Journal of Allergy and Clinical Immunology-In Practice最新文献

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Sirolimus as a possible treatment in Cleavage-resistant RIPK1-induced autoinflammatory (CRIA) syndrome. 西罗莫司可用于治疗抗裂解 RIPK1 诱导的自身炎症(CRIA)综合征。
IF 8.2 1区 医学
Journal of Allergy and Clinical Immunology-In Practice Pub Date : 2024-11-16 DOI: 10.1016/j.jaip.2024.11.003
Marco Cattalini, Manuela Cortesi, Manuela Baronio, Antonella Insalaco, Fabrizio de Benedetti, Vassilios Lougaris, Raffaele Badolato
{"title":"Sirolimus as a possible treatment in Cleavage-resistant RIPK1-induced autoinflammatory (CRIA) syndrome.","authors":"Marco Cattalini, Manuela Cortesi, Manuela Baronio, Antonella Insalaco, Fabrizio de Benedetti, Vassilios Lougaris, Raffaele Badolato","doi":"10.1016/j.jaip.2024.11.003","DOIUrl":"10.1016/j.jaip.2024.11.003","url":null,"abstract":"<p><strong>Clinical implications: </strong>We present the case of a girl with CRIA syndrome treated with sirolimus with significant reduction in the number of days with fever, the total dose of glucocorticoids used and the inflammatory markers levels, together with a reduction in the double negative T-cells and control of PI3K/mTor Activity. We propose sirolimus as a valid therapeutic choice in patients with CRIA syndrome.</p>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cough Variant Asthma: A Review of Clinical Characteristics, Diagnosis, and Pathophysiology. 咳嗽变异性哮喘:临床特征、诊断和病理生理学综述。
IF 8.2 1区 医学
Journal of Allergy and Clinical Immunology-In Practice Pub Date : 2024-11-16 DOI: 10.1016/j.jaip.2024.11.005
Joshua K Cox, Richard Lockey, Juan Carlos Cardet
{"title":"Cough Variant Asthma: A Review of Clinical Characteristics, Diagnosis, and Pathophysiology.","authors":"Joshua K Cox, Richard Lockey, Juan Carlos Cardet","doi":"10.1016/j.jaip.2024.11.005","DOIUrl":"10.1016/j.jaip.2024.11.005","url":null,"abstract":"<p><p>Chronic cough is among the most common symptoms prompting medical care. Cough variant asthma (CVA) is an asthma subset where cough is the primary symptom, without wheezing, chest tightness, or dyspnea. It is an important cause of chronic cough, estimated to account for 25% to 42% of cases, but likely underdiagnosed due to delayed recognition and pitfalls of diagnostic testing. Early recognition and treatment can reduce morbidity and delay its progression to more typical asthma. This review details the clinical characteristics, diagnosis, pathophysiology, and treatment of CVA and contrasts it with classic asthma (CA) and other causes of chronic cough.</p>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cough Reflex Hypersensitivity as a Key Treatable Trait. 咳嗽反射过敏是一种可治疗的关键特征。
IF 8.2 1区 医学
Journal of Allergy and Clinical Immunology-In Practice Pub Date : 2024-11-16 DOI: 10.1016/j.jaip.2024.10.046
Woo-Jung Song, Deepti Vellaichamy Manian, Yeonhee Kim, Mengru Zhang, Alyn H Morice
{"title":"Cough Reflex Hypersensitivity as a Key Treatable Trait.","authors":"Woo-Jung Song, Deepti Vellaichamy Manian, Yeonhee Kim, Mengru Zhang, Alyn H Morice","doi":"10.1016/j.jaip.2024.10.046","DOIUrl":"10.1016/j.jaip.2024.10.046","url":null,"abstract":"<p><p>Cough reflex hypersensitivity is emerging as a key treatable trait in chronic cough and other cough-associated respiratory conditions. This review examines the neurological basis of cough, highlighting the complex interplay between peripheral and central mechanisms. The concept of cough hypersensitivity aims to address unmet clinical needs by recognizing chronic cough as a distinct disorder rather than merely a symptom. Evidence from clinical trials supports cough hypersensitivity as a treatable trait in chronic cough, with opiates, gabapentinoids, and novel P2X3 antagonists showing efficacy. Cough hypersensitivity is also relevant in conditions presenting with persistent cough, like asthma, bronchiectasis, and idiopathic pulmonary fibrosis, though more research is needed. Recognizing cough reflex hypersensitivity as a treatable trait offers new avenues for management, particularly for patients with persistent cough despite etiology-targeted therapies. We propose redefining chronic cough as a distinct disease entity in which cough hypersensitivity is a common feature and key therapeutic target, potentially leading to better patient care and the development of novel therapies.</p>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Clinical Approach to Chronic Cough. 慢性咳嗽的临床治疗方法》。
IF 8.2 1区 医学
Journal of Allergy and Clinical Immunology-In Practice Pub Date : 2024-11-16 DOI: 10.1016/j.jaip.2024.11.004
Imran Satia, Wafa Hassan, Lorcan McGarvey, Surinder S Birring
{"title":"The Clinical Approach to Chronic Cough.","authors":"Imran Satia, Wafa Hassan, Lorcan McGarvey, Surinder S Birring","doi":"10.1016/j.jaip.2024.11.004","DOIUrl":"10.1016/j.jaip.2024.11.004","url":null,"abstract":"<p><p>Chronic cough remains a significant clinical challenge, affecting approximately 10% of the population and leading to significant impairment in psychological, social and physical quality of life. In recent years, efforts have intensified to elucidate the mechanisms underlying chronic cough and to focus on investigating and treating refractory chronic cough (RCC). A 'treatable trait' approach, which focuses on identifying and addressing the specific associated causes of chronic cough, has gained traction. In some patients, refractory chronic cough is likely driven by a neuropathic mechanism due to dysregulation of the neuronal pathways involved in the cough reflex, often clinically described as cough hypersensitivity syndrome. While the initial treatment of underlying conditions remains central to managing treatable traits, the therapeutic options for RCC have expanded to include targeting cough hypersensitivity. First-line treatments now include neuromodulators and speech therapy with one P2X3 receptor antagonist (gefapixant) recently licensed in the EU, UK and Japan. Despite these advances, patient responses remain variable, underscoring the ongoing need for research into the pathophysiology and treatment of RCC. This article reviews current investigations and management options in treating chronic cough and RCC.</p>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing the Accuracy of ChatGPT's Responses to Common Allergy Myths. 评估 ChatGPT 对常见过敏误区回应的准确性。
IF 8.2 1区 医学
Journal of Allergy and Clinical Immunology-In Practice Pub Date : 2024-11-15 DOI: 10.1016/j.jaip.2024.11.002
Ricardo J Estrada-Mendizabal, Gabriel Cojuc-Konigsberg, Ebram N Labib, Carlos De la Cruz-De la Cruz, Alexei Gonzalez-Estrada, Lyda Cuervo-Pardo, Ricardo Zwiener, Alejandra Canel-Paredes
{"title":"Assessing the Accuracy of ChatGPT's Responses to Common Allergy Myths.","authors":"Ricardo J Estrada-Mendizabal, Gabriel Cojuc-Konigsberg, Ebram N Labib, Carlos De la Cruz-De la Cruz, Alexei Gonzalez-Estrada, Lyda Cuervo-Pardo, Ricardo Zwiener, Alejandra Canel-Paredes","doi":"10.1016/j.jaip.2024.11.002","DOIUrl":"https://doi.org/10.1016/j.jaip.2024.11.002","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing Protocol Variability for Food Protein-Induced Enterocolitis Syndrome Oral Food Challenges. 评估食物蛋白诱发的小肠结肠炎综合征口服食物挑战的方案变异性。
IF 8.2 1区 医学
Journal of Allergy and Clinical Immunology-In Practice Pub Date : 2024-11-12 DOI: 10.1016/j.jaip.2024.11.001
Sara Anvari, Ankona Banerjee, Stephanie Leonard, Purificacion Gonzalez-Delgado, Duc T Nguyen, Anna Nowak-Wegrzyn
{"title":"Assessing Protocol Variability for Food Protein-Induced Enterocolitis Syndrome Oral Food Challenges.","authors":"Sara Anvari, Ankona Banerjee, Stephanie Leonard, Purificacion Gonzalez-Delgado, Duc T Nguyen, Anna Nowak-Wegrzyn","doi":"10.1016/j.jaip.2024.11.001","DOIUrl":"https://doi.org/10.1016/j.jaip.2024.11.001","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A pharmacovigilance analysis of post-marketing safety of tezepelumab. 特珠单抗上市后安全性的药物警戒分析。
IF 8.2 1区 医学
Journal of Allergy and Clinical Immunology-In Practice Pub Date : 2024-11-07 DOI: 10.1016/j.jaip.2024.10.045
Huqun Li, Chongshu Wang, Cuilian Guo
{"title":"A pharmacovigilance analysis of post-marketing safety of tezepelumab.","authors":"Huqun Li, Chongshu Wang, Cuilian Guo","doi":"10.1016/j.jaip.2024.10.045","DOIUrl":"https://doi.org/10.1016/j.jaip.2024.10.045","url":null,"abstract":"<p><strong>Background: </strong>Tezepelumab has shown promising efficacy for adult patients with severe asthma since its approval. However, the post-marketing safety evaluation of tezepelumab is currently lacking.</p><p><strong>Objective: </strong>The present study aims to investigate the post-marketing safety of tezepelumab based on the FDA Adverse Event Reporting System (FAERS) database.</p><p><strong>Methods: </strong>Adverse events (AEs) reports from January 2022 to December 2023 were extracted from the FAERS database. Disproportionality analysis by reporting odds ratio (ROR) and empirical Bayesian geometric mean (EBGM) was performed to detect potential AEs related to tezepelumab. Clinical characteristics and time to onset of AEs were also assessed.</p><p><strong>Results: </strong>A total of 1,699 tezepelumab-related AE reports were identified during the study period. Thirty tezepelumab-related AE signals were detected by simultaneously applying the two algorithms. At the system organ class (SOC) level, the most common SOC related to tezepelumab was respiratory, thoracic and mediastinal disorders. At the preferred term (PT) level, common AEs including arthralgia and back pain were detected which were also documented in the label of tezepelumab and clinical trials. New unexpected AEs such as chest pain and myalgia were also identified. The median time to onset of tezepelumab-related AEs was 7.5 days, and the majority of AEs occurred within the first 1 month after tezepelumab initiation.</p><p><strong>Conclusion: </strong>The present study presents a comprehensive evaluation of the post-marketing safety of tezepelumab in the real-world setting. Our findings will provide valuable evidence for future clinical studies and management of safety issues of tezepelumab.</p>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Safety and low incidence of anaphylaxis in performing oral drug and food challenges in mastocytosis. 对肥大细胞增多症患者进行口服药物和食物挑战安全且过敏性休克发生率低。
IF 8.2 1区 医学
Journal of Allergy and Clinical Immunology-In Practice Pub Date : 2024-11-07 DOI: 10.1016/j.jaip.2024.10.044
Rebekka Karolin Bent, Ivana Varsanova, Valentina Faihs, Claudia Kugler, Alexander Zink, Teresa Jäger, Johannes Ring, Tilo Biedermann, Ulf Darsow, Knut Brockow
{"title":"Safety and low incidence of anaphylaxis in performing oral drug and food challenges in mastocytosis.","authors":"Rebekka Karolin Bent, Ivana Varsanova, Valentina Faihs, Claudia Kugler, Alexander Zink, Teresa Jäger, Johannes Ring, Tilo Biedermann, Ulf Darsow, Knut Brockow","doi":"10.1016/j.jaip.2024.10.044","DOIUrl":"https://doi.org/10.1016/j.jaip.2024.10.044","url":null,"abstract":"<p><strong>Background: </strong>Patients with mastocytosis (MC) have an increased risk of severe anaphylaxis. They report hypersensitivity reactions to drugs and food, but causality often remains questionable. Most allergy centers avoid oral challenge tests (OCT) in MC patients.</p><p><strong>Objective: </strong>To determine the safety of food and drug OCT in patients with MC.</p><p><strong>Methods: </strong>To retrospectively evaluate the safety and outcome of challenges to drugs and food including food additives, out of 126 adult MC inpatients, 83 patients had a suspicion of food or drug hypersensitivity and 445 OCTs were performed. History, clinical data and allergy test results highlighting OCTs were analyzed.</p><p><strong>Results: </strong>Only 10 of 445 OCTs (2.2%) in 9 patients resulted in anaphylaxis. Drugs elicited reactions in 4/170 (2.4 %) patients: two patients to acetylsalicylic acid (2/39 tested patients, 5.1%), one to tramadol (1/12, 8.3%) and one to flurbiprofen (1/1). Anaphylaxis to food was recorded in 6/275 OCTs (2.2%); two out of 48 (4.1%) to α-gal, two to other foods and two to sulfites. Flushing or diarrhea occurred to histamine in 5/48 (10.4%), but also in 5/50 (10.0%) placebo challenges strongly questioning its relevance. Patients with proven anaphylaxis had more bone marrow MC and higher basal serum tryptase (71.3 vs. 44.3ug/l; p<0.05).</p><p><strong>Conclusions: </strong>Challenge-confirmed food and drug anaphylaxis was rare in MC patients. Results have to be interpreted cautiously as placebo reactions did occur. Severe anaphylaxis was seldom, but may occur and should be met by emergency preparedness.</p>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The multiple facets of cow's milk allergy. 牛奶过敏的多面性。
IF 8.2 1区 医学
Journal of Allergy and Clinical Immunology-In Practice Pub Date : 2024-11-06 DOI: 10.1016/j.jaip.2024.10.038
Rachelle Lo, Marion Groetch, Joel Brooks, Erik Anderson, Pablo Rodríguez Del Río, Aikaterini Anagnostou
{"title":"The multiple facets of cow's milk allergy.","authors":"Rachelle Lo, Marion Groetch, Joel Brooks, Erik Anderson, Pablo Rodríguez Del Río, Aikaterini Anagnostou","doi":"10.1016/j.jaip.2024.10.038","DOIUrl":"https://doi.org/10.1016/j.jaip.2024.10.038","url":null,"abstract":"<p><p>Cow's milk allergy (CMA) is one of the most common food allergies in early childhood. CMA has varied presentations and multiple facets. A detailed clinical history is key for classification. In IgE-mediated CMA skin prick testing and serum specific IgE testing are useful in the diagnosis, but an oral food challenge (OFC) may still be necessary if there is doubt or to assess tolerance. Non-IgE-mediated CMA presentations include food protein-induced allergic proctocolitis (FPIAP), food protein-induced enterocolitis syndrome (FPIES), and eosinophilic esophagitis (EoE). The diagnosis of FPIAP and FPIES is based on the clinical history. An esophageal biopsy is required for the diagnosis of EoE. Atopy patch testing, IgG or IgG4 testing are not helpful in any CMA evaluation. Children with CMA (except those with FPIAP) are at risk for poor growth and a nutritional evaluation should be part of routine care. Extensively hydrolyzed formulas are the recommended first choice alternative formula for CMA. For IgE-mediated CMA, alternative approaches to traditional strict avoidance include oral immunotherapy (OIT) and omalizumab (both as monotherapy and as an adjunct to OIT). Multiple international guidelines have addressed evaluation and management of CMA providing key information, support and guidance for clinicians in daily practice.</p>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early treatment response to mepolizumab predicts clinical remission in severe eosinophilic asthma. 对美泊利单抗的早期治疗反应可预测严重嗜酸性粒细胞性哮喘的临床缓解。
IF 8.2 1区 医学
Journal of Allergy and Clinical Immunology-In Practice Pub Date : 2024-11-06 DOI: 10.1016/j.jaip.2024.10.041
Yuto Hamada, Peter G Gibson, Erin S Harvey, Sean Stevens, Hayley Lewthwaite, Michael Fricker, Vanessa M McDonald, Andrew Gillman, Mark Hew, Vicky Kritikos, John W Upham, Dennis Thomas
{"title":"Early treatment response to mepolizumab predicts clinical remission in severe eosinophilic asthma.","authors":"Yuto Hamada, Peter G Gibson, Erin S Harvey, Sean Stevens, Hayley Lewthwaite, Michael Fricker, Vanessa M McDonald, Andrew Gillman, Mark Hew, Vicky Kritikos, John W Upham, Dennis Thomas","doi":"10.1016/j.jaip.2024.10.041","DOIUrl":"https://doi.org/10.1016/j.jaip.2024.10.041","url":null,"abstract":"<p><strong>Background: </strong>Mepolizumab can induce an early response and clinical remission in people with severe eosinophilic asthma (SEA).</p><p><strong>Objective: </strong>We questioned whether early response to mepolizumab could predict future asthma remission, and sought to identify the best predictor of treatment response to mepolizumab for achieving remission.</p><p><strong>Methods: </strong>The Australian Mepolizumab Registry was used to investigate the early response to mepolizumab at 3 and 6 months and relate this to clinical remission at 12 months. Treatment response was assessed using the Asthma Control Questionnaire (ACQ)-5, oral corticosteroid (OCS) dose, exacerbation frequency, and post-bronchodilator FEV<sub>1</sub>. Clinical remission, assessed at 12 months, was defined as ACQ-5 ≤1.0 at 12 months, no exacerbations in the previous 6 months, and no OCS use for asthma in the previous 6 months. We estimated the optimism-corrected area under the curve (AUC) for internal validation.</p><p><strong>Results: </strong>We analyzed 255 participants with SEA. Seventy-eight (30.6%) participants achieved clinical remission at 12 months. A prediction model including ACQ-5 score, exacerbation frequency, OCS dose, and post-bronchodilator FEV<sub>1</sub> at 6 months was more predictive of achieving remission than measures at 3 months. ACQ-5 score at 6 months had the highest optimism-corrected AUC of 0.778 [95% CI: 0.719-0.833]. ACQ-5 score <1.5 at 6 months had a sensitivity of 85.9% for achieving clinical remission, while ACQ-5 score <0.75 had a specificity of 84.7%.</p><p><strong>Conclusion: </strong>ACQ-5 score at 6 months was the best predictor of achieving clinical remission at 12 months in people with SEA treated with mepolizumab. These results can be used to design a treat-to-target paradigm for asthma, where treatment response is assessed at 6 months to predict clinical remission.</p>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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