Journal of Allergy and Clinical Immunology-In Practice最新文献

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CME exam: Patient-Reported Outcomes in Asthma 继续医学教育考试:哮喘患者报告结果
IF 8.2 1区 医学
Journal of Allergy and Clinical Immunology-In Practice Pub Date : 2024-10-01 DOI: 10.1016/j.jaip.2024.09.003
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引用次数: 0
Continuing Medical Education Calendar 继续医学教育日历
IF 8.2 1区 医学
Journal of Allergy and Clinical Immunology-In Practice Pub Date : 2024-10-01 DOI: 10.1016/S2213-2198(24)00901-2
{"title":"Continuing Medical Education Calendar","authors":"","doi":"10.1016/S2213-2198(24)00901-2","DOIUrl":"10.1016/S2213-2198(24)00901-2","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":null,"pages":null},"PeriodicalIF":8.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142426428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fixed drug eruption and generalized bullous fixed drug eruption: Insights from an analysis of the FDA Adverse Event Reporting System. 固定性药物喷发和全身大疱性固定性药物喷发:从 FDA 不良事件报告系统分析中获得的启示。
IF 8.2 1区 医学
Journal of Allergy and Clinical Immunology-In Practice Pub Date : 2024-10-01 DOI: 10.1016/j.jaip.2024.09.024
P Shrestha, C A Stone, E J Phillips
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引用次数: 0
Patient-Centered Practice Guidelines: GRADEing Evidence to Incorporate Certainty, Balance Between Benefits and Harms, Equity, Feasibility, and Cost-Effectiveness CME 临床评论综述:以患者为中心的实践指南:对证据进行分级,以纳入确定性、效益与危害之间的平衡、公平性、可行性和成本效益。
IF 8.2 1区 医学
Journal of Allergy and Clinical Immunology-In Practice Pub Date : 2024-10-01 DOI: 10.1016/j.jaip.2024.03.008
{"title":"Patient-Centered Practice Guidelines: GRADEing Evidence to Incorporate Certainty, Balance Between Benefits and Harms, Equity, Feasibility, and Cost-Effectiveness","authors":"","doi":"10.1016/j.jaip.2024.03.008","DOIUrl":"10.1016/j.jaip.2024.03.008","url":null,"abstract":"<div><div>The practice of medicine in recent years has emphasized the use of evidence-based clinical guidelines to help inform treatment decisions. Since its development in 2004, the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach has offered a systematic process for reviewing and summarizing the certainty of evidence found in the medical literature regarding various treatment options. To develop truly patient-centered care guidelines, this appraisal of the certainty of evidence must be combined with an understanding of the balance between benefits and harms, patient preferences, equity, feasibility, cost-effectiveness, and policy implications. This review examines each of these domains in detail, exploring the process and benefits of developing relevant, patient-focused guidelines directly applicable to the practice of modern medicine.</div></div>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":null,"pages":null},"PeriodicalIF":8.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140102811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of Antibiotics in Infancy and Asthma in Childhood: Confounded or Causal Relationship? A Critical Review of the Literature 婴儿期使用抗生素与儿童期哮喘:混杂关系还是因果关系?文献综述。
IF 8.2 1区 医学
Journal of Allergy and Clinical Immunology-In Practice Pub Date : 2024-10-01 DOI: 10.1016/j.jaip.2024.06.018
{"title":"Use of Antibiotics in Infancy and Asthma in Childhood: Confounded or Causal Relationship? A Critical Review of the Literature","authors":"","doi":"10.1016/j.jaip.2024.06.018","DOIUrl":"10.1016/j.jaip.2024.06.018","url":null,"abstract":"<div><div><span>Childhood asthma is among the most common chronic lung diseases<span> in the pediatric<span> population, having substantial consequences on the everyday life of children and their caregivers. There remains a lack of a singular, efficacious strategy for averting the inception of childhood asthma. The rate of pediatric </span></span></span>antibiotic<span> usage continues to be high, which makes it crucial to understand whether there exists a causal link between the use of antibiotics in infancy and the development of asthma in childhood. In this rostrum, we conduct a critical review of the literature concerning the association of infant antibiotic use and the onset of childhood asthma. Drawing on the results of 5 meta-analyses addressing this topic and of a recent randomized controlled trial, a notable association emerges between antibiotic exposure in the first year of life and the occurrence of childhood asthma that appears to be beyond potential study limitations (such as reverse causation, confounding by indication, and recall bias). Furthermore, we highlight the need for additional research in this field that could improve our understanding of important aspects of this association and lead to the design of an intervention aimed to deliver antibiotics safely during early life and reduce the burden of childhood asthma.</span></div></div>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":null,"pages":null},"PeriodicalIF":8.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141433332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Six-year follow-up of low-dose oral immunotherapy for children with wheat-induced anaphylaxis 小剂量口服免疫疗法治疗小麦过敏性休克患儿的六年随访。
IF 8.2 1区 医学
Journal of Allergy and Clinical Immunology-In Practice Pub Date : 2024-10-01 DOI: 10.1016/j.jaip.2024.06.029
{"title":"Six-year follow-up of low-dose oral immunotherapy for children with wheat-induced anaphylaxis","authors":"","doi":"10.1016/j.jaip.2024.06.029","DOIUrl":"10.1016/j.jaip.2024.06.029","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":null,"pages":null},"PeriodicalIF":8.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141472476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical and Economic Burden of Severe Asthma With Low Blood Eosinophil Counts 嗜酸性粒细胞计数低的重症哮喘的临床和经济负担。
IF 8.2 1区 医学
Journal of Allergy and Clinical Immunology-In Practice Pub Date : 2024-10-01 DOI: 10.1016/j.jaip.2024.07.010
{"title":"Clinical and Economic Burden of Severe Asthma With Low Blood Eosinophil Counts","authors":"","doi":"10.1016/j.jaip.2024.07.010","DOIUrl":"10.1016/j.jaip.2024.07.010","url":null,"abstract":"<div><h3>Background</h3><div>Type 2 low-severe asthma phenotype is often a result of corticosteroid-overtreated type 2 disease owing to persistent symptoms, often unrelated to asthma and unlikely to respond to high-dose corticosteroid treatment.</div></div><div><h3>Objective</h3><div>This study aimed to characterize patients with severe asthma with low eosinophil counts (&lt;300 cells/μL) and describe their disease burden and treatment across health care settings in the United Kingdom.</div></div><div><h3>Methods</h3><div>A retrospective cohort study of patients with severe asthma using linked Clinical Practice Research Datalink (CPRD) Aurum-Hospital Episode Statistics (HES) and UK Severe Asthma Registry (UKSAR) data indexed patients according to the latest blood eosinophil count (BEC). Clinical characteristics, treatment patterns, outcomes, and health care resource use were described by baseline BEC (≤150 and &gt;150 to &lt;300 cells/μL).</div></div><div><h3>Results</h3><div>Analysis included 701 (CPRD-HES) and 1,546 (UKSAR) patients; 60.5% and 59.4% had BECs 150 cells/μL or less at baseline, respectively. Across BEC groups, the proportion with uncontrolled asthma (two or more exacerbations) at follow-up (12 months after the index) was 5.4% in CPRD-HES and 45.2% in UKSAR. Maintenance oral corticosteroid use remained high across BEC groups (CPRD-HES: 29.4%; UKSAR: 51.7%), symptom control remained poor (&gt;200 μg short-acting β<sub>2</sub> agonist or &gt;500 μg terbutaline/d in CPRD-HES: 48.8%; median Asthma Control Questionnaire-6 score in UKSAR: 2.0 [range, 1.0-3.3]). Health care resource use was similar across BEC groups.</div></div><div><h3>Conclusions</h3><div>Most patients managed in primary care experienced infrequent exacerbations, whereas UKSAR patients had frequent exacerbations. Large proportions of both patient groups had poor symptom control and continued to receive high levels of maintenance oral corticosteroids, increasing the risk of corticosteroid-induced morbidity. These data highlight the need for rigorous assessment of underlying disease pathology to guide appropriate treatment.</div></div>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":null,"pages":null},"PeriodicalIF":8.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141735621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multivariate Cluster Analyses to Characterize Asthma Heterogeneity and Benralizumab Responsiveness 通过多变量聚类分析确定哮喘异质性和贝拉珠单抗反应性的特征
IF 8.2 1区 医学
Journal of Allergy and Clinical Immunology-In Practice Pub Date : 2024-10-01 DOI: 10.1016/j.jaip.2024.04.026
{"title":"Multivariate Cluster Analyses to Characterize Asthma Heterogeneity and Benralizumab Responsiveness","authors":"","doi":"10.1016/j.jaip.2024.04.026","DOIUrl":"10.1016/j.jaip.2024.04.026","url":null,"abstract":"<div><h3>Background</h3><div>An improved understanding of how severe asthma heterogeneity affects response could inform treatment decisions.</div></div><div><h3>Objectives</h3><div>Characterize heterogeneity and benralizumab responsiveness in patients grouped by predefined Severe Asthma Research Program clusters using a multivariate approach.</div></div><div><h3>Methods</h3><div>In <em>post-hoc</em> analyses of the randomized, double-blind, placebo-controlled phase III SIROCCO (NCT01928771) and CALIMA (NCT01914757) studies, patients with severe asthma who received benralizumab or placebo were assigned to clusters using an established discriminant function to analyze 11 clinical characteristics simultaneously. The annualized asthma exacerbation rate, exacerbation incidence, and lung function were analyzed across clusters.</div></div><div><h3>Results</h3><div>Patients (n = 2,281) met criteria for four of five clusters: cluster 2 (early-onset moderate asthma, n = 393), cluster 4 (early-onset severe asthma, n = 386), cluster 3 (late-onset severe asthma, n = 641), and cluster 5 (late-onset severe, obstructed asthma, n = 861); no patients met cluster 1 criteria. Exacerbation rate reductions were significant in late-onset severe asthma (−48% [95% CI, –61% to –31%]; <em>P</em> &lt; .0001) and late-onset severe, obstructed asthma (−50% [95% CI, –59% to –38%]; <em>P</em> &lt; .0001), with nonsignificant reductions in early-onset clusters. These differences could not be fully explained by blood eosinophil count differences. Values for improvements in FEV<sub>1</sub> were significant in late-onset severe asthma (+133 mL [95% CI, 66-200]; <em>P</em> = .0001) and late-onset severe, obstructed asthma (+160 mL [95% CI, 85-235]; <em>P</em> &lt; .0001) while maintaining acute bronchodilator responsiveness.</div></div><div><h3>Conclusions</h3><div>Benralizumab reduced exacerbations and improved lung function, primarily in late-onset asthma clusters. This multivariate approach to identify subphenotypes, potentially reflecting pathobiological mechanisms, can guide therapy beyond univariate approaches.</div></div>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":null,"pages":null},"PeriodicalIF":8.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140766611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
First-Line Anti-Tuberculosis Drug-Related DRESS Syndrome Challenges: Management Strategies in Patients With HIV-TB Coinfection 一线抗结核药物相关 DRESS 综合征的挑战:HIV-TB 合并感染患者的管理策略。
IF 8.2 1区 医学
Journal of Allergy and Clinical Immunology-In Practice Pub Date : 2024-10-01 DOI: 10.1016/j.jaip.2024.07.034
{"title":"First-Line Anti-Tuberculosis Drug-Related DRESS Syndrome Challenges: Management Strategies in Patients With HIV-TB Coinfection","authors":"","doi":"10.1016/j.jaip.2024.07.034","DOIUrl":"10.1016/j.jaip.2024.07.034","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":null,"pages":null},"PeriodicalIF":8.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to ‘‘Racial disparities in pediatric atopic comorbidity” 回复 "小儿特应性合并症的种族差异"。
IF 8.2 1区 医学
Journal of Allergy and Clinical Immunology-In Practice Pub Date : 2024-10-01 DOI: 10.1016/j.jaip.2024.08.005
{"title":"Reply to ‘‘Racial disparities in pediatric atopic comorbidity”","authors":"","doi":"10.1016/j.jaip.2024.08.005","DOIUrl":"10.1016/j.jaip.2024.08.005","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":null,"pages":null},"PeriodicalIF":8.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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