The Natural Products Journal最新文献

{"title":"Potential Plant-based Remedies for Gouty Arthritis: A Comprehensive Review on Counterweighing the Inflammatory Pathways","authors":"Rupama Thakuria, Purbajit Chetia, Abu Saif Mustaque","doi":"10.2174/0122103155341864250108062025","DOIUrl":"https://doi.org/10.2174/0122103155341864250108062025","url":null,"abstract":"The complex etiology of Gouty Arthritis (GA) makes it a multidimensional illness for which there are now no effective therapeutic therapies that can stop its development entirely. This review examines how effectively different plants and their constituents reduce blood uric acid levels and lessen the predisposition to gout. Research has looked at the possible roles of oxidative stress markers, inflammatory pathways, important transport and signaling proteins, and the health benefits of different plants and their components in the development of GA. Plant remedies have been used for a long time to treat human and animal ailments. Most people in developing countries use traditional plant-based medicine for basic care due to its affordability, availability, and cultural acceptability. This review aims to gather comprehensive information on plants and their compounds that exhibit anti-gout activities, focusing on in vitro and in vivo investigations. The scientific database was searched by using different keywords, and papers published between March 2008 and December 2023 were considered. The inclusion criteria were publications on inflammatory mediators, free radicals, oxidative stress, or proteins in gout etiology or evolution, along with plant-based remedies. Finally, 27 publications based on inclusion and exclusion criteria reported the active compounds and analyzed parameters and outcomes of research carried out with these medicinal plants. This paper extensively explores the potential mechanism of employing medicinal herbs for the management of gout. However, more investigation is needed to fully comprehend the role that various biomarkers play in the development of GA, as well as to investigate the possible functions of different plants and the substances found in them.","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"16 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147902573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving Antioxidant Effect of Stemona tuberosa by Fermentation with Endophytic Fungus Penicillium expansum STRB13","authors":"Jianwei Dong, Xuejiao Li, Hui Zhao, Xue-Xian Wang","doi":"10.2174/0122103155340018241210065825","DOIUrl":"https://doi.org/10.2174/0122103155340018241210065825","url":null,"abstract":"Background: Stemona tuberosa Lour. is a plant belonging to the genus Stemona (Stemonaceae) that has been utilized in traditional Chinese medicine (TCM) for its antitussive and antiparasitic properties. Endophytic fungi have been shown to play an important role in the growth and metabolism of plants. Fermentation involving endophytic fungi tends to result in the production of new or more potent pharmacological compounds. Objective: The study aims to enhance the antioxidant activity of S. tuberosa by fermenting it with a symbiotic endophytic fungus. Methods: Seven symbiotic endophytic fungi were used to screen and ferment S. tuberosa to improve antioxidant activity estimated by 2,2’-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and ferric ion-reducing antioxidant power (FRAP). The chemical constituent changes were characterized by ultraviolet (UV) spectrum and high-performance liquid chromatography (HPLC) analysis. Results: Penicillium expansum STRB13, an endophytic fungus associated with S. tuberosa, was screened for its ability to enhance antioxidant capacity through fermentation. The fermentation of S. tuberosa using P. expansum STRB13 significantly improved its DPPH radical scavenging activity, achieving an IC50 value of 24.2 μg/mL. Additionally, the ferric reducing antioxidant power (FRAP) of the fermented sample was fourteen times greater, measuring 388.1 ± 32.6 μmol/L compared to 27.5 ± 1.0 μmol/L in the blank sample. Differences observed between the blank and P. expansum STRB13 fermented S. tuberosa (FST) in UV spectra and HPLC analysis indicated the production of new aromatic phenolic compounds through fermentation, which contributed to the enhanced antioxidant activity. Conclusion: This is the first time reporting on the fermentation processing of S. tuberosa with symbiotic endophytic fungus. This study revealed that P. expansum STRB13 FST will be an alternative natural antioxidant. Fermentation with symbiotic endophytic fungus is a new approach to processing TCM and discovering new compounds.","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"16 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147889956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathway Targeting and Mechanistic Elucidation of Phyto-compounds Relevant in Triple-negative Breast Cancer (TNBC)","authors":"Wajahat Rashid Mir, Basharat Ahmad Bhat, Shazia Sofi, Nusrat Jan, Asma Jan, Manzoor Ahmad Mir","doi":"10.2174/0122103155329752241118115506","DOIUrl":"https://doi.org/10.2174/0122103155329752241118115506","url":null,"abstract":"Of the several forms of breast cancer, triple-negative breast cancer (TNBC) is the most aggressive, it is not responsive to traditional human/hormonal epithelial growth factor receptor 2 (HER2)-targeted therapies because the corresponding receptor targets are absent, TNBC tends to be more invasive in form, metastasis, have an early recurrence rate and develop medication resistance. For TNBC, some of the most popular types of treatments are resection, chemotherapy, and radiation therapy. Several studies are being carried out for the development of novel treatment approaches for improved TNBC diagnosis. As our knowledge of the molecular mechanisms behind the development of cancer has grown, a vast array of anticancer drugs has been developed. The use of chemically produced pharmaceuticals has not significantly raised the overall survival rate over the previous few decades. As such, novel approaches and cutting-edge chemopreventive medications are needed to improve the efficacy of existing TNBC therapies. Naturally occurring compounds derived from plants called phytochemicals are valuable resources for the development of novel medications for TNBC treatment. These phytochemicals often function by modulating molecular pathways associated with the onset and propagation of TNBC. Some of the specific methods include boosting antioxidant status, deactivating carcinogens, stopping proliferation, inducing cell cycle arrest, promoting apoptosis, and immune system modulation. This review's main goal is to give a summary of the active components of natural products, together with details on their molecular targets, pharmacological action, and current level of understanding. Several natural compounds that particularly target the pathways linked to TNBC in our study have been thoroughly described by us. We have done extensive research on many natural substances that could lead to the discovery of new targets for TNBC treatment.","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"16 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147893794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"4-Hydroxyderricin from Angelica keiskei: Analysis, Preparation, and Multiple Skin Care Effects","authors":"Xu Gong, Yuncai Tian, Yong Tian, Wenhuan Zhang, Wen Yan, Yong-Xin Luo, Rihui Wu, Xue-Tao Xu, Li‐She Gan","doi":"10.2174/0122103155316810240911064359","DOIUrl":"https://doi.org/10.2174/0122103155316810240911064359","url":null,"abstract":"Introduction: The content of the bioactive component 4-hydroxyderricin (4-HD) in the roots, stems, and leaves of Angelica keiskei (Umbelliferae), a well-known medicinal and edible plant, was analyzed by HPLC. The dry root contained the highest level (2. 69 ± 0.09 mg/g) of 4-HD, which was then prepared and spectroscopically identified by column chromatography. Methods: The multiple skin care activities of 4-HD, including skin whitening, anti-allergy, and antiinflammation, were evaluated on enzymatic and cellular models. 4-HD showed a significant inhibitory effect on mushroom tyrosinase, and it could also strongly suppress the activity of tyrosinase in B16F10 cells. A molecular docking study revealed that 4-HD could closely bind to tyrosinase through hydrogen bonding and hydrophobic interactions. Results: In the anti-allergic assay, 4-HD could effectively reduce the degranulation rate in the neutral red staining test and largely down-regulate the release level of β-HEX in RBL-2H3 cells at the concentration of 5 μM. 4-HD decreased the production of NO in RAW264.7 cells induced by lipopolysaccharide (LPS), showing its anti-inflammatory effect. Conclusion: The skin whitening, anti-allergic, and anti-inflammatory effects of 4-HD have clearly demonstrated its potential usage in the pharmaceutical and cosmetic industries.","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"15 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147879100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Biological Effects of Soy Isoflavones against Myocardial Ischemia-reperfusion Injuries: A Systematic Review","authors":"Saeid Heidari-Soureshjani, Negar Jafari, Shahab Masoumi, Mohsen Abbasnezhad, Catherine M.T. Sherwin","doi":"10.2174/0122103155327054240822064326","DOIUrl":"https://doi.org/10.2174/0122103155327054240822064326","url":null,"abstract":"Background: Myocardial Ischemia-Reperfusion Injury (MIRI) is associated with adverse cardiovascular outcomes that lead to the death of ischemic cardiomyocytes and, finally, dysfunction of cardiac tissue. Objectives: This systematic review aims to comprehensively investigate and systematically review the existing literature on the effects of soy isoflavones and their underlying mechanisms in mitigating MIRI injuries. Methods: A systematic search was conducted in high-coverage scientific databases, including Web of Science, MEDLINE/PubMed, Scopus, Embase, and Cochrane Library. On 6th December, 2023, an extensive literature search was done using predefined search terms (According to MeSH terms) and inclusion criteria. Any studies that investigated the effects of soy isoflavones on MIRI injuries were included. Search strategy, screening of the publications, and data extraction were performed following PRISMA guidelines 2020. Results: Diverse mechanisms underlying the cardioprotective effects of soy isoflavones against MIRI include antioxidant properties, anti-inflammatory effects, enhanced mitochondrial function, regulation of apoptosis pathways, improving angiogenesis effects, attenuating heart histological changes, modulating factors that affect hemodynamic changes, and reducing Ca+2 overload. Although most studies reported promising effects in reducing the complications of MIRI, a small number of studies also showed no significant effect in this regard. Also, they did not report any specific side effects from consuming isoflavones alone. Conclusion: The findings suggest that soy isoflavones as a complementary therapeutic strategy potentially benefit MIRI outcomes and support their role in cardiovascular health. However, further well-designed clinical trials are warranted to validate these findings and establish their clinical significance in cardiovascular disease management.","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"15 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147917498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on Fingerprint and Multiple Indicators for Quantitative Detection Method Development in Powdered Milk Thistle Extract","authors":"Tao Lan, Wenyu Zhang, Qi Zhou, Jinli Huang, Qi Wu, Congcong Yu, Shihui Luo, Xi Zhao, Ruikun He","doi":"10.2174/0122103155336785240815054045","DOIUrl":"https://doi.org/10.2174/0122103155336785240815054045","url":null,"abstract":"Introduction: Silymarins are the main active ingredient in milk thistle extract, reflecting the quality of extract products. The detection methods for silymarins in different pharmacopoeia standards may vary, which may lead to inconsistent detection results. Method: Due to the lack of research on related fingerprint spectra, its qualitative work is hard to carry out. Hence, based on existing standard methods, an HPLC method was established by optimizing the gradient program of the mobile phase. Results: The effectiveness of this method and the fingerprint was also studied. The similarity of 31 batches of samples ranged from 0.791 to 1.000, indicating the characteristic spectrum formed can be well used for qualitative analysis. Conclusion: Under optimal analytical conditions, the six silymarin compounds in the samples can achieve good baseline separation from the matrix with good resolution. At the same time, the LOD was 25 mg/kg, and the recovery rates at three levels ranged from 92% to 108%, with RSDs less than 4%. The fingerprint spectrum and content determination method established in this study had good repeatability and high accuracy, which can provide a new method for quality control of milk thistle extract.","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"15 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147878550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis and Characteristic Verification of the Quality\u0000Standard of Milk Thistle Extract","authors":"Xi Zhao, Tao Lan, Shihui Luo, Congcong Yu, Jinli Huang, Qi Zhou, Ruikun He","doi":"10.2174/0122103155315751240711060456","DOIUrl":"https://doi.org/10.2174/0122103155315751240711060456","url":null,"abstract":"\u0000\u0000Milk thistle extract is widely used in dietary supplements due to its strong\u0000hepatoprotective effect. There are some differences in the quality characteristics and standard values\u0000of milk thistle extract set by pharmacopoeias and standards in various countries and regions.\u0000\u0000\u0000\u0000To promote the standardization of quality standards for milk thistle extract, this paper\u0000summarized and compared the standard characteristics and related values settings in four different\u0000standards. At the same time, actual samples were tested for the characteristics that appeared more\u0000frequently in standard. We found that the ratio algorithm of silymarin set in the pharmacopoeia\u0000standards was not reasonable and could blur the quality of related products from the test results, especially\u0000without limiting the total amount of silymarin in the standard.\u0000\u0000\u0000\u0000We suggested setting standard values for all six silymarin characteristics, establishing more\u0000universal detection methods, and preparing relevant reference materials to match the detection methods.\u0000Based on the comparison of standards and test data, the characteristics of the ethanol content,\u0000ethyl acetate content, methanol insoluble substances, heavy metal content, and microbial characteristics\u0000should draw more attention and should be considered in the future for setting newly formulated\u0000standards.\u0000\u0000\u0000\u0000This paper lays the data foundation for developing higher quality standards for milk\u0000thistle extract, which plays an important role in promoting the international trade of milk thistle extract.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":" 45","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141825442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomic Study on the Intervention Mechanism of the Mongolian\u0000Medicine Forsythia-4 in Rats with Liver Damage Induced by Pyloric\u0000Ligation","authors":"Huan Wang, Juhua Gong, Ning Hai, Minghai Fu, L. A, Huifang Li","doi":"10.2174/0122103155315546240708114752","DOIUrl":"https://doi.org/10.2174/0122103155315546240708114752","url":null,"abstract":"\u0000\u0000Forsythia-4 is an herbal formula commonly used in traditional Mongolian\u0000Medicinal clinics to treat peptic ulcers. However, the mechanism of its pharmacological components\u0000has not yet been fully characterized.\u0000\u0000\u0000\u0000The study aimed to evaluate the biological basis for the clinical prevention and preventive\u0000treatment of uncontrolled liver function caused by metabolomics from Forsythia-4 to investigate the\u0000intervention mechanism in rats with liver injury caused by pyloric ligation (PL).\u0000\u0000\u0000\u0000PL was performed to induce gastric and duodenal ulcers in rats, which were then treated\u0000with oral Forsythia-4 (Solongga-4) for 15 days. PL-induced Liver Damage. Therapeutic effects were\u0000characterized by pathological and histological evaluations, and inflammatory indicators were analyzed using an enzyme-linked immunosorbent assay. Microarray analyses were conducted to identify\u0000liver tissue gene expression profiles in PL rats with or without Forsythia-4 treatment and detected\u0000chemical composition by UPLC-Q/TOF-MS/MS.\u0000\u0000\u0000\u0000Forsythia-4's effects on rat serum revealed that the levels of ALT and AST in the model\u0000group were significantly higher (p < 0.01) than in the control group and that they were significantly\u0000lower (p < <0.05) in the medication administration group than in the model group. The contents of\u0000BILD2 and SBIL3 in the model group were considerably higher (p < 0.01) compared with the control group and significantly lower (p < 0.05) in the medication administration group compared with\u0000the model group. These effects of Forsythia-4 in serum with pyloric ligation liver injury. In rats with\u0000liver damage brought on by pyloric ligation, Forsythia-4's serum metabolic profile study revealed 25\u0000metabolic alterations from the model group and 39 metabolites from the drug administration group.\u0000IGFBP1, which was upregulated in the model group compared to the control group and downregulated in the administration group compared to the model group, was the regulator of the differential metabolite's pathway for arachidonic acid metabolism.\u0000\u0000\u0000\u0000Pyloric ligation can alter the regulation of the IGFBP1 factor in the pathway that produces adipose tissue, and after Forsythia-4 intervention, the regulation of the IGFBP1 factor in the\u0000route that produces adipose tissue returns to normal.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":" 35","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141832900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing Drug Delivery with Plant Protein-based Nanoparticles: A\u0000Comprehensive Overview","authors":"Minal Narkhede, Nandini Patil","doi":"10.2174/0122103155306353240704072716","DOIUrl":"https://doi.org/10.2174/0122103155306353240704072716","url":null,"abstract":"\u0000\u0000The advancement of nanotechnology has made it possible to deliver small molecular\u0000drugs in nano-sized particles to target tissues. In this context, natural biomolecules, such as proteins,\u0000have gained significant attention as a safer alternative to synthetic polymers commonly used in nanoparticle production. Plant proteins, in particular, are preferred over animal proteins due to their\u0000lower risk of causing allergic reactions. Notable plant proteins include zein, soy protein, and wheat\u0000protein (gliadin, gluten). Plant protein nanoparticles can be fabricated using various methods, including emulsion, electrospray, desolvation, and complex coacervation, utilizing plant proteins like zein,\u0000gliadin, legumin, and soy protein. This review provides an overview of several plant proteins, their\u0000applications as excipients or vehicles in drug delivery, and the methods employed to fabricate plant\u0000protein nanoparticles. The review aims to shed light on the utilization of natural proteins as alternative excipients in nanotechnology\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"34 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141663718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review on Antimicrobial Properties of Prickly Pear Cactus Opuntia\u0000ficus-indica (L.) Miller: An Update","authors":"Mohamed Senouci-Bereksi, A. Khadir","doi":"10.2174/0122103155320334240626075057","DOIUrl":"https://doi.org/10.2174/0122103155320334240626075057","url":null,"abstract":"\u0000\u0000The use of aromatic and medicinal plants and their bioactive compounds in the development\u0000of new antimicrobial agents for the treatment of infectious diseases has become a very urgent\u0000issue due to the emergence of microbial strains resistant to anti-infectious treatments. Opuntia ficusindica\u0000(L.) Miller, also known as prickly pear, is a wild plant native to arid and semi-arid regions. It\u0000can be considered a source of food or used for various production purposes, and it is widely known\u0000for its beneficial properties. The different parts of this plant, such as cladodes, fruits, peels, and\u0000seeds, could have remarkable therapeutic potentials due to their content of phenolic compounds,\u0000polyunsaturated fatty acids, pigments, sterols, and other active compounds, and are safe for human\u0000use. This includes antioxidant, anti-inflammatory, gastroprotective, antiulcer, antiviral, and anticancer\u0000effects, among others. The antimicrobial action of extracts and phytochemical compounds\u0000from different parts of cactus has been shown in different scientific experiments against bacteria,\u0000fungi, and viruses, and their therapeutic potentials have been reported, thus contributing to a decrease\u0000in drug resistance. This article presents a comprehensive review of the scientific literature on the\u0000antimicrobial activity of Opuntia ficus-indica and the role of its phytocompounds in the fight against\u0000antimicrobial resistance.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":" 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141680926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}