Journal of Global Infectious Diseases最新文献

{"title":"The State of the Globe: Deep-vein Thrombosis in Dengue Fever - A Rare or Protective Association?","authors":"Suman Thakur, Vivek Chauhan","doi":"10.4103/jgid.jgid_231_25","DOIUrl":"10.4103/jgid.jgid_231_25","url":null,"abstract":"","PeriodicalId":51581,"journal":{"name":"Journal of Global Infectious Diseases","volume":"17 3","pages":"115-116"},"PeriodicalIF":1.3,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12494313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Whole-body ¹⁸F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Difficult to Treat Multifocal Pyomyositis.","authors":"Harleen Sood, Anureet, Deba Prasad Dhibar, Harpreet Singh, Vikas Suri, Rajender Kumar, Harmandeep Singh, Ashish Bhalla","doi":"10.4103/jgid.jgid_199_24","DOIUrl":"10.4103/jgid.jgid_199_24","url":null,"abstract":"<p><p>¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) has been used previously for the diagnosis of sepsis of unknown focus and pyrexia of unknown origin. Its use in the diagnosis of pyomyositis has not been fully explored. Pyomyositis was found to be an important cause of sepsis, but its cause has not been fully elucidated in previous studies exploring the role of PET. We studied the role of whole-body ¹⁸F-FDG PET/CT in the diagnosis and management of 10 patients with suspected multifocal pyomyositis. In our study, we were able to find a distant focus in 7 out of 10 patients, which led to changes in treatment and outcome.</p>","PeriodicalId":51581,"journal":{"name":"Journal of Global Infectious Diseases","volume":"17 3","pages":"156-160"},"PeriodicalIF":1.1,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12494315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous Venous Thrombosis in Patients with Dengue Fever: A Systematic Analysis of Published Case Reports.","authors":"Tanmoy Ghatak, Nidhi Singh, Rupali Awale Bhalchandra, Bhavna Gupta, Kurvatteppa Halemani, Prabhakar Mishra","doi":"10.4103/jgid.jgid_217_24","DOIUrl":"10.4103/jgid.jgid_217_24","url":null,"abstract":"<p><strong>Introduction: </strong>Spontaneous venous thrombosis (SVT) in patients with dengue fever (DF) is a rare and complex phenomenon. The coexistence of thrombosis and hemorrhagic tendencies due to thrombocytopenia and dengue hemorrhagic fever complicates management decisions. This systematic review aims to analyze the etiology, clinical presentation, management strategies, and outcomes reported in the English literature for such cases.</p><p><strong>Methods: </strong>A comprehensive search of PubMed, CINAHL, Cochrane Library, Clinical Key, and Google Scholar databases was conducted up to October 31, 2024. Studies reporting SVT in DF were included, and data on demographics, diagnostic methods, treatment modalities, complications, and outcomes were extracted. This review adheres to Cochrane collaboration guidelines and follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 statement.</p><p><strong>Results: </strong>Fifteen studies comprising 19 patients met the inclusion criteria. The mean age was 43.26 years, with a median onset of SVT occurring 6 days after fever onset. Majority (57.8%, 11/19) presented with thrombocytopenia (<52,000/mm³), and 57.8% (11/19) received subcutaneous low-molecular-weight heparin. Despite complexities, all patients survived without major bleeding complications.</p><p><strong>Conclusion: </strong>SVT in DF highlights the potential coexistence of thrombotic and hemorrhagic states. A standardized approach with anticoagulation appears effective in managing these challenging cases.</p>","PeriodicalId":51581,"journal":{"name":"Journal of Global Infectious Diseases","volume":"17 3","pages":"117-123"},"PeriodicalIF":1.1,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12494318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mycotic Thoracic Aortic Aneurysm Due to <i>Salmonella</i> Kentucky Infection.","authors":"Ayman H K Alserr, Hashim Ahmed Ba Wazir, Mansoor C Abdullah, Mohammad Salem Amer, Yousef I Salama, Feras Zaqout, Salem Ali Al Maashani","doi":"10.4103/jgid.jgid_11_24","DOIUrl":"10.4103/jgid.jgid_11_24","url":null,"abstract":"<p><p>Mycotic aortic aneurysms (MAAs) are infective aneurysms that are associated with catastrophic outcomes if not diagnosed and treated on time. Less than 3% of all aortic aneurysms are mycotic and are mostly seen in the abdominal aorta. <i>Staphylococcus</i> <i>aureus</i>, <i>Salmonella</i>, and <i>Pseudomonas aeruginosa</i> are the most common causative organisms for MAAs. <i>Salmonella</i> species commonly cause infection in humans and occasionally result in serious complications, like mycotic aneurysms. <i>Salmonella</i>, Typhimurium (serogroup B), Enteritidis (serogroup D), and Choleraesuis (serogroup C) are the most common strains found to be associated with MAA. We present the first case of mycotic aneurysm likely secondary to <i>Salmonella</i> Kentucky infection.</p>","PeriodicalId":51581,"journal":{"name":"Journal of Global Infectious Diseases","volume":"17 3","pages":"161-163"},"PeriodicalIF":1.1,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12494317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Encapsulation of a Novel <i>Enterococcus faecalis</i> Bacteriophage into Chitosan-alginate Microspheres as a Delivery System to Prevent Oral Diseases.","authors":"Sonia Bhonchal Bhardwaj, Sanjay Chhibber, Shaveta Sood, Manjula Mehta, Jyoti Sharma","doi":"10.4103/jgid.jgid_171_24","DOIUrl":"10.4103/jgid.jgid_171_24","url":null,"abstract":"<p><strong>Introduction: </strong><i>Enterococcus faecalis</i> is a Gram-positive facultative anaerobe bacteria now known to be implicated in periodontitis, tooth root infections, adimplantitis which are oral biofilm-mediated diseases. The ability of <i>E. faecalis</i> to form a biofilm even as a mono-infection makes it more resistant to antibiotics. Bacteriophages are known to cure antibiotic-resistant bacterial infections. However, the main concern in phage formulations is the bacteriophage stability and loss of \"antibacterial\" activity.</p><p><strong>Methods: </strong>In this study, a novel <i>E. faecalis</i> phage was isolated against <i>E. faecalis</i> 29212 from the sewage sample. The phage was propagated and identified using transmission electron microscope. Encapsulated phages were prepared using a biodegradable food grade chitosan-alginate coating shell suspended in honey-gelatin. The morphology of the chitosan-alginate microsphere was examined using scanning electron microscope (SEM) and pore size was determined by field emission gun-SEM. The encapsulated phages were checked for their lytic activity against host bacteria. The encapsulated bacteriophage was assayed for acid stability and thermal stability in simulated saliva.</p><p><strong>Results: </strong>The phage isolated was lytic belonging to Siphoviridae family. The mean diameter of the chitosan-alginate microspheres was 1.7 ± 0.13 mm. The pore size of the phage-loaded chitosan-alginate shell was less than 100 nm, resulting in sustained release of the phages. The chitosan-alginate encapsulated phage was stable for a long time (6 h) in simulated saliva. The encapsulated phage could withstand exposure to different pH (pH 2, pH 4, and pH 7) in simulated saliva. It was also stable at different temperatures (4°C, 37°C, and 60°C).</p><p><strong>Conclusion: </strong>The encapsulated phage has the potential to be used as phage therapy in oral diseases. Further, the chitosan-alginate encapsulated phage microsphere can be incorporated in a patch/membrane/gel in combination with antibiotics/nutritional components/anti-inflammatory agents as treatment for oral diseases induced by <i>E. faecalis</i>.</p>","PeriodicalId":51581,"journal":{"name":"Journal of Global Infectious Diseases","volume":"17 2","pages":"93-97"},"PeriodicalIF":1.1,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12294147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percent Pulmonary Damage on Hospital Admission is Predictive of COVID-19 Aggravation, but Serum Protein Electrophoresis is Not.","authors":"Stéphane Di Mascio, Fadi Khadra, Christine Tchikladzé-Mérand, Sandrine Labroy, Mélanie Decambron","doi":"10.4103/jgid.jgid_93_24","DOIUrl":"10.4103/jgid.jgid_93_24","url":null,"abstract":"<p><strong>Introduction: </strong>Electrophoresis of serum proteins (ESP) reveals the proteins present during the acute phase of a disease and enables the detection and monitoring of inflammatory syndrome. The aim of this study was to explore whether ESP could help to identify patients at risk of COVID-19 aggravation.</p><p><strong>Methods: </strong>This was a two-center, observational, prospective study carried out between March 2021 and February 2022. Patients hospitalized in a COVID-19 unit, with an oxygen requirement of <6 L/min, were included. ESP was carried out every 4 days until clinical aggravation or discharge. Aggravation was defined by the requirement for >6 L/min oxygen, intensive care unit admission, or death. Risk factors for aggravation evaluated included age, comorbidities, serum proteins (albumin, globulins), % pulmonary damage (%PD) on computed tomography scans, D-dimers, C-reactive protein (CRP), ferritin, lymphocytes, and PO₂. Student's <i>t</i>-test or Wilcoxon-Mann-Whitney test (quantitative variables) and Chi-square or Fisher's test (qualitative variables) were used for univariate analysis. Risk factors for COVID-19 aggravation were analyzed by logistic regression. The threshold of significance was 5%.</p><p><strong>Results: </strong>A total of 161 patients were analyzed (mean [±standard deviation (SD)] age: 67.3 ± 16.6 years; 50.9% female). COVID-19 aggravated in 37 patients, within a mean (±SD) of 4.1 ± 2.6 days. In univariate analysis, α-1 globulins (<i>P</i> = 0.04), %PD (<i>P</i> = 0.02), and CRP (<i>P</i> = 0.02) at inclusion were significantly higher in patients whose disease aggravated. In multivariate analysis, %PD at inclusion was the only factor significantly linked to aggravation (OR = 2.3 [95% CI: 1.3‒4.7]; <i>P</i> = 0.01).</p><p><strong>Conclusions: </strong>ESP was not predictive of clinical aggravation in hospitalized COVID-19 patients.</p>","PeriodicalId":51581,"journal":{"name":"Journal of Global Infectious Diseases","volume":"17 2","pages":"87-92"},"PeriodicalIF":1.1,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12294150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact, Trends, and Visibility of Scientific Publications on Neurological Effects of COVID-19 Vaccine: A Scientometric Analysis.","authors":"Ana Paula Sangama Ramírez, Raúl Sebastián Tello Cavero, Frank Mayta-Tovalino","doi":"10.4103/jgid.jgid_159_24","DOIUrl":"10.4103/jgid.jgid_159_24","url":null,"abstract":"<p><strong>Introduction: </strong>Neurological complications associated with the COVID-19 vaccine can include different neurological diseases. Although these cases are rare, it is crucial for healthcare professionals to recognize them for timely diagnosis and treatment. The aim of this study was to analyze the impact, trend, and visibility of scientific publications on the neurological effects of the COVID-19 vaccine during 2020-2023 in Scopus.</p><p><strong>Methods: </strong>A bibliometric, descriptive, and retrospective study was conducted. Through Scopus (SciVal), variables were measured objectively. Data were sought from December 2018 to August 2023. All papers on neurological effects associated with the COVID-19 vaccine were published between January 2020 and August 2023 in the Scopus database. On August 18, 2023, 65 articles were identified, of which 59 met the inclusion criteria. They were downloaded and exported in.csv format and subsequently analyzed in Microsoft Excel® 2019 using tables.</p><p><strong>Results: </strong>The United States was the country with the highest number of authors (six) publishing on the subject in Scopus, followed by India with two authors. In addition, it was observed that the United States was the country with the highest production, with 30 publications and 411 countable citations. However, India, being the second in scientific production, was the country with the highest impact. Of the most productive institutions, six were from the United States, with Harvard University being the institution with the highest scientific production. With respect to the journals, six obtained two publications on the subject under study, where \"<i>Journal of Neurology</i>\" and \"<i>Journal of Clinical Medicine</i>\" stand out with 100 and 80 publications, respectively.</p><p><strong>Conclusions: </strong>The bibliometric analysis reveals that the USA leads in publications on adverse neurological effects of COVID-19 vaccine. India stands out for its impact, especially through institutions such as Ahmedabad Civil Hospital and B. J. Medical College. It is suggested to expand the research to other databases.</p>","PeriodicalId":51581,"journal":{"name":"Journal of Global Infectious Diseases","volume":"17 2","pages":"98-103"},"PeriodicalIF":1.1,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12294153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The State of the Globe - Overview of Liver Involvement in Scrub Typhus.","authors":"Tarun Sharma","doi":"10.4103/jgid.jgid_158_25","DOIUrl":"10.4103/jgid.jgid_158_25","url":null,"abstract":"","PeriodicalId":51581,"journal":{"name":"Journal of Global Infectious Diseases","volume":"17 2","pages":"69-70"},"PeriodicalIF":1.3,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12294142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Presentations and Species Spectrum of Nontuberculous Mycobacteria in Suspected Pulmonary Tuberculosis Cases.","authors":"Sivasankar Das, Prasanta Raghab Mohapatra, Sutapa Rath, Sourin Bhuniya, Baijayantimala Mishra","doi":"10.4103/jgid.jgid_152_24","DOIUrl":"10.4103/jgid.jgid_152_24","url":null,"abstract":"<p><strong>Introduction: </strong>The prevalence of nontuberculous mycobacteria (NTM) is on the rise worldwide. The diagnosis of NTM lung disease (NTM-LD) is a dilemma. The 2020 guidelines jointly established by the American Thoracic Society (ATS) and Infectious Diseases Society of America (IDSA) outline the criteria for diagnosing pulmonary NTM disease. Herein, we report a series of cases with an analysis of relevant literature to gain insight into the pathogenicity of NTM species, the risk factors involved, and treatment strategies.</p><p><strong>Methods: </strong>This is a prospective observational study starting from April 2023 to December 2023. A total of 370 suspected pulmonary tuberculosis (TB) patients were included. Clinical specimens were processed for Ziehl-Neelsen staining, GeneXpert <i>Mycobacterium tuberculosis</i> (MTB)/RIF assay, and culture. Culture-positive mycobacteria were classified as MTB complex or NTM based on detection of MPT64 antigen. The NTM isolates were speciated by line probe assay using GenoType^® Mycobacterium common mycobacteria (Hain Lifescience, Nehren, Germany). The criteria of ATS/IDSA were applied to confirm NTM-LD.</p><p><strong>Results: </strong>Nine (<i>n</i> = 9) patients were diagnosed as cases of NTM-LD. Bronchiectasis and previous TB were the most common comorbidities. <i>Mycobacterium scrofulaceum</i> (<i>n</i> = 2), <i>Mycobacterium szulgai</i> (<i>n</i> = 2), <i>Mycobacterium intracellulare</i> (<i>n</i> = 1), <i>Mycobacterium kansasii</i> (<i>n</i> = 1), <i>Mycobacterium abscessus</i> (<i>n</i> = 1), <i>Mycobacterium fortuitum</i> (<i>n</i> = 1), and <i>Mycobacterium interjectum</i> (<i>n</i> = 1) were the species involved. Specific therapeutic drug regimens were administered in four cases, which resulted in clinical improvement.</p><p><strong>Conclusion: </strong>People with comorbid (LDs) are at risk of NTM-LD. The severity of NTM-LD and mortality also depend on the species involved. New guidelines with evidence-based recommendations should be formulated to simplify the diagnosis and treatment of NTM-LD caused by an array of more than 190 species.</p>","PeriodicalId":51581,"journal":{"name":"Journal of Global Infectious Diseases","volume":"17 2","pages":"77-86"},"PeriodicalIF":1.1,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12294139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Eikenella corrodens</i>: An Extremely Rare Cause of Brain Abscess.","authors":"Siew Ping Lau, Chee Yik Chang","doi":"10.4103/jgid.jgid_81_25","DOIUrl":"10.4103/jgid.jgid_81_25","url":null,"abstract":"","PeriodicalId":51581,"journal":{"name":"Journal of Global Infectious Diseases","volume":"17 2","pages":"112-113"},"PeriodicalIF":1.1,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12294148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}