Journal of Allergy and Clinical Immunology-In Practice最新文献

{"title":"Thunderstorm Asthma: Current Perspectives and Emerging Trends","authors":"Francis Thien MD, FRACP ,&nbsp;Janet M. Davies PhD ,&nbsp;Jo A. Douglass MD, FRACP ,&nbsp;Mark Hew PhD, FRACP","doi":"10.1016/j.jaip.2025.04.001","DOIUrl":"10.1016/j.jaip.2025.04.001","url":null,"abstract":"<div><div>Isolated episodes and epidemic outbreaks of thunderstorm asthma have now been documented for over 40 years, with global geographical reach across Europe, North America, Middle East, Asia, Oceania, and Africa. This phenomenon encompasses specific environmental and meteorological factors, interacting with aeroallergen propagation and exposure in susceptible allergen-sensitized individuals and populations. There is a likely contribution from climate change with prolonged allergenic pollen seasons combined with increased pollen allergenicity, as well as heightened likelihood of extreme weather events. Differential population susceptibility to thunderstorm asthma presentations, hospitalizations, and deaths with increased vulnerability of certain ethnic groups suggests a gene-environment interaction. This clinical commentary reviews the characteristics and updates the epidemiology of thunderstorm asthma; examines the role of aerobiology and climate change; discusses risk factors for emergency presentations, hospital admissions, and deaths; considers latest research and predictors of thunderstorm asthma; and proposes strategies to manage and mitigate risk.</div></div>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages 1273-1280"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indoor Allergen Interventions in Homes and Schools for Managing Asthma","authors":"Ramin Beheshti MD ,&nbsp;Wanda Phipatanakul MD, MS ,&nbsp;Emily DiMango MD ,&nbsp;Torie L. Grant MD, MHS","doi":"10.1016/j.jaip.2025.04.027","DOIUrl":"10.1016/j.jaip.2025.04.027","url":null,"abstract":"<div><div>Asthma remains a prevalent and burdensome chronic disease in the United States, disproportionately affecting low-income populations and placing a significant strain on the health care system. Environmental allergen exposure, particularly in urban areas, has been extensively linked to asthma development and exacerbations. Identifying effective strategies for reducing allergen exposure could help mitigate asthma morbidity, decrease health care utilization, and improve patients’ quality of life. Studies evaluating environmental interventions, including home- and school-based allergen reduction strategies, have reported mixed results. Although some interventions, such as targeted allergen reduction, pest management, and air filtration, demonstrate improvements in asthma symptoms and health care utilization, others show limited impact on long-term asthma control and controller medication use. In this review, we assess the impact of environmental allergens on asthma prevalence, morbidity, and health care burden in the United States. We also examine the effectiveness of various allergen-reduction strategies in achieving sustained clinical benefits for asthma management and make practical recommendations for patient care.</div></div>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages 1256-1265"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal evaluation of the Cough Hypersensitivity Questionnaire in a cohort of chronic cough","authors":"Mi-Yeong Kim MD, PhD ,&nbsp;Hwa Young Lee MD, PhD ,&nbsp;Ji-Yoon Oh MD ,&nbsp;Noeul Kang MD, PhD ,&nbsp;Sung-Yoon Kang MD, PhD ,&nbsp;Eun-Jung Jo MD, PhD ,&nbsp;Han-Ki Park MD, PhD ,&nbsp;Seung-Eun Lee MD, PhD ,&nbsp;Ji-Yong Moon MD, PhD ,&nbsp;Youngsang Yoo MD ,&nbsp;Ha-Kyeong Won MD, PhD ,&nbsp;Jin An MD, PhD ,&nbsp;Kyung Eun Park MD (Candidate) ,&nbsp;Yeonhee Kim MD ,&nbsp;Joon-Woo Bahn MD, PhD ,&nbsp;Min-Kyung Oh PhD ,&nbsp;Surinder S. Birring MD ,&nbsp;Woo-Jung Song MD, PhD ,&nbsp;Korean Chronic Cough Registry Investigators","doi":"10.1016/j.jaip.2025.02.025","DOIUrl":"10.1016/j.jaip.2025.02.025","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages 1471-1473.e1"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hereditary Angioedema With Normal C1 Inhibitor: A Quarter Century of Forward Progress and Persisting Obstacles","authors":"Sandra C. Christiansen MD ,&nbsp;Aleena Banerji MD ,&nbsp;Jonathan A. Bernstein MD ,&nbsp;Paula J. Busse MD ,&nbsp;Timothy Craig DO ,&nbsp;H. Henry Li MD, PhD ,&nbsp;Mark Davis-Lorton MD ,&nbsp;William R. Lumry MD ,&nbsp;Marc A. Riedl MD, MS ,&nbsp;Bruce L. Zuraw MD","doi":"10.1016/j.jaip.2025.02.036","DOIUrl":"10.1016/j.jaip.2025.02.036","url":null,"abstract":"<div><div>Hereditary angioedema with normal C1 inhibitor (HAE-nl-C1INH) was initially described almost a quarter century ago. Considerable progress toward unraveling the mysteries of this complex disease has been made during the intervening years. The ability to diagnose, classify, and treat HAE-nl-C1INH, however, continues to present daunting clinical challenges. In this article we have attempted to summarize current areas of scientific consensus and provide some insights to assist physicians caring for affected individuals. Coherently describing the field of HAE-nl-C1INH in many ways embodies a precarious balance between assertions anchored by data versus conjecture. In this Rostrum we have tried to encapsulate the numerous scientific developments over the past 25 years into a proposed classification schema intended to facilitate decisions when evaluating patients with recurrent angioedema. Founded on an accurate diagnosis in conjunction with an appreciation of the underlying pathomechanism, targeted patient treatment strategies can be appropriately designed. It is hoped that this approach will lay the groundwork for future advances in our understanding of HAE-nl-C1INH while bringing patients ever closer to the goal of leading a normal life.</div></div>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages 1300-1309"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to “Considerations for enhancing dupilumab research in hypereosinophilic syndromes”","authors":"Ejiofor Ezekwe Jr. MD, PhD,&nbsp;Amy Klion MD","doi":"10.1016/j.jaip.2025.03.029","DOIUrl":"10.1016/j.jaip.2025.03.029","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Page 1499"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indoor and Outdoor Fungal Allergens and Impacts on Respiratory Allergic Disease","authors":"","doi":"10.1016/j.jaip.2025.05.007","DOIUrl":"10.1016/j.jaip.2025.05.007","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Page 1272"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144213240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Profiling Blood Hypereosinophilia in Patients on Dupilumab Treatment for Respiratory Conditions: A Real-Life Snapshot","authors":"Marco Caminati MD ,&nbsp;Matteo Maule MD ,&nbsp;Diego Bagnasco MD ,&nbsp;Bianca Beghè MD ,&nbsp;Fulvio Braido MD ,&nbsp;Luisa Brussino MD ,&nbsp;Paolo Cameli MD ,&nbsp;Maria Giulia Candeliere MD ,&nbsp;Giovanna Elisiana Carpagnano MD ,&nbsp;Giulia Costanzo MD ,&nbsp;Claudia Crimi MD ,&nbsp;Mariella D'Amato MD ,&nbsp;Stefano Del Giacco MD ,&nbsp;Gabriella Guarnieri MD ,&nbsp;Mona-Rita Yacoub MD ,&nbsp;Claudio Micheletto MD ,&nbsp;Filippo Moletta MD ,&nbsp;Stefania Nicola MD ,&nbsp;Bianca Olivieri MD ,&nbsp;Laura Pini MD ,&nbsp;Roberto Benoni PhD","doi":"10.1016/j.jaip.2025.01.040","DOIUrl":"10.1016/j.jaip.2025.01.040","url":null,"abstract":"<div><h3>Background</h3><div>A transient and usually asymptomatic increase in blood eosinophil count (BEC) associated with dupilumab treatment has been described. Predicting factors related to the increase in BEC and the occurrence of symptoms are still poorly investigated.</div></div><div><h3>Objective</h3><div>To investigate frequency, timing, duration, clinical relevance, and potential predictors of the increase in BEC in a real-life multicenter cohort of patients affected by asthma and/or chronic rhinosinusitis with nasal polyps (CRSwNP) treated with dupilumab.</div></div><div><h3>Methods</h3><div>BEC and clinical conditions at baseline and every 3 months after the start of dupilumab treatment were assessed. Any adverse drug reaction was also recorded. Remission of dupilumab-associated eosinophilia was defined by follow-up BEC values &lt;0.5 × 10⁹ cells/L.</div></div><div><h3>Results</h3><div>Overall, 108 of 195 (55%) patients experienced an increased BEC after dupilumab initiation, but only 29 of 195 (14.9%) showed hypereosinophilia. BEC peak occurred 6 months after the start of treatment and resolved after 9 months (median time). The probability of developing hypereosinophilia was 3.3 times higher in patients with the baseline BEC between 0.5 × 10⁹ and 1.5 × 10⁹ cells/L. The occurrence of symptoms during BEC peak was higher in patients with comorbidities and in patients showing any increase in BEC.</div></div><div><h3>Conclusions</h3><div>In a real-life setting, dupilumab treatment in patients with asthma and/or CRSwNP was often associated with a transient increase in BEC, but hypereosinophilia rarely occurred. Onset of symptoms co-occurring with BEC peak was observed in a minority of subjects. BEC should not preclude dupilumab initiation or continuation but should be monitored for at least 8 months after treatment begins, particularly in the case of baseline eosinophilia/hypereosinophilia and/or comorbidities.</div></div>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages 1367-1374.e4"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indoor and Outdoor Fungal Allergens and Impacts on Respiratory Allergic Disease","authors":"Charles S. Barnes PhD ,&nbsp;Gurjit K. Khurana Hershey MD, PhD","doi":"10.1016/j.jaip.2025.03.023","DOIUrl":"10.1016/j.jaip.2025.03.023","url":null,"abstract":"<div><div>Humans have a historic and intimate relationship with fungi. Fungi cause decay in the environment and a variety of human disease states including respiratory disease. Immunocompromised persons are particularly susceptible to fungal infection; however, the greater impact of fungi in general is through allergic mechanisms. This impact has been extensively documented in epidemiologic studies. Typically, fungal spore exposure has been examined in the outdoor environment; however, in recent decades, lifestyle changes have resulted in increased concern about fungi in the indoor environment. This review examines evidence for the relationship between fungal exposure and respiratory disease as indicated by documented physician interactions comparing times of high spore exposure with times of low exposure. The taxa Alternaria has been especially associated with respiratory difficulties, but there is extensive cross-reactivity among fungal allergens. We examine recent evidence that damp housing and associated indoor fungal load relate to respiratory disease and some possible mechanisms by which fungal products might cause sensitivity. We also offer some steps allergists might suggest to their patients that may help alleviate fungal exposure.</div></div>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages 1267-1271"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Household cleaning product exposure and severe bronchiolitis in infancy: A case-control study","authors":"Orianne Dumas PhD ,&nbsp;Isis Felippe Baroni MD ,&nbsp;Geneva D. Mehta MD ,&nbsp;Ashley F. Sullivan MPH ,&nbsp;Zhaozhong Zhu ScD ,&nbsp;Carlos A. Camargo Jr. MD, DrPH","doi":"10.1016/j.jaip.2025.03.032","DOIUrl":"10.1016/j.jaip.2025.03.032","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages 1468-1470.e2"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interrupting a vicious cycle can result in cessation of refractory chronic cough","authors":"Miles Weinberger MD ,&nbsp;Ran D. Anbar MD ,&nbsp;Dennis Buettner","doi":"10.1016/j.jaip.2025.03.044","DOIUrl":"10.1016/j.jaip.2025.03.044","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Page 1502"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}