Neural Plasticity最新文献_第7页

Reversed Effects of Intermittent Theta Burst Stimulation following Motor Training That Vary as a Function of Training-Induced Changes in Corticospinal Excitability. 运动训练后间歇性θ波爆发刺激的反向效应随训练引起的皮质脊髓兴奋性变化而变化。

IF 3.1 4区医学

Neural Plasticity Pub Date : 2015-01-01 Epub Date: 2015-06-17 DOI: 10.1155/2015/578620

Tino Stöckel, Jeffery J Summers, Mark R Hinder

{"title":"Reversed Effects of Intermittent Theta Burst Stimulation following Motor Training That Vary as a Function of Training-Induced Changes in Corticospinal Excitability.","authors":"Tino Stöckel, Jeffery J Summers, Mark R Hinder","doi":"10.1155/2015/578620","DOIUrl":"https://doi.org/10.1155/2015/578620","url":null,"abstract":"Intermittent theta burst stimulation (iTBS) has the potential to enhance corticospinal excitability (CSE) and subsequent motor learning. However, the effects of iTBS following motor learning are unknown. The purpose of the present study was to explore the effect of iTBS on CSE and performance following motor learning. Therefore twenty-four healthy participants practiced a ballistic motor task for a total of 150 movements. iTBS was subsequently applied to the trained motor cortex (STIM group) or the vertex (SHAM group). Performance and CSE were assessed before motor learning and before and after iTBS. Training significantly increased performance and CSE in both groups. In STIM group participants, subsequent iTBS significantly reduced motor performance with smaller reductions in CSE. CSE changes as a result of motor learning were negatively correlated with both the CSE changes and performance changes as a result of iTBS. No significant effects of iTBS were found for SHAM group participants. We conclude that iTBS has the potential to degrade prior motor learning as a function of training-induced CSE changes. That means the expected LTP-like effects of iTBS are reversed following motor learning. ","PeriodicalId":51299,"journal":{"name":"Neural Plasticity","volume":"2015 ","pages":"578620"},"PeriodicalIF":3.1,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/578620","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34282470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Retrosplenial Cortex and Long-Term Memory: Molecules to Behavior. 后脑皮质与长期记忆：从分子到行为。

IF 3.1 4区医学

Neural Plasticity Pub Date : 2015-01-01 Epub Date: 2015-08-25 DOI: 10.1155/2015/414173

Travis P Todd, David J Bucci

引用次数: 0

Coincidence Anticipation Timing Performance during an Acute Bout of Brisk Walking in Older Adults: Effect of Stimulus Speed. 老年人快走急性发作时的巧合预期时间表现:刺激速度的影响。

IF 3.1 4区医学

Neural Plasticity Pub Date : 2015-01-01 Epub Date: 2015-08-31 DOI: 10.1155/2015/210213

Michael J Duncan, Michelle Stanley, Mike Smith, Michael J Price, Sheila Leddington Wright

{"title":"Coincidence Anticipation Timing Performance during an Acute Bout of Brisk Walking in Older Adults: Effect of Stimulus Speed.","authors":"Michael J Duncan, Michelle Stanley, Mike Smith, Michael J Price, Sheila Leddington Wright","doi":"10.1155/2015/210213","DOIUrl":"https://doi.org/10.1155/2015/210213","url":null,"abstract":"This study examined coincidence anticipation timing (CAT) performance at slow and fast stimulus speeds before, during, and after an acute bout of walking in adults aged 60-76 years. Results from a series of repeated measures ANOVAs indicated significant rest versus exercise × stimulus speed × time interactions for absolute and variable errors (both P = 0.0001) whereby absolute and variable error scores, when stimulus speed was slow, improved as the duration of exercise increased. When stimulus speed was fast there were significantly greater absolute and variable errors at 18 minutes of the walking bout. There was also greater error at 18 minutes during walking compared to rest. These results suggest that, in a task involving walking and CAT, stimulus speeds plays an important role; specifically walking (exercise) enhances CAT performance at slow stimulus speeds but reduces CAT performance at fast stimulus speeds. The implications are that in everyday situations, where events require dual-task responses to be made at different speeds, for example, walking on the pavement whilst avoiding a crowd, compared to crossing a busy road, an understanding of how different stimulus speeds influence dual-task performance is extremely important, particularly in the older adult population. ","PeriodicalId":51299,"journal":{"name":"Neural Plasticity","volume":"2015 ","pages":"210213"},"PeriodicalIF":3.1,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/210213","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34113222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Increase in Short-Interval Intracortical Facilitation of the Motor Cortex after Low-Frequency Repetitive Magnetic Stimulation of the Unaffected Hemisphere in the Subacute Phase after Stroke. 在中风后亚急性期，低频重复磁刺激未受影响的脑半球后，运动皮层的短间隔内易化性增加。

IF 3.1 4区医学

Neural Plasticity Pub Date : 2015-01-01 Epub Date: 2015-04-28 DOI: 10.1155/2015/407320

Eduardo Arruda Mello, Leonardo G Cohen, Sarah Monteiro Dos Anjos, Juliana Conti, Karina Nocelo F Andrade, Fernanda Tovar Moll, Theo Marins, Corina A Fernandes, Waldyr Rodrigues, Adriana Bastos Conforto

{"title":"Increase in Short-Interval Intracortical Facilitation of the Motor Cortex after Low-Frequency Repetitive Magnetic Stimulation of the Unaffected Hemisphere in the Subacute Phase after Stroke.","authors":"Eduardo Arruda Mello, Leonardo G Cohen, Sarah Monteiro Dos Anjos, Juliana Conti, Karina Nocelo F Andrade, Fernanda Tovar Moll, Theo Marins, Corina A Fernandes, Waldyr Rodrigues, Adriana Bastos Conforto","doi":"10.1155/2015/407320","DOIUrl":"https://doi.org/10.1155/2015/407320","url":null,"abstract":"Low-frequency repetitive transcranial magnetic stimulation of the unaffected hemisphere (UH-LF-rTMS) in patients with stroke can decrease interhemispheric inhibition from the unaffected to the affected hemisphere and improve hand dexterity and strength of the paretic hand. The objective of this proof-of-principle study was to explore, for the first time, effects of UH-LF-rTMS as add-on therapy to motor rehabilitation on short-term intracortical inhibition (SICI) and intracortical facilitation (ICF) of the motor cortex of the unaffected hemisphere (M1UH) in patients with ischemic stroke. Eighteen patients were randomized to receive, immediately before rehabilitation treatment, either active or sham UH-LF-rTMS, during two weeks. Resting motor threshold (rMT), SICI, and ICF were measured in M1UH before the first session and after the last session of treatment. There was a significant increase in ICF in the active group compared to the sham group after treatment, and there was no significant differences in changes in rMT or SICI. ICF is a measure of intracortical synaptic excitability, with a relative contribution of spinal mechanisms. ICF is typically upregulated by glutamatergic agonists and downregulated by gabaergic antagonists. The observed increase in ICF in the active group, in this hypothesis-generating study, may be related to M1UH reorganization induced by UH-LF-rTMS. ","PeriodicalId":51299,"journal":{"name":"Neural Plasticity","volume":"2015 ","pages":"407320"},"PeriodicalIF":3.1,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/407320","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34193616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

CRMP4 and CRMP2 Interact to Coordinate Cytoskeleton Dynamics, Regulating Growth Cone Development and Axon Elongation. CRMP4和CRMP2相互作用协调细胞骨架动力学，调节生长锥发育和轴突伸长。

IF 3.1 4区医学

Neural Plasticity Pub Date : 2015-01-01 Epub Date: 2015-05-10 DOI: 10.1155/2015/947423

Minghui Tan, Caihui Cha, Yongheng Ye, Jifeng Zhang, Sumei Li, Fengming Wu, Sitang Gong, Guoqing Guo

{"title":"CRMP4 and CRMP2 Interact to Coordinate Cytoskeleton Dynamics, Regulating Growth Cone Development and Axon Elongation.","authors":"Minghui Tan, Caihui Cha, Yongheng Ye, Jifeng Zhang, Sumei Li, Fengming Wu, Sitang Gong, Guoqing Guo","doi":"10.1155/2015/947423","DOIUrl":"https://doi.org/10.1155/2015/947423","url":null,"abstract":"Cytoskeleton dynamics are critical phenomena that underpin many fundamental cellular processes. Collapsin response mediator proteins (CRMPs) are highly expressed in the developing nervous system, mediating growth cone guidance, neuronal polarity, and axonal elongation. However, whether and how CRMPs associate with microtubules and actin coordinated cytoskeletal dynamics remain unknown. In this study, we demonstrated that CRMP2 and CRMP4 interacted with tubulin and actin in vitro and colocalized with the cytoskeleton in the transition-zone in developing growth cones. CRMP2 and CRMP4 also interacted with one another coordinately to promote growth cone development and axonal elongation. Genetic silencing of CRMP2 enhanced, whereas overexpression of CRMP2 suppressed, the inhibitory effects of CRMP4 knockdown on axonal development. In addition, knockdown of CRMP2 or overexpression of truncated CRMP2 reversed the promoting effect of CRMP4. With the overexpression of truncated CRMP2 or CRMP4 lacking the cytoskeleton interaction domain, the promoting effect of CRMP was suppressed. These data suggest a model in which CRMP2 and CRMP4 form complexes to bridge microtubules and actin and thus work cooperatively to regulate growth cone development and axonal elongation. ","PeriodicalId":51299,"journal":{"name":"Neural Plasticity","volume":"2015 ","pages":"947423"},"PeriodicalIF":3.1,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/947423","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34197202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 60

Fractalkine Signaling and Microglia Functions in the Developing Brain. 脑发育过程中Fractalkine信号传导和小胶质细胞功能。

IF 3.1 4区医学

Neural Plasticity Pub Date : 2015-01-01 Epub Date: 2015-08-04 DOI: 10.1155/2015/689404

Isabelle Arnoux, Etienne Audinat

{"title":"Fractalkine Signaling and Microglia Functions in the Developing Brain.","authors":"Isabelle Arnoux, Etienne Audinat","doi":"10.1155/2015/689404","DOIUrl":"https://doi.org/10.1155/2015/689404","url":null,"abstract":"Microglial cells are the resident macrophages of the central nervous system (CNS). Besides their classical roles in pathological conditions, these immune cells also dynamically interact with neurons and influence their structure and function in physiological conditions. The neuronal chemokine fractalkine and its microglial receptor CX3CR1 are one important signaling pathway involved in these reciprocal interactions. In the present review, we will discuss recent evidence indicating that fractalkine signaling also determines several functions of microglial cells during normal CNS development. It has been known for a decade that microglial cells influence the neuronal death that normally occurs during CNS development. Surprisingly, recent evidence indicates that they can also support survival of developing neurons, control axon outgrowth, and laminar positioning of subsets of interneurons in the forebrain. Moreover, microglial cells influence the maturation of synaptic circuits at early postnatal stages: their phagocytic activity allows them to eliminate inappropriate synapses and they can also influence the functional expression of synaptic proteins by releasing mediators. Fractalkine signaling controls these functions of microglial cells in part by regulating their timely recruitment at sites of developing synapses. Finally, on-going research suggests that this signaling pathway is also a key player in neurodevelopmental disorders. ","PeriodicalId":51299,"journal":{"name":"Neural Plasticity","volume":"2015 ","pages":"689404"},"PeriodicalIF":3.1,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/689404","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33985498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 94

Long-Term Spatiotemporal Reconfiguration of Neuronal Activity Revealed by Voltage-Sensitive Dye Imaging in the Cerebellar Granular Layer. 电压敏感染料成像揭示小脑颗粒层神经元活动的长期时空重构。

IF 3.1 4区医学

Neural Plasticity Pub Date : 2015-01-01 Epub Date: 2015-07-29 DOI: 10.1155/2015/284986

Daniela Gandolfi, Jonathan Mapelli, Egidio D'Angelo

{"title":"Long-Term Spatiotemporal Reconfiguration of Neuronal Activity Revealed by Voltage-Sensitive Dye Imaging in the Cerebellar Granular Layer.","authors":"Daniela Gandolfi, Jonathan Mapelli, Egidio D'Angelo","doi":"10.1155/2015/284986","DOIUrl":"https://doi.org/10.1155/2015/284986","url":null,"abstract":"Understanding the spatiotemporal organization of long-term synaptic plasticity in neuronal networks demands techniques capable of monitoring changes in synaptic responsiveness over extended multineuronal structures. Among these techniques, voltage-sensitive dye imaging (VSD imaging) is of particular interest due to its good spatial resolution. However, improvements of the technique are needed in order to overcome limits imposed by its low signal-to-noise ratio. Here, we show that VSD imaging can detect long-term potentiation (LTP) and long-term depression (LTD) in acute cerebellar slices. Combined VSD imaging and patch-clamp recordings revealed that the most excited regions were predominantly associated with granule cells (GrCs) generating EPSP-spike complexes, while poorly responding regions were associated with GrCs generating EPSPs only. The correspondence with cellular changes occurring during LTP and LTD was highlighted by a vector representation obtained by combining amplitude with time-to-peak of VSD signals. This showed that LTP occurred in the most excited regions lying in the core of activated areas and increased the number of EPSP-spike complexes, while LTD occurred in the less excited regions lying in the surround. VSD imaging appears to be an efficient tool for investigating how synaptic plasticity contributes to the reorganization of multineuronal activity in neuronal circuits. ","PeriodicalId":51299,"journal":{"name":"Neural Plasticity","volume":"2015 ","pages":"284986"},"PeriodicalIF":3.1,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/284986","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34007313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Genotype-Dependent Difference in 5-HT2C Receptor-Induced Hypolocomotion: Comparison with 5-HT2A Receptor Functional Activity. 5-HT2C受体诱导的基因型差异:与5-HT2A受体功能活性的比较

IF 3.1 4区医学

Neural Plasticity Pub Date : 2015-01-01 Epub Date: 2015-08-26 DOI: 10.1155/2015/846589

Darya V Bazovkina, Elena M Kondaurova, Vladimir S Naumenko, Evgeni Ponimaskin

{"title":"Genotype-Dependent Difference in 5-HT2C Receptor-Induced Hypolocomotion: Comparison with 5-HT2A Receptor Functional Activity.","authors":"Darya V Bazovkina, Elena M Kondaurova, Vladimir S Naumenko, Evgeni Ponimaskin","doi":"10.1155/2015/846589","DOIUrl":"https://doi.org/10.1155/2015/846589","url":null,"abstract":"In the present study behavioral effects of the 5-HT2C serotonin receptor were investigated in different mouse strains. The 5-HT2C receptor agonist MK-212 applied intraperitoneally induced significant dose-dependent reduction of distance traveled in the open field test in CBA/Lac mice. This effect was receptor-specific because it was inhibited by the 5-HT2C receptor antagonist RS102221. To study the role of genotype in 5-HT2C receptor-induced hypolocomotion, locomotor activity of seven inbred mouse strains was measured after MK-212 acute treatment. We found that the 5-HT2C receptor stimulation by MK-212 decreased distance traveled in the open field test in CBA/Lac, C57Bl/6, C3H/He, and ICR mice, whereas it failed to affect locomotor activity in DBA/2J, Asn, and Balb/c mice. We also compared the interstrain differences in functional response to 5-HT2C and 5-HT2A receptors activation measured by the quantification of receptor-mediated head-twitches. These experiments revealed significant positive correlation between 5-HT2C and 5-HT2A receptors functional responses for all investigated mouse strains. Moreover, we found that 5-HT2A receptor activation with DOI did not change locomotor activity in CBA/Lac mice. Taken together, our data indicate the implication of 5-HT2C receptors in regulation of locomotor activity and suggest the shared mechanism for functional responses mediated by 5-HT2C and 5-HT2A receptors. ","PeriodicalId":51299,"journal":{"name":"Neural Plasticity","volume":"2015 ","pages":"846589"},"PeriodicalIF":3.1,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/846589","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34013211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Effects of Exercise in Immersive Virtual Environments on Cortical Neural Oscillations and Mental State. 沉浸式虚拟环境中的运动对皮层神经振荡和精神状态的影响

IF 3.1 4区医学

Neural Plasticity Pub Date : 2015-01-01 Epub Date: 2015-08-20 DOI: 10.1155/2015/523250

Tobias Vogt, Rainer Herpers, Christopher D Askew, David Scherfgen, Heiko K Strüder, Stefan Schneider

{"title":"Effects of Exercise in Immersive Virtual Environments on Cortical Neural Oscillations and Mental State.","authors":"Tobias Vogt, Rainer Herpers, Christopher D Askew, David Scherfgen, Heiko K Strüder, Stefan Schneider","doi":"10.1155/2015/523250","DOIUrl":"10.1155/2015/523250","url":null,"abstract":"Virtual reality environments are increasingly being used to encourage individuals to exercise more regularly, including as part of treatment those with mental health or neurological disorders. The success of virtual environments likely depends on whether a sense of presence can be established, where participants become fully immersed in the virtual environment. Exposure to virtual environments is associated with physiological responses, including cortical activation changes. Whether the addition of a real exercise within a virtual environment alters sense of presence perception, or the accompanying physiological changes, is not known. In a randomized and controlled study design, moderate-intensity Exercise (i.e., self-paced cycling) and No-Exercise (i.e., automatic propulsion) trials were performed within three levels of virtual environment exposure. Each trial was 5 minutes in duration and was followed by posttrial assessments of heart rate, perceived sense of presence, EEG, and mental state. Changes in psychological strain and physical state were generally mirrored by neural activation patterns. Furthermore, these changes indicated that exercise augments the demands of virtual environment exposures and this likely contributed to an enhanced sense of presence. ","PeriodicalId":51299,"journal":{"name":"Neural Plasticity","volume":"2015 ","pages":"523250"},"PeriodicalIF":3.1,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34068311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preclinical Evidences for an Antimanic Effect of Carvedilol. 卡维地洛抗躁作用的临床前证据

IF 3.1 4区医学

Neural Plasticity Pub Date : 2015-01-01 Epub Date: 2015-05-14 DOI: 10.1155/2015/692541

Greicy Coelho de Souza, Julia Ariana de S Gomes, Ana Isabelle de Góis Queiroz, Maíra Morais de Araújo, Lígia Menezes Cavalcante, Michel de Jesus Souza Machado, Aline Santos Monte, David Freitas de Lucena, João Quevedo, André Ferrer Carvalho, Danielle Macêdo

{"title":"Preclinical Evidences for an Antimanic Effect of Carvedilol.","authors":"Greicy Coelho de Souza, Julia Ariana de S Gomes, Ana Isabelle de Góis Queiroz, Maíra Morais de Araújo, Lígia Menezes Cavalcante, Michel de Jesus Souza Machado, Aline Santos Monte, David Freitas de Lucena, João Quevedo, André Ferrer Carvalho, Danielle Macêdo","doi":"10.1155/2015/692541","DOIUrl":"10.1155/2015/692541","url":null,"abstract":"Oxidative imbalance, alterations in brain-derived neurotrophic factor (BDNF), and mitochondrial dysfunction are implicated in bipolar disorder (BD) pathophysiology and comorbidities, for example, cardiovascular conditions. Carvedilol (CVD), a nonselective beta-blocker widely used for the treatment of hypertension, presents antioxidant and mitochondrial stabilizing properties. Thus, we hypothesized that CVD would prevent and/or reverse mania-like behavioral and neurochemical alterations induced by lisdexamfetamine dimesylate (LDX). To do this, male Wistar rats were submitted to two different protocols, namely, prevention and reversal. In the prevention treatment the rats received daily oral administration (mg/kg) of CVD (2.5, 5 or 7.5), saline, valproate (VAL200), or the combination of CVD5 + VAL100 for 7 days. From the 8th to 14th day LDX was added. In the reversal protocol LDX was administered for 7 days with the drugs being added from the 8th to 14th day of treatment. Two hours after the last administration the behavioral (open field and social interaction) and neurochemical (reduced glutathione, lipid peroxidation, and BDNF) determinations were performed. The results showed that CVD prevented and reversed the behavioral and neurochemical alterations induced by LDX. The administration of CVD5 + VAL100 potentiated the effect of VAL200 alone. Taken together these results demonstrate a possible antimanic effect of CVD in this preclinical model. ","PeriodicalId":51299,"journal":{"name":"Neural Plasticity","volume":"2015 ","pages":"692541"},"PeriodicalIF":3.1,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34205686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0