Journal of Allergy and Clinical Immunology-In Practice最新文献

{"title":"Household cleaning product exposure and severe bronchiolitis in infancy: A case-control study","authors":"Orianne Dumas PhD , Isis Felippe Baroni MD , Geneva D. Mehta MD , Ashley F. Sullivan MPH , Zhaozhong Zhu ScD , Carlos A. Camargo Jr. MD, DrPH","doi":"10.1016/j.jaip.2025.03.032","DOIUrl":"10.1016/j.jaip.2025.03.032","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages 1468-1470.e2"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interrupting a vicious cycle can result in cessation of refractory chronic cough","authors":"Miles Weinberger MD , Ran D. Anbar MD , Dennis Buettner","doi":"10.1016/j.jaip.2025.03.044","DOIUrl":"10.1016/j.jaip.2025.03.044","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Page 1502"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expert-Based, Institutional Approaches for Reducing the Diagnostic Odyssey of Patients With Inborn Errors of Immunity","authors":"Nicholas L. Rider DO ,&nbsp;Lisa Bastarache MS ,&nbsp;John T. Anderson MD ,&nbsp;Edward M. Behrens MD ,&nbsp;Natalia Chaimowitz MD, PhD ,&nbsp;Shanmuganathan Chandrakasan MD ,&nbsp;Brian Hartline MD ,&nbsp;Anne Liu MD ,&nbsp;Rebecca A. Marsh MD ,&nbsp;James A. Connelly MD","doi":"10.1016/j.jaip.2025.03.040","DOIUrl":"10.1016/j.jaip.2025.03.040","url":null,"abstract":"<div><div>Inborn errors of immunity (IEIs) are a heterogeneous group of genetic disorders with long diagnostic delay that negatively impacts patient outcomes. To combat delay, 8 multidisciplinary experts from different disciplines convened to generate 11 consensus-based statements that address approaches that could reduce the diagnostic journey of patients with IEIs. Nine of these statements relate to the development and implementation of automated decision support tools to improve rapidity of diagnosis by augmenting clinical decision-making for practitioners with or without IEI experience. Strengths and limitations of such tools as well as considerations for development and implementation are discussed. Two consensus statements were generated to support the development of successful multidisciplinary care teams to facilitate optimal evaluation of patients identified to be at risk of IEI. We discuss essential components for developing a multidisciplinary care team, including clinical interest, institutional and financial support, and crucial team members. Both of these approaches may increase diagnostic accuracy for patients with IEIs and lead to improvements in care.</div></div>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages 1317-1324"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding Social Inequalities in Childhood Asthma: Quantifying the Mediating Role of Modifiable Early-Life Risk Factors in Seven European Birth Cohorts","authors":"Angela Pinot de Moira PhD ,&nbsp;Anne V. Aurup MSc ,&nbsp;Demetris Avraam PhD ,&nbsp;Daniela Zugna PhD ,&nbsp;Aksel Karl Georg Jensen PhD ,&nbsp;Marieke Welten MSc ,&nbsp;Timothy Cadman PhD ,&nbsp;Blandine de Lauzon-Guillain PhD ,&nbsp;Liesbeth Duijts PhD ,&nbsp;Ahmed Elhakeem PhD ,&nbsp;Ana Esplugues PhD ,&nbsp;Judith Garcia-Aymerich PhD ,&nbsp;Gonzalo García-Baquero PhD ,&nbsp;Llúcia González Safont PhD ,&nbsp;Jennifer R. Harris PhD ,&nbsp;Carmen Iñiguez PhD ,&nbsp;Vincent W.V. Jaddoe PhD ,&nbsp;Rosemary R.C. McEachan PhD ,&nbsp;Johanna L.T. Nader PhD ,&nbsp;Loreto Santa Marina PhD ,&nbsp;Anne-Marie Nybo Andersen PhD","doi":"10.1016/j.jaip.2025.02.032","DOIUrl":"10.1016/j.jaip.2025.02.032","url":null,"abstract":"<div><h3>Background</h3><div>Children growing up in disadvantaged socioeconomic circumstances (SECs) have an increased risk of asthma.</div></div><div><h3>Objective</h3><div>To increase our understanding of the pathways to inequalities in asthma and potential targets for intervention by (1) examining how the social patterning of asthma and its early-life risk factors varies across countries and (2) quantifying the mediation of observed inequalities by early-life risk factors.</div></div><div><h3>Methods</h3><div>We used data for 107,884 mother-child dyads from 7 European birth cohorts across 6 countries. Maternal education was the primary exposure measure of early-life SECs. The outcome was current asthma in childhood (3-12 years). Inequalities were examined using multivariable regression and random effects meta-analysis. The mediating effects of early-life risk factors (maternal smoking during pregnancy, adverse birth outcomes, and breastfeeding duration) were examined using counterfactual mediation analysis.</div></div><div><h3>Results</h3><div>In meta-analysis, children of mothers with low/medium versus high education had a 17% (95% confidence interval: 8%-27%, <em>I</em>² = 21.6%) increased risk of asthma. Cohort-specific risk ratios ranged between 1.07 (0.97-1.18, Danish National Birth Cohort, Denmark) and 1.61 (1.08-2.40, study on the pre- &amp; early postnatal determinants of child health &amp; development, France). The early-life risk factors were similarly socially patterned, but with greater heterogeneity across cohorts (<em>I</em>² range = 66.2%-95.3%). The mediation analysis suggested that these factors play a relevant role in mediating observed inequalities (proportion mediated range: 0.08-0.72).</div></div><div><h3>Conclusions</h3><div>There was a consistent tendency for children from disadvantaged SECs to be at greater risk of asthma in the European cohorts examined. Our results suggest that early-life risk factors partially mediate these disparities and, therefore, that public health interventions in the perinatal period may help to address inequalities in asthma.</div></div>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages 1385-1396"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Original Article Highlights From This Issue","authors":"","doi":"10.1016/S2213-2198(25)00441-6","DOIUrl":"10.1016/S2213-2198(25)00441-6","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages A11-A14"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to “Catamenial anaphylaxis”","authors":"Dehlia Moussaoui MD ,&nbsp;Stephanie Richards BSc (Hons), MBBS, FRACP, FRCPA ,&nbsp;Tracy Foran BMed, FRANZCOG ,&nbsp;Sonia R. Grover MBBS, FRANZCOG, FFPMANZCA, MD","doi":"10.1016/j.jaip.2025.03.043","DOIUrl":"10.1016/j.jaip.2025.03.043","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages 1500-1502"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"March 2025 Practice Notes","authors":"","doi":"10.1016/S2213-2198(25)00445-3","DOIUrl":"10.1016/S2213-2198(25)00445-3","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages A19-A20"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144213149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic norovirus infection in immunodeficiency: A UK national case series","authors":"Alexandros Grammatikos FRCPath ,&nbsp;Anisha Mangtani MBBS ,&nbsp;Mark Ponsford FRCPath ,&nbsp;Stephen Jolles FRCPath ,&nbsp;Elizabeth McDermott FRCPath ,&nbsp;Sarah Johnston FRCPath ,&nbsp;Marina Frleta-Gilchrist MRCP ,&nbsp;Patrick Yong FRCPath ,&nbsp;Fiona Moghaddas FRACP ,&nbsp;Moira Thomas FRCPath ,&nbsp;Smita Patel FRCPath ,&nbsp;Caitlin Blundell MBiochem ,&nbsp;Phil Bright FRCPath ,&nbsp;Elizabeth Drewe FRCPath ,&nbsp;Suzanne Elcombe FRCPath ,&nbsp;Archana Herwadkar FRCPath ,&nbsp;Sai Murng FRCPath ,&nbsp;Da-In Kim MRCP ,&nbsp;Mark Gompels FRCPath ,&nbsp;David Lowe FRCPath","doi":"10.1016/j.jaip.2025.02.026","DOIUrl":"10.1016/j.jaip.2025.02.026","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages 1489-1492"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Five Patients With Two Novel Homozygous Variants in CD3 Subunits and Comprehensive Review of the Literature","authors":"Gamze Sonmez MD ,&nbsp;Alp Kazancıoglu MD ,&nbsp;Yigit Yazarkan ,&nbsp;Ates Kutay Tenekeci MD ,&nbsp;Ismail Yaz PhD ,&nbsp;Saliha Esenboga MD ,&nbsp;Diclehan Orhan MD, PhD ,&nbsp;Mirjam van der Burg PhD ,&nbsp;Ozden Sanal MD ,&nbsp;Ilhan Tezcan MD, PhD ,&nbsp;Deniz Cagdas MD, PhD","doi":"10.1016/j.jaip.2025.03.022","DOIUrl":"10.1016/j.jaip.2025.03.022","url":null,"abstract":"<div><h3>Background</h3><div>CD3 subunit deficiency (CD3SD) causes combined immunodeficiency (CID) and severe CID (SCID).</div></div><div><h3>Objective</h3><div>To elucidate the clinical, laboratory, and genetic features of patients with different CD3SD subtypes.</div></div><div><h3>Methods</h3><div>We evaluated the data of five patients with CD3ε (two), CD3γ (two), and CD3δ (one) deficiencies from our institution. In addition, we reviewed the medical literature for cases of CD3SD.</div></div><div><h3>Results</h3><div>We identified two novel homozygous CD3 variants. In addition, we identified 44 CD3SD cases in the literature. In total, we analyzed the results of 49 patients. Our review of the medical literature revealed 11, 12, 18, and three patients with CD3ε, CD3γ, CD3δ, and CD3ζ deficiency, respectively. Of the 49 patients, 40 had an SCID profile, whereas nine with CD3γ variants had a CID profile. The patients with SCID presented with typical symptoms, including recurrent infections (18 of 40; 45%), diarrhea (13 of 40; 33%), and candidiasis (12 of 40, 30%). Recurrent sinopulmonary infections (four of nine; 45%), thyroiditis (four of nine; 45%), and bronchiectasis (four of nine; 45%) were common in patients with CID. Almost 70% of patients with SCID (27 of 40) underwent hematopoietic stem cell transplantation.</div></div><div><h3>Conclusions</h3><div>Our results show that patients with CD3δ, CD3ε, and CD3ζ deficiencies typically present with a classic SCID phenotype. In contrast, patients with CD3γ deficiency may either show an SCID phenotype or a milder, less severe CID phenotype. Importantly, autoimmunity may be the sole manifestation of CD3γ deficiency.</div></div>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages 1430-1439.e7"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hereditary α-tryptasemia is Associated With Anaphylaxis to Antibiotics and Monoclonal Antibodies","authors":"Peter Korošec PhD ,&nbsp;Jonathan J. Lyons MD ,&nbsp;Manca Svetina MSc ,&nbsp;Monika Koudová MD ,&nbsp;Martina Bittóová MSc ,&nbsp;Mihaela Zidarn MD, PhD ,&nbsp;Lenka Sedláčková MD ,&nbsp;Matija Rijavec PhD ,&nbsp;Peter Kopač MD, PhD","doi":"10.1016/j.jaip.2025.04.013","DOIUrl":"10.1016/j.jaip.2025.04.013","url":null,"abstract":"<div><h3>Background</h3><div>Hereditary α-tryptasemia, a genetic trait caused by increased α-tryptase copy number, is associated with idiopathic and venom anaphylaxis.</div></div><div><h3>Objective</h3><div>We aimed to determine the impact of tryptase genotypes on drug-induced anaphylaxis.</div></div><div><h3>Methods</h3><div>A prospective discovery cohort of 99 patients from a referral center in Slovenia with acute anaphylaxis to drugs underwent tryptase genotyping by droplet digital PCR. For validation, we included a cohort of 26 patients from the Czech Republic. Associated inciting agents and the severity of the reactions were subsequently examined.</div></div><div><h3>Results</h3><div>Hereditary α-tryptasemia was associated with drug-induced anaphylaxis with a prevalence of 13% (n = 13 of 99) in the discovery cohort and 15% in the validation cohort (n = 4 of 26). Hereditary α-tryptasemia was identified in every individual with elevated basal serum tryptase levels (11.6-21.9 ng/mL; n = 14) within both cohorts of patients. Hereditary α-tryptasemia was more prevalent in individuals with antibiotic- or mAb-induced anaphylaxis in both the discovery and validation cohorts (n = 13 of 51; 26%) compared to those with anaphylaxis resulting from neuromuscular blocking agents, nonsteroidal anti-inflammatory drugs, contrast, chlorhexidine, or other drugs (n = 5 of 74; 7%; <em>P</em> = .02; odds ratio = 4.1; 95% CI, 1.3-11.1). Overall, we found fewer individuals with no ⍺-tryptase than in the general population, and there was a trend for subjects with more ⍺-tryptase copies to have more severe reactions. Thus, among subjects with three ⍺-tryptase copies, the prevalence of severe anaphylaxis was 73%, compared with 59% with one to two ⍺-tryptase copies and 58% for subjects without ⍺-tryptase.</div></div><div><h3>Conclusions</h3><div>Risk for anaphylaxis to antibiotics and biologics is associated with inherited differences in α-tryptase–encoding copies at <em>Tryptase α/β1</em>.</div></div>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages 1449-1456.e4"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}