The Natural Products Journal最新文献

{"title":"An Insight into the Mechanism, Safety and Efficacy for Photoprotection\u0000and Dermatological Conditions of Polypodium leucotomos Extract","authors":"Darthan Mawia, Aparoop Das, Yasangam Umbon, Riya Saikia, K. Pathak, M. Pathak","doi":"10.2174/0122103155268659231129071641","DOIUrl":"https://doi.org/10.2174/0122103155268659231129071641","url":null,"abstract":"\u0000\u0000Numerous photoprotective techniques have been employed to successfully shield against\u0000the harmful effects of ultraviolet radiation. Current photoprotective techniques have limitations due\u0000to the amount of topical application, insufficient physical protection, and adverse responses to topical\u0000agents. A newer option that offers a promising defense against solar radiation is systemic agents, the\u0000well-researched Polypodium leucotomos is significant in this category, and several studies have found\u0000to be effective ―oral sunscreenǁ. Polypodium leucotomos (PL) extract has gained significant attention\u0000as a potential therapeutic agent in the field of dermatology, particularly in the photoprotection and\u0000management of various dermatological conditions. This abstract provides a comprehensive overview\u0000of the mechanism, safety, and efficacy of Polypodium leucotomos extract in relation to photoprotection\u0000and dermatological conditions. Our primary aim is to review Polypodium leucotomos' photoprotective\u0000results from studies that are currently available, and our secondary goal is to describe Polypodium\u0000leucotomos' applications in different dermatological conditions. Articles discussing Polypodium\u0000leucotomos uses in photoprotection and dermatologic conditions are searched and downloaded from\u0000publicly available databases such as PubMed, JSTOR, PLOS, Science Direct, DOAJ, Google Scholar,\u0000and Web of Science and evaluate the outcomes of the Polypodium leucotomos effect. Firstly, we\u0000delve into the mechanisms underlying the photoprotective properties of PL extract. Extensive research\u0000has demonstrated that PL extract exerts its protective effects through multiple pathways, including\u0000antioxidant activity, DNA repair stimulation, immunomodulation, and inhibition of inflammatory\u0000mediators. These mechanisms collectively contribute to the prevention of photodamage,\u0000such as sunburn, DNA damage, and photoaging. Furthermore, we explore the safety profile\u0000of PL extract, emphasizing its remarkable tolerability and minimal adverse effects reported in clinical\u0000studies. The absence of systemic absorption and its compatibility with other treatments make PL\u0000extract a promising option for long-term use in photoprotection and dermatological care. A promising\u0000alternative to traditional photoprotection may be Polypodium leucotomos. Additional thorough\u0000clinical trials are necessary to ascertain its role and effectiveness more accurately. The efficacy of PL\u0000extract in managing various dermatological conditions is also discussed. Multiple studies have\u0000demonstrated its beneficial effects in conditions such as vitiligo, melasma, psoriasis, and atopic dermatitis.\u0000The anti-inflammatory and immunomodulatory properties of PL extract have shown promise\u0000in reducing disease severity, improving skin symptoms, and enhancing the quality of life for patients.\u0000Additionally, the abstract highlights the potential future directions and areas of research for PL extract.\u0000Investigating its combination therapy wi","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"78 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140503263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Herbal Medicinal Nanoformulations for Psoriasis Treatment: Current\u0000State of Knowledge and Future Directions","authors":"Himanshu Sharma, Neha Gupta, Nitika Garg, Sanchit Dhankhar, Samrat Chauhan, Suresh Beniwal, Deepak Saini","doi":"10.2174/0122103155273976231126141100","DOIUrl":"https://doi.org/10.2174/0122103155273976231126141100","url":null,"abstract":"\u0000\u0000Psoriasis is a persistent immune system disorder that influences the skin,\u0000leading to red, flaky patches that can be painful and irritated.\u0000\u0000\u0000\u0000Traditional treatments for psoriasis, such as topical creams and oral medications, may be\u0000effective but also have potential side effects. Herbal remedies have been used for centuries to treat\u0000skin conditions, and advancements in nanotechnology have led to the development of herbal\u0000nanoformulations that offer several advantages over traditional herbal remedies, such as efficacy,\u0000safety, and targeted delivery.\u0000\u0000\u0000\u0000The studies and reviews published under the title were looked up in several databases (including PubMed, Elsevier, and Google Scholar).\u0000\u0000\u0000\u0000Several herbal nanoformulations, including those containing curcumin, aloe vera, and neem,\u0000have been shown to exhibit anti-inflammatory and immunomodulatory impacts, which will be useful\u0000within the treatment of psoriasis. However, more study is required to decide the efficacy and safety\u0000of these details, as well as the optimal dosing, duration of treatment, and potential side effects.\u0000\u0000\u0000\u0000Overall, herbal nanoformulations represent a promising area of research for the treatment of psoriasis, and may offer a safe and effective alternative or adjunct therapy to conventional\u0000treatments. This review article summarizes the present state of information for the herbal nanoformulations role in the treatment of psoriasis and their future perspectives.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"120 28","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139614939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Correlation between Gene Mutations and Metabolic Changes in\u0000Acute Myeloid Leukemia","authors":"Aili Jiang, Zhiying Hou, Bingyan Yu, Ning Wang, Bin Zhang","doi":"10.2174/0122103155277735231122105519","DOIUrl":"https://doi.org/10.2174/0122103155277735231122105519","url":null,"abstract":"\u0000\u0000Acute myeloid leukemia (AML) is a common type of leukemia. However, the understanding\u0000of AML remains insufficient. The pathological progression of AML is closely related to chromosome\u0000abnormalities and genetic mutations. Gene mutation is an important factor in the pathogenesis\u0000of AML and a potential cause of drug resistance. Recent studies have shown that gene mutations in\u0000AML can cause metabolic changes. Metabolites, as downstream products of human physiological\u0000activities, can amplify physiological and disease-related signals. Therefore, the analysis of metabolite\u0000markers related to gene mutations can be used for early prediction of the occurrence of the disease.\u0000This review describes the types and significance of AML gene mutations and analyzes the characteristics\u0000of metabolic changes related to gene mutations.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"24 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140506059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detailed Analysis of the Anti-Inflammatory, Anti-oxidant, and Neuroprotective\u0000Effects of the Potent Phytochemical Bacoside A","authors":"Pranay Wal, Neha Verma, Bhagawati Saxena, Damini Singh, A. Wal, Akash Ved, A. Rai, Vibhu Sahani","doi":"10.2174/0122103155270841231122100242","DOIUrl":"https://doi.org/10.2174/0122103155270841231122100242","url":null,"abstract":"\u0000\u0000Bacoside A is a vital bioactive component of the Indian medicinal herb Bacopa monnieri,\u0000which ranks second among the most significant medicinal plants. Bacoside A was discovered\u0000to have more pharmacological activity than bacoside B. It has been used in Ayurvedic medicine to\u0000treat mental problems and memory loss. It also possesses antioxidant, antidepressant, antiulcer,\u0000hepatoprotective, ant-cancerous, vasodilator and other pharmacological properties. The main objective\u0000of this review is to highlight the importance of Bacoside A in the treatment of various diseases.\u0000Several sources were used to acquire the material, including review articles published in\u0000various publications, such as PubMed, Scopus, Bentham Science, Elsevier, Springer Nature,\u0000Wiley, and Research Gate, which were used to compile the data for the article following a thorough\u0000analysis of the various research findings connected that had keywords, such as Bacoside A,\u0000Ayurvedic medicine, Brahmi, jujubogenin. Bacoside-A, derived from the Bacopa monniera plant,\u0000is a traditional medicine said to have therapeutic qualities. Various studies have found that bacoside-\u0000A has considerable therapeutic benefits. All of the evidence suggests that Bacoside-A has\u0000multiple therapeutic properties in regulating the various biological processes as well as paving the\u0000path for the treatment of various disorders in modern medicine. The current review focused on the\u0000pharmacological action of bacoside A. The results of the pharmacological investigations indicated\u0000that Bacoside A had a wide range of pharmacological effects, including those on the central nervous\u0000system (memory improvement), antioxidant, anti-inflammatory, antiparkinsonian, anticancer,\u0000and more.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"29 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140505887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moringa oleifera and its Secondary Metabolites: Chemistry, Properties and\u0000Antidiabetic Potentiality","authors":"Dilipkumar Pal, Takeshwar Sahu, Sujoy Thakur","doi":"10.2174/0122103155279969231123022102","DOIUrl":"https://doi.org/10.2174/0122103155279969231123022102","url":null,"abstract":"\u0000\u0000Secondary metabolites present in different natural resources possess multiple biological\u0000activities. Diabetes is one of the leading disease all over the world in current time, and higher in\u0000numbersthan the deadliest cancer disease. According to the WHO about 422 million people are suffering\u0000from diabetes and most of them are even unaware that they are living with the condition. In\u0000recent times research in natural medicinal plants has achieved a great success in the management of\u0000different diseases and disorders. Moringa oleifera is one of the most common medicinal and nutritious\u0000plant among the family of moringaceae, found in almost all over India. The tree with it's almost\u0000every edible part makes it a versatile natural medicinal source. The secondary metabolites present\u0000within it make this plant a rich biological resource. Among various classes of secondary metabolites\u0000alkaloids, flavonoids, glycosides, terpenoids, sterols etc. are present in moringa tree. The principle\u0000potent compound responsible for emerging antidiabetic property of Moringa is 4-(α-Lrhamnopyranosyloxy)\u0000benzyl glucosinolate. In this review we summarise specifically the antidiabetic\u0000activity of this multipurpose natural plant and it's phytochemistry. Since ancient times this plant has\u0000been used as anti-diabetic agent in sub continental regions. Mostly phytoconstituents obtained from\u0000leaves are responsible for its outstanding antidiabetic property. Research on antidiabetic property of\u0000M. oleifera by different scientists proved that Moringa is one of the finest natural medicinal plants in\u0000the management of diabetes with least toxicity.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140506315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibacterial Polyketides from the Plant Endophytic Fungus Fusarium sp.","authors":"Ru Wang, Ying Shi, Qianqian Liu, Liyan Sun, Ling Liu","doi":"10.2174/0122103155287212240101091448","DOIUrl":"https://doi.org/10.2174/0122103155287212240101091448","url":null,"abstract":"\u0000\u0000Endophytic fungi have been recognized as new sources of natural products\u0000with a variety of biological activities, providing lead compounds for drug discovery and development.\u0000\u0000\u0000\u0000Endophytic fungi have been recognized as new sources of natural products with a variety of biological activities, providing lead compounds for drug discovery and development.\u0000\u0000\u0000\u0000The objective of this study is to isolate and identify the secondary metabolites from the\u0000plant endophytic fungus Fusarium sp. HJY2 and evaluate their antibacterial activities.\u0000\u0000\u0000\u0000The objective of this study is to isolate and identify the secondary metabolites from the plant endophytic fungus Fusarium sp. HJY2 and evaluate their antibacterial activities.\u0000\u0000\u0000\u0000The compounds were isolated and purified by the methods of silica gel column chromatography,\u0000Sephadex LH-20 gel chromatography, and semi-preparative high performance liquid chromatography\u0000(HPLC). The structures of the isolated compounds were elucidated by comparing the NMR\u0000and MS spectroscopic data with those of pieces of literature. The antibacterial activities were evaluated\u0000by the broth microdilution method.\u0000\u0000\u0000\u0000Seven polyketides were isolated from the fermented extracts of the fungus Fusarium sp.\u0000HJY2 and identified as sydowinol (1), dihydrolateropyrone (2), 13-oxo-9Z,11E-octadecadienoic acid\u0000(3), (E)-ferulic acid (4), 4-hydroxyphenylacetic acid (5), methyl 2-(2-hydroxyphenyl)acetate (6) and\u00004-hydroxy-3-methoxyacetophenone (7). Compound 3 exhibited moderate antibacterial activities\u0000against Bacillus subtilis, Mycobacterium smegmatis, Ralstonia solanacearum, and Xanthomonas\u0000campestris pv. campestris with MIC values of 40, 40, 80 and 40 μg/mL, respectively.\u0000\u0000\u0000\u0000Seven compounds were isolated from the plant endophytic fungus Fusarium sp. HJY2.\u0000Compound 1 was isolated from the Fusarium genus for the first time. Compound 3 showed moderate\u0000antibacterial activities.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"11 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140506677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extraction, Phytochemistry & Pharmacological Potential of Camellia\u0000sinensis: A Comprehensive Review","authors":"Prabhjot Kaur, Simran Gandhi, Rubal Sharma, Lovepreet Kaur, Mahak Pal, Geeta Deswal, B. Chopra, A. Grewal, A. Dhingra","doi":"10.2174/0122103155278901231122130727","DOIUrl":"https://doi.org/10.2174/0122103155278901231122130727","url":null,"abstract":"\u0000\u0000Camellia sinensis (L.) is acknowledged globally as the second most consumed beverage\u0000after water. Researchers have dedicated substantial efforts to validate the claims surrounding this\u0000plant through rigorous pharmacological screening, aiming to substantiate its traditional applications\u0000in treating various ailments. This work extensively delves into aspects such as marketed formulations\u0000of green tea, extraction techniques, phytochemistry, pharmacology, interactions between drugs and\u0000green tea, and its distinctive characteristics. Key research unequivocally suggests that green tea holds\u0000substantial health benefits for individuals. Presently, a multitude of pharmacologically active constituents\u0000have been successfully isolated and identified from green tea, encompassing polyphenols, alkaloids,\u0000amino acids, polysaccharides, and volatile components. Recent investigations have illuminated\u0000the broad spectrum of pharmacological properties exhibited by green tea, encompassing antioxidant,\u0000anticancer, hypoglycemic, antibacterial, antiviral, and neuroprotective attributes. The review amalgamates\u0000current research findings to present a thorough understanding of the diverse bioactive compounds\u0000found in Camellia sinensis, such as polyphenols, catechins, and alkaloids, and their contributions\u0000to its health-promoting properties. The review further highlights the significance of extraction\u0000techniques in preserving and enhancing the bioactivity of these compounds. Overall, this comprehensive\u0000review serves as a valuable resource for researchers, practitioners, and enthusiasts, consolidating\u0000the current knowledge surrounding Camellia sinensis and its multifaceted role in promoting human\u0000health.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140505634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Withania coagulans Dunal.: A Narrative Review of an Anti-diabetic Shrub\u0000of the Desert Biome","authors":"A. Balkrishna, Shalini Mishra, Shalini Singh, Maneesha Rana, V. Arya, R. Mishra, Satyendra Kumar Rajput, Ashwani Kumar","doi":"10.2174/0122103155273189231119065235","DOIUrl":"https://doi.org/10.2174/0122103155273189231119065235","url":null,"abstract":"\u0000\u0000Diabetes mellitus is a chronic disease affecting more than 300 million people worldwide.\u0000Even after advances in medicine, we are still away from a permanent solution to this problem. Longterm\u0000use of currently available treatments are associated with adverse effects ranging from cardiovascular\u0000conditions, renal disorders, liver ailments, and weight gain. Subsequently, a significant diabetic\u0000population seeks herbal medicines that are said to control blood sugar levels. Several plants\u0000have been explored in this context; one such plant is Withania coagulans Dunal., which is known for\u0000the hypoglycemic property due to its fruits. Different plant parts and bioactive components like withanolides\u0000exhibited anti-diabetic activity in type 2 diabetes models in vivo and in vitro. However,\u0000clinical studies are limited and more research is warranted. Bioactive composition of W. coagulans\u0000include Withanolide J, F; Coagulin C, E, L; Ajugin E, Withaperuvin C and others. Bioavailability of\u0000Withaferin A from W. coagulans was enhanced by co-administration of Piperine. Herbal quality\u0000control and commercialization aspects are also highlighted. W. coagulans can be employed in managing\u0000type 2 diabetes mellitus after detailed follow-up studies.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":" 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139624758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Polyphenols and Lignans of Phyllanthus amarus Schumach. and Thonn. on IL-1β and TNF-α Secretions from LPS-induced THP-1-derived\u0000Macrophages","authors":"Javaid Alam, I. Jantan, Yuandani, M. A. Nafiah, M. A. Mesaik, Sarah Ibrahim","doi":"10.2174/0122103155285107231229060123","DOIUrl":"https://doi.org/10.2174/0122103155285107231229060123","url":null,"abstract":"\u0000\u0000Phyllanthus amarus exhibited immunosuppressive and anti-inflammatory\u0000effects in several in vitro and in vivo studies. However, there is no report on the inhibitory effects of\u0000its secondary metabolites on pro-inflammatory cytokines secretion from human THP-1-derived\u0000macrophages.\u0000\u0000\u0000\u0000Phyllanthus amarus exhibited immunosuppressive and anti-inflammatory effects in several in vitro and in vivo studies. However, there is no report on the inhibitory effects of its secondary metabolites on pro-inflammatory cytokines secretion from human THP-1-derived macrophages.\u0000\u0000\u0000\u0000The objective of this study was to correlate the polyphenols (ellagic acid (EA), gallic acid\u0000(GA), geraniin (GER), and corilagin (COR)) and lignans ((phyllanthin (PHY), hypophyllanthin\u0000(HYPO), niranthin (NIR), phyltetralin (PHYLT), and isolintetralin (ISO)) of 80% ethanol extract of\u0000P. amarus with their inhibitory effect against IL-1β and TNF-α secretions from LPS-induced THP-1-\u0000derived macrophages.\u0000\u0000\u0000\u0000Chemical profiling of P. amarus was carried out by LC-MS/MS analysis. Validated\u0000qualitative and quantitative reversed-phase HPLC analyses of the P. amarus extract were performed\u0000for the determination of lignan and polyphenol contents. Human THP-1-derived macrophages were prepared\u0000by treatment of THP-1 cells with phorbol 12-myristate 13-acetate (PMA). The inhibition of\u0000cytokines released by the extract, lignans and polyphenols in the cells was investigated using ELISA assay.\u0000\u0000\u0000\u0000Chemical profiling of P. amarus was carried out by LC-MS/MS analysis. Validated qualitative and quantitative reversed phase HPLC analyses of the P. amarus extract were performed for determination of lignan and polyphenol contents. Human THP-1 derived macrophages were prepared by treatment of THP-1 cells with phorbol 12-myristate 13-acetate (PMA). The inhibition of cytokines release by the extract, lignans and polyphenols in the cells were investigated using ELISA assay.\u0000\u0000\u0000\u0000P. amarus extract and its chemical constituents significantly reduced the levels of IL-1β and\u0000TNF-α in a dose-dependent manner. At a dose of 50 μM, COR exhibited a maximum inhibition of\u000081.11% on TNF-α secretion, while GER showed 72.56% inhibition on IL-1β secretion. COR demonstrated\u0000the strongest inhibition of TNF-α secretion, exhibiting an IC50 value of 9.06 μM, which was\u0000comparable to that of dexamethasone (7.07 μM). Meanwhile, GER was the most potent against IL-\u00001β secretion, exhibiting an IC50 value of 20.09 μM. In the case of TNF-α secretion, the order of potency\u0000observed among the active compounds, with regard to IC50 value, was COR > GER > HYPO >\u0000PHY > NIR > GA > EA >ISO > PHYLT. For IL-1β secretion, the order of potency was GER > NIR\u0000> COR > GA > EA > PHY > HYPO > PHYLT > 1SO.\u0000\u0000\u0000\u0000The polyphenol contents of P. amarus, especially COR and GER, contributed significantly\u0000to the suppression of cytokines secretion, and they have the potential to be developed into\u0000agents for the treatment of pathologic inflammation.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":" 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139627612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mairin from Huangqi Decoction Mitigates Liver Cirrhosis through\u0000Suppression of Pro-inflammatory Signaling Pathways: A Network\u0000Pharmacology and Experimental Study","authors":"Di Meng, Shuang Ren","doi":"10.2174/0122103155273345231210170121","DOIUrl":"https://doi.org/10.2174/0122103155273345231210170121","url":null,"abstract":"\u0000\u0000Liver cirrhosis is a consequence of various chronic liver conditions and may\u0000lead to liver failure and cancer. Huangqi Decoction (HQD) is a Traditional Chinese Medicine (TCM)\u0000effective for treating liver conditions, including cirrhosis. Therefore, both the active ingredients and\u0000the pharmacological actions of HQD deserve further exploration. The active components and pharmacological\u0000actions of HQD in preventing and treating liver cirrhosis were investigated using network\u0000pharmacology. The actions of the principal active ingredient, Mairin, were investigated empirically.\u0000\u0000\u0000\u0000Using network pharmacology, the critical components of HQD were identified from multiple\u0000databases, and UPLC screening and targets were investigated using Swiss Target Prediction.\u0000Targets associated with liver cirrhosis were identified using the GeneCards database. GO and KEGG\u0000enrichment analysis of targets that overlapped between HQD and cirrhosis were analyzed in DAVID,\u0000and a “component-target-pathway” network for HQD was created in Cytoscape 3.7.2. The biological\u0000functions of the key active component, Mairin, were investigated using in silico docking, cell experiments,\u0000and evaluation in a carbon-tetrachloride (CCl4)-induced mouse model of liver cirrhosis.\u0000CCK-8 and F-actin assays were used to measure cell viability and hepatic stellate cell (HSC) activation,\u0000respectively; fibrosis was measured by histological and immunohistochemical evaluations, and\u0000the levels of the cirrhosis-related protein α-SMA and predicted essential target proteins in the PI3KAKT,\u0000NFκB-IκBα, and NLRP3-IL18 pathways were determined by western blotting.\u0000\u0000\u0000\u0000Fourteen active HQD components, 72 targets, and 10 pathways common to HQD and cirrhosis\u0000were identified. Network analysis indicated the association of Mairin with most targets and\u0000with inflammation through the PI3K/Akt, NF-κB, and NLRP3 pathways. Dose-dependent reductions\u0000in the activation and proliferation of LX-2 cells after Mairin treatment were observed. Mairin reversed\u0000the histopathological changes in the livers of cirrhosis model mice. Mairin also significantly\u0000reduced the α-SMA, NF-κB, IκBα, NLRP3, and IL-18 protein levels while increasing those of p-\u0000PI3K and p-Akt, suggesting that Mairin mitigates liver cirrhosis through modulation of the PI3KAKT,\u0000NFκB-IκBα, and NLRP3-IL18 pathways.\u0000\u0000\u0000\u0000Using a comprehensive investigative process involving network pharmacology, bioinformatics,\u0000and experimental verification, it was found that Mairin, an active component of HQD,\u0000may be useful for developing specific treatments for preventing and treating liver cirrhosis.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"63 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139535285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}