Vitamins and Hormones最新文献_第9页

Essential and subtype-dependent function of thyroid hormone receptors during Xenopus metamorphosis. 非洲爪蟾变态过程中甲状腺激素受体的基本和亚型依赖性功能。

4区医学

Vitamins and Hormones Pub Date : 2023-01-01 Epub Date: 2023-03-25 DOI: 10.1016/bs.vh.2023.02.004

Yun-Bo Shi, Yuta Tanizaki, Shouhong Wang, Liezhen Fu

{"title":"Essential and subtype-dependent function of thyroid hormone receptors during Xenopus metamorphosis.","authors":"Yun-Bo Shi, Yuta Tanizaki, Shouhong Wang, Liezhen Fu","doi":"10.1016/bs.vh.2023.02.004","DOIUrl":"10.1016/bs.vh.2023.02.004","url":null,"abstract":"Thyroid hormone (T3) plays critical roles in organ metabolism and development in vertebrates. Anuran metamorphosis is perhaps the most dramatic and best studied developmental process controlled by T3. Many changes in different organs/tissues during anuran metamorphosis resemble the maturation/remodeling of the corresponding organs/tissues during mammalian postembryonic development. The plasma T3 level peaks during both anuran metamorphosis and mammalian postembryonic development. T3 exerts its developmental function through transcriptional regulation via T3 receptors (TRs). Studies on the metamorphosis of two highly related anurans, pseudo-tetraploid Xenopus laevis and diploid Xenopus tropicalis, have led to a dual function model for TRs during development. This has been supported by strong molecular and genetic evidence. Here we review some of the evidence with a focus on more recent gene knockout studies in Xenopus tropicalis. These studies have not only supported the model but also revealed novel and TR subtype-specific roles during Xenopus development, particularly a critical role of TRα in controlling developmental timing and rate.","PeriodicalId":51209,"journal":{"name":"Vitamins and Hormones","volume":"123 ","pages":"503-523"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11285022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10307498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

About the editor. 关于编辑

4区医学

Vitamins and Hormones Pub Date : 2023-01-01 DOI: 10.1016/S0083-6729(23)00021-3

引用次数: 0

DNA methylation in the pathogenesis of type 2 diabetes. DNA甲基化在2型糖尿病发病中的作用。

4区医学

Vitamins and Hormones Pub Date : 2023-01-01 DOI: 10.1016/bs.vh.2022.11.002

Suneesh Kaimala, Suraiya Anjum Ansari, Bright Starling Emerald

引用次数: 1

Epigenetics, endometriosis and sex steroid receptors: An update on the epigenetic regulatory mechanisms of estrogen and progesterone receptors in patients with endometriosis. 表观遗传学、子宫内膜异位症和性类固醇受体:子宫内膜异位症患者雌激素和孕激素受体的表观遗传学调控机制的最新进展。

4区医学

Vitamins and Hormones Pub Date : 2023-01-01 DOI: 10.1016/bs.vh.2023.01.007

Margherita Rossi, Isabelle Seidita, Silvia Vannuccini, Matteo Prisinzano, Chiara Donati, Felice Petraglia

{"title":"Epigenetics, endometriosis and sex steroid receptors: An update on the epigenetic regulatory mechanisms of estrogen and progesterone receptors in patients with endometriosis.","authors":"Margherita Rossi, Isabelle Seidita, Silvia Vannuccini, Matteo Prisinzano, Chiara Donati, Felice Petraglia","doi":"10.1016/bs.vh.2023.01.007","DOIUrl":"https://doi.org/10.1016/bs.vh.2023.01.007","url":null,"abstract":"Endometriosis is a benign gynecological disease affecting ∼10% of reproductive-aged women and is defined as the presence of endometrial glands and stroma outside the uterine cavity. Endometriosis can cause a variety of health problems, from pelvic discomfort to catamenial pneumothorax, but it's mainly linked with severe and chronic pelvic pain, dysmenorrhea, and deep dyspareunia, as well as reproductive issues. The pathogenesis of endometriosis involves an endocrine dysfunction, with estrogen dependency and progesterone resistance, and inflammatory mechanism activation, together with impaired cell proliferation and neuroangiogenesis. The present chapter aims to discuss the main epigenetic mechanisms related to estrogen receptors (ERs) and progesterone receptors (PRs) in patients with endometriosis. There are numerous epigenetic mechanisms participating in endometriosis, regulating the expression of the genes encoding these receptors both indirectly, through the regulation of transcription factors, and directly, through DNA methylation, histone modifications, micro RNAs and long noncoding RNAs. This represents an open field of investigation, which may lead to important clinical implications such as the development of epigenetic drugs for the treatment of endometriosis and the identification of specific and early biomarkers for the disease.","PeriodicalId":51209,"journal":{"name":"Vitamins and Hormones","volume":"122 ","pages":"171-191"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9324234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Hormone-linked redox status and its modulation by antioxidants. 激素相关的氧化还原状态及其抗氧化剂的调节。

4区医学

Vitamins and Hormones Pub Date : 2023-01-01 DOI: 10.1016/bs.vh.2022.10.007

Dipak Kumar Sahoo, Gagan B N Chainy

{"title":"Hormone-linked redox status and its modulation by antioxidants.","authors":"Dipak Kumar Sahoo, Gagan B N Chainy","doi":"10.1016/bs.vh.2022.10.007","DOIUrl":"https://doi.org/10.1016/bs.vh.2022.10.007","url":null,"abstract":"Hormones have been considered as key factors involved in the maintenance of the redox status of the body. We are making considerable progress in understanding interactions between the endocrine system, redox status, and oxidative stress with the dynamics of life, which encompasses fertilization, development, growth, aging, and various pathophysiological states. One of the reasons for changes in redox states of vertebrates leading to oxidative stress scenario is the disruption of the endocrine system. Comprehending the dynamics of hormonal status to redox state and oxidative stress in living systems is challenging. It is more difficult to come to a unifying conclusion when some hormones exhibit oxidant properties while others have antioxidant features. There is a very limited approach to correlate alteration in titers of hormones with redox status and oxidative stress with growth, development, aging, and pathophysiological stress. The situation is further complicated when considering various tissues and sexes in vertebrates. This chapter discusses the beneficial impacts of hormones with antioxidative properties, such as melatonin, glucagon, insulin, estrogens, and progesterone, which protect cells from oxidative damage and reduce pathophysiological effects. Additionally, we discuss the protective effects of antioxidants like vitamins A, E, and C, curcumin, tempol, N-acetyl cysteine, α-lipoic acid, date palm pollen extract, resveratrol, and flavonoids on oxidative stress triggered by hormones such as aldosterone, glucocorticoids, thyroid hormones, and catecholamines. Inflammation, pathophysiology, and the aging process can all be controlled by understanding how antioxidants and hormones operate together to maintain cellular redox status. Identifying the hormonal changes and the action of antioxidants may help in developing new therapeutic strategies for hormonal imbalance-related disorders.","PeriodicalId":51209,"journal":{"name":"Vitamins and Hormones","volume":"121 ","pages":"197-246"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10597072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Membrane estrogen receptor and follicle-stimulating hormone receptor. 膜雌激素受体和促卵泡激素受体。

4区医学

Vitamins and Hormones Pub Date : 2023-01-01 Epub Date: 2022-12-29 DOI: 10.1016/bs.vh.2022.12.005

Livio Casarini, Manuela Simoni

引用次数: 0

Structures of the arginine-vasopressin and oxytocin receptor signaling complexes. 精氨酸加压素和催产素受体信号复合物的结构。

4区医学

Vitamins and Hormones Pub Date : 2023-01-01 Epub Date: 2023-01-13 DOI: 10.1016/bs.vh.2022.12.003

Julien Bous, Aurélien Fouillen, Hélène Orcel, Sébastien Granier, Patrick Bron, Bernard Mouillac

{"title":"Structures of the arginine-vasopressin and oxytocin receptor signaling complexes.","authors":"Julien Bous, Aurélien Fouillen, Hélène Orcel, Sébastien Granier, Patrick Bron, Bernard Mouillac","doi":"10.1016/bs.vh.2022.12.003","DOIUrl":"10.1016/bs.vh.2022.12.003","url":null,"abstract":"Arginine-vasopressin (AVP) and oxytocin (OT) are neurohypophysial hormones which share a high sequence and structure homology. These are two cyclic C-terminally amidated nonapeptides with different residues at position 3 and 8. In mammals, AVP and OT exert their multiple biological functions through a specific G protein-coupled receptor family: four receptors are identified, the V1a, V1b, V2 receptors (V1aR, V1bR and V2R) and the OT receptor (OTR). The chemical structure of AVP and OT was elucidated in the early 1950s. Thanks to X-ray crystallography and cryo-electron microscopy, it took however 70 additional years to determine the three-dimensional structures of the OTR and the V2R in complex with their natural agonist ligands and with different signaling partners, G proteins and β-arrestins. Today, the comparison of the different AVP/OT receptor structures gives structural insights into their orthosteric ligand binding pocket, their molecular mechanisms of activation, and their interfaces with canonical Gs, Gq and β-arrestin proteins. It also paves the way to future rational drug design and therapeutic compound development. Indeed, agonist, antagonist, biased agonist, or pharmacological chaperone analogues of AVP and OT are promising candidates to regulate different physiological functions and treat several pathologies.","PeriodicalId":51209,"journal":{"name":"Vitamins and Hormones","volume":"123 ","pages":"67-107"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10671466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The human glucocorticoid receptor. 人类糖皮质激素受体。

4区医学

Vitamins and Hormones Pub Date : 2023-01-01 Epub Date: 2023-07-10 DOI: 10.1016/bs.vh.2023.06.005

Nicolas C Nicolaides, George P Chrousos

引用次数: 3

The androgen receptor. 雄激素受体。

4区医学

Vitamins and Hormones Pub Date : 2023-01-01 Epub Date: 2023-08-17 DOI: 10.1016/bs.vh.2023.01.001

Greg Van-Duyne, Ian A Blair, Cynthia Sprenger, Vera Moiseenkova-Bell, Stephen Plymate, Trevor M Penning

{"title":"The androgen receptor.","authors":"Greg Van-Duyne, Ian A Blair, Cynthia Sprenger, Vera Moiseenkova-Bell, Stephen Plymate, Trevor M Penning","doi":"10.1016/bs.vh.2023.01.001","DOIUrl":"10.1016/bs.vh.2023.01.001","url":null,"abstract":"The Androgen Receptor (AR) is a ligand (androgen) activated transcription factor and a member of the nuclear receptor (NR) superfamily. It is required for male sex hormone function. AR-FL (full-length) has the domain structure of NRs, an N-terminal domain (NTD) required for transactivation, a DNA-binding domain (DBD), a nuclear localization signal (NLS) and a ligand-binding domain (LBD). Paradoxes exist in that endogenous ligands testosterone (T) and 5α-dihydrotestosterone (DHT) have differential effects on male sexual development while binding to the same receptor and transcriptional specificity is achieved even though the androgen response elements (AREs) are identical to those seen for the progesterone, glucocorticoid and mineralocorticoid receptors. A high resolution 3-dimensional structure of AR-FL by either cryo-EM or X-ray crystallography has remained elusive largely due to the intrinsic disorder of the NTD. AR function is regulated by post-translational modification leading to a large number of proteoforms. The interaction of these proteoforms in multiprotein complexes with co-activators and co-repressors driven by interdomain coupling mediates the AR transcriptional output. The AR is a drug target for selective androgen receptor modulators (SARMS) that either have anabolic or androgenic effects. Protstate cancer is treated with androgen deprivation therapy or by the use of AR antagonists that bind to the LBD. Drug resistance occurs due to adaptive AR upregulation and the appearance of splice variants that lack the LBD and become constitutively active. Bipolar T treatment and NTD-antagonists could surmount these resistance mechanisms, respectively. These recent advances in AR signaling are described.","PeriodicalId":51209,"journal":{"name":"Vitamins and Hormones","volume":"123 ","pages":"439-481"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10307497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Ascorbic acid as antioxidant. 抗坏血酸作为抗氧化剂。

4区医学

Vitamins and Hormones Pub Date : 2023-01-01 DOI: 10.1016/bs.vh.2022.10.008

Agnieszka Gęgotek, Elżbieta Skrzydlewska

{"title":"Ascorbic acid as antioxidant.","authors":"Agnieszka Gęgotek, Elżbieta Skrzydlewska","doi":"10.1016/bs.vh.2022.10.008","DOIUrl":"https://doi.org/10.1016/bs.vh.2022.10.008","url":null,"abstract":"Ascorbic acid, as one of the basic exogenous vitamins, is known for its tremendous antioxidant properties. This review has been prepared to show not only the importance of ascorbic acid as a free radical scavenger, but also to summarize its antioxidant action based on other mechanisms, including activation of intracellular antioxidant systems. Ascorbic acid interacts with small molecule antioxidants, including tocopherol, glutathione and thioredoxin, but also can stimulate the biosynthesis and activation of antioxidant enzymes, such as superoxide dismutase, catalase or glutathione peroxidase. Moreover, ascorbic acid promotes the activity of several transcription factors (Nrf2, Ref-1, AP-1), which enables the expression of genes encoding antioxidant proteins. Additionally, it supports the action of other exogenous antioxidants, mainly polyphenols. In this connection, both DNA, protein and lipids are protected against oxidation. Although ascorbic acid has strong antioxidant properties, it can also have pro-oxidant effects in the presence of free transition metals. However, its role in prevention of DNA mutation and cellular apoptosis, especially in relation to cancer cells is controversial.","PeriodicalId":51209,"journal":{"name":"Vitamins and Hormones","volume":"121 ","pages":"247-270"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10589894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3