Journal of UltrasoundPub Date : 2026-09-01Epub Date: 2026-03-17DOI: 10.1007/s40477-026-01134-y
Hasan Nawaz Tahir
{"title":"Comment on \"Artificial intelligence-assisted muscular ultrasonography for assessing inflammation and muscle mass in patients at risk of malnutrition\".","authors":"Hasan Nawaz Tahir","doi":"10.1007/s40477-026-01134-y","DOIUrl":"10.1007/s40477-026-01134-y","url":null,"abstract":"","PeriodicalId":51528,"journal":{"name":"Journal of Ultrasound","volume":" ","pages":"775-776"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13589036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147476366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of UltrasoundPub Date : 2026-09-01Epub Date: 2025-04-29DOI: 10.1007/s40477-025-01021-y
L Tarantino, P Di Sario, R A Nasto, A Nasto, L Pellegrini, S Sellitto
{"title":"Ultrasound diagnosis of appendiceal tumor with synchronous liver metastasis mimicking acute appendicitis and liver abscess.","authors":"L Tarantino, P Di Sario, R A Nasto, A Nasto, L Pellegrini, S Sellitto","doi":"10.1007/s40477-025-01021-y","DOIUrl":"10.1007/s40477-025-01021-y","url":null,"abstract":"<p><p>Appendiceal tumors (AT) are rare gastrointestinal cancers with high incidence of synchronous and metachronous colorectal cancer metastases. AT are rarely associated with hepatic metastases. Sometimes, metastases are the first evidence of the tumor. We report the clinical, surgical and imaging records of a female patient, 81 years old, admitted for a suspect liver abscess, only subsequently diagnosed as metastasis from an undiagnosed AT. Ultrasound (US) based imaging techniques, such as Color-Doppler Ultrasound, Contrast enhanced US, US-guided biopsy of the hepatic nodule played an important role in the assessment of the definitive diagnosis.</p>","PeriodicalId":51528,"journal":{"name":"Journal of Ultrasound","volume":" ","pages":"763-766"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13589024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of UltrasoundPub Date : 2026-09-01Epub Date: 2026-07-24DOI: 10.1007/s40477-026-01180-6
Carmine Cristiano Di Gioia, Alice Alame, Michela D'Apolito, Claudia Ceravolo, Daniele Orso
{"title":"The ABCDEFG point-of-care ultrasound protocol for acute non-traumatic abdominal pain: a prospective observational study.","authors":"Carmine Cristiano Di Gioia, Alice Alame, Michela D'Apolito, Claudia Ceravolo, Daniele Orso","doi":"10.1007/s40477-026-01180-6","DOIUrl":"10.1007/s40477-026-01180-6","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate whether the structured ABCDEFG point-of-care ultrasound protocol was associated with faster diagnostic resolution and improved emergency department efficiency in adults with acute non-traumatic abdominal pain.</p><p><strong>Methods: </strong>We conducted a prospective single-centre observational cohort study in the emergency department of Baggiovara Hospital, Modena, Italy, between January and April 2025. Consecutive adults with acute non-traumatic abdominal pain were managed according to one of three provider-practice-based strategies: ABCDEFG POCUS, non-protocol POCUS, or standard care without bedside POCUS. The primary outcome was time to diagnosis.</p><p><strong>Results: </strong>The analytic cohort included 218 patients: 66 in the ABCDEFG POCUS group, 70 in the non-protocol POCUS group, and 82 in the standard care group. Median time to diagnosis was shorter with ABCDEFG POCUS than with non-protocol POCUS or standard care: 91 min (IQR 59-134) versus 162 min (85-209) and 162 min (82-270), respectively (p < 0.001). ED processing time was 122, 180, and 206 min, respectively, and ED length of stay was 245, 314, and 325 min, respectively. CT use was 15.9%, 24.6%, and 32.9%, and plain abdominal radiography use was 12.3%, 26.1%, and 39.0%. Pathology-specific diagnoses were documented in 98.5%, 73.9%, and 75.6% of patients, respectively. Thirty-day revisits and mortality did not differ significantly across groups.</p><p><strong>Conclusion: </strong>In this single-centre observational cohort, structured ABCDEFG POCUS was associated with faster diagnosis, shorter ED process times, lower selected imaging use, and fewer non-specific abdominal pain diagnoses. Multicentre studies are needed to assess reproducibility and patient-centred outcomes.</p>","PeriodicalId":51528,"journal":{"name":"Journal of Ultrasound","volume":" ","pages":"629-637"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13588981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of UltrasoundPub Date : 2026-09-01Epub Date: 2026-07-22DOI: 10.1007/s40477-026-01175-3
Sergey Filist, Riad Taha Al-Kasasbeh, Tigran Gevorkyan, Dmitry Sergeevich Kondrashov, Olga Shatalova, Nikolay A Korenevskiy, Ahmad Telfah
{"title":"Multi-window scanning method for region-of-interest selection in pancreatic endoscopic ultrasound images.","authors":"Sergey Filist, Riad Taha Al-Kasasbeh, Tigran Gevorkyan, Dmitry Sergeevich Kondrashov, Olga Shatalova, Nikolay A Korenevskiy, Ahmad Telfah","doi":"10.1007/s40477-026-01175-3","DOIUrl":"10.1007/s40477-026-01175-3","url":null,"abstract":"<p><p>This study presents a method for semantic segmentation of pancreatic endoscopic ultrasound (EUS) images. We developed a hybrid method to automatically select relevant frames from EUS video sequences, employing two nested dynamic windows: a smaller window scans local regions of each frame, while a larger window defines the overall scanning area, capturing spatial context. Texture features, including mode, mean, and standard deviation, are extracted from both windows to construct a feature vector for a fully connected neural network classifier (NNC), which predicts the class of each pixel. Following pixel-wise classification, a heatmap is generated for each frame to highlight regions of interest (ROI), allowing specialists to identify echotextural features. The method uses hierarchical image decomposition to improve ROI identification. Custom software was implemented to enable interactive segmentation, division into local windows, ROI classification, and structured database formation. Based on expert endoscopist evaluation, the optimal window size was determined to be 32 × 32 pixels. A curated dataset of local windows containing normal and pathological pancreatic echotextures was compiled from the selected frames. Experimental evaluation on 114 test frames demonstrated that the proposed method achieves an overall accuracy of 95.6% (PPV 96.3%; sensitivity 97.5%; specificity 91.2%), distinguishing relevant frames for subsequent semantic segmentation. This framework supports clinical assessment and automated ROI extraction in pancreatic EUS imaging.</p>","PeriodicalId":51528,"journal":{"name":"Journal of Ultrasound","volume":" ","pages":"581-594"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13589020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148551343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of UltrasoundPub Date : 2026-09-01Epub Date: 2026-07-27DOI: 10.1007/s40477-026-01205-0
Alessio Frisone, Giuseppe Balice, Matteo Serroni, Gianmaria D'Addazio, Antonella Berardicurti, Andrea Boccatonda
{"title":"CEUS in the evaluation of focal salivary gland lesions: a systematic review.","authors":"Alessio Frisone, Giuseppe Balice, Matteo Serroni, Gianmaria D'Addazio, Antonella Berardicurti, Andrea Boccatonda","doi":"10.1007/s40477-026-01205-0","DOIUrl":"10.1007/s40477-026-01205-0","url":null,"abstract":"<p><strong>Background: </strong>Preoperative differentiation of benign and malignant salivary gland lesions remains challenging. Contrast-enhanced ultrasound (CEUS) enables real-time assessment of tumor microvascularization and has emerged as a promising adjunct to conventional ultrasound.</p><p><strong>Purpose: </strong>To systematically review the evidence on CEUS in focal salivary gland lesions and to evaluate its diagnostic accuracy, including feature-level diagnostic performance.</p><p><strong>Materials and methods: </strong>A systematic search of PubMed was conducted for studies published from database inception to December 2025, evaluating contrast-enhanced ultrasound (CEUS) in focal salivary gland lesions, using histopathology as the reference standard. Qualitative and quantitative CEUS features were synthesized. Diagnostic accuracy evidence was assessed at both study and feature levels. Risk of bias was evaluated using the QUADAS-2 tool.</p><p><strong>Results: </strong>Ten studies comprising 663 focal salivary gland lesions (470 benign and 193 malignant) were included in the qualitative synthesis. Malignant lesions were consistently associated with heterogeneous enhancement, ill-defined or blurred margins, non-enhancing areas suggestive of necrosis, and altered contrast kinetics. Quantitative CEUS analyses demonstrated shorter time to peak enhancement, higher peak enhancement, steeper wash-in slopes, and larger areas under the time-intensity curve in malignant tumors compared with benign lesions. Only a limited number of studies reported diagnostic accuracy outcomes using predefined criteria, and substantial heterogeneity in diagnostic thresholds and study design precluded reliable pooled meta-analysis. Across the two studies reporting complete diagnostic accuracy data, CEUS sensitivity ranged from 72.1 to 80.0%, whereas specificity ranged from 78.9 to 91.7%. Feature-level analysis indicated that ill-defined enhancement margins were highly specific for malignancy, whereas inhomogeneous enhancement showed higher sensitivity but limited specificity. Wash-in and wash-out kinetics demonstrated variable diagnostic performance across studies.</p><p><strong>Conclusion: </strong>CEUS provides valuable functional information for the evaluation of focal salivary gland lesions and complements conventional ultrasound by depicting tumor microvascular characteristics. While several qualitative and quantitative CEUS features are associated with malignancy and may aid preoperative risk stratification, methodological heterogeneity and the limited number of high-quality diagnostic accuracy studies currently restrict definitive conclusions. CEUS should be considered an adjunctive imaging tool rather than a standalone alternative to histopathological diagnosis.</p>","PeriodicalId":51528,"journal":{"name":"Journal of Ultrasound","volume":" ","pages":"527-535"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13589002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148609921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of UltrasoundPub Date : 2026-09-01Epub Date: 2026-07-29DOI: 10.1007/s40477-026-01186-0
Miriana Zanconato, Marco Senzolo, Alberto Zanetto, Giulio Barbiero, Michele Battistel, Stefano Groff, Francesco Paolo Russo, Martina Gambato, Giacomo Germani, Patrizia Burra, Alberto Ferrarese
{"title":"A composite Doppler ultrasound score for early identification of TIPS dysfunction in cirrhosis.","authors":"Miriana Zanconato, Marco Senzolo, Alberto Zanetto, Giulio Barbiero, Michele Battistel, Stefano Groff, Francesco Paolo Russo, Martina Gambato, Giacomo Germani, Patrizia Burra, Alberto Ferrarese","doi":"10.1007/s40477-026-01186-0","DOIUrl":"10.1007/s40477-026-01186-0","url":null,"abstract":"<p><strong>Background and aims: </strong>Transjugular intrahepatic portosystemic shunt (TIPS) is an established treatment for portal hypertension complications, but efficacy may be limited by shunt dysfunction. This study evaluated the utility of early post-procedural Doppler ultrasound for detecting TIPS dysfunction in patients with cirrhosis.</p><p><strong>Methods: </strong>This prospective single-centre observational study included patients with cirrhosis undergoing TIPS placement at Padova University Hospital between December 2023 and September 2025 and had Doppler ultrasound examination in 8-30 days after procedure. Doppler assessment included intra-shunt flow and flow direction in intrahepatic portal branches. Early TIPS dysfunction was angiographically defined. A composite Doppler ultrasound score incorporated three parameters: detectable intra-stent flow, hepatofugal flow in right and left intrahepatic portal branches, separately. For ROC analysis, the score was inverted: higher values indicated higher probability of TIPS dysfunction.</p><p><strong>Results: </strong>Sixty-nine patients were included. The first ultrasound examination was performed after a median of 21 days from TIPS placement. Early TIPS dysfunction was confirmed in 5 patients (7.2%). These patients showed significantly lower median intra-shunt flow velocity and less frequent hepatofugal flow in the left and, more markedly, in the right intrahepatic portal branches. The composite score showed good discriminatory performance for early TIPS dysfunction. Using an abnormal composite score > = 1, sensitivity was 80.0%, specificity 87.5%, positive predictive value 33.3%, and negative predictive value 98.2%.</p><p><strong>Conclusions: </strong>A composite Doppler ultrasound score based on intra-shunt flow and intrahepatic portal branch flow direction showed good rule-out performance for early TIPS dysfunction. Because of the limited number of dysfunction events, these findings require validation in larger cohorts.</p>","PeriodicalId":51528,"journal":{"name":"Journal of Ultrasound","volume":" ","pages":"647-652"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13588761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148622447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of UltrasoundPub Date : 2026-09-01Epub Date: 2026-03-11DOI: 10.1007/s40477-026-01137-9
Yalin Yang, Yi Lan, Yujie Yang, Fuqin Yang, Yusong Chen, Ya Wang, Lieming Wen
{"title":"The risk factors of anatomical cystocele recurrence: the hiatal area and the lowest vaginal mesh location observed by pelvic floor ultrasound.","authors":"Yalin Yang, Yi Lan, Yujie Yang, Fuqin Yang, Yusong Chen, Ya Wang, Lieming Wen","doi":"10.1007/s40477-026-01137-9","DOIUrl":"10.1007/s40477-026-01137-9","url":null,"abstract":"<p><strong>Objectives: </strong>To explore the risk factors for the anatomical cystocele recurrence (ACR) after transvaginal mesh (TVM) implantation.</p><p><strong>Methods: </strong>Patients with a TVM between 2015 and 2023 were enrolled. ACR is determined as the bladder descended ≥ 10 mm below the pubic symphysis or a cystocele stage II or higher. The lowest mesh position (LMP) determined by ultrasound corresponded to the caudal mesh end relative to the bladder neck at maximum descent. Positions below the bladder neck were noted as negative values. The hiatal area (HA) was measured using four-dimensional pelvic floor ultrasound. The differences between women with ACR and without were analyzed.</p><p><strong>Results: </strong>We enrolled 111 women with a median follow-up of 13 months. Group I included 25 (22.5%) women with ACR. Group II had 86 controls. The median LMP was - 7.0 mm (range - 23 to 18). It was higher in Group I than in Group II (- 3.0 mm vs. - 7.0 mm; p = 0.005). In predicting ACR, LMP had an odds ratio of 1.08 (p = 0.015) and a cutoff of - 3.0 mm (52.3% sensitivity and 72.0% specificity). Multivariate regression analysis revealed odds ratios of 4.3, 3.2, 10.7, and 5.0 (all p < 0.05) for preoperative cystocele stage IV, preoperative HA ≥ 30 cm<sup>2</sup>, postoperative HA ≥ 29 cm<sup>2</sup>, and LMP ≥ -3 mm, respectively.</p><p><strong>Conclusions: </strong>The larger the HA, the higher the risk of postoperative cystocele. If the caudal mesh end is located more than 3 mm below the bladder neck, the risk of ACR is 500%.</p>","PeriodicalId":51528,"journal":{"name":"Journal of Ultrasound","volume":" ","pages":"553-561"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13588771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147437472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of UltrasoundPub Date : 2026-09-01Epub Date: 2026-07-26DOI: 10.1007/s40477-026-01184-2
Tang Yixin
{"title":"Defining the incremental value of posterior-zone lung ultrasound in BPD prediction.","authors":"Tang Yixin","doi":"10.1007/s40477-026-01184-2","DOIUrl":"10.1007/s40477-026-01184-2","url":null,"abstract":"","PeriodicalId":51528,"journal":{"name":"Journal of Ultrasound","volume":" ","pages":"777-778"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13589037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148594384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A machine learning model integrating two-dimensional ultrasound radiomics and clinical parameters for differentiating membranous nephropathy from IgA nephropathy.","authors":"Haizhi Ma, Fugao Huang, Anxin Liu, Biwu Chen, Xiubo Qin, Chengcai Chen","doi":"10.1007/s40477-026-01159-3","DOIUrl":"10.1007/s40477-026-01159-3","url":null,"abstract":"<p><strong>Background: </strong>Membranous nephropathy (MN) and IgA nephropathy (IgAN) are the two most common primary glomerular diseases in China, with distinct pathophysiological mechanisms, treatment strategies, and prognoses. Although renal biopsy remains the diagnostic gold standard, its invasiveness limits routine use. Developing a non-invasive, accurate, and reproducible method for differentiating MN from IgAN is clinically important.</p><p><strong>Objective: </strong>To develop a machine learning model integrating two-dimensional ultrasound radiomics and clinical parameters for non-invasive differentiation of MN from IgAN.</p><p><strong>Methods: </strong>A total of 267 patients (145 with MN, 122 with IgAN) who underwent renal biopsy were retrospectively enrolled and randomly divided into training (n = 186) and validation (n = 81) sets at a 7:3 ratio. Radiomic features were extracted from renal ultrasound images, and independent clinical predictors were identified using multivariate logistic regression. A combined radiomics-clinical model was constructed using the Extra Trees algorithm. Model performance was evaluated using the area under the receiver operating characteristic curve (AUC), accuracy, sensitivity, and specificity.</p><p><strong>Results: </strong>Multivariate logistic regression identified PLA2R antibody (OR = 0.086, 95% CI 0.040-0.184, P < 0.001), 24-h urine protein quantification (OR = 0.874, 95% CI 0.807-0.946, P = 0.006), and age (OR = 1.019, 95% CI 1.005-1.035, P = 0.031) as independent clinical predictors. The combined radiomics-clinical model achieved an AUC of 0.920 (95% CI: 0.859-0.980) in the validation set, with an accuracy of 0.877, sensitivity of 0.946, and specificity of 0.818, significantly outperforming the radiomics model <math><mrow><mi>A</mi> <mi>U</mi> <mi>C</mi> <mo>=</mo> <mn>0.811</mn> <mo>,</mo> <mi>P</mi> <mo>=</mo> <mn>0.001</mn></mrow> </math> and showing a marginally significant improvement over the clinical model <math><mrow><mi>A</mi> <mi>U</mi> <mi>C</mi> <mo>=</mo> <mn>0.840</mn> <mo>,</mo> <mi>P</mi> <mo>=</mo> <mn>0.065</mn></mrow> </math> in the test cohort.</p><p><strong>Conclusion: </strong>The machine learning model integrating two-dimensional ultrasound radiomic features with PLA2R antibody, 24-h urine protein quantification, and age demonstrated excellent performance for non-invasive differentiation of MN from IgAN. This model offers a promising auxiliary diagnostic tool that may help optimize clinical decision-making under non-invasive conditions.</p>","PeriodicalId":51528,"journal":{"name":"Journal of Ultrasound","volume":" ","pages":"595-606"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13588976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148229104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of UltrasoundPub Date : 2026-09-01Epub Date: 2026-08-10DOI: 10.1007/s40477-026-01209-w
Melanie Norton, Jude Hamilton
{"title":"Chorionic bumps in early pregnancy and their link to miscarriage.","authors":"Melanie Norton, Jude Hamilton","doi":"10.1007/s40477-026-01209-w","DOIUrl":"10.1007/s40477-026-01209-w","url":null,"abstract":"<p><strong>Introduction: </strong>Chorionic bumps are a rare first‑trimester ultrasound finding with uncertain prognostic significance.</p><p><strong>Objective: </strong>To estimate the risk of miscarriage in pregnancies with a chorionic bump compared with the institutional baseline miscarriage rate in our Early Pregnancy Unit (EPU).</p><p><strong>Methods: </strong>Retrospective cohort of consecutive pregnancies with a sonographically confirmed chorionic bump (January 2020-May 2025). Outcomes were benchmarked against the EPU's baseline miscarriage rate derived from all attendances during the study period. Prespecified secondary analyses explored whether maternal age, subchorionic haematoma (SCH), or bump size predicted outcome.</p><p><strong>Results: </strong>Among 151 pregnancies with a chorionic bump, 81 miscarried (53.6%). This was substantially higher than the EPU baseline of 14.2% (2,295 miscarriages among 16,115 patients), corresponding to a near‑sevenfold increase in odds (OR 6.99; z = 9.72; p < 0.0001). Bump size and the presence of SCH were not associated with outcome. Increasing maternal age had a modest effect (OR 1.09 per year, p = 0.014). Outcomes following IVF conception were similar to, or slightly better than, spontaneous conception.</p><p><strong>Conclusion: </strong>The presence of a chorionic bump is a clinically important prognostic marker of miscarriage, independent of bump size or SCH.</p>","PeriodicalId":51528,"journal":{"name":"Journal of Ultrasound","volume":" ","pages":"573-579"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13589028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148708415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}