The Natural Products Journal最新文献

{"title":"The Effect of Circulating Exosomes Obtained from Young and Old Individuals on the Aging Related hTERT and P16 Expression in Hematopoietic Stem Cells","authors":"Vida Farrokhi, Reza Afrisham, Masoud Soleimani, Mohammad Ahmadvand, Seyed Hadi Mousavi, Zahra Kashanikhatib, Somayeh Owchi, Fatemeh Mohammadali, Shaban Alizadeh","doi":"10.2174/0122103155285692240301052306","DOIUrl":"https://doi.org/10.2174/0122103155285692240301052306","url":null,"abstract":"\u0000\u0000Functional reduction of telomeres can induce DNA damage response\u0000through cell cycle checkpoints and contribute to the senescence of stem cells. The effect of exosomes\u0000on the aging and rejuvenation of hematopoietic stem cells (HSCs) is not well known. Therefore, the\u0000present study is designed to examine the impact of plasma exosomes derived from young and old\u0000individuals on hTERT and P16 expression involved in the cellular aging process.\u0000\u0000\u0000\u0000Functional reduction of telomeres can induce DNA damage response through cell cycle checkpoints and contribute to the senescence of stem cells. The effect of exosomes on the aging and rejuvenating in hematopoietic stem cells (HSCs) is not well known. Therefore, the present study designed to examine the impact of plasma exosomes derived from young and old individuals on hTERT and P16 expression involved in cellular aging process.\u0000\u0000\u0000\u0000Exosomes isolated from four young (Y-Exo) and four old (O-Exo) men were evaluated for\u0000CD63 protein expression, morphology, size and zeta potential. HSCs were treated with exosomes,\u0000and then, the cell viability and the mRNA expression (hTERT and P16) were evaluated using MTT\u0000and qRT-PCR methods, respectively. To measure the hTERT protein level, a western blot technique\u0000was performed.\u0000\u0000\u0000\u0000The gene expression of hTERT was significantly decreased in HSCs treated with 5 μg/ml\u0000(O5-Exo) and 10 μg/ml (O10-Exo) doses of exosomes obtained from elderly individuals compared to\u0000the cells treated with young exosomes and the untreated HSCs (p < 0.05). In addition, there was a\u0000profound elevation of hTERT protein in the HSCs treated with both doses of young exosomes in\u0000comparison with the cells treated with both doses of old exosomes (p < 0.05). Moreover, P16 expression\u0000was markedly upregulated in the O5-Exo and O10-Exo groups compared to the untreated group\u0000(p < 0.05).\u0000\u0000\u0000\u0000Our findings reinforce the concept that depending on the age of individuals, circulating\u0000exosomes may acquire properties that affect the pathways involved in the aging process in HSCs.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"15 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140241471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Botany, Phytochemistry, Pharmacology, Toxicology, and Quality\u0000Control of Epimedium: A Review","authors":"Tao Wang, Xiangfeng Kong, Xiaomeng Tang, Mingxia Xie, Xia Zhang, Jianjun Zhao, Xiaojuan Gao, Hanqing Wang","doi":"10.2174/0122103155284336240227092937","DOIUrl":"https://doi.org/10.2174/0122103155284336240227092937","url":null,"abstract":"\u0000\u0000Epimedium has long been used as an ethnic drug in Asia and Europe for its high medicinal\u0000value and health benefits, which is often used for anti-tumor, anti-osteoporosis, sexual dysfunction,\u0000and other related diseases. In this research, Epimedium isreviewed in the botany, phytochemistry,\u0000pharmacology, toxicology, processing, and quality control to make it better for clinical services.\u0000More than 106 compounds, including flavonoids, polysaccharides, alkaloids, lignans, and others,\u0000were isolated from Epimedium. Based on multiple chemically active components, Epimedium has a\u0000wide range of pharmacological action. Several studies have demonstrated Epimedium has multiple\u0000biological activities, including neuroprotective effects, anti-inflammatory, anti-aging, and antioxidant\u0000effects, anti-osteoporosis, anti-cancer, anti-tumor, anti-diabetes, anti-influenza, effects on sexual\u0000dysfunction, etc. Recently, the toxicity of Epimedium has been brought into focus, and its hepatotoxicity\u0000has been confirmed through animal experiments. Moreover, it is particularly important to control\u0000its quality. To date, great progress has been made in the study of Epimedium. This study systematically\u0000reviews the achievements of research on Epimedium. Moreover, the shortcomings of the\u0000current research on Epimedium were pointed out, and some suggestions were given.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"137 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140251508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Neuroprotective Properties of Thymol and Carvacrol: A Review\u0000Study","authors":"M. Asle-Rousta","doi":"10.2174/0122103155288752240219095244","DOIUrl":"https://doi.org/10.2174/0122103155288752240219095244","url":null,"abstract":"\u0000\u0000Over the past few decades, researchers have become interested in natural compounds and\u0000their potential to prevent and treat diseases. Thymol, carvacrol, and phenolic monoterpenoids are\u0000compounds quickly absorbed into the bloodstream through the gastrointestinal tract. Studies conducted\u0000in vitro and in vivo have shown that both thymol and carvacrol have anti-inflammatory, antioxidant,\u0000and antiapoptotic properties. Research indicates these compounds can easily cross the\u0000blood-brain barrier and offer neuroprotective effects. They are both very safe and have no toxicity in\u0000therapeutic doses. This review focuses on the neuroprotective effects of thymol and carvacrol and\u0000analyzes their impact on the central nervous system, including their antioxidant and antiinflammatory\u0000effects. The report also highlights their potential influence on neurodegenerative diseases\u0000like Parkinson's and Alzheimer's, emotional disorders, and brain and spinal cord ischemia.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"8 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140411445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Taraxerol: A Promising Natural Product in the Management of\u0000Inflammation","authors":"Uma Jyoti, Neeraj Mittal, Thakur Gurjeet Singh, Randhir Singh, Sushma Devi","doi":"10.2174/0122103155277711231204060922","DOIUrl":"https://doi.org/10.2174/0122103155277711231204060922","url":null,"abstract":"\u0000\u0000Inflammation is a complex biological process that plays an important role in many clinical\u0000disorders. The natural plant and its secondary metabolites play an important role in the prevention\u0000and treatment of inflammation. Taraxerol is a pentacyclic triterpenoid found in medicinal plants,\u0000fruits, and vegetables, and is a potent anti-inflammatory agent. This review explains the molecular\u0000mechanism of the anti-inflammatory effects of taraxerol and its interactions with many molecular\u0000targets, including NF-κB, MAPKs, and COX. Furthermore, the effects of taraxerol on oxidative\u0000stress, cell function, and inflammatory cell signaling have been comprehensively described. This\u0000review addresses the limitations and obstacles in taraxerol research, as well as provides insights for\u0000future investigations. The findings highlight the need for additional research to completely understand\u0000the therapeutic potential and clinical applications of taraxerol in the treatment of inflammatory\u0000diseases.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"14 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140408940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marine Seaweed Polysaccharides: An Insight into Biological Activities and Biomedical Applications","authors":"Jegadeshwari B, Saraswathy Sd","doi":"10.2174/0122103155273481240215073356","DOIUrl":"https://doi.org/10.2174/0122103155273481240215073356","url":null,"abstract":"\u0000\u0000Natural products from various sources play a major role in the healthcare sector, mainly in\u0000the pharmaceutical, cosmetic, agro and medical divisions. Polysaccharides are one of the important\u0000biomacromolecules present in higher plants, animals, fungi and algae, and aid in the growth and\u0000development of an organism. They play a vital role in regulating and maintaining cellular homeostasis\u0000in all forms of life. They are considered bioactive polymers and possess promising beneficial\u0000effects on human health without any harmful side effects. Among different biopolymers, polysaccharides\u0000have gained greater attention in the area of natural products and biomedical research due to\u0000their unique physio-chemical properties, bioactivities and health-promoting effects. The molecular\u0000structure of the polysaccharides is highly complex, depending on their origin and the structural diversity.\u0000Carbohydrate polymers differ largely based on their molecular weight, composition, functional\u0000derivatives, pattern of glycosidic linkages and degree of polymerization. In recent years, seaweed\u0000polysaccharides have been identified in large numbers and are effectively used by the food and\u0000biotechnology industries for the production of nutraceutical and pharmaceutical products. Several\u0000researches have demonstrated the biological activities of seaweed polysaccharides such as antioxidant,\u0000antiviral, hypoglycemic, antidiabetic, antitumor and immunomodulatory. Moreover, there has\u0000been a substantial increase in the utilization of natural polymeric biomaterials in the biomedical field.\u0000This review summarizes the diverse biological effects of polysaccharides derived from different\u0000types of seaweeds as well as their biomedical applications. The information reviewed here provides\u0000an insight into the biopotential efficiency of algal-based polysaccharides, further help in the development\u0000of novel pharmaceutical and biomedical products.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"13 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140440908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monteverdia ilicifolia as a Herbal Medicine for Treating Gastric Disorders: An Insight into its Quality Control","authors":"Luciana de Almeida Gomes, José Luiz Pinto Ferreira, Jefferson Rocha de Andrade Silva, Ana Claudia Fernandes Amaral, Aline de Souza Ramos","doi":"10.2174/0122103155283762240213072144","DOIUrl":"https://doi.org/10.2174/0122103155283762240213072144","url":null,"abstract":"\u0000\u0000Monteverdia ilicifolia, popularly known as “espinheira santa”, is a plant\u0000native to southern Brazil and is widely used in popular therapeutics to treat gastric disturbances. M.\u0000ilicifolia is commonly adulterated, intentionally or not, with the plant species Zollernia ilicifolia and\u0000Sorocea bonplandii due to the morphological similarity of their leaves.\u0000\u0000\u0000\u0000The aim of this review was to search for changes in the quality control method of M. ilicifolia\u0000products to support the correct identification of the botanical species. In addition, the search\u0000covered clinical studies, patents, and registered products of herbal medicines based on M. ilicifolia.\u0000\u0000\u0000\u0000This study is an integrative literature review that was developed using databases, indexed\u0000articles, and books. The bibliographic searches were performed using Scopus®, SciFinder®, Scielo®,\u0000and Science Direct®. Patent documents and herbal medicines containing M. ilicifolia were searched\u0000in the INPI and WIPO databases.\u0000\u0000\u0000\u0000The pharmacological activities of M. ilicifolia, the main chemical constituents, and leaf\u0000morpho-anatomical characteristics of Monteverdia spp., Z. ilicifolia, and S. bonplandii were summarized.\u0000The results also demonstrated herbal medicines based on M. ilicifolia marketed in Brazil, patents\u0000in Brazil, and patents in the world market.\u0000\u0000\u0000\u0000Quality control for the species M. ilicifolia presents opportunities for improvement. The\u0000officially recommended method presents weaknesses concerning species identification. Other chemical\u0000markers should be included in the chromatographic analyses. There are seven medicines with\u0000valid registrations in Brazil. Furthermore, patents filed in Brazil and at WIPO demonstrate that M.\u0000ilicifolia has therapeutic potential in the world market.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"32 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140441730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Jaboticaba Peel Extract Exerts Chemopreventive Effects in Transgenic\u0000Mouse Model of Prostate Cancer","authors":"Ellen Nogueira-Lima, Celina Almeida Lamas, A. Baseggio, F. C. D. Veiga, Lucia Elvira Álvares, Mario Roberto Maróstica Júnior, V. Cagnon","doi":"10.2174/0122103155281770240104091620","DOIUrl":"https://doi.org/10.2174/0122103155281770240104091620","url":null,"abstract":"\u0000\u0000Angiogenesis, oxidative stress, and epigenetic alterations involved in prostate\u0000cancer (PCa) are associated with different risk factors, such as a high-fat diet (HFD), overweight,\u0000and obesity. Jaboticaba peel extract (PJE) has shown antiproliferative, antiangiogenic, and antioxidant\u0000activities in the prostate of senile mice.\u0000\u0000\u0000\u0000This study aimed to evaluate the effect of PJE on the dorsolateral prostate microenvironment\u0000in male transgenic mice for the prostate adenocarcinoma model, considering different pathological\u0000alterations, changed or unchanged by HFD, focusing on histopathology, and molecules related to\u0000extracellular matrix (ECM), oxidative stress, angiogenesis, and Dact-1. Western blotting and immunohistochemistry\u0000were performed on Dact-1-associated tumor suppressor genes in transgenic\u0000mice. Mice were fed HFD and received patented jaboticaba peel extract (PJE) treatment. The plasma\u0000levels of systemic oxidative stress were evaluated.\u0000\u0000\u0000\u0000Our results showed that PJE protected the dorsolateral prostate against proliferation and\u0000increased MMP9, TGFβ, and VEGF levels. PJE reduced oxidative stress and lipid peroxidation by\u0000modulating catalase, SOD 2, and 4HNE. PJE exhibited an epigenetic action, evidenced by increased\u0000Dact-1 gene expression in PCa.\u0000\u0000\u0000\u0000PJE could be a natural protector of PCa and prostate lesions associated with HFD intake.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"100 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140444178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implications of Ultrasonication-assisted Extraction with Response Surface Methodology on Phytochemical Compositions and Antioxidant Activity of\u0000Polysaccharide Extract from Phellinus rimosus (Berk.) Pilát Cultivated Mycelia in Northeastern Thailand","authors":"Chonlada Maingam, Watchara Kanchanarach, Nipaporn Chutiman, A. Wanthong, P. Srivilai, P. Loutchanwoot","doi":"10.2174/0122103155293542240118063111","DOIUrl":"https://doi.org/10.2174/0122103155293542240118063111","url":null,"abstract":"\u0000\u0000Polysaccharides from the medicinal mushroom Phellinus rimosus (Berk.)\u0000Pilát (PR) are the major functional bioactive ingredients. However, there has been a marked natural\u0000decrease in the number of PR fruit bodies, leading to their increased cost. Moreover, the natural\u0000growth and development of mature PR fruit bodies takes several decades.\u0000\u0000\u0000\u0000The objective of this study was to produce a polysaccharide extract from cultured PR\u0000mycelia (PEPRM) by using ultrasonic-assisted extraction with response surface methodology (RSM),\u0000and determine its physicochemical composition and antioxidant potential.\u0000\u0000\u0000\u0000Polysaccharide and monosaccharide composition analyses were carried out by Fouriertransform\u0000infrared spectroscopy (FT-IR) and High-performance liquid chromatography (HPLC).\u0000Total contents of polysaccharides, beta-glucans, phenolic compounds, and flavonoids were investigated\u0000utilizing the phenol-sulfuric acid method, enzymatic-based commercial test kit, Folin-Ciocalteu\u0000method, and aluminium chloride colorimetric method, respectively. Antioxidant activity was determined\u0000by using 2,2-diphenyl-1-picrylhydrazyl-hydrate (DPPH) radical scavenging assay and 2,2-\u0000azino-bis (3-ethylbenzothiazol-6-sulfonic acid) (ABTS) radical cation decolorization assay.\u0000\u0000\u0000\u0000Optimal conditions for the production of PEPRM included a ratio of 51.29 mL water to 1 g\u0000PR mycelia and an extraction time of 46.23 minutes, resulting in a total polysaccharide content of\u0000577.5 mg/g of PEPRM. FT-IR spectra of PEPRM showed two broad bands at 3272.08 cm-1 and\u00002924.8 cm-1 in the carbohydrate region and the peaks at 1078.44, 1019.05, and 853.0 cm-1 indicated\u0000the presence of the pyranose ring skeleton, glycosidic linkage, and glucans. PEPRM had molar ratios\u0000of glucose: mannose: rhamnose: fucose, i.e., 21.86: 1.00: 2.08: 3.40, respectively. PEPRM had total\u0000contents of beta-glucans, phenolic compounds, and flavonoids as percentages of dry weight, i.e.,\u000021.22, 2.51, and 5.71, respectively. PEPRM showed better inhibitory activity against ABTS radicals\u0000than DPPH radicals.\u0000\u0000\u0000\u0000Optimal conditions for the production of PEPRM were a ratio of 51.29 ml water to 1 g PR mycelia and extraction time of 46.23 min, yielding a total polysaccharide content of 577.5 mg/g of PEPRM. FT-IR spectra of PEPRM showed two broad bands at 3272.08 cm-1 and 2924.8 cm-1 in the carbohydrate region and the peaks at 1078.44, 1019.05, and 853.0 cm-1 indicated the presence of the pyranose ring skeleton, glycosidic linkage, and glucans. PEPRM had molar ratios of glucose: mannose: rhamnose: fucose, i.e., 21.86: 1.00: 2.08: 3.40, respectively. PEPRM had total contents of beta-glucan, phenolic compounds, and flavonoids as percentages of dry weight, i.e., 21.22, 2.51, and 5.71, respectively. PEPRM showed better inhibitory activity against ABTS radicals than DPPH radicals.\u0000\u0000\u0000\u0000This is the first finding to reveal that ultrasonic-assisted extraction with RSM was an\u0000environmentally friendly alternative to produce antioxidant polysaccharides from cu","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"114 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139963827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical and Bioactive Profile of Medicinal Plants Used Traditionally\u0000in Bosnia and Herzegovina","authors":"Saida Ibragić, Aisa Mesinovic, Selma Arnaut, Emina Delic, R. Bešta-Gajević, Sabina Dahija, Muamer Dizdar, E. Karalija","doi":"10.2174/0122103155293731231230095516","DOIUrl":"https://doi.org/10.2174/0122103155293731231230095516","url":null,"abstract":"\u0000\u0000This paper aimed to characterize the phytochemical profile and bioactivities\u0000of 22 plant species used in the traditional medicine of Bosnia and Herzegovina. The utilization of\u0000plants in traditional medicine in Bosnia and Herzegovina holds significant importance, not only as a\u0000reflection of cultural heritage but also as a sustainable and time-tested approach to healthcare, fostering\u0000a harmonious connection between nature and well-being.\u0000\u0000\u0000\u0000The comprehensive analyses encompassed the determination of total phenolic and flavonoid\u0000content, alongside assessing antioxidant activity using DPPH and FRAP assays. Additionally,\u0000antimicrobial activity was tested against S. aureus. ssp. aureus, MRSA, P. aeruginosa, S. abony and\u0000C. albicans. Many of the analyzed plant extracts showed a high phenolic content (C. avellana, V.\u0000myrtillus) and antioxidant activity (C. avellana, V. myrtillus, B. pendula, S. officinale, E. angustifolium,\u0000J. globifera ssp. hirta).\u0000\u0000\u0000\u0000The majority of extracts showed good antimicrobial activity for S. aureus ssp. aureus and\u0000MRSA. The E. angustifolium extract was effective against all tested bacterial strains, with MIC values\u0000ranging from 1.25-10 mg/mL. The research identified significant levels of secondary metabolites\u0000and identified plant species with potent antioxidant and antimicrobial activity.\u0000\u0000\u0000\u0000The study also revealed significant correlations among various phytochemical parameters\u0000and bioactivities.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"35 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139782147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review on Nanocarrier-based Polyherbal Drug Delivery Systems for Wound Healing","authors":"Vaibhav Rastogi, Mayur Porwal, Athar Aalam","doi":"10.2174/0122103155294431240129063752","DOIUrl":"https://doi.org/10.2174/0122103155294431240129063752","url":null,"abstract":"\u0000\u0000Nanotechnology-based polyherbal drug delivery systems are considered a\u0000new and rapidly emerging area in the pharmaceutical field. They improved the drug loading capacity\u0000or enhanced encapsulation efficiency of herbal drugs and thus improved permeation efficiency, accelerated\u0000wound healing, promoted tissue remodelling, and reduced scarring.\u0000\u0000\u0000\u0000A wound on the skin is an injury of the skin tissues that arises due to a cut or damage and\u0000also by an impact, blow, or other forces like a cut, surgery, chemical, heat, cold, friction, or illness\u0000like leg ulcers or carcinomas. These wounds result in the loss of skin's protective function by the\u0000removal of epithelium or connective tissues (i.e., muscle, bone, nerves). The four sequential but\u0000overlapping phases of the typical wound healing process are hemostasis, inflammation, proliferation,\u0000and remodeling. By encouraging the growth and movement of fibroblasts and keratinocytes, as well\u0000as angiogenesis at the site of damage, it has been demonstrated that a polyherbal mixture composed\u0000of plant extraction accelerates the lesion recovery process. Polyherbal formulations contain phytoconstituents\u0000such as triterpenoids, flavonoids, coumarins, quinones, and carotenoids etc. All these\u0000phytoconstituents are used for anti-inflammatory, anti-microbial, antioxidant, and lesion recovery. At\u0000the same time, nanotechnology-based polyherbal formulation has the potential to overcome the limitations\u0000of traditional polyherbal formulation in wound healing. Wounds are better managed by polyherbal\u0000combination rather than an individual plant due to its synergism and fewer side effects. To\u0000include these polyherbal components and deliver them to the wound site in a more focused and sustained\u0000way, novel drug delivery systems are also being developed.\u0000\u0000\u0000\u0000This review discussed many nanotechnology-based polyherbal topical formulations for\u0000efficient and faster wound healing and recovery. Nanotechnology-based polyherbal formulations\u0000prove their success in promoting wound healing which is a unique approach to improving wound\u0000care and development of healthy skin.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"56 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139856236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}