Journal of Allergy and Clinical Immunology-In Practice最新文献

{"title":"Reply to “The pathogenesis of primary acquired cold urticaria”","authors":"Alan Wanderer MD","doi":"10.1016/j.jaip.2025.03.041","DOIUrl":"10.1016/j.jaip.2025.03.041","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages 1497-1498"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indoor Allergen Interventions in Homes and Schools for Managing Asthma","authors":"","doi":"10.1016/j.jaip.2025.05.006","DOIUrl":"10.1016/j.jaip.2025.05.006","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Page 1266"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144213239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Efficacy and Safety of Benralizumab Treatment for PDGFRA-Negative Hypereosinophilic Syndrome","authors":"Fei Li Kuang MD, PhD ,&nbsp;Michelle A. Makiya MS ,&nbsp;JeanAnne M. Ware MSN, MPH ,&nbsp;Lauren Wetzler MHC, PA-C ,&nbsp;Celeste Nelson MS, CRNP ,&nbsp;Thomas Brown BSN, CCRP ,&nbsp;Paneez Khoury MD, MHS ,&nbsp;Amy D. Klion MD","doi":"10.1016/j.jaip.2025.03.016","DOIUrl":"10.1016/j.jaip.2025.03.016","url":null,"abstract":"<div><h3>Background</h3><div>Therapies for hypereosinophilic syndromes (HES) have variable efficacy and significant toxicity. Benralizumab (BENRA), an afucosylated monoclonal antibody that binds interleukin 5 receptor α expressed on eosinophils, reduced blood and tissue eosinophils in a 48-week, phase 2 study in <em>PDGFRA</em>-negative HES.</div></div><div><h3>Objective</h3><div>To assess safety and efficacy of long-term BENRA treatment in <em>PDGFRA</em>-negative HES.</div></div><div><h3>Methods</h3><div>Twenty <em>PDGFRA</em>-negative HES patients with severe and diverse clinical manifestations were treated in a double-blind, placebo-controlled clinical trial of BENRA (NCT02130882). Fourteen were followed on an open-label extension. Efficacy and safety were reviewed at each visit.</div></div><div><h3>Results</h3><div>Among 14 long-term participants, 3 withdrew owing to loss of efficacy, and 1 owing to death unrelated to drug after 2 to 6 years. The remaining 10 participants received BENRA for at least 8 years (maximum exposure 10.1 y). Peripheral eosinophil counts remained suppressed in all participants. Eight participants attempted to taper from monthly to every-2-month dosing, of which 5 resumed monthly dosing owing to increased symptoms and/or eosinophil count. There were 11 serious adverse events: 10 hospitalizations (3 for infections, 5 for surgeries, and 2 for drug desensitization or observation) and 1 death from antibiotic-associated toxic epidermal necrolysis. None were attributed to BENRA. Eight participants reported injection-site reactions (23 total), all mild in severity and self-limited. Three malignancies and no parasitic infections were reported. Despite sustained eosinophil depletion, immunoglobulin levels and peripheral T-, B-, and natural killer–cell counts were stable for the duration of the study.</div></div><div><h3>Conclusions</h3><div>Long-term BENRA therapy is effective and well-tolerated in HES patients without significant adverse effects.</div></div>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages 1421-1429.e2"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotypic Characteristics of Occupational Asthma Caused by Persulfate Salts in Hairdressers: A Multicenter Cohort Study","authors":"Virginie Doyen MD, PhD ,&nbsp;Robin Thirionet MD ,&nbsp;Nicolas Migueres MD, PhD ,&nbsp;Olivier Vandenplas MD, PhD ,&nbsp;Joaquin Sastre MD ,&nbsp;Marcela Valverde-Monge MD ,&nbsp;Thomas Blix Grydeland MD, PhD ,&nbsp;Xavier Munoz MD, PhD ,&nbsp;Christian Romero-Mesones MD, PhD ,&nbsp;Hille Suojalehto MD, PhD ,&nbsp;Katri Suuronen PhD ,&nbsp;Vera van Kampen PhD ,&nbsp;Christian Eisenhawer MD ,&nbsp;Ilenia Folletti MD ,&nbsp;Iben Brock Jacobsen MD ,&nbsp;Jolanta Walusiak-Skorupa MD ,&nbsp;Paola Mason MD, PhD ,&nbsp;Alexandra M. Preiser MD ,&nbsp;Santiago Quirce MD, PhD ,&nbsp;Gareth Walters MB, ChB, MD ,&nbsp;Cecilie Svanes MD, PhD","doi":"10.1016/j.jaip.2025.03.015","DOIUrl":"10.1016/j.jaip.2025.03.015","url":null,"abstract":"<div><h3>Background</h3><div>The clinical and inflammatory characteristics of occupational asthma (OA) caused by persulfate salts (PS) in hair bleaches have not yet been comprehensively characterized.</div></div><div><h3>Objective</h3><div>This study aimed to compare the phenotypic characteristics of PS-induced OA with those of OA due to other low-molecular-weight (LMW) agents.</div></div><div><h3>Methods</h3><div>This study was conducted in a retrospective multicenter cohort of subjects with OA ascertained by a positive specific inhalation challenge (SIC). The clinical and inflammatory characteristics of hairdressers with PS-induced OA (n = 107) were compared with those of subjects who showed a positive SIC to isocyanates (n = 128) or various other LMW agents (n = 164).</div></div><div><h3>Results</h3><div>Subjects with PS-induced OA had a longer duration of exposure to the offending agent before the onset of asthma than those with OA caused the other LMW agents. They reported more frequently work-related rhinitis (76%) and showed a lower post-SIC level of fractional exhaled nitric oxide (median, 18 ppb [25th-75th percentile, 13–26]) compared with OA caused by both isocyanates (36%, <em>P</em> &lt; .001 and 35 ppb [21–80], <em>P</em> &lt; .001, respectively) and the other LMW agents (53%, <em>P</em> &lt; .001 and 27 ppb [14–52], <em>P</em> &lt; .001). Subjects with PS-induced OA showed the highest rate of isolated late asthmatic reactions (49%), but the difference reached statistical significance only when compared with LMW agents other than isocyanates (31%, <em>P</em> &lt; .002).</div></div><div><h3>Conclusions</h3><div>The PS-induced OA is associated with a higher prevalence of work-related rhinitis and lower levels of fractional exhaled nitric oxide compared with OA caused by other LMW agents. These findings further indicate substantial phenotypic heterogeneity among this broad category of agents.</div></div>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages 1397-1404.e5"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to “Interrupting a vicious cycle in order to produce cessation of refractory chronic cough”","authors":"Woo-Jung Song MD, PhD ,&nbsp;Deepti Vellaichamy Manian MD ,&nbsp;Yeonhee Kim MD ,&nbsp;Mengru Zhang MD ,&nbsp;Alyn H. Morice MD","doi":"10.1016/j.jaip.2025.03.045","DOIUrl":"10.1016/j.jaip.2025.03.045","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages 1502-1503"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early-Life Allergen Exposure and Its Influence on Risk of Atopic Disease","authors":"Elizabeth Huiwen Tham MRCPCH ,&nbsp;Soo-Jong Hong MD, PhD ,&nbsp;Eun Lee MD, PhD ,&nbsp;James E. Gern MD","doi":"10.1016/j.jaip.2025.02.043","DOIUrl":"10.1016/j.jaip.2025.02.043","url":null,"abstract":"<div><div>Childhood allergic diseases and asthma have their origins in early life, and allergen exposures during this period could be a critical determinant of the progression to tolerance versus disease. Mechanisms for sensitization may be different but overlapping for food and aeroallergen sensitization in children. This suggests differences in how exposure to food and aeroallergens influence allergic sensitization. For food allergy, introducing foods such as peanut and egg proteins into the diet at an early age reduces the risk of peanut and egg allergy, respectively, across a broad demographic, whereas evidence is less established for other foods. The relationship between allergen exposure and sensitization to aeroallergens is more complex but critical, given the close relationship between specific immunoglobulin E and respiratory disease. Several factors could mediate the progression from allergen exposure and allergic sensitization versus tolerance, including epithelial barrier function and altered immune development at the skin and mucosal surfaces, exposure to irritants and pollutants, and genetic susceptibility. Collectively, the current evidence base provides a compelling rationale for the primary prevention of food allergy by introducing common allergens such as peanut and egg early. In contrast, primary prevention of aeroallergen sensitization is more complex and perhaps more challenging to achieve by manipulating allergen exposures. Even so, recent advances in understanding how the microbiome and environmental toxins and irritants modulate the mucosal immune response have identified potential new strategies for primary prevention of food and aeroallergen sensitization.</div></div>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages 1243-1253"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Utility of Biomarkers in Anaphylaxis: A Systematic Review and Meta-Analysis","authors":"Roy Khalaf ,&nbsp;Connor Prosty MD ,&nbsp;William Davalan ,&nbsp;Elissa Abrams MD ,&nbsp;Mohammed Kaouache PhD ,&nbsp;Moshe Ben-Shoshan MD","doi":"10.1016/j.jaip.2025.04.008","DOIUrl":"10.1016/j.jaip.2025.04.008","url":null,"abstract":"<div><h3>Background</h3><div>Anaphylaxis is a life-threatening allergic reaction commonly triggered by food, venom, or drugs. Clinical criteria are central to diagnosing anaphylaxis. However, laboratory biomarkers could provide valuable confirmation when clinical diagnosis is challenging.</div></div><div><h3>Objective</h3><div>We aimed to evaluate key biomarkers including tryptase, histamine, platelet-activating factor (PAF), PAF-acetylhydrolase (PAF-AH), and urinary prostaglandin D2 (PGD2) for their diagnostic utility in anaphylaxis.</div></div><div><h3>Methods</h3><div>A systematic review was conducted following PRISMA-DTA (Preferred Reporting Items for a Systematic Review and Meta-analysis of Diagnostic Test Accuracy studies) guidelines. Studies published between 2004 and 2024 from Embase and MEDLINE were included if they evaluated the diagnostic test accuracy of tryptase, histamine, PAF, PAF-AH, or urinary PGD2 in confirmed anaphylaxis cases. Pooled sensitivity and specificity estimates were calculated using the diagmeta package in R.</div></div><div><h3>Results</h3><div>Twenty-eight studies with 18,749 patients were included, of whom 3329 had anaphylaxis. Tryptase was the most frequently studied biomarker (24 studies), with a pooled sensitivity and specificity of 0.49 and 0.82, respectively. Histamine had a pooled sensitivity of 0.76 and a specificity of 0.69. Limited data were available for PAF, PAF-AH, and urinary PGD2.</div></div><div><h3>Conclusions</h3><div>Studies suggest that tryptase remains the most widely used and accessible biomarker for diagnosing anaphylaxis mainly using the “Rule of Twos” diagnosis strategy. Histamine and urinary PGD2 show potential, though their application is limited by practical challenges. Further research is needed to establish the diagnostic roles of PAF and PAF-AH, particularly in non–IgE-mediated anaphylaxis pathways.</div></div>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages 1342-1349.e12"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ureteral Edema and Hydronephrosis Associated With Hereditary Angioedema Attack","authors":"Zuleyha Galata MD ,&nbsp;Mustafa Harman MD ,&nbsp;Kutay Kirdok MD ,&nbsp;Adil Bahadır MD ,&nbsp;Nihal Mete Gökmen MD","doi":"10.1016/j.jaip.2025.03.020","DOIUrl":"10.1016/j.jaip.2025.03.020","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages 1457-1458"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Early Food Introduction and Skin Emollients on Pollen Sensitization: A Randomized Trial (PreventADALL) Sub-Study","authors":"Sabina Wärnberg Gerdin MSc ,&nbsp;Håvard O. Skjerven PhD ,&nbsp;Jon R. Konradsen PhD ,&nbsp;Magnus P. Borres PhD ,&nbsp;Berit Granum PhD ,&nbsp;Christine Monceyron Jonassen PhD ,&nbsp;Marissa LeBlanc PhD ,&nbsp;Morten Nilsen PhD ,&nbsp;Eva Maria Rehbinder PhD ,&nbsp;Knut Rudi PhD ,&nbsp;Anne Cathrine Staff PhD ,&nbsp;Cilla Söderhäll PhD ,&nbsp;Marianne van Hage PhD ,&nbsp;Riyas Vettukattil PhD ,&nbsp;Karin C. Lødrup Carlsen PhD ,&nbsp;Björn Nordlund PhD","doi":"10.1016/j.jaip.2025.03.046","DOIUrl":"10.1016/j.jaip.2025.03.046","url":null,"abstract":"<div><h3>Background</h3><div>Pollen sensitization may be directed toward proteins also found in plant foods.</div></div><div><h3>Objective</h3><div>We explored whether early food introduction and skin emollients prevented birch and grass sensitization at age 3 years and whether the effect was mediated by skin barrier function or modified by season of birth.</div></div><div><h3>Methods</h3><div>In the population-based, randomized, controlled Preventing Atopic Dermatitis and Allergy in Children trial, information on allergic sensitization by age 3 years was available in 2,066 children. Newborns were randomized (1:1:1:1) to no (controls); to food (tastes of peanut, cow’s milk, wheat, and egg from 3 months) or skin (oil baths and facial cream from 2 weeks); or to both interventions. Sensitization was defined as specific IgE 0.1 kU_A/L or greater and/or skin prick test wheal 3 mm or greater. A mediator analysis assessed the skin intervention’s effect through transepidermal water loss at 3 months. An interaction analysis estimated effect modification by month of birth.</div></div><div><h3>Results</h3><div>At age 3 years, 117 of 1,492 children (7.8%) were sensitized to birch and 40 of 1,482 children (2.7%) to timothy. Compared with controls, crude odds ratio (95% CI) in the food, skin, and combined intervention groups, respectively, was 1.10 (0.63-1.93), 2.38 (1.43-3.95), and 0.70 (0.37-1.34) for birch, and 0.58 (0.21-1.60), 1.73 (0.77-3.91), and 1.00 (0.40-2.49) for grass sensitization. A significant indirect effect of the skin intervention through transepidermal water loss was observed, but there was no significant modification by month of birth for either intervention.</div></div><div><h3>Conclusions</h3><div>Early food introduction did not affect the risk of pollen sensitization. Infants with skin intervention had increased risk only of birch sensitization, mediated by reduced skin barrier function in early infancy.</div></div>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages 1325-1334"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Information for Readers","authors":"","doi":"10.1016/S2213-2198(25)00444-1","DOIUrl":"10.1016/S2213-2198(25)00444-1","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Page A18"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}