β-cyclodextrin-based nanosponge incorporated with lyophilized platelet concentrate (Ly-PRF) and a modified triple antibiotic paste (m-TAP) to support endodontic regeneration.</p><p><strong>Materials and methods: </strong>β-cyclodextrin-based nanosponge was fabricated and combined with Ly-PRF, ciprofloxacin, metronidazole, and clindamycin (m-TAP) to obtain the drug-loaded nanosponge (DLNS). It was characterized for surface morphology (SEM), crystallinity (XRD), particle size and polydispersity (PDI), functional group interactions (FTIR), drug release (UV), pH analysis, calcium ion release profile, solubility and zeta potential.</p><p><strong>Results: </strong>The DLNS exhibited a porous, sponge-like morphology, whereas the XRD analysis confirmed their amorphous state. Drug release profile revealed a moderate, short-term release of antibiotics followed by sustained release over 14 days. Calcium ions released peaked on day 7 and then declined. The formulation demonstrated a zeta potential value of -24.32 mV, indicating moderate stability and a limited aqueous solubility of 4.9%, suitable for sustained drug release.</p><p><strong>Conclusion: </strong>The DLNS formulation demonstrated several favorable physicochemical characteristics essential for intra-canal delivery of drugs and growth factors to support regeneration.</p>","PeriodicalId":516842,"journal":{"name":"Journal of conservative dentistry and endodontics","volume":"29 9","pages":"985-992"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13600720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149043182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Getting your publication right - Part 3 structuring a research manuscript: A guide to writing clinical trials.","authors":"Aditya Mitra, R S Mohan Kumar, Shishir Singh, Velmurugan Natanasabapathy, Sonali Sharma, Geeta Asthana, Sonali Taneja, Suparna Ganguly Saha","doi":"10.4103/JCDE.JCDE_794_26","DOIUrl":"10.4103/JCDE.JCDE_794_26","url":null,"abstract":"<p><p>Clinical trials form the cornerstone of evidence-based healthcare and play a crucial role in translating research into clinical practice. However, successful publication of clinical trials requires not only scientific rigor but also strategic planning, ethical transparency, accurate reporting, and effective scientific writing. This narrative review explores the \"art\" of publishing clinical trials, highlighting essential components from protocol development to manuscript submission and peer-review navigation. Key aspects discussed include formulation of a focused research question, trial registration, adherence to Consolidated Standards of Reporting Trials guidelines, ethical considerations, statistical reporting, authorship integrity, and journal selection. Common reasons for manuscript rejection and practical approaches to improve acceptance rates are also reviewed. The review further emphasizes the importance of clarity, reproducibility, data presentation, and avoidance of publication bias. By integrating methodological standards with effective communication skills, researchers can enhance the quality, visibility, and impact of their clinical trial publications. This review aims to guide clinicians, academicians, and early-career researchers in preparing scientifically robust and publishable clinical trial manuscripts.</p>","PeriodicalId":516842,"journal":{"name":"Journal of conservative dentistry and endodontics","volume":"29 9","pages":"955-967"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13600717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149043159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}