Rob Forsyth, Colin Hamilton, Matthew Ingram, Gemma Kelly, Tim Grove, Lorna Wales, Mark S Gilthorpe
{"title":"Demonstration of functional rehabilitation treatment effects in children and young people after severe acquired brain injury.","authors":"Rob Forsyth, Colin Hamilton, Matthew Ingram, Gemma Kelly, Tim Grove, Lorna Wales, Mark S Gilthorpe","doi":"10.1080/17518423.2021.1964631","DOIUrl":"https://doi.org/10.1080/17518423.2021.1964631","url":null,"abstract":"<p><strong>Purpose: </strong>To examine relationships between functional outcomes after pediatric acquired brain injury (ABI) and measures of rehabilitation dose.</p><p><strong>Methods: </strong>An observational study of children receiving residential neurorehabilitation after severe ABI.</p><p><strong>Results: </strong>Basic total rehabilitation dose shows a paradoxical <i>inverse</i> relationship to global outcome. This is due to confounding by both initial injury severity and length of stay, and variation in treatment content for a given total rehabilitation dose. Content-aware rehabilitation dose measures show robust <i>positive</i> correlations between fractions of rehabilitation treatment received and plausibly related aspects of outcome: specifically, between rates of recovery of gross motor function and the fraction of rehabilitation effort directed to active practice and motor learning. This relationship was robust to adjustment for therapists' expectations of recovery.</p><p><strong>Conclusion: </strong>Content-aware measures of rehabilitation dose are robustly causally related to pertinent aspects of outcome. These findings are step toward a goal of comparative effectiveness research in pediatric neurorehabilitation.</p>","PeriodicalId":51227,"journal":{"name":"Developmental Neurorehabilitation","volume":"25 4","pages":"239-245"},"PeriodicalIF":1.3,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39370206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hsing-Ching Kuo, Jennifer Litzenberger, Alberto Nettel-Aguirre, Ephrem Zewdie, Adam Kirton
{"title":"Exploring Clinical and Neurophysiological Factors Associated with Response to Constraint Therapy and Brain Stimulation in Children with Hemiparetic Cerebral Palsy.","authors":"Hsing-Ching Kuo, Jennifer Litzenberger, Alberto Nettel-Aguirre, Ephrem Zewdie, Adam Kirton","doi":"10.1080/17518423.2021.1964103","DOIUrl":"https://doi.org/10.1080/17518423.2021.1964103","url":null,"abstract":"<p><strong>Background: </strong>Perinatal stroke causes hemiparetic cerebral palsy (HCP) and lifelong disability. Constraint-induced movement therapy (CIMT) and neurostimulation may enhance motor function, but the individual factors associated with responsiveness are undetermined.</p><p><strong>Objective: </strong>We explored the clinical and neurophysiological factors associated with responsiveness to CIMT and/or brain stimulation within a clinical trial.</p><p><strong>Methods: </strong>PLASTIC CHAMPS was a randomized, blinded, sham-controlled trial (n = 45) of CIMT and neurostimulation paired with intensive, goal-directed therapy. Primary outcome was the Assisting Hand Assessment (AHA). Classification trees created through recursive partitioning suggested clinical and neurophysiological profiles associated with improvement at 6-months.</p><p><strong>Results: </strong>Both clinical (stroke side (left) and age >14 years) and neurophysiological (intracortical inhibition/facilitation and motor threshold) were associated with responsiveness across treatment groups with positive predictive values (PPV) approaching 80%.</p><p><strong>Conclusion: </strong>This preliminary analysis suggested sets of variables that may be associated with response to intensive therapies in HCP. Further modeling in larger trials is required.</p>","PeriodicalId":51227,"journal":{"name":"Developmental Neurorehabilitation","volume":"25 4","pages":"229-238"},"PeriodicalIF":1.3,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39322973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lwme Beckers, Rjem Smeets, Mac de Mooij, B Piškur, Jjw van der Burg, Eaa Rameckers, Pbm Aarts, Coad Author Group, Yjm Janssen-Potten
{"title":"Process Evaluation of Home-based Bimanual Training in Children with Unilateral Cerebral Palsy (The COAD-study): A Mixed Methods Study.","authors":"Lwme Beckers, Rjem Smeets, Mac de Mooij, B Piškur, Jjw van der Burg, Eaa Rameckers, Pbm Aarts, Coad Author Group, Yjm Janssen-Potten","doi":"10.1080/17518423.2021.2011459","DOIUrl":"https://doi.org/10.1080/17518423.2021.2011459","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the processes and factors that influenced implementation and impact of a home-based bimanual training program in children with unilateral cerebral palsy aged 2 through 7 years.</p><p><strong>Methods: </strong>The program encompassed bimanual task-specific training (3.5 hours/week for 12 weeks) adopting either implicit or explicit motor learning. A therapist and remedial educationalist coached parents. This mixed methods study included course attendance monitoring, questionnaires, registration form, video analysis, interviews, focus group discussion, and drop-out monitoring.</p><p><strong>Results: </strong>Fourteen families participated. The program was not fully implemented as intended. Parents positively experienced the training and were well able to provide it. The program was demanding for the children and time-consuming for parents. Several components positively contributed to the program: task-analysis, instructional videos, and coaching by a therapist and remedial educationalist. Several modifications to the program were proposed.</p><p><strong>Conclusion: </strong>Home-based bimanual training forms a demanding but promising therapeutic approach with potential for optimization.</p>","PeriodicalId":51227,"journal":{"name":"Developmental Neurorehabilitation","volume":"25 4","pages":"246-262"},"PeriodicalIF":1.3,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39624434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of upper extremity constraints on functional and dynamic postural control in children with hemiplegic cerebral palsy.","authors":"Meysam Roostaei, Parvin Raji, Khosro Khademi Kalantari, Elham Faghihzadeh, Maria Fragala-Pinkham","doi":"10.1080/17518423.2021.2020351","DOIUrl":"https://doi.org/10.1080/17518423.2021.2020351","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the effects of upper extremity constraints on functional and dynamic postural control in children with hemiplegic cerebral palsy.</p><p><strong>Materials and methods: </strong>Twelve children with hemiplegic cerebral palsy and 12 typically developing children ages 5 to 12 years (GMFCS I-II) were evaluated with the Timed Up and Go (TUG) and Biodex Balance System during three upper extremity (UE) conditions: 1) Free UEs (no constraints), 2) Simple UE constraint (unaffected/dominant UE constrained with a sling), and 3) Difficult UE constraint (Simple constraint plus the other UE holding cup of water).</p><p><strong>Results: </strong>The UE condition had significant effects on Overall Stability Index (OSI) (F<sub>(2,44)</sub> = 24.899, <i>p</i> < .001), Medial-Lateral Stability Index (MLSI) (F<sub>(2,44)</sub> = 4.380, <i>p</i> = .018), Anterior-Posterior Stability Index (F<sub>(2,44)</sub> = 6.187, <i>p</i> = .004), and TUG scores (F<sub>(2,44)</sub> = 113.372, <i>p</i> < .001). Group was significant for OSI (F<sub>(1,22)</sub> = 7.906, <i>p</i> = .010), MLSI (F<sub>(1,22)</sub> = 13.113, <i>p</i> = .002), and TUG (F<sub>(1,22)</sub> = 36.282, <i>p</i> < .001).</p><p><strong>Conclusions: </strong>The upper extremity appears to have a role in maintaining functional balance and postural stability in children with hemiplegic cerebral palsy and should be considered during intervention programs.</p>","PeriodicalId":51227,"journal":{"name":"Developmental Neurorehabilitation","volume":"25 4","pages":"281-288"},"PeriodicalIF":1.3,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39775231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Geraldine Leader, Emma Dooley, Sally Whelan, Shawn P Gilroy, June L Chen, Autumn Farren Barton, Rory Coyne, Arlene Mannion
{"title":"Attention-Deficit/Hyperactivity Disorder Symptoms, Gastrointestinal Symptoms, Sleep Problems, Challenging Behavior, Adaptive Behavior, and Quality of Life in Children and Adolescents with Autism Spectrum Disorder.","authors":"Geraldine Leader, Emma Dooley, Sally Whelan, Shawn P Gilroy, June L Chen, Autumn Farren Barton, Rory Coyne, Arlene Mannion","doi":"10.1080/17518423.2021.1964005","DOIUrl":"https://doi.org/10.1080/17518423.2021.1964005","url":null,"abstract":"<p><p>This study investigated the relationship between sleep, gastrointestinal symptoms, challenging behavior, adaptive behavior, and quality of life between children and adolescents with autism spectrum disorder (ASD), with and without attention-deficit/hyperactivity disorder (AD/HD) symptoms. Parents of 118 children and adolescents with ASD completed the Conners Early Childhood Rating Scale-Parent Short Form or the Conners 3-Parent Short Form, Children's Sleep Habits Questionnaire, Gastrointestinal Symptom Inventory, Behavior Problems Inventory-Short Form, Pediatric Quality of Life Inventory and the Vineland Adaptive Behavior Scales, Second Edition. The ASD group and the ASD with AD/HD groups differed significantly in sleep problems, gastrointestinal symptoms, and quality of life. Regressions indicated that AD/HD symptoms accounted for a small proportion of the variance for the differences in sleep problems and quality of life. AD/HD symptoms contribute to the complex needs of individuals with ASD. Research is necessary to investigate how these symptoms exacerbate comorbidities.</p>","PeriodicalId":51227,"journal":{"name":"Developmental Neurorehabilitation","volume":"25 4","pages":"217-228"},"PeriodicalIF":1.3,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39291866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Pilot Study Exploring Social Validity Ratings of Social Profiles for College Students.","authors":"Helena Bush, John T Rapp, Nadrat Nuhu","doi":"10.1080/17518423.2021.2011460","DOIUrl":"https://doi.org/10.1080/17518423.2021.2011460","url":null,"abstract":"<p><p>Nuhu and Rapp identified three profiles undergraduates displayed during social interactions. We evaluated the social validity of these three profiles in two studies. In Study 1 we presented video exemplars of speakers representing each profile to undergraduate participants and asked them to rate the speaker in respect to various statements. Results showed that one profile was rated significantly different than the other two profiles on all but one statement. In Study 2 we further evaluated the role of eye contact in the profile that participants rated differently in Study 1. Results from Study 2 showed that a speaker engaging in low eye contact was rated lower than a speaker engaging in either a validated or high level of eye contact. Likewise, participants with self-reported high social competency provided more negative ratings of a speaker who displayed low eye contact than participants with self-reported Moderate and Low social competency.</p>","PeriodicalId":51227,"journal":{"name":"Developmental Neurorehabilitation","volume":"25 4","pages":"263-273"},"PeriodicalIF":1.3,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39693843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of the Upper and Lower Extremity and Trunk Muscle Masses between Children with Down Syndrome and Children with Typical Development.","authors":"Mitsuhiro Masaki, Seina Maruyama, Yukika Inagaki, Yukine Ogawa, Yoshino Sato, Minori Yokota, Moeka Takeuchi, Maki Kasahara, Kota Minakawa, Kana Kato, Kenji Sakaino","doi":"10.1080/17518423.2021.2018518","DOIUrl":"https://doi.org/10.1080/17518423.2021.2018518","url":null,"abstract":"<p><strong>Purpose: </strong>Comparison of not only the upper and lower extremity but also trunk muscle masses measured by means of an ultrasound imaging device between children with Down syndrome (DS) and children with typical development (TD).</p><p><strong>Methods: </strong>The study included 35 children with TD (TD group) and 26 children with DS (DS group). The upper and lower extremity and trunk muscle thicknesses were measured using an ultrasound imaging device.</p><p><strong>Results: </strong>The thicknesses of the rectus abdominis, obliquus externus and internus abdominis, rectus femoris, and short head of the biceps femoris muscles were significantly lower in the DS group than in the TD group. The thicknesses of the other upper and lower extremity and trunk muscles did not differ significantly between the groups.</p><p><strong>Conclusions: </strong>The results of this study demonstrated lower masses of trunk flexor and knee extensor and flexor muscles in children with DS compared to those in children with TD.</p>","PeriodicalId":51227,"journal":{"name":"Developmental Neurorehabilitation","volume":"25 4","pages":"274-280"},"PeriodicalIF":1.3,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39829878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Use of the Physical Abilities and Mobility Scale (PAMS) in Children Receiving Inpatient Rehabilitation for Spinal Cord Related Paralysis.","authors":"Cynthia Salorio, Kelsey Rogers, Erin Neuland, Julie Cagney, Cristina Sadowsky","doi":"10.1080/17518423.2021.1962424","DOIUrl":"https://doi.org/10.1080/17518423.2021.1962424","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the performance of the Physical Abilities and Mobility Scale (PAMS) in children receiving inpatient rehabilitation for paralysis related to spinal cord disease and injury (SCD/SCI).</p><p><strong>Methods: </strong>Participants were 146 children with paralysis related to SCD/SCI, aged 2-21, admitted between January 2010 and 2017 for inpatient rehabilitation at a single free-standing academically affiliated pediatric rehabilitation hospital. Retrospective chart review was performed to obtain admission and discharge scores on the PAMS and the functional independence measure for children (WeeFIM®), collected as part of clinical care. Internal consistency was evaluated using Cronbach's alpha. Inter-rater reliability was evaluated through overall agreement, Pearson correlations, and intraclass correlations. Construct validity was examined through exploratory factor analysis. Criterion validity was explored through correlations of PAMS overall and item scores with WeeFIM® total and subscale scores. Sensitivity to change was tested using paired t-tests examining differences between admission and discharge scores for each item and for the total score on the PAMS.</p><p><strong>Results: </strong>Internal consistency and inter-rater reliability were high (0.94 at admission and 0.95 at discharge). Total PAMS scores are highly correlated with total WeeFIM®, mobility, self-care, and cognitive subscores at admission and discharge. Correlations with the WeeFIM® ranged from low (cognitive) to strong (mobility). Total PAMS score and all individual items increased significantly between admission and discharge.</p><p><strong>Conclusions: </strong>The PAMS is a useful measure capturing incremental and granular functional motor skills changes occurring during inpatient rehabilitation for children with spinal cord-related paralysis.</p>","PeriodicalId":51227,"journal":{"name":"Developmental Neurorehabilitation","volume":"25 3","pages":"186-192"},"PeriodicalIF":1.3,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/17518423.2021.1962424","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9225224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. L. Dornonville de la Cour, Michelle Barner Bærentzen, Birgit Forchhammer, Sigrid Tibæk, A. Norup
{"title":"Reducing fatigue following acquired brain injury: A feasibility study of high intensity interval training for young adults","authors":"F. L. Dornonville de la Cour, Michelle Barner Bærentzen, Birgit Forchhammer, Sigrid Tibæk, A. Norup","doi":"10.1080/17518423.2022.2052374","DOIUrl":"https://doi.org/10.1080/17518423.2022.2052374","url":null,"abstract":"ABSTRACT The aim was to evaluate feasibility of high-intensity interval training (HIIT) in fatigued adults (20–40 years old) with acquired brain injury (ABI). A prospective pre-post single-arm intervention trial was conducted, including 6–8 months follow-up assessment and interview. Intervention was 18 sessions of intermittent exercise on a cycle ergometer over six weeks. Six out of ten participants without motor impairments completed the intervention (all females, mean age = 30.2 years, months post-injury = 22). On average, participants attended 88% of sessions and achieved high intensity (93% of max heart rate). VO2max improved by 0.53 l/min (SD = 0.29), and participants continued exercising post-intervention. All participants were satisfied with HIIT, were more inclined to exercise, and reported positive effects of exercising for self-management of fatigue. Three sessions a week were demanding to some participants. Findings support feasibility of HIIT as a promising intervention for young adults with post-ABI fatigue.","PeriodicalId":51227,"journal":{"name":"Developmental Neurorehabilitation","volume":"25 1","pages":"349 - 360"},"PeriodicalIF":1.3,"publicationDate":"2022-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49568949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Kang, S. Orlandi, N. Lorenzen, T. Chau, M. Thaut
{"title":"Does music induce interbrain synchronization between a non-speaking youth with cerebral palsy (CP), a parent, and a neurologic music therapist? A brief report","authors":"K. Kang, S. Orlandi, N. Lorenzen, T. Chau, M. Thaut","doi":"10.1080/17518423.2022.2051628","DOIUrl":"https://doi.org/10.1080/17518423.2022.2051628","url":null,"abstract":"ABSTRACT Shared emotional experiences during musical activities among musicians can be coupled with brainwave synchronization. For non-speaking individuals with CP, verbal communication may be limited in expressing mutual empathy. Therefore, this case study explored interbrain synchronization among a non-speaking CP (female, 18 yrs), her parent, and a music therapist by measuring their brainwaves simultaneously during four music and four storytelling sessions. In only the youth-parent dyad, we observed a significantly higher level of interbrain synchronization during music rather than story-telling condition. However, in both the youth-parent and youth-therapist dyad, regardless of condition type, significant interbrain synchronization emerged in frontal and temporal lobes in the low-frequency bands, which are associated with socio-emotional responses. Although interbrain synchronization may have been induced by multiple factors (e.g., external stimuli, shared empathetic experiences, and internal physiological rhythms), the music activity setting deserves further study as a potential facilitator of neurophysiological synchrony between youth with CP and caregivers/healthcare providers.","PeriodicalId":51227,"journal":{"name":"Developmental Neurorehabilitation","volume":"25 1","pages":"426 - 432"},"PeriodicalIF":1.3,"publicationDate":"2022-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48184241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}