Journal of Allergy and Clinical Immunology-In Practice最新文献

{"title":"Tolerance of piperacillin-tazobactam in patients with amoxicillin allergy.","authors":"Alicia Moncada-Salinero, María González-Labrador, Miguel Angel Tejedor-Alonso, Ana Rosado-Ingelmo","doi":"10.1016/j.jaip.2025.08.015","DOIUrl":"10.1016/j.jaip.2025.08.015","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Menopause is not associated with asthma or severe asthma.","authors":"Si Li, Patricia Silveyra, Bo Hu, Battoul Fakhry, Hyun Jo Kim, Amy Attaway, Joe G Zein","doi":"10.1016/j.jaip.2025.08.014","DOIUrl":"10.1016/j.jaip.2025.08.014","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detecting Small Airways Dysfunction in Asthma: Rationale, Findings, and Future of ATLANTIS.","authors":"Salman Siddiqui, Christopher Brightling, Dave Singh, Janwillem Kocks, Leonardo M Fabbri, Alberto Papi, Klaus F Rabe, Marielle van der Deijl, Maarten van den Berge, Monica Kraft","doi":"10.1016/j.jaip.2025.08.013","DOIUrl":"10.1016/j.jaip.2025.08.013","url":null,"abstract":"<p><p>Small airway dysfunction (SAD) is both common and clinically relevant in patients with asthma. However, there is no recognized \"gold standard\" approach for the identification of SAD in clinical practice. The ATLANTIS (AssessmenT of smalL Airways involvemeNT In aSthma) study was a prospective (1-year follow-up), multicenter, international observational study that aimed to identify the best, or best combination of biomarkers, physiological tests, and imaging markers for the determination of the presence of SAD, and to evaluate the contribution of SAD across all asthma severities to meaningful clinical asthma outcomes. A large number of analyses from the ATLANTIS study have been conducted or are planned. This narrative review summarizes the key findings to date and the future directions. Perhaps the most important finding so far is that a \"toolbox\" of spirometry, oscillometry, and a small airways dysfunction questionnaire can detect SAD with high accuracy (area under the receiver operating characteristic curve 0.96 and positive likelihood ratio 12.8). Further, collaboration with other consortia has demonstrated the use of oscillometry to identify asthma phenotypes. We advocate the adoption of the ATLANTIS toolbox into interventional studies in asthma-and if validated, this could form a useful part of research and daily clinical practice.</p>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Pilot Pragmatic Cluster Randomized Trial of School-Supervised Therapy to Improve Pediatric Asthma Control.","authors":"Michelle Trivedi, Michelle Spano, Christine Frisard, Sybil Crawford, Grace Ryan, Melissa Goulding, Sonia Radu, Juliana Arenas, Sarah Becker, Layana Al-Halbouni, Jordan Alter, Nancy Byatt, Wanda Phipatanakul, Milagros C Rosal, Stephenie C Lemon, Lynn B Gerald, Lori Pbert","doi":"10.1016/j.jaip.2025.07.022","DOIUrl":"10.1016/j.jaip.2025.07.022","url":null,"abstract":"<p><strong>Background: </strong>Although school-supervised inhaled corticosteroid administration has potential to improve asthma morbidity, there has yet to be an evaluation of the pediatric practice as a setting to identify children with asthma and connect them to school-supervised asthma therapy.</p><p><strong>Objective: </strong>Conduct a pragmatic pilot trial of Asthma Link, a model that connects children with asthma seen in pediatric practice to supervised asthma therapy in the school setting.</p><p><strong>Methods: </strong>Four pediatric practices were pair-matched and randomized to (1) Asthma Link plus an asthma educational workbook or (2) Enhanced Usual Care, the same workbook alone. We recruited children 6 to 17 years old with poorly controlled asthma, prescribed a daily inhaled corticosteroid. Parent-child dyads completed surveys at baseline and 3, 6, and 12 months.</p><p><strong>Primary outcomes: </strong>recruitment/retention of pediatric practices and parent-child dyads and intervention fidelity.</p><p><strong>Secondary outcomes: </strong>asthma symptoms, medication adherence, emergency room visits, hospital admissions, oral steroid use, missed schooldays.</p><p><strong>Results: </strong>Four pediatric practices and 66 parent-child dyads were recruited (average child age 9 y, 44% female, 65% Hispanic, 23% Black, 62% low income). All (4 of 4) practices were retained throughout the study and retention of parent-child dyads was 95%, 91%, and 89% at 3, 6, and 12 months, respectively. All (31 of 31) Asthma Link families brought their child's preventive inhaler into school; children received school health staff-supervised therapy on more than 95% of schooldays over 12 months. Children in the Asthma Link group had greater improvement in Asthma Control Test scores, longer time to first asthma exacerbation, less oral steroid use, and better medication adherence compared with the Enhanced Usual Care group.</p><p><strong>Conclusions: </strong>Extending the reach of pediatric practices to facilitate the delivery of daily asthma prevention medication at school was feasible and improved pediatric asthma morbidity.</p>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12380124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cat, dog and exotic animal allergy.","authors":"Shannon Sotoudeh, Humdoon Choudhry, José Fernando Cantillo, Mary Ann Miranda, Enrique Fernández-Caldas, Richard F Lockey","doi":"10.1016/j.jaip.2025.08.011","DOIUrl":"https://doi.org/10.1016/j.jaip.2025.08.011","url":null,"abstract":"<p><p>Cats and dogs are the primary and most common sources of indoor allergens from domestic animals. These allergens are mainly found in saliva, epithelium, and hair and are dispersed in the air as small particles. They are detected in schools and homes even without cats or dogs, transported attached to fomites and people in contact with these animals. Allergy to exotic pets, such as gerbils, guinea pigs, ferrets, iguanas, and others also exists, especially in a day and age when 68% and 38% families in the United States and Europe, respectively, have a pet in their home. This document is intended to be a tool to aid decision-making by professionals who care for people who suffer from dog, cat, or exotic animal allergies, to establish diagnostic and therapeutic strategies, and to improve the patient's quality of life.</p>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Molecular Evaluations in the Biology, Diagnosis and Prognostication of Patients with Mastocytosis.","authors":"Gregor Hoermann, Alberto Orfao, Jonathan J Lyons, Yannick Chantran, Sigurd Broesby-Olsen, Vito Sabato, Michel Arock","doi":"10.1016/j.jaip.2025.07.055","DOIUrl":"https://doi.org/10.1016/j.jaip.2025.07.055","url":null,"abstract":"<p><p>Mastocytosis represents a group of rare clonal disorders characterized by accumulation of neoplastic mast cells (MC). Disease presentations range from indolent to highly aggressive forms. The discovery of somatic mutations in KIT, particularly KIT p.D816V, has revolutionized diagnosis, classification, and management of mastocytosis. KIT p.D816V, found in >85% of systemic mastocytosis (SM) cases, drives disease progression through constitutive activation of the KIT receptor. Highly sensitive techniques, such as allele-specific oligonucleotide quantitative PCR (ASO-qPCR), digital PCR (dPCR) and Flow-Super Rolling Circle Amplification (Flow-SuperRCA) have enhanced detection of KIT p.D816V, while next-generation sequencing (NGS) has allowed detection of other mutations, improving not only diagnostics and prognostication, but also monitoring of KIT p.D816V-targeted therapies. Of note, higher KIT p.D816V allele burdens, together with the presence of additional mutations in genes like DNMT3A, SRSF2, ASXL1, EZH2 and/or RUNX1, termed high risk mutations (HRM), correlate with advanced SM subtypes. Hereditary alpha-tryptasemia (HαT) is a genetic condition where increased TPSAB1 gene copy encoding alpha-tryptase usually leads to elevated serum tryptase. The incidence of HαT is increased in mastocytosis and may exacerbate mediator-related symptoms, emphasizing the importance of searching for this genetic condition in mastocytosis. To conclude, despite remaining challenges in standardization, molecular investigations may now improve diagnostics, prognostication and treatment monitoring in mastocytosis.</p>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjunctive therapy use following Janus kinase inhibitors versus dupilumab in atopic dermatitis.","authors":"Serena Yun-Chen Tsai, Hana B Ruran, Elena B Hawryluk, Wanda Phipatanakul, Michiko K Oyoshi, Lynda C Schneider, Kevin Sheng-Kai Ma","doi":"10.1016/j.jaip.2025.08.007","DOIUrl":"10.1016/j.jaip.2025.08.007","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Peds-AIRQ: The Next Evolution in Asthma Control Questionnaires?","authors":"William C Anderson, Piotr Łacwik","doi":"10.1016/j.jaip.2025.08.005","DOIUrl":"10.1016/j.jaip.2025.08.005","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144856963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AIR Therapy: Improving Patient and Planetary Health.","authors":"Lee Hatter, Richard Beasley","doi":"10.1016/j.jaip.2025.08.006","DOIUrl":"10.1016/j.jaip.2025.08.006","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144856961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HLA-B Alleles With Shared Peptide Binding Specificities Define Global Risk of Co-trimoxazole-Induced Severe Cutaneous Adverse Drug Reactions.","authors":"Yueran Li, Andrew Gibson, Hajirah N Saeed, Mohammadali Ashraf, Danmeng Li, David A Ostrov, Matthew S Krantz, Simon A Mallal, Eric Alves, Abha Chopra, Linda Choo, Roni P Dodiuk-Gad, Benjamin Kaffenberger, Aaron M Drucker, Michelle S Goh, Elizabeth Ergen, Robert Micheletti, Misha Rosenbach, Michelle D Martin-Pozo, Rama Gangula, Elizabeth A Williams, Alexis Yu, April O'Connor, Kelby Mahan, James T Kwan, Derek Metcalfe, Ramy Rashad, Swapna S Shanbhag, Mohammed Ali Tahboub, Sarah Pedretti, Phuti Choshi, Tafadzwa Chimbetete, Rose Selim, Ian James, Jason A Trubiano, Rannakoe Lehloenya, Jonny G Peter, Elizabeth J Phillips","doi":"10.1016/j.jaip.2025.08.001","DOIUrl":"10.1016/j.jaip.2025.08.001","url":null,"abstract":"<p><strong>Background: </strong>Co-trimoxazole is a leading global cause of severe cutaneous adverse drug reactions (SCAR) including Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) and drug reaction with eosinophilia and systemic symptoms (DRESS). Co-trimoxazole-induced SCAR are associated with HLA class I alleles including HLA-B∗13:01 and HLA-B∗38:02 in Southeast Asian (SEA) populations. However, the global generalizability of these associations is unknown but critical for population-appropriate risk stratification and diagnosis.</p><p><strong>Objective: </strong>To determine HLA risk factors associated with co-trimoxazole-induced SJS/TEN and DRESS in populations from the United States and South Africa.</p><p><strong>Methods: </strong>We performed high-resolution HLA typing on dermatologist-adjudicated co-trimoxazole-induced patients with SCAR in the United States (n = 63) and South Africa (n = 26) compared with population controls. Peptide binding and docking analyses were performed using MHCcluster2.0 and CB-Dock2.</p><p><strong>Results: </strong>In a multiple logistic regression model, HLA-B^∗44:03 (corrected P [Pc] < .001; odds ratio [OR] = 4.08), HLA-B^∗38:01 (Pc < .001; OR = 5.66), and HLA-C^∗04:01 (Pc = .003; OR = 2.50) were independently associated with co-trimoxazole-induced SJS/TEN in the United States. HLA-B^∗44:03 was also associated with co-trimoxazole-induced DRESS in South Africa (Pc = .019; OR = 10.69). Distinct HLA-B variants with shared peptide binding specificities (SPBS) and HLA-C^∗04:01 identified 94% and 78% of co-trimoxazole-induced SJS/TEN and DRESS in the United States, respectively. The SEA risk allele HLA-B^∗13:01, with SPBS to HLA-B^∗44:03, was identified in just one of 63 US patients with SCAR.</p><p><strong>Conclusions: </strong>HLA alleles with SPBS to SEA-related risk alleles, including HLA-B^∗44:03 (SPBS with HLA-B^∗13:01) and HLA-B^∗38:01 (SPBS with HLA-B^∗38:02) but also HLA-C^∗04:01, predisposed to co-trimoxazole-induced SCAR in the United States and South Africa. These findings provide biological plausibility and strategies for global risk prediction and diagnosis of co-trimoxazole-induced SCAR.</p>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}