The Natural Products Journal最新文献

{"title":"Role of Polyphenols to Attenuate Depressive Disorders and Cognitive\u0000Impairments Associated with Diabetes Mellitus – A Comprehensive\u0000Review","authors":"Sejuti Ray Chowdhury, Sourav Ghosh, Monosiz Rahaman, Srabona Dutta","doi":"10.2174/0122103155295956240529155913","DOIUrl":"https://doi.org/10.2174/0122103155295956240529155913","url":null,"abstract":"\u0000\u0000Diabetes Mellitus and its associated brain disorders become more prevalent across the\u0000globe. Several comorbidity factors are associated with diabetic mellitus as well as the nervous system.\u0000Static molecular variations in the Central Nervous System (CNS) due to Hyperglycemia may be\u0000a major cause of psychiatric disorders. Carbohydrates and proteins imbalance as metabolic parameters\u0000impact the downregulation of neurotransmitters in the brain region. Glucose metabolism has a\u0000key role in brain physiology as well as in neuro-energetics, transmission, and defensive mechanisms\u0000of the brain. Several studies revealed that CNS-acting medications overstated the glucose homeostasis\u0000associated with brain functioning as well as pharmacological effects. Polyphenols are an assembly\u0000of plant-derived composites with anti-inflammatory properties working on the inflammatory\u0000markers as well as antioxidant possessions that decrease the oxidative stress that is accompanied by a\u0000low pervasiveness of metabolic conditions categorized by insulin resistance. Those Natural products\u0000influenced the molecular signaling pathway, which is directly related to depression, cognitive impairment\u0000and neurotransmission. Currently, there are not any exact pharmacotherapies accessible for\u0000CNS form-induced diabetes. However, around some prebiotics, probiotics with natural remedies\u0000show promise in treating these central nervous system difficulties. Consequently, proof-based research\u0000concluded the translational study with a clinical setting understanding the connotation among\u0000brain glucose homeostasis and central nervous system complications is warranted, and the progress\u0000of pharmacologically dynamic therapy for active treatment of comorbidities diseases related to diabetes\u0000mellitus.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"21 36","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141379998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Herbal Therapy in Dermatology: A Review of Malaysian Medicinal\u0000Plants","authors":"Nuraina Izzati Zulkepli, Nurul Izzati Osman","doi":"10.2174/0122103155309168240529105952","DOIUrl":"https://doi.org/10.2174/0122103155309168240529105952","url":null,"abstract":"\u0000\u0000Dermatology is a medical aspect that revolves around the diseases of the skin. The incorporation\u0000of medicinal plants in the treatment of skin diseases has been widely used since ancient\u0000days. Malaysia is blessed with various plant species and rich biodiversity with tropical weather yearround.\u0000With the emerging use of medicinal plants in dermatology, more studies on their potential\u0000therapeutic effects need to be reviewed thoroughly. Thus, the purpose of this work is to critically\u0000review relevant publications on related pharmacological activities and potential use of Malaysian\u0000plants for dermatological purposes. The articles that were found related to the research field were\u0000retrieved from several online databases like PubMed, Google Scholar, Scopus, Hindawi, and\u0000ScienceDirect published from 2016 to 2022. The pharmacological activities that were commonly\u0000associated with the treatment of skin diseases include anti-inflammatory, antioxidant, antibacterial,\u0000and wound healing. Various phytochemical compounds such as flavonoids, alkaloids, phenols,\u0000tannins, and vitamins were found to contribute to the therapeutic potential of plant extracts against\u0000skin diseases. In conclusion, the understanding of the plant’s pharmacological activities is important\u0000to evaluate its therapeutic potential to be used against specific skin diseases. More reliable references\u0000are required to ensure safety and efficacy of medicinal plants in dermatology.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"64 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141381560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Herbal Medicine on Insulin Signaling Pathways and Insulin\u0000Resistance in Metabolic Dysfunction-associated Fatty Liver Disease: A\u0000Review","authors":"Amds Karunaratna, Sagarika Ekanayake","doi":"10.2174/0122103155308948240528050738","DOIUrl":"https://doi.org/10.2174/0122103155308948240528050738","url":null,"abstract":"\u0000\u0000Metabolic dysfunction-associated fatty liver disease (MAFLD) is the most\u0000common chronic liver disease progressing towards a substantial global health concern. A multitude\u0000of therapeutic agents are being used to treat MAFLD. The high prevalence and adverse effects of\u0000drugs have increased the global popularity of herbal medicines (HMs) as effective therapeutic agents\u0000to treat MAFLD. Among the causes of pathogenesis, insulin resistance (IR) plays a crucial role in\u0000MAFLD. Hence, the amelioration of IR has emerged as a promising target for potential therapeutic\u0000approaches in MAFLD.\u0000\u0000\u0000\u0000This study aimed to explore in vitro and in vivo mechanisms that unveil recent advances in\u0000HMs that target the amelioration of IR in MAFLD.\u0000\u0000\u0000\u0000Electronic databases, including PubMed and MEDLINE, were used to\u0000search literature for HMs in the management or treatment of NAFLD published up to March, 2023.\u0000The three primary search terms were “MAFLD” “NAFLD” and “HM”. MeSH of NAFLD, such as\u0000(Non-alcoholic fatty liver disease, Non-alcoholic Steatohepatitis) and HM (Medicinal plants, Plant\u0000extracts), and keywords were used to optimize the search strategy\u0000\u0000\u0000\u0000HMs act on a multitude of molecular pathways that increase insulin sensitization including\u0000upregulation of the secretion and activation of insulin receptor substrate (IRS) proteins, upregulation\u0000of phosphatidylinositol 3-kinase (PI3K)/AKT (also known as PKB or protein kinase B) signaling\u0000pathway, activation of the 5' AMP-activated protein kinase (AMPK) pathway and modulation of\u0000enzymes of glucose homeostasis, regeneration of the pancreatic β-cell mass, modulation of secretion\u0000of adipokines, enhancement of the uptake of glucose into tissues via increased expression of GLUT\u0000in tissues, and upregulation of FGF1/FGF1R signaling pathway.\u0000\u0000\u0000\u0000HMs possess a multitude of potential actions that reduce the IR and improve glucose\u0000homeostasis. Hence, HMs are a promising resource as effective medications for the treatment of\u0000MAFLD.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"52 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141387540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revolutionizing Plant Tissue Culture: Harnessing Artificial Intelligence\u0000for Precision Propagation and Optimization","authors":"Preeti Kaushik, Madhu Rani, Neha Khurana, P. Pandey, Payal, Sonia Kapoor","doi":"10.2174/0122103155302871240527094915","DOIUrl":"https://doi.org/10.2174/0122103155302871240527094915","url":null,"abstract":"\u0000\u0000Plant tissue culture is a process of in-vitro regeneration requiring numerous resources and\u0000intensive labour to mass produce disease-free clones. Diverse factors such as sterilizing agents, media\u0000composition, and environmental conditions contribute toward successful regeneration and decide\u0000the production, such as the total shoot number, shoot length, in vitro rooting, and adaptation of plants\u0000to the external environment. Plant tissue culture, the successful induction of rapid shoot production,\u0000and subsequent root formation in plants are influenced by the utilization of appropriate growing conditions\u0000customized to each specific explant type. By carefully manipulating environmental factors,\u0000such as temperature, light, and nutrient availability, it is possible to stimulate the growth and development\u0000of new shoots in a time-efficient manner. This strategic combination of optimal growing\u0000conditions and hormone supplementation holds great promise in the domain of efficient propagation\u0000of plants through tissue culture techniques. The recent progress in artificial techniques such as artificial\u0000neural networks (ANN) and machine learning (ML) algorithms has presented promising opportunities\u0000for the development of sustainable and precise plant tissue culture processes. These techniques\u0000are widely recognized as robust techniques for assessing outcomes and enhancing the accuracy\u0000of predicting outputs in the domain of plant tissue culture. AI techniques and optimization algorithms\u0000have been applied to predict and optimize callogenesis, embryogenesis, several shoots, shoot\u0000length, hairy root culture, in vitro rooting, and plant acclimatization by helping predict sterilizing\u0000conditions, optimal culture conditions, and formulation of a suitable medium. Patents, modeling, and\u0000formulation of each stage of plant tissue culture using tools like artificial neural networks (ANNs),\u0000neuro-fuzzy logic, support vector machines (SVMs), decision trees (DT), random forests (FR), and\u0000genetic algorithms (GA) are presented.\u0000\u0000\u0000\u0000In this article, the current state of Artificial Intelligence (AI) algorithms, including their\u0000applications in all elements of plant tissue culture, as well as the patents that have been gained for\u0000these algorithms, are dissected in great detail\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"74 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141387291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting the Receptor Complexes by Structure-based Natural Drug Compounds in Seizures: A New Dimension in Drug Discovery and Design","authors":"Elahe Aleebrahim-Dehkordi, Ali Jafari, A. A. Bala, Ahmadreza Lagzian, Hamed Ghoshouni, Pooneh Koochaki, Neda Faal Hamedanchi, Sayedeh Zohreh Azadeh-Ghahfaroghi, Fariba Azadikhah, Nafiseh Taei, Sahar Valizadeh, Shirin Saberianpour, Hamidreza Zalpoor","doi":"10.2174/0122103155289394240522110321","DOIUrl":"https://doi.org/10.2174/0122103155289394240522110321","url":null,"abstract":"\u0000\u0000A seizure is the brain's uncontrolled, abnormal electrical activity, which may result in\u0000altered states of consciousness, behavior, memory, or emotion. Seizures start biologically with the\u0000activation of susceptible brain neurons, which causes synchronized discharges of larger groups of\u0000connected neurons. A few potential causes of seizures include medications, genetics, electrolyte abnormalities,\u0000sleep state, infections, brain inflammation, and injuries. Medicinal plants are a rich\u0000source of various chemical molecules with distinct structures and biological activity. Most plants\u0000contain active components, including coumarin, glycosides, alkaloids, terpenoids, flavonoids, peptidoglycans,\u0000and other elements often associated with the effects of antiseizures. Isolating and identifying\u0000biologically active compounds and molecules from nature have resulted in the development of\u0000novel treatments, which in turn have contributed to the advancement of the health and pharmaceutical\u0000sectors throughout the history of humanity. In this review, we thoroughly summarize the information\u0000on the anti-seizure activities of medicinal plants and bioactive chemicals, focusing on molecular\u0000targets and cellular signaling pathways. All available research has contributed to medicinal\u0000plants as a reasonable option for seizure prevention and treatment, as well as drug development and\u0000manufacturing. To better comprehend the underlying molecular mechanisms, more research is required.\u0000If these mechanisms are discovered, it will be easier to identify new targets and create innovative\u0000anti-seizure therapeutic drugs to enhance patient survival and life quality. This work is expected\u0000to provide insights and ideas for the further research of Bioactive compounds from medicinal\u0000plants, their qualities, and the scientific basis for their improved clinical use.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141387981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolites of Culinary-medicinal Mushroom Hericium erinaceus Showed Anti-neuroinflammatory Activity in BV2 Cells and Anti-H2O2-induced\u0000Oxidative Stress Activity in SH-SY5Y Cells","authors":"Jing Wei, Chao Lin, Zhen-xin Wang, Yi-Lin Zhang, Shi-Xi Li, Xuan-Sheng Hu, He-Ping Hui, Zhe Wang, Yi-Qi Zhao, Xue-Jun Wang, Jianzhao Qi","doi":"10.2174/0122103155295894240528061315","DOIUrl":"https://doi.org/10.2174/0122103155295894240528061315","url":null,"abstract":"\u0000\u0000Hericium erinaceus is a versatile mushroom with potential therapeutic benefits.\u0000A variety of bioactive compounds have been found in this mushroom that have anti-ulcer, antiinflammatory,\u0000immunomodulatory, and blood sugar and lipid regulating effects.\u0000\u0000\u0000\u0000The aim is to isolate and characterize compounds from the rice medium of H. erinaceus\u0000and evaluate their potential therapeutic effects on oxidative stress-associated diseases.\u0000\u0000\u0000\u0000Fifteen compounds were isolated and characterized using NMR spectra and ESI-MS. The\u0000effects of compounds 3 and 7 on LPS-induced nitric oxide (NO) generation in BV2 cells and H2O2-\u0000induced cytotoxicity in SH-SY5Y cells were investigated. The regulation of nitric oxide production\u0000and apoptosis-associated proteins Bcl-2 and Bax were also examined.\u0000\u0000\u0000\u0000Compounds 3 and 7 exhibited potent inhibitory effects on LPS-induced NO generation in\u0000microglial cells and significant resistance to H2O2-induced cytotoxicity in neuronal cells. Molecular\u0000docking simulations demonstrated the interaction of compounds 3 and 7 with iNOS and Bax, respectively.\u0000Western blot analysis revealed that 7 inhibited NO production and regulated the expression of\u0000Bax and Bcl-2, suggesting a protective effect against H2O2-induced apoptosis.\u0000\u0000\u0000\u0000Compounds 3 and 7 isolated from H. erinaceus are potential therapeutic candidates for\u0000oxidative stress-associated diseases, possibly through their regulation of nitric oxide production and\u0000apoptosis-related proteins. Further investigations are warranted to elucidate their mechanisms of\u0000action and therapeutic potential.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"85 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141388872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systemic Review of Pre-clinical Studies of Herbal Plants having Anti-Polycystic Ovarian Syndrome Activity: A PAN-India Study","authors":"Manashi Karmakar, Binita Chakraborty, Amisha Sultana Hussain, Pervej Alom Barbhuiya, Noksensangla Y Chang, Ireenia Warjri, Wankupar Wankhar, Utpal Barman, Mrinmoy Basak, Saikat Sen, M. Pathak","doi":"10.2174/0122103155303329240509115336","DOIUrl":"https://doi.org/10.2174/0122103155303329240509115336","url":null,"abstract":"\u0000\u0000Polycystic ovarian syndrome (PCOS) is a prevalent endocrine and metabolic\u0000condition seen in premenopausal women. A number of pharmacological agents like metformin,\u0000oral contraceptives, and anti-androgen agents have been used to treat PCOS and its associated implications,\u0000but it has been associated with numerous negative effects like fatal and nonfatal lactic acidosis,\u0000weight gain, cardiovascular, and hepatic toxicity.\u0000\u0000\u0000\u0000This study considered the Preferred Reporting Items for Systematic Review and Meta-\u0000Analysis (PRISMA) guideline where a vast number of article sources from different scientific databases\u0000like Google Scholar (https://scholar.google.com/), PubMed (https://pubmed.ncbi.nlm.nih.gov/),\u0000and Web of Science (https://mjl.clarivate.com/search-results) were screened out.\u0000\u0000\u0000\u0000From a total of 154 studies, 24 studies were screened out following the inclusion and exclusion\u0000criteria, which reported 24 different plants that were used against PCOS preclinically. Details of\u0000various plants used, including their respective families, plant parts utilized, extraction methods employed,\u0000formulations developed, animal models of polycystic ovary syndrome (PCOS) utilized, and\u0000the geographical locations within India where the research has been conducted are all documented.\u0000\u0000\u0000\u0000This systematic review is the first in India to report the pre-clinical studies of medicinal\u0000plants against PCOS, and it provides a thorough summary of the application of medicinal plants for\u0000the management of PCOS. Nonetheless, molecular level investigations on the plants utilized, their\u0000bioactive phytoconstituent responsible for the anti-PCOS activity, the probable mechanism of action\u0000and the pathway through which they conserve their effect, the effective dose, and the potential adverse\u0000effects are the need of time.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":" 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141126794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytotoxic Secondary Metabolites from the Ascomycetous Fungus\u0000Pseudogymnoascus roseus","authors":"Jie Lin, Yingchao He, Ruofei Weng, Jingru Jiao, Peixin Zheng, Qun Dai, Ling Liu","doi":"10.2174/0122103155302795240430043401","DOIUrl":"https://doi.org/10.2174/0122103155302795240430043401","url":null,"abstract":"\u0000\u0000Fungi found in unique and competitive environments are abundant in bioactive compounds.\u0000\u0000\u0000\u0000The objective of this study is to isolate and identify secondary metabolites from fungi of\u0000unique ecological niches and evaluate their cytotoxicity.\u0000\u0000\u0000\u0000The compounds were isolated and purified using silica gel column chromatography, Sephadex LH-20 gel chromatography, and semi-preparative high-performance liquid chromatography\u0000(HPLC). The structures of the isolated compounds were determined using NMR and MS. The cytotoxic activities of these compounds were tested by the MTS assay.\u0000\u0000\u0000\u0000Three diphenyl ethers, dechlorodihydromaldoxin (1), violaceol-I (2) and violaceol-II (3),\u0000one quinolinone compound, 2-(2-heptenyl)-3-methyl-4(1H)-quinolinone (4), and one α-pyrone\u0000nafuredin (5) were isolated from the fermented extracts of Pseudogymnoascus roseus S161. Compound 1 showed modest cytotoxicity against two human tumor cell lines A549 and MCF-7, with IC50\u0000values of 87.12 and 51.07 µM, respectively.\u0000\u0000\u0000\u0000Five compounds were isolated from the fungus P. roseus S161. Compound 1 showed\u0000moderate cytotoxicity. This study provided a basis for the development of antitumor drugs.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"56 41","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141009682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epigallocatechin Gallate (EGCG) Formulations: Unlocking Potential in Nutraceutical and Pharmaceutical Sectors","authors":"R. Mittal, Raghav Mishra, Rehan Uddin, Ranjeet Bhargav, Neeraj Kumar","doi":"10.2174/0122103155295035240330065048","DOIUrl":"https://doi.org/10.2174/0122103155295035240330065048","url":null,"abstract":"\u0000\u0000This review aims to evaluate the latest techniques used in formulating epigallocatechin\u0000gallate (EGCG), analyse the difficulties encountered in the process, and offer perspectives\u0000on potential future advancements in epigallocatechin gallate formulations for both nutraceutical and\u0000pharmaceutical applications.\u0000\u0000\u0000\u0000This work provides a thorough literature review, examines current epigallocatechin gallate\u0000formulation strategies, assesses solubility improvement approaches, examines obstacles, and summarises\u0000results regarding benefits and drawbacks. In nutraceuticals and pharmaceuticals, it identifies\u0000knowledge gaps and suggests future research avenues.\u0000\u0000\u0000\u0000This comprehensive review presents a synthesis of pivotal discoveries about epigallocatechin\u0000gallate formulations, particularly emphasising notable progress in enhancing solubility and the\u0000concomitant obstacles encountered in this pursuit. This review weighs the benefits and drawbacks,\u0000shedding light on areas that need further investigation in the pharmaceutical and nutraceutical fields.\u0000\u0000\u0000\u0000This review synthesises current research on formulations containing epigallocatechin\u0000gallate, focusing on their various applications and the obstacles accompanying their implementation.\u0000Despite facing various challenges, the methodologies that have been investigated demonstrate potential.\u0000The comprehensive evaluation of both strengths and limitations highlights the imperative nature\u0000of continuous research. The conclusion provides opportunities for research in pharmaceuticals and\u0000nutraceuticals, outlining future directions.\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"84 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141010915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ginsenoside Rh2 Reduced Neurogenesis Dysfunction to Alleviate\u0000Depression-like Behaviour in CSDS-induced Mice","authors":"Wei Guan, Xiang Jin, Yang Yang","doi":"10.2174/0122103155289279240430070314","DOIUrl":"https://doi.org/10.2174/0122103155289279240430070314","url":null,"abstract":"\u0000\u0000Depression is a mental health disorder with high morbidity and disability\u0000rates that has harmful effects on public health worldwide. Despite many hypotheses about its mechanism have been put forward, its deeper mechanism is still unclear. Nowadays, there are many antidepressants developed by pharmaceutical companies, such as fluoxetine, ketamine, and paroxetine used\u0000in clinical practice, but the therapeutic effects are not satisfactory, with serious adverse reactions and\u0000drug addiction.\u0000\u0000\u0000\u0000Ginsenoside Rh2 (G-Rh2) is one of the major bioactive ginsenosides extracted from\u0000Panax ginseng that has been conducted for the treatment of many inflammatory diseases. However,\u0000the possible mechanisms of G-Rh2 involved in these neuroprotective effects on neuroinflammation\u0000are currently unclear.\u0000\u0000\u0000\u0000We established a CSDS depression model in normal mice, and then the depressive symptoms of mice were evaluated by a series of behavioral testing. Finally, molecular biology experiments were conducted to demonstrate that G-Rh2 had anti-inflammatory and antidepressant effects.\u0000\u0000\u0000\u0000We showed that G-Rh2 (30 mg/kg) significantly relieved depressive behavior in mice via\u0000attenuating oxidative stress injury and release of proinflammatory cytokines. Moreover, G-Rh2 reduced impaired neurogenesis in the hippocampus of CSDS-induced mice.\u0000\u0000\u0000\u0000We demonstrated the anti-inflammatory and antioxidative effects of G-Rh2 to alleviate\u0000depression through improved neurogenesis in depressive mice for the first time. What's more, we\u0000aimed to verify the protective effects of G-Rh2 on neuroinflammation and provide novel insights for\u0000understanding the roles of G-Rh2 in the treatment of depression\u0000","PeriodicalId":515404,"journal":{"name":"The Natural Products Journal","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141007310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}