The Natural Products Journal最新文献

{"title":"Antiphytopathogenic Diphenyl Ethers from the Marine-derived Fungus Aspergillus sydowii","authors":"Ying Shi, Xiao Yang, Jinwei Ren, Ling Liu","doi":"10.2174/0122103155287990240117100232","DOIUrl":"https://doi.org/10.2174/0122103155287990240117100232","url":null,"abstract":"\u0000\u0000Natural products from the marine-derived Aspergillus sp. have great potential\u0000in agricultural usage due to their broad biological activities.\u0000\u0000\u0000\u0000This study was designed to investigate the antiphytopathogenic compounds from marinederived\u0000fungus Aspergillus sydowii LW09.\u0000\u0000\u0000\u0000The compounds were isolated and purified by chromatography methods, and their structures\u0000were elucidated by analysis of the NMR and MS spectroscopic data as well as comparison with\u0000those of literature. All compounds were evaluated for antibacterial activities against phytopathogenic\u0000bacteria Pseudomonas syringae and Ralstonia solanacarum, along with spore germination inhibition\u0000of phytopathogenic fungi Fusarium oxysporum and Alternaria alternata.\u0000\u0000\u0000\u0000Two diphenyl ethers violaceols I (1) and II (2), along with two alkaloids acremolin (3) and\u0000WIN 64821 (4) were isolated from the fermentation extracts of A. sydowii LW09. Compound 1\u0000showed significant antibacterial activity against P. syringae and R. solanacarum with the same MIC\u0000values of 4 μg/mL, while compound 2 showed obvious antibacterial activity against P. syringae and\u0000R. solanacarum with MIC values of 2 and 1 μg/mL, respectively. Moreover, both 1 and 2 could inhibit\u0000the spore germination of F. oxysporum in the concentration range of 64–128 μg/mL. In addition,\u0000violaceol I (1) also inhibited the spore germination of A. alternata at 128 μg/mL.\u0000\u0000\u0000\u0000This study provided the potential antiphytopathogenic drug candidate for further studies.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139797085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review on Nanocarrier-based Polyherbal Drug Delivery Systems for Wound Healing","authors":"Vaibhav Rastogi, Mayur Porwal, Athar Aalam","doi":"10.2174/0122103155294431240129063752","DOIUrl":"https://doi.org/10.2174/0122103155294431240129063752","url":null,"abstract":"\u0000\u0000Nanotechnology-based polyherbal drug delivery systems are considered a\u0000new and rapidly emerging area in the pharmaceutical field. They improved the drug loading capacity\u0000or enhanced encapsulation efficiency of herbal drugs and thus improved permeation efficiency, accelerated\u0000wound healing, promoted tissue remodelling, and reduced scarring.\u0000\u0000\u0000\u0000A wound on the skin is an injury of the skin tissues that arises due to a cut or damage and\u0000also by an impact, blow, or other forces like a cut, surgery, chemical, heat, cold, friction, or illness\u0000like leg ulcers or carcinomas. These wounds result in the loss of skin's protective function by the\u0000removal of epithelium or connective tissues (i.e., muscle, bone, nerves). The four sequential but\u0000overlapping phases of the typical wound healing process are hemostasis, inflammation, proliferation,\u0000and remodeling. By encouraging the growth and movement of fibroblasts and keratinocytes, as well\u0000as angiogenesis at the site of damage, it has been demonstrated that a polyherbal mixture composed\u0000of plant extraction accelerates the lesion recovery process. Polyherbal formulations contain phytoconstituents\u0000such as triterpenoids, flavonoids, coumarins, quinones, and carotenoids etc. All these\u0000phytoconstituents are used for anti-inflammatory, anti-microbial, antioxidant, and lesion recovery. At\u0000the same time, nanotechnology-based polyherbal formulation has the potential to overcome the limitations\u0000of traditional polyherbal formulation in wound healing. Wounds are better managed by polyherbal\u0000combination rather than an individual plant due to its synergism and fewer side effects. To\u0000include these polyherbal components and deliver them to the wound site in a more focused and sustained\u0000way, novel drug delivery systems are also being developed.\u0000\u0000\u0000\u0000This review discussed many nanotechnology-based polyherbal topical formulations for\u0000efficient and faster wound healing and recovery. Nanotechnology-based polyherbal formulations\u0000prove their success in promoting wound healing which is a unique approach to improving wound\u0000care and development of healthy skin.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"350 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139796588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiphytopathogenic Diphenyl Ethers from the Marine-derived Fungus Aspergillus sydowii","authors":"Ying Shi, Xiao Yang, Jinwei Ren, Ling Liu","doi":"10.2174/0122103155287990240117100232","DOIUrl":"https://doi.org/10.2174/0122103155287990240117100232","url":null,"abstract":"\u0000\u0000Natural products from the marine-derived Aspergillus sp. have great potential\u0000in agricultural usage due to their broad biological activities.\u0000\u0000\u0000\u0000This study was designed to investigate the antiphytopathogenic compounds from marinederived\u0000fungus Aspergillus sydowii LW09.\u0000\u0000\u0000\u0000The compounds were isolated and purified by chromatography methods, and their structures\u0000were elucidated by analysis of the NMR and MS spectroscopic data as well as comparison with\u0000those of literature. All compounds were evaluated for antibacterial activities against phytopathogenic\u0000bacteria Pseudomonas syringae and Ralstonia solanacarum, along with spore germination inhibition\u0000of phytopathogenic fungi Fusarium oxysporum and Alternaria alternata.\u0000\u0000\u0000\u0000Two diphenyl ethers violaceols I (1) and II (2), along with two alkaloids acremolin (3) and\u0000WIN 64821 (4) were isolated from the fermentation extracts of A. sydowii LW09. Compound 1\u0000showed significant antibacterial activity against P. syringae and R. solanacarum with the same MIC\u0000values of 4 μg/mL, while compound 2 showed obvious antibacterial activity against P. syringae and\u0000R. solanacarum with MIC values of 2 and 1 μg/mL, respectively. Moreover, both 1 and 2 could inhibit\u0000the spore germination of F. oxysporum in the concentration range of 64–128 μg/mL. In addition,\u0000violaceol I (1) also inhibited the spore germination of A. alternata at 128 μg/mL.\u0000\u0000\u0000\u0000This study provided the potential antiphytopathogenic drug candidate for further studies.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"34 5-8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139856847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive Constituents and the Molecular Mechanism of Melastoma dodecandrum Lour. in the Treatment of Inflammation Based on Network\u0000Pharmacology and Molecular Docking","authors":"Shuang Liu, Weiwen Qiu, Qizhao Yin, Zhao Meilu, Mingrong Mei, Houxing Lei, Xiaoqin Zhang","doi":"10.2174/0122103155274363231221112226","DOIUrl":"https://doi.org/10.2174/0122103155274363231221112226","url":null,"abstract":"\u0000\u0000Melastoma dodecandrum Lour. (MD) is a component used in traditional\u0000Chinese medicine that is widely distributed in southern China. MD has long been used clinically to\u0000treat various diseases, such as inflammation. However, the potential anti-inflammatory mechanism of\u0000MD remains to be elucidated.\u0000\u0000\u0000\u0000In this study, network pharmacology and experimental validation have been used to explore\u0000the underlying mechanism of MD in inflammation.\u0000\u0000\u0000\u0000The chemical composition of MD was determined using ultra-high performance liquid\u0000chromatography-electrospray ionization-high resolution mass spectrometry (UHPLC-ESI-HRMS).\u0000The effects of MD on pro-inflammatory cytokines, such as NO, i-NOS, IL-1β, and TNF-α, in\u0000RAW264.7 cells stimulated by lipopolysaccharide (LPS) were determined by ELISA and QRT-PCR.\u0000Through the analysis of multiple databases, targets for the treatment of inflammation with MD were\u0000identified. Other extensive analyses included PPI, GO, and KEGG pathway enrichment, which were\u0000completed through the use of the STRING database, Cytoscape software, and the DAVID database.\u0000Key targets and key components have been selected for molecular docking.\u0000\u0000\u0000\u0000A total of 33 active components were identified in MD, and 134 common targets were obtained\u0000and used to construct the networks. Of these, 10 core components and 10 core targets of MD\u0000in the treatment of inflammation were identified. The GO and KEGG enrichment analyses revealed\u0000that the common targets were involved in multiple signaling pathways, including the PI3K-Akt signaling\u0000pathway, NOD-like receptor signaling pathway, chemokine signaling pathway, and IL-17\u0000signaling pathway. The molecular docking methods confirmed the high affinity between bioactive\u0000molecules of MD and their targets in inflammation. Two core targets (PIK3CA and AKT) and three\u0000core components (asiatic acid, apigenin, and kaempferol) were found to be closely related to MD in\u0000the treatment of inflammation. In vitro, MD exerted a significant effect on LPS-stimulated NO, IL-\u00001β, and TNF-α secretion, and iNOS, IL-1β, and TNF-α expressions in macrophages.\u0000\u0000\u0000\u0000This study has demonstrated the bioactive constituents and mechanisms of MD in inhibiting\u0000the secretion of inflammatory factors and the multicomponent, multitarget, and multipathway\u0000treatment characteristics involved in inflammation, but this still needs further in vivo/in\u0000vitro experiments.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"11 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140482438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenolic Bisabolane Sesquiterpene Derivatives from an Arctic Marine-derived\u0000Fungus Aspergillus sydowii MNP-2","authors":"Zhiyang Fu, Xiangzhou Gong, Zhe-Ying Hu, Yujie Zhao, Huawei Zhang","doi":"10.2174/0122103155279752240104050411","DOIUrl":"https://doi.org/10.2174/0122103155279752240104050411","url":null,"abstract":"\u0000\u0000Filamentous fungi in the genus Aspergillus are well known for their important roles in the\u0000production of bioactive secondary metabolites with diverse chemical structures and potential applications in the pharmaceutical industry. In this work, chemical investigation of an Arctic marine-derived\u0000strain A. sydowii MNP-2, led to the isolation of 11 phenolic bisabolane-type sesquiterpenes (PBSs, 1-\u000011) using various chromatographic methods. Their chemical structures were unambiguously determined by 1\u0000H NMR spectroscopy and mass spectrometry analyses as well as comparison with literature data. It is noteworthy that compounds 1, 7 and 11 were first obtained from A. sydowii. Antimicrobial assay showed that these chemicals had no potent inhibitory effect on Staphylococcus aureus,\u0000Escherichia coli, and Candida albicans with MIC values > 16 µg/mL. Additionally, the inhibition of\u0000nitric oxide (NO) production in lipopolysaccharide (LPS)-induced inflammation in mouse macrophages (RAW264.7) and BV2 microglial cells were all below 10% for compounds 4-6 and 8, indicating almost negligible anti-inflammatory efficacy. Among the tested compounds 4-6 and 8 for\u0000tumor-cell proliferation inhibition activities, compound 5 demonstrated the strongest inhibitory effect\u0000against human acute promyelocytic leukemia cells (HL-6) with a 44.76% inhibition rate\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140493906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caenorhabditis Elegans as an Outstanding Model to Explore Flavonoids\u0000Under Stress Conditions","authors":"Maria Cristina Vasconcellos, Iverson Conrado Bezerra, Daniel Charles dos Santos Macedo, B. Fernandes, Priscila Gubert","doi":"10.2174/0122103155288344240104071427","DOIUrl":"https://doi.org/10.2174/0122103155288344240104071427","url":null,"abstract":"\u0000\u0000Plants produce promising chemicals called secondary metabolites in response to stress,\u0000which protect against oxidative damage in both plants and humans. Reactive oxygen species (ROS)\u0000levels combined with an imbalance in the antioxidant responses can trigger oxidative stress that is\u0000related to many conditions such as Alzheimer's disease, diabetes, and cancer. One way to counteract\u0000or avoid the stress excess is by flavonoid administration, a class of plant metabolites with a consistent antioxidant action and the ability to inactivate the free radical excess. The mechanisms, as\u0000well as the benefits and toxicity of antioxidant products, can be tested in alternative animal models.\u0000The mechanisms, as well as the benefits and toxicity of antioxidant products, can be tested in alternative animal models. In this review, we explored how Caenorhabditis elegans, a nematode with high\u0000genetic similarity to human genes and the antioxidant response pathway conserved, can be considered an attractive model organism for testing flavonoid compounds. Here, we emphasize the crucial\u0000results regarding C. elegans and the flavonoid quercetin, focusing on oxidative stress and aging investigations. Also, this review highlights the quercetin benefits in C. elegans lifespan, healthspan,\u0000neurodegeneration, and impacts on insulin/IGF-1 signaling (IIS).\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"56 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140493985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Advancements in Applications of Alginates in Drug Delivery, Tissue Engineering, and Biomedical Field","authors":"saurabh morparia, V. Suvarna","doi":"10.2174/0122103155284365240103063024","DOIUrl":"https://doi.org/10.2174/0122103155284365240103063024","url":null,"abstract":"\u0000\u0000Alginates, originating from the cell walls of brown algae, constitute a class of biopolymers\u0000known for their linear, unbranched architecture. Comprising both homopolymeric and heteropolymeric\u0000blocks, these polymers are constructed through glycosidic bonds linking β-D mannuronic acid\u0000and α-L-guluronic acid units in a 1-4 configuration. The specific arrangement of these monomers,\u0000whether in alternate, sequential, or random configurations, imparts distinct physical and chemical\u0000properties to the polysaccharide. The composition and organization of alginates play a pivotal role in\u0000dictating their performance and potential applications, particularly within the realm of biomedicine.\u0000A comprehensive understanding of their intricate chemistry and characterization is imperative for\u0000effective utilization. This knowledge serves as the cornerstone for designing tailored delivery systems\u0000and strategies to leverage the unique attributes of alginates for therapeutic and diagnostic purposes.\u0000Commercially, alginates are offered in diverse forms and hues, encompassing sodium, potassium,\u0000or ammonium salts. Alginates show commendable biocompatibility and biodegradability and\u0000exhibit a marked absence of antigenicity and toxicity. In addition, their ability to form chelates with\u0000divalent cations and to facilitate the creation of pH-responsive gels through crosslinking with calcium\u0000and magnesium significantly enhances their versatility. Alginates possess a molecular weight\u0000range of from 60,000 to 700,000 Da, a parameter capable of adjusting to align with specific applications.\u0000This inherent versatility positions them as valuable assets across a spectrum of fields, including\u0000pharmaceuticals, tissue regeneration scaffolds, drug delivery systems, and imaging agents. The review\u0000article provides a comprehensive exploration of the diverse applications of alginates in tissue\u0000engineering, drug delivery, and various domains within biomedicine. By delving into the nuanced\u0000characteristics and behaviors of alginates, we aspire to unlock their full potential in advancing therapeutic\u0000and diagnostic interventions.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140492963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Updated Review on the Role of Phytoconstituents in Modulating Signalling Pathways to Combat Skin Ageing: Nature’s Own Weapons and Approaches","authors":"Mayur Porwal, Swati Shukla, Vaibhav Rastogi, Phool Chandra","doi":"10.2174/0122103155273789231122104742","DOIUrl":"https://doi.org/10.2174/0122103155273789231122104742","url":null,"abstract":"\u0000\u0000Various geographical areas exhibit varying degrees of prevalence and severity of dermatological\u0000issues. The most commonly observed skin issues among adolescents during their growth\u0000period on a global scale encompass dry skin, dyspigmentation, wrinkles, fungal infections, as well as\u0000benign and malignant tumors. These conditions arise as a consequence of diminished functional capacity\u0000and heightened skin susceptibility. The primary manifestation of the whole process of skin\u0000ageing is its visual presentation, which encompasses changes in both the structure and function of the\u0000skin. The look and function of human skin exhibit particular variations as individuals age, representing\u0000a time-dependent phenomenon. This review article primarily examines the discussion surrounding\u0000the diverse phytoconstituents and their impact on signalling pathways in cellular metabolism, as\u0000well as their interaction with environmental factors and xenobiotic agents that contribute to skin\u0000aging. Ultraviolet (UV) light induces the rapid formation and subsequent accumulation of reactive\u0000oxygen species (ROS) within skin cells, hence accelerating oxidative stress and the ageing process of\u0000the skin. One effective approach to addressing age-related skin disorders entails the utilization of\u0000exogenous supplementation through the consumption of dietary antioxidants, as well as the application\u0000of antioxidant-based lotions to the skin prior to sun exposure. Several plant species include phenolic\u0000components, including ascorbic acid, ellagitannins, and carotenoids, which have the ability to\u0000protect the skin from harmful UV radiation, reduce inflammation and oxidative stress, and influence\u0000several survival signalling pathways. This comprehensive study elucidated multiple processes by\u0000which phytoconstituents exert their effects for intervention purposes. Additionally, it highlighted the\u0000ability of these phytoconstituents to modulate the NF-κB signalling pathway, MAPK signalling, Nrf2\u0000signalling, and other pathways, hence demonstrating their potential anti-aging properties.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"60 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139598622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological Approaches and Herbal Interventions for Alzheimer's Disease","authors":"Shivendra Kumar, Shubham Singh, Dharmendra Rajput, Bhavna Sharma, Kumkum Chaturvedi, Nidhi Singh, S. Saha, Kuldeep Singh, S. Mukherjee","doi":"10.2174/0122103155275266231123090138","DOIUrl":"https://doi.org/10.2174/0122103155275266231123090138","url":null,"abstract":"\u0000\u0000This comprehensive review extensively examines the utilization of herbal remedies and\u0000pharmacological techniques for managing Alzheimer's disease (AD). It delves deeply into the active\u0000constituents and modes of operation of diverse herbal medications such as Withania somnifera,\u0000Bacopa monnieri, Ginkgo biloba, and Curcuma longa, emphasizing their qualities in reducing\u0000inflammation, acting as antioxidants, and safeguarding neural tissue. Additionally, it assesses conventional\u0000pharmaceuticals like cholinesterase inhibitors (Donepezil, rivastigmine) and memantine,\u0000investigating their mechanisms of action and potential adverse effects. The study also encompasses\u0000non-pharmacological therapies like interventions aimed at cognition, physical exercise, and methods\u0000of stimulating the brain, all of which exhibit potential in enhancing cognitive capacity and\u0000neural adaptability. Furthermore, it delves into the amalgamation of therapies to tackle numerous\u0000facets of AD pathology. In essence, this review furnishes valuable insights into alternative strategies\u0000for managing AD, underscoring the potential of herbal interventions in enhancing cognitive\u0000function and addressing the underlying issues of AD. Additionally, it presents a fresh avenue for\u0000exploring the collaborative impacts of combining conventional pharmaceuticals with herbal remedies.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"9 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139608513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiologic Effects of Hibiscus Sabdariffa (Sorrel) on Biological Systems:\u0000Advances in Sorrel Research","authors":"Garsha McCalla, Bethany Smith","doi":"10.2174/0122103155273914231206094057","DOIUrl":"https://doi.org/10.2174/0122103155273914231206094057","url":null,"abstract":"\u0000\u0000Hibiscus sabdariffa (sorrel) is a member of the hibiscus genus and Malvaceae\u0000family. An important attribute is its therapeutic characteristic, which has been validated by research\u0000that shows some success in treating several diseases.\u0000\u0000\u0000\u0000Owing to limited information and research deficits, this study aimed to investigate the\u0000physiologic effects of Hibiscus sabdariffa on biological systems and the advances made in the last\u0000century.\u0000\u0000\u0000\u0000PubMed Central search for “Hibiscus sabdariffa OR sorrel” was conducted from November\u00002021 to March 2022, covering articles from 1921 to 2020. The results were documented in Microsoft\u0000Excel 2016 and grouped based on physiological systems.\u0000\u0000\u0000\u0000Sorrel research publications mushroomed in the last decade. Studies from 1921-2010 reported\u0000on the endocrine and cardiovascular systems, while additional biological systems (nervous,\u0000urinary, gastrointestinal, integumentary, hematopoietic, reproductive, and skeletal) were later investigated.\u0000Sorrel positively treated diabetes, hypertension, and a multitude of other illnesses due to its\u0000antioxidant, antibacterial, and anti-inflammatory potential, chiefly via its anthocyanins. Hypertension\u0000was mostly reported, predominantly from Nigeria (Africa), and toxicity exceeded 2000 mg/kg b.w.\u0000\u0000\u0000\u0000Sorrel has multifaceted uses, mostly involving hypertension treatment. Despite increased\u0000publications and advances in research, all areas of physiology still require sorrel research,\u0000especially in the Caribbean, which lacked publication, amidst Jamaica being known for the consumption\u0000of sorrel drinks.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"398 4-6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140503051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}