Journal of Allergy and Clinical Immunology-In Practice最新文献

How to adjust asthma management once asthma is controlled on long term biologic therapy. 长期生物治疗控制哮喘后如何调整哮喘管理。

IF 8.2 1区医学

Journal of Allergy and Clinical Immunology-In Practice Pub Date : 2025-05-26 DOI: 10.1016/j.jaip.2025.05.031

Michael E Wechsler, David J Jackson, Wendy C Moore, Monica Kraft

{"title":"How to adjust asthma management once asthma is controlled on long term biologic therapy.","authors":"Michael E Wechsler, David J Jackson, Wendy C Moore, Monica Kraft","doi":"10.1016/j.jaip.2025.05.031","DOIUrl":"https://doi.org/10.1016/j.jaip.2025.05.031","url":null,"abstract":"Monoclonal antibodies that target IgE, IL5 or the IL5 receptor, the IL4 receptor alpha, or TSLP, have improved outcomes, reducing exacerbations, minimizing symptoms, improving lung function, and facilitating corticosteroid withdrawal. While it is even possible to achieve remission with these biologics, many patients inquire about the feasibility of discontinuing their biologic, their inhalers, or consideration of alternative dosing strategies. In this commentary, we review available data regarding the safety and efficacy of different asthma medication management options once asthma is controlled on long-term biologic therapy. We evaluate stopping of biologics while continuing inhaler therapy, stopping background therapy while continuing biologics, reducing biologic dose, increasing biologic interval, and other strategies including seasonal administration of biologics. It is clear that many patients can safely adopt some of these approaches that will make their lives easier, and potentially less expensive for patient and payers. What is needed is more research to tell us who, when, and how to adopt these alternative regimens.","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eliminating the Common Food Allergy Panel from In-House Laboratory: How We Did It and Why You Should Too! 从内部实验室消除常见的食物过敏小组：我们是如何做到的，为什么你也应该这样做！

IF 8.2 1区医学

Journal of Allergy and Clinical Immunology-In Practice Pub Date : 2025-05-22 DOI: 10.1016/j.jaip.2025.05.025

Ethan Canty, Andrew White, John Kelso, Kevin Cook

引用次数: 0

Continued symptom and quality of life improvement with favorable safety shown with long-term avapritinib in indolent systemic mastocytosis. 长期阿伐替尼治疗无性全身肥大细胞增多症的持续症状和生活质量改善及良好的安全性。

IF 8.2 1区医学

Journal of Allergy and Clinical Immunology-In Practice Pub Date : 2025-05-22 DOI: 10.1016/j.jaip.2025.05.026

Mariana Castells, Cem Akin, Karin Hartmann, Sigurd Broesby-Olsen, Tracy I George, Dakota Powell, Ilda Bidollari, Hui-Min Lin, Ben Lampson, Ashley Doyle, Frank Siebenhaar, Vito Sabato

引用次数: 0

Specific Clinical Features Define HLA-A*32:01 Positive Vancomycin Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) A Multi-institution Cross-sectional Study. HLA-A*32:01万古霉素阳性药物反应伴嗜酸性粒细胞增多和全身症状（DRESS）一项多机构横断面研究

IF 8.2 1区医学

Journal of Allergy and Clinical Immunology-In Practice Pub Date : 2025-05-22 DOI: 10.1016/j.jaip.2025.05.027

Matthew S Krantz, Chantal Lemoine, Li Zhou, Andrew J King, Daniela Kroshinsky, Elizabeth J Phillips, Kimberly G Blumenthal

引用次数: 0

Strategic Directions for Advancing Equity in Food Allergy: Takeaways from CFAAR's Summit for Advancing Equity in Food Allergy. 促进食物过敏公平的战略方向：CFAAR促进食物过敏公平峰会的要点。

IF 8.2 1区医学

Journal of Allergy and Clinical Immunology-In Practice Pub Date : 2025-05-19 DOI: 10.1016/j.jaip.2025.05.024

Michael S Yang, Christopher M Warren, Melissa L Engel, Waheeda Samady, Samantha R Sansweet, Madeleine K Kanaley, Elizabeth V W Folger, Sanjana Shankar, Ruchi S Gupta, Lucy A Bilaver

{"title":"Strategic Directions for Advancing Equity in Food Allergy: Takeaways from CFAAR's Summit for Advancing Equity in Food Allergy.","authors":"Michael S Yang, Christopher M Warren, Melissa L Engel, Waheeda Samady, Samantha R Sansweet, Madeleine K Kanaley, Elizabeth V W Folger, Sanjana Shankar, Ruchi S Gupta, Lucy A Bilaver","doi":"10.1016/j.jaip.2025.05.024","DOIUrl":"https://doi.org/10.1016/j.jaip.2025.05.024","url":null,"abstract":"In the United States, food allergy (FA) affects an estimated 10.6% of adults and 7.6% of children, totaling over 30 million individuals. Beyond their medical implications, FA places a substantial emotional, social, and economic burden on individuals, families, and caregivers. Disparities in FA education and access to clinical care have been found across socioeconomic and racial groups. To identify and address barriers to equity in FA, Northwestern's Center for Food Allergy and Asthma Research hosted the Summit for Advancing Equity in Food Allergy (SAEFA), a conference bringing together 35 leading experts as panelists and over five dozen diverse FA stakeholders for four key FA panels: Daily Life, Diagnosis, Prevention, and Daily Treatment. Live transcription of the discussions by scribes and real-time projection of notes to the front of the conference room allowed attendees to actively review, contribute to, and refine insights as conversations evolved. The results from the SAEFA conference led to the creation of 5 strategic directions for advancing equity in the field: (1) Enhance Food Allergy Safety in Public Spaces, (2) Expand Community-Based Health Initiatives, (3) Increase Equitable Access to Allergy Care, (4) Strengthen Industry Collaboration and Policy Reform, and (5) Drive Research Innovation. Results from the SAEFA conference help elucidate how tackling FA inequalities demands a comprehensive, multi-sector approach. Implementing strategies to expand access to care, improve patient education, and promote inclusive policies-while drawing from successful models in other areas of healthcare-can drive meaningful progress in improving equity in FA management.","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SKIN MANIFESTATIONS IN ADULTS WITH CHRONIC GRANULOMATOUS DISEASE IN THE UNITED KINGDOM. 英国成人慢性肉芽肿病的皮肤表现。

IF 8.2 1区医学

Journal of Allergy and Clinical Immunology-In Practice Pub Date : 2025-05-16 DOI: 10.1016/j.jaip.2025.04.058

Luiza Campos, Carla Arteaga Henríquez, George Meligonis, Susan Tadros, David M Lowe, B Grimbacher, Siobhan O Burns, Catherine H Orteu

{"title":"SKIN MANIFESTATIONS IN ADULTS WITH CHRONIC GRANULOMATOUS DISEASE IN THE UNITED KINGDOM.","authors":"Luiza Campos, Carla Arteaga Henríquez, George Meligonis, Susan Tadros, David M Lowe, B Grimbacher, Siobhan O Burns, Catherine H Orteu","doi":"10.1016/j.jaip.2025.04.058","DOIUrl":"https://doi.org/10.1016/j.jaip.2025.04.058","url":null,"abstract":"Background: Chronic Granulomatous Disease (CGD) is a rare inborn error of immunity caused by mutations affecting individual components of the NADPH oxidase complex. Resultant defective neutrophil function leads to infectious and inflammatory complications, resulting in reduced quality of life and survival. Although haematopoietic stem cell transplant is a curative option, a significant proportion of patients are managed conservatively into adulthood. Skin manifestations are common in patients with uncorrected CGD but are poorly documented with no existing treatment guidelines.Objective: To document skin disease and response to treatment in adults with uncorrected CGD.Methods: We conducted a retrospective review in a large cohort of adults with CGD conservatively managed at a single centre in a joint Immunology/Dermatology clinic. Clinical, photographic, histological and treatment data were collected to assign distinct skin diagnoses and assess response to treatment.Results: 34/50 patients with X-linked or Autosomal Recessive CGD had skin involvement, typically with more than one skin diagnosis. Pustular eruptions, seborrheic dermatitis, rosacea and skin infections were most commonly seen. Mucocutaneous lupus, oro-facial granulomatosis and other pre-dominantly inflammatory diagnoses were seen in a smaller subset. Culture was positive in only 32.5% of the tests, even from pustular lesions. Typically, skin disease was difficult to treat with variable responses to treatment and frequent relapses.Conclusions: A broad range of skin manifestations are seen in adults with CGD. It remains unclear to what extent CGD skin disease is contributed to by infection and/or an excessive inflammatory response, for example to skin microorganisms. Prolonged and intensive therapy is often required.","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Addressing Anxiety and Depression in the Allergy Clinic Through Motivational Interviewing, Brief Cognitive Behavioral Therapy, and Curious Questions. 通过动机性访谈、简短认知行为疗法和好奇问题来解决过敏临床中的焦虑和抑郁。

IF 8.2 1区医学

Journal of Allergy and Clinical Immunology-In Practice Pub Date : 2025-05-16 DOI: 10.1016/j.jaip.2025.05.020

Marylee Verdi, Dominic Candido, Juliette Madan, Jonathan A Bernstein, Don Bukstein, Aikaterini Anagnostou, Matthew Greenhawt, S Shahzad Mustafa, Julie Wang, Anna Nowak-Wegrzyn, Elissa M Abrams, John Oppenheimer, Alexandra E Conway, Andrew A White, Taylor A Doherty, Richard P Morse, Marcus Shaker

{"title":"Addressing Anxiety and Depression in the Allergy Clinic Through Motivational Interviewing, Brief Cognitive Behavioral Therapy, and Curious Questions.","authors":"Marylee Verdi, Dominic Candido, Juliette Madan, Jonathan A Bernstein, Don Bukstein, Aikaterini Anagnostou, Matthew Greenhawt, S Shahzad Mustafa, Julie Wang, Anna Nowak-Wegrzyn, Elissa M Abrams, John Oppenheimer, Alexandra E Conway, Andrew A White, Taylor A Doherty, Richard P Morse, Marcus Shaker","doi":"10.1016/j.jaip.2025.05.020","DOIUrl":"https://doi.org/10.1016/j.jaip.2025.05.020","url":null,"abstract":"Allergic diseases, particularly food allergy, can be associated with significant psychosocial impairment. Allergist-immunologists can provide evidence-based information to correct misperceptions and misunderstandings regarding food allergy that may perpetuate cycles of fear and anxiety. While motivational interviewing can be an empathetic approach to empower patients to actualize health goals, cognitive behavioral therapy (CBT) aims to provide disease-state insight to facilitate an understanding of risk which can facilitate transformation of health beliefs and behavior. Brief CBT (bCBT) is a clinical approach that can help address ineffective management paradigms through conversations that begin with curious questions. In this review we discuss evidence supporting implementation of an integrated method of CBT in the allergy-immunology clinic and provide resources for this approach.","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contact Dermatitis and Patch Testing Education: A Workgroup Report from the Allergic Skin Diseases Committee of the AAAAI. 接触性皮炎和斑贴试验教育：来自AAAAI过敏性皮肤病委员会的工作组报告。

IF 8.2 1区医学

Journal of Allergy and Clinical Immunology-In Practice Pub Date : 2025-05-15 DOI: 10.1016/j.jaip.2025.03.055

Ryan Steele, Karin Pacheco, Ellen Sher, Jacqueline Ross, Ray Tanzer, Luz Fonacier, Marcella R Aquino

{"title":"Contact Dermatitis and Patch Testing Education: A Workgroup Report from the Allergic Skin Diseases Committee of the AAAAI.","authors":"Ryan Steele, Karin Pacheco, Ellen Sher, Jacqueline Ross, Ray Tanzer, Luz Fonacier, Marcella R Aquino","doi":"10.1016/j.jaip.2025.03.055","DOIUrl":"https://doi.org/10.1016/j.jaip.2025.03.055","url":null,"abstract":"Allergic Contact dermatitis (ACD) is effectively diagnosed and treated through the identification of causative allergens via patch testing (PT). Selection of allergens, along with the application and interpretation of PT results, necessitates specialized education and training. Our objective was to investigate the extent to which contact dermatitis (CD) education and PT training are components of the curriculum in Allergy and Immunology (A/I) training programs in the United States, and to assess where knowledge gaps may exist. A voluntary 16 item survey was sent to Program and Associate Program Directors (PDs) in A/I associated with the American Academy of Allergy, Asthma, and Immunology (AAAAI) in 2021. A total of 23 out of 84 (27%) A/I training programs responded. Of the responding programs, 22% did not have a faculty member who performs PT and 25% do not have fellows perform PT. However, programs that performed more patch tests tended to use custom and expanded series, used the patient's personal products, and provided patients with a personal avoidance plan (loadings > 0.65). With respect to scholarly activity, 30% of programs had published an article on CD in the last 3 years. In conclusion, the key findings of our survey include that programs that perform PT are more likely to provide expanded and customized panels, provide patients with an individualized avoidance plan, and present scholarly activity on the topic. Given the importance of CD in allergy practices, our results indicate that more instruction in this topic is needed in A&I fellowship programs.","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Controversies in the Management of Preschool Asthma. 学龄前哮喘管理中的争议。

IF 8.2 1区医学

Journal of Allergy and Clinical Immunology-In Practice Pub Date : 2025-05-15 DOI: 10.1016/j.jaip.2025.04.057

Heidi Makrinioti, Bradley Chipps, Leonard B Bacharier, Andrew Bush

{"title":"Controversies in the Management of Preschool Asthma.","authors":"Heidi Makrinioti, Bradley Chipps, Leonard B Bacharier, Andrew Bush","doi":"10.1016/j.jaip.2025.04.057","DOIUrl":"https://doi.org/10.1016/j.jaip.2025.04.057","url":null,"abstract":"Preschool asthma - one of the most common pediatric conditions - continues to spark significant debate around its management. In this article, we critically examine controversies in preschool asthma management by focusing on definition, diagnosis, management goals, acute and routine management, patient advocacy, and care coordination. We address controversial questions around the definition of preschool asthma, the role of biomarkers, the efficacy of oral corticosteroids in preschool asthma attacks, the use of maintenance inhaled corticosteroids, the use of montelukast, and the possible use of targeted antibiotics. Furthermore, we emphasize the critical role of structured preschool asthma management plans and the involvement of nursery teachers and nurses in optimizing preschool asthma care. Overall, our review supports a shift towards individualized treatment strategies and improved healthcare coordination. Future research should prioritize the validation of predictive biomarkers to refine individualized treatment decisions that will be evaluated against patient-reported outcomes. To this direction, we make suggestions about the development and validation of biomarkers and different approaches in clinical trials design.","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

JAK inhibitors in pediatric patients with corticosteroids-resistant drug reaction with eosinophilia and systemic symptoms (DRESS). JAK抑制剂在伴有嗜酸性粒细胞增多和全身症状（DRESS）的皮质类固醇耐药反应患儿中的应用

IF 8.2 1区医学

Journal of Allergy and Clinical Immunology-In Practice Pub Date : 2025-05-14 DOI: 10.1016/j.jaip.2025.05.014

Lei Jiao, Chun Ping Shen, Chen Wang, Ying Gu, Zi Gang Xu, Yuan Liang

引用次数: 0