Journal of Allergy and Clinical Immunology-In Practice最新文献

{"title":"In Lasting Tribute: Professor Marcus Maurer (1966-2024)—A visionary in allergy research and a highly respected physician","authors":"Jonathan A. Bernstein MD , Michael Schatz MD, MS , Torsten Zuberbier MD, PhD","doi":"10.1016/j.jaip.2025.01.025","DOIUrl":"10.1016/j.jaip.2025.01.025","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 3","pages":"Pages 452-453"},"PeriodicalIF":8.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Information for Readers","authors":"","doi":"10.1016/S2213-2198(25)00107-2","DOIUrl":"10.1016/S2213-2198(25)00107-2","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 3","pages":"Page A18"},"PeriodicalIF":8.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143549177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cough-Variant Asthma: A Review of Clinical Characteristics, Diagnosis, and Pathophysiology","authors":"Joshua K. Cox MD,&nbsp;Richard Lockey MD,&nbsp;Juan Carlos Cardet MD","doi":"10.1016/j.jaip.2024.11.005","DOIUrl":"10.1016/j.jaip.2024.11.005","url":null,"abstract":"<div><div>Chronic cough is among the most common symptoms prompting medical care. Cough-variant asthma (CVA) is an asthma subset where cough is the primary symptom, without wheezing, chest tightness, or dyspnea. It is an important cause of chronic cough, estimated to account for 25% to 42% of cases, but likely underdiagnosed due to delayed recognition and pitfalls of diagnostic testing. Early recognition and treatment can reduce morbidity and delay its progression to more typical asthma. This review details the clinical characteristics, diagnosis, pathophysiology, and treatment of CVA and contrasts it with classic asthma and other causes of chronic cough.</div></div>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 3","pages":"Pages 490-498"},"PeriodicalIF":8.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asthma Increases Long-Term Risk of Death by Suicide: A Nationwide Population-Based Cohort Study","authors":"Sang Hyuk Kim MD ,&nbsp;Hyun Lee MD, PhD ,&nbsp;Jin-Hyung Jung PhD ,&nbsp;Bo-Guen Kim MD, PhD ,&nbsp;Dong Won Park MD, PhD ,&nbsp;Tai Sun Park MD, PhD ,&nbsp;Ji-Yong Moon MD, PhD ,&nbsp;Tae-Hyung Kim MD, PhD ,&nbsp;Jang Won Sohn MD, PhD ,&nbsp;Ho Joo Yoon MD, PhD ,&nbsp;Kyungdo Han PhD ,&nbsp;Sang-Heon Kim MD, PhD","doi":"10.1016/j.jaip.2024.11.013","DOIUrl":"10.1016/j.jaip.2024.11.013","url":null,"abstract":"<div><h3>Background</h3><div>Previous studies have identified an increased risk of suicidal behaviors among individuals with asthma.</div></div><div><h3>Objective</h3><div>To evaluate the long-term risk and factors related to suicide in the adult population with asthma.</div></div><div><h3>Methods</h3><div>This study used the Korean National Health Insurance Service data. We investigated the risk of suicide concerning the presence or absence of asthma and potential risk factors for suicide among 3,914,041 adults aged 20 years or more.</div></div><div><h3>Results</h3><div>During a median follow-up of 12.3 years (interquartile range, 12.1-12.6 years), 1383 (0.48%) individuals with asthma died by suicide. Individuals with asthma had an increased risk of suicide compared with controls (adjusted hazard ratio [aHR], 1.26; 95% CI, 1.19-1.33). Suicide risk was especially high in individuals with asthma phenotypes: hospitalization-prone (aHR, 1.61; 95% CI, 1.40-1.84), nonobese (aHR, 1.37; 95% CI, 1.27-1.64), and asthma-chronic obstructive pulmonary disease overlap (aHR, 1.47; 95% CI, 1.22-1.76). Coexisting underweight status (aHR, 2.54; 95% CI, 2.05-3.16), mental health disorders (schizophrenia [aHR, 3.38; 95% CI, 2.28-5.02], depression [aHR, 3.24; 95% CI, 2.85-3.68], and anxiety disorder [aHR, 2.47; 95% CI, 2.00-3.05]), and cancers (aHR, 2.22; 95% CI, 1.73-2.84) further increased the suicide risk.</div></div><div><h3>Conclusions</h3><div>Asthma was associated with an increased risk of suicide, particularly in hospitalization-prone, nonobese, and asthma-chronic obstructive pulmonary disease overlap phenotypes. The risk was further increased when asthma coexisted with underweight status, mental health disorders, or cancers.</div></div>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 3","pages":"Pages 559-567.e3"},"PeriodicalIF":8.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Mastocytosis Control Test: A Patient-Reported Outcome Measure Assessing Disease Control","authors":"Frank Siebenhaar MD ,&nbsp;Senan Sofi MD ,&nbsp;Sophia Neisinger MD ,&nbsp;Cem Akin MD, PhD ,&nbsp;Polina Pyatilova MD ,&nbsp;Eva Grekowitz MD ,&nbsp;Antje Haendel ,&nbsp;Tomasz Hawro MD ,&nbsp;Lea Kiefer MD ,&nbsp;Markus Magerl MD ,&nbsp;Martin Metz MD ,&nbsp;Marcus Maurer MD ,&nbsp;Karsten Weller MD","doi":"10.1016/j.jaip.2024.11.021","DOIUrl":"10.1016/j.jaip.2024.11.021","url":null,"abstract":"<div><h3>Background</h3><div>Mastocytosis is characterized by expanding neoplastic mast cells in organs such as the skin, bone marrow, and gastrointestinal tract. The release of mast cell mediators triggers cutaneous, gastrointestinal, and other symptoms. Currently, no validated mastocytosis-specific patient-reported outcome measure (PROM) exists to assess disease control.</div></div><div><h3>Objective</h3><div>Here, we developed a disease-specific instrument, the Mastocytosis Control Test (MCT), for evaluating and monitoring disease control in patients with nonadvanced disease.</div></div><div><h3>Methods</h3><div>Six potential MCT items were generated using a combined approach consisting of a literature review, patient interviews, and expert input. Item selection and reduction were performed by impact analysis and interitem correlation, followed by expert reviews and cognitive debriefings. In a validation study, the resulting MCT was tested for validity and reliability by assessing internal consistency, test-retest reliability, convergent validity, known-groups validity, and receiver operating characteristics (ROC) analysis.</div></div><div><h3>Results</h3><div>Ten patients participated in the item generation phase and 101 in the item reduction and validation phase. The final MCT consisted of 5 items. Our methods showed a valid total score, high internal consistency, and test-retest reliability. Convergent and known-groups validity demonstrated a strong correlation with related anchors. The ROC curve analysis suggested a cutoff value of ≥13 points to identify patients with good disease control.</div></div><div><h3>Conclusions</h3><div>The MCT is a disease-specific, valid, and reliable PROM for adult patients with nonadvanced disease. It may measure and monitor disease control in routine daily practice and clinical trials.</div></div>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 3","pages":"Pages 647-657.e3"},"PeriodicalIF":8.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insect Allergy: Barriers in Training and Practice—A Work Group Report of the AAAAI Anaphylaxis Committee","authors":"Karla Adams MD ,&nbsp;Matthew Greenhawt MD, MBA, MS ,&nbsp;Theresa Bingemann MD ,&nbsp;James Tracy DO ,&nbsp;Joel Brooks DO ,&nbsp;Hans Otto MD ,&nbsp;Daniel Steigelman MD ,&nbsp;Yvonne Hsieh MD ,&nbsp;Aikaterini Anagnostou MD, MS, PhD ,&nbsp;John Carlson MD, PhD ,&nbsp;Jeffrey Demain MD ,&nbsp;Aasha Harish MD ,&nbsp;Nina Hein MD ,&nbsp;Anil Nanda MD ,&nbsp;Monica Hajirawala MD ,&nbsp;Susan Waserman MS, MD ,&nbsp;David B.K. Golden MDCM","doi":"10.1016/j.jaip.2024.12.037","DOIUrl":"10.1016/j.jaip.2024.12.037","url":null,"abstract":"<div><h3>Background</h3><div>The evaluation and management of insect sting allergy is a complex core competency taught in Allergy and Immunology fellowship programs. It is unclear whether current training on insect allergy is sufficient to meet the needs of the field and what training barriers exist.</div></div><div><h3>Objective</h3><div>To investigate the extent of training on stinging insect allergy and factors currently impacting stinging insect allergy clinical practice through a pilot needs-assessment survey.</div></div><div><h3>Methods</h3><div>A Web-based questionnaire was designed and sent to a 20% random sample of American Academy of Allergy, Asthma &amp; Immunology member categories. Data were analyzed for descriptive frequencies.</div></div><div><h3>Results</h3><div>A total of 78 responses were received (11% response rate). Respondents’ mean age was 53.7 years, 52% were female, and 92.3% were physicians. The mean time since training completion was 18.4 years. During fellowship training, 95.7% were educated on stinging insect allergy, 87.1% reported conducting testing, and 82.6% ordered venom immunotherapy (VIT). During training, 50% of respondents managed 1 to 5 patients with venom allergy (38% managed &gt; 5, and 12% none). After fellowship, 97.3% reported evaluating patients with stinging insect allergy, 90.3% report evaluating 1 to 5 patients per month, and 93.2% and 87.5% offer testing and VIT, respectively. A patient’s decision to not start VIT was the most common barrier reported by 81.8%.</div></div><div><h3>Conclusions</h3><div>In this pilot needs-assessment survey, the majority reported training and education on insect allergy during fellowship, although patient exposure was low for most. After fellowship, insect allergy evaluations increased up to 24-fold compared with fellowship training and patient-driven decisions are the most common deterrent for VIT.</div></div>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 3","pages":"Pages 501-510"},"PeriodicalIF":8.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cough Reflex Hypersensitivity as a Key Treatable Trait","authors":"","doi":"10.1016/j.jaip.2025.01.027","DOIUrl":"10.1016/j.jaip.2025.01.027","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 3","pages":"Page 479"},"PeriodicalIF":8.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143549081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Original Article Highlights From This Issue","authors":"","doi":"10.1016/S2213-2198(25)00104-7","DOIUrl":"10.1016/S2213-2198(25)00104-7","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 3","pages":"Pages A11-A14"},"PeriodicalIF":8.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143549175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic rhinosinusitis and the development of non-cystic fibrosis bronchiectasis","authors":"Nien-Yi Wu RN ,&nbsp;Hui-Chin Chang MLS ,&nbsp;Shuo-Yan Gau MD, FRSPH","doi":"10.1016/j.jaip.2025.01.008","DOIUrl":"10.1016/j.jaip.2025.01.008","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 3","pages":"Page 720"},"PeriodicalIF":8.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143549238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of eosinophilic esophagitis in pediatric patients undergoing oral immunotherapy for food allergies: A 2-center case series","authors":"Grace Hardwick BS ,&nbsp;Twan Sia BA ,&nbsp;Leeon Bacchus BA ,&nbsp;Xiaolin Jia MD ,&nbsp;Andrew R. Chin PhD ,&nbsp;Nasim Khavari MD ,&nbsp;Marwa Abu El Haija MD ,&nbsp;Sean McGhee MD ,&nbsp;R. Sharon Chinthrajah MD ,&nbsp;John Leung MD ,&nbsp;Sayantani B. Sindher MD","doi":"10.1016/j.jaip.2024.11.016","DOIUrl":"10.1016/j.jaip.2024.11.016","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 3","pages":"Pages 702-704"},"PeriodicalIF":8.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}