Vitamins and Hormones最新文献_第10页

Preface. 序言

4区医学

Vitamins and Hormones Pub Date : 2023-01-01 DOI: 10.1016/S0083-6729(23)00022-5

Gerald Litwack

引用次数: 0

Preface. 序言

4区医学

Vitamins and Hormones Pub Date : 2023-01-01 DOI: 10.1016/S0083-6729(23)00038-9

Gerald Litwack

引用次数: 0

Signaling mechanism of growth hormone-releasing hormone receptor. 生长激素释放激素受体的信号传导机制。

4区医学

Vitamins and Hormones Pub Date : 2023-01-01 Epub Date: 2023-07-07 DOI: 10.1016/bs.vh.2023.06.004

Gabor Halmos, Zsuzsanna Szabo, Eva Juhasz, Andrew V Schally

{"title":"Signaling mechanism of growth hormone-releasing hormone receptor.","authors":"Gabor Halmos, Zsuzsanna Szabo, Eva Juhasz, Andrew V Schally","doi":"10.1016/bs.vh.2023.06.004","DOIUrl":"10.1016/bs.vh.2023.06.004","url":null,"abstract":"The hypothalamic peptide growth hormone-releasing hormone (GHRH) stimulates the secretion of growth hormone (GH) from the pituitary through binding and activation of the pituitary type of GHRH receptor (GHRH-R), which belongs to the family of G protein-coupled receptors with seven potential membrane-spanning domains. Splice variants of GHRH-Rs (SV) in human tumors and other extra pituitary tissues were identified and their cDNA was sequenced. Among the SVs, splice variant 1 (SV1) possesses the greatest similarity to the full-length GHRH-R and remains functional by eliciting cAMP signaling and mitogenic activity upon GHRH stimulation. A large body of work have evaluated potential clinical applications of agonists and antagonists of GHRH in diverse fields, including endocrinology, oncology, cardiology, diabetes, obesity, metabolic dysfunctions, Alzheimer's disease, ophthalmology, wound healing and other applications. In this chapter, we briefly review the expression and potential function of GHRH-Rs and their SVs in various tissues and also elucidate and summarize the activation, molecular mechanism and signalization pathways of these receptors. Therapeutic applications of GHRH analogs are also discussed.","PeriodicalId":51209,"journal":{"name":"Vitamins and Hormones","volume":"123 ","pages":"1-26"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10299004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early-life AFB1 exposure: DNA methylation and hormone alterations. 早期AFB1暴露:DNA甲基化和激素改变。

4区医学

Vitamins and Hormones Pub Date : 2023-01-01 DOI: 10.1016/bs.vh.2022.11.004

Oluwakemi A Rotimi, Opeyemi C De Campos, Isaacson B Adelani, Tolulope D Olawole, Solomon O Rotimi

引用次数: 2

Effects of stress and mindfulness on epigenetics. 压力和正念对表观遗传学的影响。

4区医学

Vitamins and Hormones Pub Date : 2023-01-01 DOI: 10.1016/bs.vh.2022.11.003

Ayman Mukerji Househam

引用次数: 1

On the road to resilience: Epigenetic effects of meditation. 在恢复力的道路上:冥想的表观遗传效应。

4区医学

Vitamins and Hormones Pub Date : 2023-01-01 DOI: 10.1016/bs.vh.2022.12.009

Loredana Verdone, Micaela Caserta, Tal Dotan Ben-Soussan, Sabrina Venditti

{"title":"On the road to resilience: Epigenetic effects of meditation.","authors":"Loredana Verdone, Micaela Caserta, Tal Dotan Ben-Soussan, Sabrina Venditti","doi":"10.1016/bs.vh.2022.12.009","DOIUrl":"https://doi.org/10.1016/bs.vh.2022.12.009","url":null,"abstract":"Many environmental and lifestyle related factors may influence the physiology of the brain and body by acting on fundamental molecular pathways, such as the hypothalamus-pituitary-adrenal axis (HPA) and the immune system. For example, stressful conditions created by adverse early-life events, unhealthy habits and low socio-economic status may favor the onset of diseases linked to neuroendocrine dysregulation, inflammation and neuroinflammation. Beside pharmacological treatments used in clinical settings, much attention has been given to complementary treatments such as mind-body techniques involving meditation that rely on the activation of inner resources to regain health. At the molecular level, the effects of both stress and meditation are elicited epigenetically through a set of mechanisms that regulate gene expression as well as the circulating neuroendocrine and immune effectors. Epigenetic mechanisms constantly reshape genome activities in response to external stimuli, representing a molecular interface between organism and environment. In the present work, we aimed to review the current knowledge on the correlation between epigenetics, gene expression, stress and its possible antidote, meditation. After introducing the relationship between brain, physiology, and epigenetics, we will proceed to describe three basic epigenetic mechanisms: chromatin covalent modifications, DNA methylation and non-coding RNAs. Subsequently, we will give an overview of the physiological and molecular aspects related to stress. Finally, we will address the epigenetic effects of meditation on gene expression. The results of the studies reported in this review demonstrate that mindful practices modulate the epigenetic landscape, leading to increased resilience. Therefore, these practices can be considered valuable tools that complement pharmacological treatments when coping with pathologies related to stress.","PeriodicalId":51209,"journal":{"name":"Vitamins and Hormones","volume":"122 ","pages":"339-376"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9694640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Epigenetic regulation during 1,25-dihydroxyvitamin D₃-dependent gene transcription. 1,25-二羟基维生素d3依赖性基因转录过程中的表观遗传调控。

4区医学

Vitamins and Hormones Pub Date : 2023-01-01 DOI: 10.1016/bs.vh.2023.01.005

Daniel Moena, Esther Vargas, Martin Montecino

{"title":"Epigenetic regulation during 1,25-dihydroxyvitamin D3-dependent gene transcription.","authors":"Daniel Moena, Esther Vargas, Martin Montecino","doi":"10.1016/bs.vh.2023.01.005","DOIUrl":"https://doi.org/10.1016/bs.vh.2023.01.005","url":null,"abstract":"Multiple evidence accumulated over the years, demonstrates that vitamin D-dependent physiological control in vertebrates occurs primarily through the regulation of target gene transcription. In addition, there has been an increasing appreciation of the role of the chromatin organization of the genome on the ability of the active form of vitamin D, 1,25(OH)2D3, and its specific receptor VDR to regulate gene expression. Chromatin structure in eukaryotic cells is principally modulated through epigenetic mechanisms including, but not limited to, a wide number of post-translational modifications of histone proteins and ATP-dependent chromatin remodelers, which are operative in different tissues during response to physiological cues. Hence, there is necessity to understand in depth the epigenetic control mechanisms that operate during 1,25(OH)2D3-dependent gene regulation. This chapter provides a general overview about epigenetic mechanisms functioning in mammalian cells and discusses how some of these mechanisms represent important components during transcriptional regulation of the model gene system CYP24A1 in response to 1,25(OH)2D3.","PeriodicalId":51209,"journal":{"name":"Vitamins and Hormones","volume":"122 ","pages":"51-74"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9694642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural-product-inspired bioactive alkaloids agglomerated with potential antioxidant activity: Recent advancements on structure-activity relationship studies and future perspectives. 具有潜在抗氧化活性的天然产物激发的生物活性生物碱:构效关系研究的最新进展和未来展望。

4区医学

Vitamins and Hormones Pub Date : 2023-01-01 DOI: 10.1016/bs.vh.2022.10.002

Pooja Prakash Atpadkar, Sumanth Gopavaram, Sandeep Chaudhary

{"title":"Natural-product-inspired bioactive alkaloids agglomerated with potential antioxidant activity: Recent advancements on structure-activity relationship studies and future perspectives.","authors":"Pooja Prakash Atpadkar, Sumanth Gopavaram, Sandeep Chaudhary","doi":"10.1016/bs.vh.2022.10.002","DOIUrl":"https://doi.org/10.1016/bs.vh.2022.10.002","url":null,"abstract":"Alkaloids derived from natural sources have been shown to have substantial antioxidant activity, suggesting that these natural-product-inspired bioactive entities may have major beneficial influence on human health and food processing sector. The primary process intricates in the etiology of several disorders such as neurodegenerative, inflammatory cardiovascular, and other chronic diseases appear to be either oxidative injury or a cellular damage caused by reactive oxygen species (ROS) or free-radicals. The alkaloid class of bio-heterocycles have been divided into numerous groups based on their biosynthetic precursor and heterocyclic ring systems i.e., piperidine, imidazole, purine, pyrrolizidine, indole, quinolozidine, isoquinoline, tropane, and pyrrolidine alkaloids. Distinct biological properties have been attributed to various compounds belonging to this chemical groups, including antirheumatic, cardiovascular, antispasmodic, anti-ulcer, anti-inflammatory, antibacterial, antinociceptive etc. For many years, natural products and their analogs have been recognized as a possible source of medicinal agents. Recently, research has been concentrated on the synthesis, separation/purification, and identification of new alkaloids derived from a variety of natural sources. This book chapter aims to summarize on the latest developments on the current knowledge on the relationship between the structural features of promising class of bioactive alkaloids with their antioxidant activities.","PeriodicalId":51209,"journal":{"name":"Vitamins and Hormones","volume":"121 ","pages":"355-393"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10589892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

In silico study of natural antioxidants. 天然抗氧化剂的计算机研究。

4区医学

Vitamins and Hormones Pub Date : 2023-01-01 DOI: 10.1016/bs.vh.2022.09.001

Shahin Ahmadi, Azizeh Abdolmaleki, Marjan Jebeli Javan

{"title":"In silico study of natural antioxidants.","authors":"Shahin Ahmadi, Azizeh Abdolmaleki, Marjan Jebeli Javan","doi":"10.1016/bs.vh.2022.09.001","DOIUrl":"https://doi.org/10.1016/bs.vh.2022.09.001","url":null,"abstract":"Antioxidants are the body's defense system against the damage of reactive oxygen species, which are usually produced in the body through various physiological processes. There are various sources of these antioxidants such as endogenous antioxidants in the body and exogenous food sources. This chapter provides important information on methods used to investigate antioxidant activity and sources of plant antioxidants. Over the past two decades, numerous studies have demonstrated the importance of in silico research in the development of novel natural and synthesized antioxidants. In silico methods such as quantitative structure-activity relationships (QSAR), pharmacophore, docking, and virtual screenings are play critical roles in designing effective antioxidants that may be synthesized and tested later. This chapter introduces the available in silico approaches for different classes of antioxidants. Many successful applications of in silico methods in the development and design of novel antioxidants are thoroughly discussed. The QSAR, pharmacophore, molecular docking techniques, and virtual screenings process summarized here would help readers to find out the proper mechanism for the interaction between the free radicals and antioxidant compounds. Furthermore, this chapter focuses on introducing new QSAR models in combination with other in silico methods to predict antioxidants activity and design more active antioxidants. In silico studies are essential to explore largely unknown plant tissue, food sources for antioxidant synthesis, as well as saving time and money in such studies.","PeriodicalId":51209,"journal":{"name":"Vitamins and Hormones","volume":"121 ","pages":"1-43"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10597071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Steroid hormone signaling: What we can learn from insect models. 类固醇激素信号：我们可以从昆虫模型中学到什么。

4区医学

Vitamins and Hormones Pub Date : 2023-01-01 Epub Date: 2023-02-06 DOI: 10.1016/bs.vh.2022.12.006

Naoki Okamoto, Daiki Fujinaga, Naoki Yamanaka

引用次数: 0