Journal of Allergy and Clinical Immunology-In Practice最新文献

{"title":"Reply to “Rethinking Early Cow’s Milk Formula Exposure: Is Timing Enough?”","authors":"Erin Pitt PhD, Adrian J. Lowe PhD, Kirsten P. Perrett MD, PhD, Vicki McWilliam PhD, Mimi L.K. Tang MD, PhD, Rachel Peters PhD, Jennifer Koplin PhD","doi":"10.1016/j.jaip.2026.08.014","DOIUrl":"10.1016/j.jaip.2026.08.014","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"14 10","pages":"Pages 2443-2444"},"PeriodicalIF":7.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149096383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Underlying assumptions used in a network meta-analysis can alter the conclusions","authors":"Martin C. Michel MD, Eli O. Meltzer MD, Robert Naclerio MD","doi":"10.1016/j.jaip.2026.07.025","DOIUrl":"10.1016/j.jaip.2026.07.025","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"14 10","pages":"Pages 2433-2434"},"PeriodicalIF":7.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149096562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to “Time to Complete Delabeling Among Eventual Completers”","authors":"Thanaporn Ratchataswan MD, Rebecca Lee MPH, Amir Asiaee PhD, Matthew S. Krantz MD, Grace Koo MD, Cosby A. Stone Jr. MD, MPH, FAAAAI, Elizabeth J. Phillips MD, FAAAAI, FIDSA","doi":"10.1016/j.jaip.2026.08.016","DOIUrl":"10.1016/j.jaip.2026.08.016","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"14 10","pages":"Pages 2444-2445"},"PeriodicalIF":7.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149094317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Testing in Clinical Immunology: What to Know and How to Do It","authors":"","doi":"10.1016/j.jaip.2026.08.034","DOIUrl":"10.1016/j.jaip.2026.08.034","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"14 10","pages":"Pages 2209-2210"},"PeriodicalIF":7.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149094318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Eosinophils: Predicting Mucus Plugs in Asthma","authors":"Maria A. Forero Molina MD, James G. Krings MD, MSc, Ting Fan Leung MBChB, MD, FRCPCH, FAAAAI","doi":"10.1016/j.jaip.2026.07.047","DOIUrl":"10.1016/j.jaip.2026.07.047","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"14 10","pages":"Pages 2319-2321"},"PeriodicalIF":7.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149096263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From environmental to endogenous airway exposures: Rethinking gastroesophageal reflux as more than an asthma comorbidity","authors":"Ernesto Aitella MD, Corrado Astarita MD, PhD (Former Professor of Internal Medicine), Gianluca Azzellino RN, MSc, Massimo De Martinis MD, PhD, Lia Ginaldi MD, PhD","doi":"10.1016/j.jaip.2026.08.006","DOIUrl":"10.1016/j.jaip.2026.08.006","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"14 10","pages":"Pages 2440-2441"},"PeriodicalIF":7.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149096380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to “From environmental to endogenous airway exposures: Rethinking gastroesophageal reflux as more than an asthma comorbidity”","authors":"Andrea Portacci MD, Corrado Pelaia MD, Diego Bagnasco MD, Giovanni Paoletti MD, Santi Nolasco MD, PhD, Amato De Paulis MD","doi":"10.1016/j.jaip.2026.08.007","DOIUrl":"10.1016/j.jaip.2026.08.007","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"14 10","pages":"Pages 2441-2442"},"PeriodicalIF":7.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149096381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food oral immunotherapy patient selection, dosing, and monitoring practices among a network of US food allergy centers","authors":"Punita Ponda MD, J. Andrew Bird MD, Jennifer L. Bufford MS, Antonella Cianferoni MD, PhD, Walter Faig PhD, Gary I. Kleiner MD, PhD, Abigail Lang MD, MSCI, Amy M. Scurlock MD, Wayne G. Shreffler MD, PhD, Pooja Varshney MD","doi":"10.1016/j.jaip.2026.06.043","DOIUrl":"10.1016/j.jaip.2026.06.043","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"14 10","pages":"Pages 2423-2426.e1"},"PeriodicalIF":7.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148413655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple Antibiotic Allergy Evaluation Strategy (MAAES): A Comparative Effectiveness Study","authors":"Thanaporn Ratchataswan MD,&nbsp;Rebecca Lee MPH,&nbsp;Amir Asiaee PhD,&nbsp;Matthew S. Krantz MD,&nbsp;Grace Koo MD,&nbsp;Cosby A. Stone Jr. MD, MPH,&nbsp;Elizabeth J. Phillips MD","doi":"10.1016/j.jaip.2026.07.005","DOIUrl":"10.1016/j.jaip.2026.07.005","url":null,"abstract":"<div><h3>Background</h3><div>Inaccurate multiple antibiotic allergy labels to first-line agents (penicillins, cephalosporins, and sulfonamides) restrict optimal therapy and often require sequential evaluations across multiple visits, delaying delabeling and increasing loss to follow-up.</div></div><div><h3>Objective</h3><div>To conduct a comparative effectiveness study of the Multiple Antibiotic Allergy Evaluation Strategy (MAAES), comparing its effectiveness, safety, and patient-reported outcomes (PRO) with traditional sequential evaluation (non-MAAES).</div></div><div><h3>Methods</h3><div>This retrospective cohort study (2014-2024) compared same-day multi-antibiotic testing (MAAES) with non-MAAES in patients with 2 or more low-risk labels. Multivariable regression adjusted for baseline differences and testing era. Inverse probability of treatment weighting (IPTW) and a restricted post-2020 subcohort analysis addressed selection bias and temporal shifts. Outcomes included delabeling efficacy, time to complete delabeling, loss to follow-up, relabeling, adverse events (AEs), and PRO.</div></div><div><h3>Results</h3><div>Baseline differences were present between the MAAES and non-MAAES groups, including penicillin anaphylaxis (1.4% vs 6.6%, <em>P</em> = .002), angioedema (12.4% vs 19.1%, <em>P</em> = .049), maculopapular rash (13.1% vs 24.3%, <em>P</em> = .002), and unknown sulfonamide history (9.5% vs 3.7%, <em>P</em> = .03). MAAES removed 97.4% of labels versus 79.6% for non-MAAES (adjusted odds ratio [aOR]: 9.41, 95% confidence interval [CI]: 5.22-16.95, <em>P</em> &lt; .001). MAAES achieved faster complete delabeling (log-rank χ² = 42.4, <em>P</em> &lt; .001), with 84.9% versus 21.1% delabeled at the initial visit (restricted mean survival time difference: 2.1 months). Results remained robust in post-2020 and IPTW models. Loss to follow-up (1.3% vs 17.2%; aOR: 0.06, 95% CI: 0.03-0.13, <em>P</em> &lt;.001) and AEs (&lt;1% vs 2.8%; aOR: 0.26, 95% CI: 0.09-0.78, <em>P</em> = .02) were significantly lower with MAAES. Favorable PRO was sustained, with no significant differences between groups.</div></div><div><h3>Conclusions</h3><div>A consolidated multidrug evaluation strategy substantially improves the effectiveness of first-line antibiotic allergy delabeling while maintaining excellent safety profiles and PRO.</div></div>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"14 10","pages":"Pages 2356-2365.e5"},"PeriodicalIF":7.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148450499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding and Leveraging Implementation Science Within a Clinical Informatics Framework for Allergy/Immunology","authors":"Michael Nordness MD,&nbsp;Sharmilee M. Nyenhuis MD, FAAAAI,&nbsp;Nicholas L. Rider DO,&nbsp;Stanley J. Szefler MD,&nbsp;Sujani Kakumanu MD","doi":"10.1016/j.jaip.2026.05.026","DOIUrl":"10.1016/j.jaip.2026.05.026","url":null,"abstract":"<div><div>The integration of research discoveries into routine clinical care is often slow and resource-intensive, particularly in allergy and immunology, where advances in biologics, immunotherapy, precision diagnostics, and guideline-driven management continue to evolve rapidly. Implementation science provides a structured approach to understand and address the gaps between research discovery and real-world patient care. In asthma, food allergy, atopic dermatitis, drug allergy, and primary immune disorders, variation in clinician knowledge, health system infrastructure, reimbursement models, patient demographics, and staffing patterns contribute to inconsistent uptake of evidence-based interventions. Implementation science offers tools to systematically evaluate these contextual factors and develop strategies that improve adoption, fidelity, sustainability, and equity in allergic and immunologic care. By offering theory-informed frameworks to design, adapt, and evaluate interventions across diverse clinical settings, implementation science advances the study of evidence-to-practice care gaps in allergy and immunology. When applied thoughtfully, these methods enhance implementation of specialty guidelines, practice parameters, and emerging therapies, while addressing multilevel determinants of care delivery. With the rapidly growing application of precision medicine and augmented intelligence to allergy and immunology practice, the study of how to best apply technological and research discovery to clinical practice will be needed to promote equitable uptake of evidence-based care.</div></div>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"14 10","pages":"Pages 2189-2197.e1"},"PeriodicalIF":7.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149096166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}