Journal of Allergy and Clinical Immunology-In Practice最新文献

{"title":"Considerations for enhancing dupilumab research in hypereosinophilic syndromes","authors":"An-An Ku BS , Wen-Chun Lo BS , Szu-Yu Huang BS , Su-Boon Yong MD, PhD , Chin-Yuan Yii MD","doi":"10.1016/j.jaip.2025.03.028","DOIUrl":"10.1016/j.jaip.2025.03.028","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages 1498-1499"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catamenial anaphylaxis","authors":"Öner Özdemir MD","doi":"10.1016/j.jaip.2025.03.042","DOIUrl":"10.1016/j.jaip.2025.03.042","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages 1499-1500"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Collateral Adverse Reactions Through Cross-Reactive Allergen Families","authors":"Robert G. Hamilton PhD, DABMLI","doi":"10.1016/j.jaip.2025.03.039","DOIUrl":"10.1016/j.jaip.2025.03.039","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages 1464-1467"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144213005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early-Life Allergen Exposure and Its Influence on Risk of Atopic Disease","authors":"","doi":"10.1016/j.jaip.2025.05.005","DOIUrl":"10.1016/j.jaip.2025.05.005","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages 1254-1255"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144213238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Changing Impacts of Allergens on the Host: From Early-Life Exposures Through Indoor Interventions to Climatic Influences","authors":"Ting F. Leung MBChB, MD , Elizabeth C. Matsui MD, MHS","doi":"10.1016/j.jaip.2025.04.026","DOIUrl":"10.1016/j.jaip.2025.04.026","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages 1298-1299"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144213241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shared Decision-Making in Food Protein–Induced Enterocolitis Syndrome","authors":"Marcus Shaker MD, MS ,&nbsp;Elissa M. Abrams MD ,&nbsp;Matthew Greenhawt MD, MBA, MSc ,&nbsp;Shyam Joshi MD ,&nbsp;Jay Lieberman MD ,&nbsp;S. Shahzad Mustafa MD ,&nbsp;Aikaterini Anagnostou MD, MSc, PhD","doi":"10.1016/j.jaip.2025.03.008","DOIUrl":"10.1016/j.jaip.2025.03.008","url":null,"abstract":"<div><div>Food protein–induced enterocolitis syndrome (FPIES) is a non–IgE-mediated food allergy presenting with profuse vomiting, lethargy, and potential progression to severe dehydration and hypotension. Delayed-onset bloody diarrhea may also be a feature, though generally in neonates. FPIES can be misdiagnosed due to nonspecific symptoms and the fact that there is no laboratory test specific for the disease. There is currently very limited understanding of the FPIES pathophysiology. Clinical management relies mostly on case series, case reports, uncontrolled observational studies, and expert opinion rather than controlled studies and a plethora of mechanistic research. As a result, there are multiple areas in FPIES where care is preference-sensitive and dependent on patient values and preferences, given the lack of high-quality trials that clearly indicate a single best course of action. While in some vain this may signify major knowledge gaps and unmet needs in research and patient care, in another sense, this represents an opportunity to evolve patient care in a way that may be more tailored toward individual patient or family values and preferences through shared decision-making as the research continues to evolve. There has been increased recognition that the burden of FPIES on patients and families is substantial, and there is opportunity to take advantage of particular care options to help mitigate this burden. This rostrum wishes to discuss areas where current FPIES care can be evolved to incorporate a more contextualized, preference-sensitive approach, involving shared decision-making, to provide the optimal management to each individual patient.</div></div>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages 1310-1316"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin testing improves predictive value of midrange peanut-specific IgE and Ara h 2 levels in the LEAP study","authors":"Joshua S. Bernstein MD ,&nbsp;Thao Vu PhD ,&nbsp;Carolyn H. Baloh MD ,&nbsp;Michelle F. Huffaker MD ,&nbsp;George Du Toit MB, BCh ,&nbsp;Stephen C. Dreskin MD, PhD","doi":"10.1016/j.jaip.2025.02.041","DOIUrl":"10.1016/j.jaip.2025.02.041","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages 1478-1480.e2"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacokinetics and Pharmacodynamics of neffy, Epinephrine Nasal Spray, in Pediatric Allergy Patients","authors":"David M. Fleischer MD ,&nbsp;H. Henry Li MD, PhD ,&nbsp;Neetu Talreja MD ,&nbsp;Richard F. Lockey MD ,&nbsp;Michael A. Kaliner MD ,&nbsp;Richard D. Wainford PhD ,&nbsp;Matthew J. Greenhawt MD ,&nbsp;Thomas B. Casale MD ,&nbsp;Richard Lowenthal MSc ,&nbsp;Sarina Tanimoto MD, PhD","doi":"10.1016/j.jaip.2025.03.019","DOIUrl":"10.1016/j.jaip.2025.03.019","url":null,"abstract":"<div><h3>Background</h3><div>Epinephrine is the gold-standard treatment for severe allergic reactions, including anaphylaxis, and is typically administered via intramuscular injection. Despite epinephrine’s well-documented safety and efficacy, patients may be hesitant to administer/receive injections, thereby increasing the risk of complications. <em>neffy</em> epinephrine nasal spray was developed to provide an additional option that may reduce dosing hesitancy.</div></div><div><h3>Objective</h3><div>This study was conducted to characterize <em>neffy’s</em> pharmacokinetic and pharmacodynamic profiles in pediatric subjects, and to compare profiles between pediatric and adult subjects.</div></div><div><h3>Methods</h3><div>This was a phase 1, multicenter, single-dose, pharmacokinetic/pharmacodynamic study. Forty-two pediatric patients were dosed with 1 or 2 mg of <em>neffy</em>, based on weight. Pharmacokinetic and pharmacodynamic parameters were summarized with descriptive statistics and analyzed using a linear mixed effects model.</div></div><div><h3>Results</h3><div>In pediatric subjects, <em>neffy</em> 1 mg resulted in a slightly lower mean maximum concentrations relative to <em>neffy</em> 2 mg (651 vs 690 pg/mL), which were higher than the maximum concentrations in adult subjects (481 pg/mL). Although adult subjects demonstrated a marked postdose increase in systolic blood pressure, the systolic blood pressure increase observed in pediatric patients was significantly lower and was accompanied by minimal differences in diastolic blood pressure. The effect on heart rate was similar between both pediatric and adult subjects.</div></div><div><h3>Conclusions</h3><div>In pediatric subjects, both the 1 and 2 mg doses of <em>neffy</em> resulted in mean maximum concentration values that are expected to be both safe and efficacious. Age-related differences in pharmacodynamic responses were noted; however, these differences are likely attributable to expected age-based differences in physiology.</div></div>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages 1335-1341.e1"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic cat and dog allergenic products contain galactose-α-1,3-galactose","authors":"Tina K. Merritt MD ,&nbsp;Max D. Bermingham BSc ,&nbsp;Sayeh Agah PhD ,&nbsp;Rhys T. Meredith MRes ,&nbsp;Bryan R.E. Smith BA ,&nbsp;Martin D. Chapman PhD","doi":"10.1016/j.jaip.2025.03.012","DOIUrl":"10.1016/j.jaip.2025.03.012","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages 1461-1463.e1"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood food allergy and participation in free or reduced-price meal programs at school","authors":"Roxanne Dupuis PhD ,&nbsp;Gabrielle D’Ambrosi MPH ,&nbsp;Linda J. Herbert PhD ,&nbsp;Michael C. Monuteaux ScD ,&nbsp;Michael C. Young MD ,&nbsp;Erica L. Kenney ScD ,&nbsp;Catherine C. Peterson PhD ,&nbsp;Wanda Phipatanakul MD, MS ,&nbsp;Lisa M. Bartnikas MD","doi":"10.1016/j.jaip.2025.03.024","DOIUrl":"10.1016/j.jaip.2025.03.024","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages 1481-1484.e2"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}