The Natural Products Journal最新文献

{"title":"Salacia reticulata: An Integrative Review of Its Antioxidant, Lipid-Lowering,\u0000and Glucose-Regulating Properties in Diabetes and Obesity","authors":"Muskan, Lakshay Panwar, B. Chopra, Geeta Deswal, Ajmer Singh Grewal, Ashwani K. Dhingra, Kumar Guarve","doi":"10.2174/0122103155298189240415092518","DOIUrl":"https://doi.org/10.2174/0122103155298189240415092518","url":null,"abstract":"\u0000\u0000Across the globe, approximately half of the population diagnosed with diabetes use complementary\u0000medicines for the treatment of diabetes. Salacia reticulata (family Hypocrataceae), is an\u0000indigenous woody climber flowering plant commonly employed within the Ayurvedic healthcare\u0000framework for addressing diabetes and obesity. It is also known as KothalaHimbutu and grows in the\u0000dry zone forests of India and Sri Lanka. It is documented to exhibit antioxidant, lipid-lowering, hypertrophy-\u0000reducing, and fibrosis-inhibiting properties and hepatoprotective activity. We critically\u0000analyze the available in-vitro, animal, and clinical research supporting the utilization of Salacia reticulata\u0000in managing type 2 diabetes and obesity. Compounds that have been recognized for their\u0000ability to counteract diabetes include salacinol, kotalanol, ponkoranol, and salaprinol. Various invitro\u0000research depicted salacia's capacity to impede intestinal alpha-glucosidase function. Furthermore,\u0000it enhances the breakdown of stored fat (lipolysis) and reduces insulin resistance by increasing\u0000the production of messenger RNA for hormone-sensitive lipase (HSL) as well as adiponectin, respectively,\u0000in the mouse mesenteric fat. Salacia reticulata treatment up-regulates the lipolysis factors\u0000while downregulating the 3T3-L1 adipocytes lipogenesis factors. Both animal studies and clinical\u0000research consistently showed significant improvement in levels of glucose when fasting compared to\u0000being exposed to sucrose and maltose. Furthermore, 6 weeks to 3 months of treatment showed a\u0000substantial reduction in the HbA1C and plasma Insulin. Salacia reticulata efficiently decreases obesity\u0000and insulin resistance while enhancing glucose metabolism therefore, more substantial evidence\u0000derived from meticulously designed research is necessary to confirm its effectiveness and safety.\u0000Moreover, the research aimed at improving the growth of callus, increasing polyphenolic content,\u0000promoting mangiferin synthesis, and assessing the biological properties of the salaciagenus suggests\u0000its potential as a valuable source for the industrial production of important industrial secondary compounds.\u0000At the same time, data indicate cumulative knowledge, highlighting its strong antioxidant\u0000effect and unveiling its capabilities without impacting natural reserves.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140662684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Plant Secondary Metabolites against Lung Cancer: A Comprehensive\u0000Review on Apoptosis Induction and Synergistic Potential","authors":"Nirupama Rani Dewangan, Prachi Agrawal, Priyanka Sahu, Dalchand Sahu, Megha Yadav, Priyanka Gupta, B. Ahirwar","doi":"10.2174/0122103155293700240408043538","DOIUrl":"https://doi.org/10.2174/0122103155293700240408043538","url":null,"abstract":"\u0000\u0000Lung carcinoma is the most ubiquitous and fundamental cause of cancer-related mortality\u0000globally. The conventional therapeutic approaches for lung cancer have consistently encountered\u0000several challenges and complexities, prompting the exploration of novel tactics for the detection and\u0000management of cancer. Lung cancer is a highly preventable disease, and early-stage detection significantly improves patient’s survival rates. Several distinct medicinal substances from plants aid in\u0000treating human illnesses and promoting good health. Plants, including Astragalus propinquus, Curcuma longa, Anethum graveolens, Allium cepa, etc., are utilized as medicines to treat lung cancer. It\u0000can be effectively treated using plant secondary metabolites like flavonoids, phenolics, terpenoids,\u0000steroids, alkaloids, and polyphenols. This review describes the structures of plant metabolites and the\u0000process by which they induce apoptosis against lung cancer. This data will assist in the comprehensive awareness and understanding of the factors that combat phytochemicals against lung cancers\u0000and the production of new anti-cancer medications.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"87 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140702540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of the Molecular Mechanism Underlying the Antidiabetic\u0000Activity of a Northeast Indian Plant Zingiber rubens Roxb. through\u0000Modulation of PKC Phosphorylation","authors":"Sujit Das, Piyali Devroy, Suraj Kumar Chatterjee, Sandipan Jana, Srijon Gayen, Suparna Ghosh, Manas Bhowmik, A. Bala, P. Haldar","doi":"10.2174/0122103155292112240407113802","DOIUrl":"https://doi.org/10.2174/0122103155292112240407113802","url":null,"abstract":"\u0000\u0000Zingiber rubens Roxb., a new species of the Zingiberaceae family, is found\u0000profoundly in the Northeastern region of India. It is a rhizomatous geophyte and grows primarily in\u0000the seasonally dry tropical biome native to Indo-China regimens.\u0000\u0000\u0000\u0000The aim is to research the root part of this plant to discover active constituents and evaluate the molecular mechanism of antidiabetic activity\u0000\u0000\u0000\u0000The hydroalcoholic root extract of this plant (HAZR) was evaluated for in-vitro antioxidant assays α-amylase and α-glucosidase inhibition assay. Further, the antidiabetic activity assay was\u0000evaluated, exploring the molecular mechanism for modulating oxidative stress in tissue biochemical\u0000parameters and HbA1c. To explore the molecular mechanism, we also investigated the inhibition\u0000assay of protein kinase C (PKC) phosphorylation in mouse peritoneal macrophages.\u0000\u0000\u0000\u0000The experiments' results helped to conclude that HAZR has potent antioxidant and antidiabetic activity and could have been embedded with potent active molecules. They also revealed the\u0000mechanism of action as inhibition of PKC phosphorylation, meriting further studies.\u0000\u0000\u0000\u0000The present study revealed that HAZR demonstrated its antidiabetic activity against\u0000diabetic animal models through oxidative stress-mediated PKC and TGF-β regulation in diabetic\u0000individuals.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"17 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140702941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Potential of Dicentrine in Human Disorders: A Review On\u0000Medicinal Importance and Pharmacological Activities of Aporphine\u0000Alkaloid","authors":"K. Patel, D. Patel","doi":"10.2174/0122103155280229240404041828","DOIUrl":"https://doi.org/10.2174/0122103155280229240404041828","url":null,"abstract":"\u0000\u0000Plants have always been an important source of food and drugs, in addition\u0000to their application in medical and cosmetic sectors. The popularity of herbal remedies has increased\u0000in many countries in recent decades. Herbal medicines contain numerous active phytocomponents\u0000with different biological activities. Alkaloid class phytochemicals have diverse chemical structures\u0000and pharmacological activities in nature. Additionally, Aporphinoids are an important class of plant\u0000secondary metabolites that have been used for the treatment of numerous human disorders for a long\u0000time in traditional medicine. Dicentrine is an aporphine class phytochemical isolated from numerous\u0000medicinal plants, including Actinodaphne sesquipedalis and Lindera megaphylla.\u0000\u0000\u0000\u0000The biological potential of dicentrine, an aporphine alkaloid derivative, has been described\u0000in the present work. Scientific data on dicentrine were collected here from different scientific databases and presented in this paper in order to know the biological importance of dicentrine in medicine for the treatment of human complications. Further, detailed pharmacological activities and scientific data on dicentrine were also analyzed in order to determine its therapeutic potential in medicine. Moreover, its analytical aspects were also described in this work to understand its separation\u0000and isolation methods.\u0000\u0000\u0000\u0000The present work described the biological potential of dicentrine in medicine and its analytical aspects. It signified the biological potential of dicentrine in cancer, breast cancer, oral squamous\u0000cell carcinoma, lung adenocarcinoma, blood pressure, inflammatory disorders, hyperlipidaemia,\u0000arrhythmia, stomach muscle, and glomerulonephropathy. Further, its effectiveness in medicine was\u0000found to be mainly because of its antiplatelet, alpha 1-adrenoceptor, epidermal growth factor, antiprotozoal, larvicidal, antimicrobial, topoisomerase II, and acetylcholinesterase inhibitory potential.\u0000Moreover, other scientific data also signified its metabolism and pharmacokinetic parameters in\u0000terms of its analytical aspects in medicine.\u0000\u0000\u0000\u0000The present review gives us an updated summary of the scientific information for\u0000pharmacological activities and analytical aspects of dicentrine in medicine. It also signified the potential contribution of dicentrine in medicine for the development of a newer class of drug molecules\u0000for human disorders.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"8 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140700940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunological Implications in Diabetes: A Review on Various Diseases\u0000and Conditions","authors":"Sanskriti Upadhyay, AvijitAvijit Mazumder, Bhavani Pentela, Priyanka Bansal, Neeraj Agarwal, Dileep Singh Baghel","doi":"10.2174/0122103155298605240303181317","DOIUrl":"https://doi.org/10.2174/0122103155298605240303181317","url":null,"abstract":"\u0000\u0000Diabetes Mellitus (DM) is a long-term metabolic condition that has significant social,\u0000health, and economic consequences. There are various forms of diabetes mellitus, but the two most\u0000common varieties are type I and type II. Insulin-dependent diabetes (IDDM) is one of the most wellknown\u0000autoimmune illnesses that cause insulin insufficiency and hyperglycemia by either damaging\u0000or destroying Langerhans' beta cells. Available scientific data evidenced the greatest genetic contribution\u0000of Human Leukocyte Antigen class II in the IDDM. Hyperglycemia and individual components\u0000of the insulin resistance (metabolic) syndrome put people with type II diabetes at increased risk\u0000for microvascular consequences (retinopathy, nephropathy, and neuropathy) as well as macrovascular\u0000issues (cardiovascular comorbidities). A number of pathophysiological abnormalities, including\u0000obesity, poor diet, and physical inactivity, as well as genetic variables, are involved in the disturbed\u0000glucose homeostasis associated with type II diabetes. Diseases like lipid abnormalities contribute to\u0000the progression of diabetes, whereas obesity and its related medical disorders (such as hypertension,\u0000diabetes, insulin resistance, and sleep apnea syndrome) are eventually linked to an elevated cardiovascular\u0000risk. Diabetes raises the incidence, intensity, and duration of peri-densities in people with\u0000diabetes compared to healthy persons, making it a risk factor for periodontal disease. Diabetes conditions\u0000in patients concurrently also increase the progression or risk of other diseases, i.e., cardiovascular-\u0000related diseases (hypertension, oxidative stress, hyperlipidemia), nervous system-related diseases,\u0000and COVID-19, by increasing the overall infection rate. There is widespread evidence that correlates\u0000the direct connection between diabetes and other diseases, including immunity disorders, CVS disorders,\u0000etc. This review provides a correlation between diabetes and another disease with an overall\u0000impact on the progression of cardiovascular diseases, neurological diseases, COVID-19, and periodontal\u0000diseases. This current review focuses on the collation of some plants that show antidiabetic\u0000activity, including plant part, family, chemical constituent, mechanism of action, and chemical used\u0000for extraction. Studies on the role, causes, clinical management, prevention, and treatment of diabetes\u0000heavily rely on epidemiological evidence. This review also explains different factors responsible\u0000for diabetes, like genetic factors, environmental factors, and viral infections.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"91 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140746834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review on the Evolution of Natural Mutation-dependent\u0000Antiviral Drug Resistance in Hepatitis C Virus (HCV) Genotypes\u0000Prevalent in Saudi Arabia: A Genomic and Therapeutic Perspective","authors":"M. Izhari","doi":"10.2174/0122103155291056240327033157","DOIUrl":"https://doi.org/10.2174/0122103155291056240327033157","url":null,"abstract":"\u0000\u0000Background: The characterization of resistance-associated amino acid substitution\u0000(RAAS) in direct-acting antivirals (DAA) molecular targets could reshape the treatment strategy for\u0000HCV infection. Hence, this review aimed to provide evidence on the impact of the RAASs on DAA\u0000treatment for HCV.\u0000\u0000Methods: PRISMA model was followed for the literature survey and evaluation (sources: PubMed,\u0000Sci-Hub, and Google Scholar). RAASs in DAA target proteins and their locations were mapped on\u00003-D proteins using two reference protein sequences: NS3/ID: AAA72945.1 and NS5A/NS5B/ID:\u0000NP_671491.1. NCBI-Basic Local Alignment Tool, UniProt and AlphaFold2/MMSeqs2, PyMol, and\u0000R-base/R-studio were used for alignment, retrieval of protein sequences, 3-D protein structure modeling,\u0000visualization of locations of RAASs, and diagrammatic representations, respectively.\u0000\u0000Results: Genotype 4 afterwards genotype 1 was the most prevalent in Saudi Arabia. L2003M,\u0000Y2065N, M2000T, L2003V, and Q2002H RAASs were anti-NS5A inhibitor. NS5A-Q2002H was\u0000anti-daclatasvir in genotype 4. NS5A-Y2065H and NS5B-S2702T in genotype 1 were antisofosbuvir-\u0000resistant. NS3-A1182V, NS3-Q1106K/R, and NS3-T1080S RAASs exhibited resistance\u0000to double antivirals. NS3-D1194A RAAS was a multi-drug resistant variant (against 3 DAAs). NS3-\u0000V1062A, NS3-D1194G, NS3-D1194E/T, NS3- S1148R, NS3-V1196A, NS3-V1062LNS3-S1148A,\u0000and NS3-S1148G RAASs in genotype 1 were single drug-resistant variants. NS3- S1148R and NS3-\u0000S1148A in genotypes 2 and 5 were anti-simeprevir-resistant variants.\u0000\u0000Conclusions: An array of identified RAASs, RAAS-dependent DAA treatment failure, and recommended\u0000combination DAA therapy in such clinical scenarios of RAASs are the significant outcomes\u0000of this research. RAAS-linked in vitro and in vivo resistance profiling at genotype/sub-genotype level\u0000will be crucial in treatment choice and for future DAA design strategies.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"1010 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140749328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of Omics Approaches in Unravelling the Potency of\u0000Cordyceps militaris in Drug Discovery","authors":"Ewen Se Thoe, Yoke Yin Chia, Yinquan Tang, Sunita Chamyuang","doi":"10.2174/0122103155294164240323134513","DOIUrl":"https://doi.org/10.2174/0122103155294164240323134513","url":null,"abstract":"\u0000\u0000Natural products have long garnered the interest of scientific communities as they have\u0000proven to be an effective therapeutic resource that paved the path for medicinal research and drug\u0000development. Among them, Cordyceps militaris is an entomopathogenic caterpillar fungus with a\u0000renowned history of being utilized as a medicinal remedy for centuries in Eastern civilizations. The\u0000number of pharmacological functions reported by this specific fungus resulted in continuous efforts\u0000to unravel new effective bioactive compounds and their corresponding mechanism of action. As time\u0000progresses, computational techniques become the forefront of genomic and proteomic analysis, besides\u0000acting as a platform for integrating various up-to-date multidisciplinary data sources. This review\u0000briefly introduces Cordyceps militaris alongside the latest known biologically active compounds\u0000and their respective therapeutic potential. The need to implement computational applications\u0000to cope with the continuous phytochemical evolution of Cordyceps militaris will be illustrated.\u0000Moreover, many databases, mathematical algorithms, or sourcing tools that could benefit data visualization,\u0000dissemination, and interpretation aligned to fungal-based research are enumerated, in addition\u0000to describing some of the broad discoveries relative to Cordyceps militaris in the past. In conclusion,\u0000using advanced computational technology may be the foundation to leverage natural product\u0000discovery about Cordyceps militaris and contribute to future mass production of this fungus for\u0000commercial purposes in the world pharmaceutical industry.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"247 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140749905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanism and Research Progress of Agarwood in Improving Recurrent Oral Aphthous Ulcer and Ulcerative Colitis","authors":"Xiang Guo, Diwas Sunchuri, Zhu-Ling Guo","doi":"10.2174/0122103155291829240327110121","DOIUrl":"https://doi.org/10.2174/0122103155291829240327110121","url":null,"abstract":"\u0000\u0000Recurrent oral aphthous ulcer (RAU) is a common oral disease closely associated with\u0000oral flora disorders, immune dysfunction, and gastrointestinal dysfunction. Ulcerative colitis (UC)\u0000is a chronic inflammatory disease in the intestinal tract that manifests as infiltration of intestinal\u0000inflammatory cells and damage to the intestinal mucosa, often involving extraintestinal manifestations,\u0000including RAU in the UC population. The oral cavity and intestinal tract are the two major\u0000parts of the body rich in microbiota, each constituting the beginning and end of the digestive tract,\u0000and are particularly closely linked. Quercetin, a flavonoid of sedum, is a natural class of drugs with\u0000antioxidant, anti-inflammatory, antibacterial, and analgesic properties. This paper mainly reviews\u0000the interconnection between recurrent oral aphthous ulcer and ulcerative colitis and aims to investigate\u0000the mechanism of action of sedum quercetin in relieving oral and intestinal inflammation and\u0000conclude that sedum quercetin exerts anti-RAU and UC effects by regulating oral-intestinal axis\u0000flora disorder, strengthening mucosal barrier, and relieving inflammation and pain. It provides new\u0000insights for the adjuvant treatment of RAU and UC.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140751813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Development and Application on Inclusion of Herbal Phytochemicals\u0000in Novel Herbal Drug Delivery System","authors":"Aziz Ahmed, Rizwan Ahmad, Surbhi Jangir, Deeksha Sharma","doi":"10.2174/0122103155281428240320091344","DOIUrl":"https://doi.org/10.2174/0122103155281428240320091344","url":null,"abstract":"\u0000\u0000Herbal phytochemicals as secondary metabolites are present in herbal medicines. Herbal\u0000medicines can be used to treat a wide range of illnesses and diseases. The Novel herbal drug delivery\u0000system approach includes transfersomes, ethosomes, microspheres, phytosomes, liposomes, polymeric\u0000nanoparticles, and nanocapsules. The novel herbal drug delivery systems have several benefits\u0000over conventional herbal remedies. Herbal medicines are less expensive and have fewer serious side\u0000effects than generic medications. The novel herbal drug delivery systems have several benefits over\u0000conventional herbal remedies. These include improved solubility and bioavailability, protection from\u0000side effects, improved pharmacological action, increased stability, better delivery to tissue macrophages,\u0000consistent delivery, and defense against active ingredients' physical and chemical breakdown.\u0000There is a need for a novel method of active components of drugs to apply on target organs or\u0000sites of the human body to avoid repeated administration of dosage forms and enhance patient adherence.\u0000Scientists have tried to focus on advanced mechanisms or processes for delivering herbal components\u0000into the human body. Novel Herbal Drug Delivery System helps to boost drug efficacy by\u0000lessening side effects and enhancing the blood level of the drug. Novel herbal formulations can reduce\u0000recurrent administration of medicines and noncompliance of patients.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":" 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140385190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Deep Insight into Chemistry and Pharmacology of Genus Angelica.: An\u0000Up-to-date Systematic Review","authors":"A.K. Mishra, S.K. Paliwal","doi":"10.2174/0122103155287588240314065437","DOIUrl":"https://doi.org/10.2174/0122103155287588240314065437","url":null,"abstract":"\u0000\u0000Healthcare providers globally need plant-derived bioactive compounds for\u0000the treatment of ailments. The present systematic review article emphasizes the chemistry and pharmacology\u0000parts of various Angelica species, family Apiaceae. The species of Angelica genus, native\u0000to the Indian Himalayan, are beneficial for several therapeutic and edible purposes. Aromatherapy\u0000uses essential oils obtained from various species of the Angelica genus. The population of various\u0000Angelica species is declining quickly due to premature destructive harvesting. The traditional medicinal\u0000system involves Angelica glauca Edgew and other Angelica species to treat respiratory, Central\u0000Nervous System (CNS) disorders and many more ailments.\u0000\u0000\u0000\u0000An extensive literature survey on the chemistry and pharmacological aspects of various\u0000Angelica species, including A. glauca, secondary metabolites, mechanism behind various pharmacological\u0000activities, and marketed products of plants of Genus Angelica was conducted using scientific\u0000databases. The search terms Angelica species, botanical description, wild Angelica, important phytoconstituents\u0000and their pharmacological responses, plant parts used, and the molecular mechanism\u0000behind observed prominent activities were used for data collection. In total, 92 publications were\u0000included from year 1983 to 2023. Articles focusing on other than Angelica species and other than the\u0000English language were excluded from the study. Also, the papers with no full-text availability were\u0000excluded from the present study. Species of the Angelica genus have been known for a wide range of\u0000biological activities, including antioxidant, anti-inflammatory, antimicrobial and immunotoxic.\u0000\u0000\u0000\u0000The present paper highlights the secondary metabolites present in the Angelica species and\u0000their scientific uses.\u0000Ancient Ayurvedic treatise claims several other pharmacological activities, but scientific validation\u0000of some indications, including the exact mechanism of action, is underway.\u0000\u0000\u0000\u0000This review compiles 30 years of data on Angelica species related to their phytochemistry,\u0000pharmacology, molecular mechanisms of bioactivity, recent advancements and possible future\u0000scope of applied and translational research.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"37 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140229037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}