Noropsikiyatri Arsivi-Archives of Neuropsychiatry最新文献_第4页

The Association Between Serum Levels of Glial Biomarkers, Clinical Severity and Electro-encephalography Features in Idiopathic West and Lennox-Gastaut Syndromes. 128 特发性韦斯特综合征和伦诺克斯-加斯塔特综合征中神经胶质生物标志物血清水平、临床严重程度和脑电图特征之间的关联。

IF 1 4区医学

Noropsikiyatri Arsivi-Archives of Neuropsychiatry Pub Date : 2024-02-02 eCollection Date: 2024-01-01 DOI: 10.29399/npa.28669

Minara Cherkezzade, Selen Soylu, Erdem Tüzün, Vuslat Yılmaz, Mine Sezgin, Zuhal Yapıcı, Cem İsmail Küçükali, Pınar Topaloğlu

{"title":"The Association Between Serum Levels of Glial Biomarkers, Clinical Severity and Electro-encephalography Features in Idiopathic West and Lennox-Gastaut Syndromes.","authors":"Minara Cherkezzade, Selen Soylu, Erdem Tüzün, Vuslat Yılmaz, Mine Sezgin, Zuhal Yapıcı, Cem İsmail Küçükali, Pınar Topaloğlu","doi":"10.29399/npa.28669","DOIUrl":"10.29399/npa.28669","url":null,"abstract":"Introduction: Although the contribution of enhanced glial activity in seizure induction is increasingly recognized, the role of glia-induced neuroinflammation in the physiopathology of epileptic encephalopathy (EE) has been scarcely investigated.Methods: To delineate the contribution of glial activity in EE, we measured levels of glia-derived mediators with previously described biomarker value, including glial fibrillary acidic protein (GFAP), high mobility group box 1 (HMGB1), chitinase-3-like protein 1 (CHI3L1), soluble CD163 (sCD163) and triggering receptor expressed on myeloid cells 2 (TREM2) by ELISA in sera of patients with idiopathic West syndrome (WS, n=18), idiopathic Lennox-Gastaut syndrome (LGS, n=13) and healthy controls (n=31).Results: Patients with EE showed significantly higher CHI3L1 levels compared to healthy controls. Levels of HMGB1, CHI3L1, sCD163 and TREM2 were higher in LGS patients than WS patients and/or healthy controls. One or more of the investigated mediators were associated with treatment responsiveness, disease severity and presence of pathological features on electroencephalography (EEG).Conclusions: To our knowledge, our findings provide the initial patient-based evidence that astrocyte- and microglia-mediated neuroinflammation might be involved in the pathogenesis of LGS and WS. Moreover, glial mediators may serve as prognostic biomarkers in patients with idiopathic EE.","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"61 2","pages":"128-134"},"PeriodicalIF":1.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11165615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141312175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

c.4168G>A(p.Ala 1390Thr) Variation in KMT2D Gene Detected in an Ultra-treatment-resistant Schizophrenia Patient: A Case Report and Literature Review. 在一名超耐药精神分裂症患者中发现的 KMT2D 基因 c.4168G>A(p.Ala 1390Thr)变异：病例报告和文献综述。

IF 1.1 4区医学

Noropsikiyatri Arsivi-Archives of Neuropsychiatry Pub Date : 2023-11-22 eCollection Date: 2023-01-01 DOI: 10.29399/npa.28417

Anıl Alp, Elçin Özçelik Eroğlu, M İrem Yıldız, Ahmet Cevdet Ceylan, Başaran Demir, Suzan Özer

{"title":"c.4168G>A(p.Ala 1390Thr) Variation in KMT2D Gene Detected in an Ultra-treatment-resistant Schizophrenia Patient: A Case Report and Literature Review.","authors":"Anıl Alp, Elçin Özçelik Eroğlu, M İrem Yıldız, Ahmet Cevdet Ceylan, Başaran Demir, Suzan Özer","doi":"10.29399/npa.28417","DOIUrl":"https://doi.org/10.29399/npa.28417","url":null,"abstract":"Schizophrenia has a multifactorial etiology with a significant genetic component. Genome-wide association studies have identified common variants in candidate genes. However, the common variant can only account for a portion of the genetic variation underlying the disorder. Therefore, researchers suggest that rare variants may be one source of missing heritability in schizophrenia. We report the case of a 20-year-old male patient diagnosed with early-onset and ultra-treatment-resistant schizophrenia and mild intellectual disability and discuss certain rare genetic variants that may be involved in the etiology. He was hospitalized for the initiation of clozapine treatment and was referred to the department of genetics because he had macrocephaly, high arched palate, a prominent forehead, hearing impairment, and hyperpigmented skin lesions. The whole exome sequencing analysis revealed a heterozygous 4168G>A(p.Ala1390Thr) variant in exon 15 of KMT2D (Lysine N-Methyltransferase 2D) (NM_003482.4) gene, which is associated with Kabuki Syndrome. The variants in KMT2D have been reported to be associated with brain development and may play a role in schizophrenia. We discussed the relationship between schizophrenia and genetic variants detected in this case in light of the literature.","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"60 4","pages":"380-384"},"PeriodicalIF":1.1,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10709702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138805538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anaplastic Ependymoma and Atypical Refractory Longitudinal Expansive Transverse Myelitis Due to Immune Reaction After COVID-19 - A Case Discussion That Raises Many Unknown Questions About Covid-19. COVID-19后免疫反应致间变性室管膜瘤和非典型难治性纵向扩张性横贯脊髓炎——一例对COVID-19提出许多未知问题的讨论

IF 1 4区医学

Noropsikiyatri Arsivi-Archives of Neuropsychiatry Pub Date : 2023-11-21 eCollection Date: 2024-01-01 DOI: 10.29399/npa.28464

Yağmur İnalkaç Gemici, Fatih Çelik, Zeynep Zerrin Göz, Aydın İşisağ, Gülgün Yılmaz Ovalı, Mehmet Zileli, Mustafa Barutçuoğlu, Hatice Mavioğlu

{"title":"Anaplastic Ependymoma and Atypical Refractory Longitudinal Expansive Transverse Myelitis Due to Immune Reaction After COVID-19 - A Case Discussion That Raises Many Unknown Questions About Covid-19.","authors":"Yağmur İnalkaç Gemici, Fatih Çelik, Zeynep Zerrin Göz, Aydın İşisağ, Gülgün Yılmaz Ovalı, Mehmet Zileli, Mustafa Barutçuoğlu, Hatice Mavioğlu","doi":"10.29399/npa.28464","DOIUrl":"10.29399/npa.28464","url":null,"abstract":"Inflammatory neurologic manifestations, both infectious and non-infectious, have been reported secondary to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2/COVID-19). However, the relationship of spinal tumor and COVID-19 longitudinally extensive transverse myelitis (LETM) coexistence has never been reported in our knowledge. The clinical presentation and response to treatment of a 24-year-old female patient diagnosed with COVID-19 LETM and anaplastic ependymoma are described in this case report. The Patient's cerebrospinal fluid COVID-19 antibody level was higher than serum and she was resistant to immunosuppressive treatment. The interaction between COVID-19 and spinal tumor was discussed in the light of the literature. It is thought that COVID-19 infection could trigger tumor growth in this patient. Also, this is the first case of anaplastic ependymoma and COVID-19 myelitis coexistence in the literature.","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"98 1","pages":"370-373"},"PeriodicalIF":1.0,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11638568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73602011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parietal Cortex Volume and Functions in Major Depression and Bipolar Disorder: A Cloud-Based Magnetic Resonans Imaging Study 重度抑郁症和双相情感障碍的顶叶皮质体积和功能:基于云的磁共振成像研究

IF 1.1 4区医学

Noropsikiyatri Arsivi-Archives of Neuropsychiatry Pub Date : 2023-01-01 DOI: 10.29399/npa.28253

Fatma Kartal, Fatma Kılıç, M. Erbay, R. Karlıdağ

引用次数: 0

Evaluation of the impact of hypocretin receptor 1 rs2271933 polymorphism on sleep components in chronic migraine patients with poor sleep quality: A subgroup analysis 下丘脑分泌素受体1 rs2271933多态性对睡眠质量差的慢性偏头痛患者睡眠成分影响的评估:亚组分析

IF 1.1 4区医学

Noropsikiyatri Arsivi-Archives of Neuropsychiatry Pub Date : 2023-01-01 DOI: 10.29399/npa.28553

H. Genç, Emel Ur Özçelik, İ. O. Barlas, Nevra Öksüz, A. Özge

引用次数: 0

Comparison of epidural analgesia combined to general anesthesia and general anesthesia for postoperative cognitive dysfunction in elderly patients 硬膜外联合全麻与全麻治疗老年患者术后认知功能障碍的比较

IF 1.1 4区医学

Noropsikiyatri Arsivi-Archives of Neuropsychiatry Pub Date : 2019-01-01 DOI: 10.29399/npa.24863

G. Orhun, Z. Sungur, K. Koltka, M. Karadeniz, A. Yavru, H. Gurvit, M. Senturk

{"title":"Comparison of epidural analgesia combined to general anesthesia and general anesthesia for postoperative cognitive dysfunction in elderly patients","authors":"G. Orhun, Z. Sungur, K. Koltka, M. Karadeniz, A. Yavru, H. Gurvit, M. Senturk","doi":"10.29399/npa.24863","DOIUrl":"https://doi.org/10.29399/npa.24863","url":null,"abstract":"BACKGROUND: Cognitive dysfunction in the early postoperative course is common for the elderly population. Anesthetic management may affect postoperative cognitive decline. Effective analgesia, early recovery and modulation of the stress response are advantages of neuraxial blocks. This study aims to compare the effects of general anesthesia and the combination of general anesthesia with epidural analgesia for postoperative cognitive dysfunction (POCD). We hypothesized that neuraxial block combined with general anesthesia (GA) would have a favorable influence on POCD prevention. METHODS: Patients above 60 years undergoing non-cardiac surgery were included in this randomized, prospective study and randomized into two groups. Patients in the first group (GI) were treated under GA, whereas in the second group (GII), epidural analgesia was combined with GA. Patients’ cognitive function was assessed before and one week after surgery using a neuropsychological test battery. POCD was defined as a drop of one standard deviation from baseline on two or more tests. RESULTS: A total of 116 patients were allocated for the final analysis. Demographic and operative data were similar between groups, except maximum pain scores, which were significantly higher in GI than GII (4.9±2.8 vs. 1.7±1.7; p<0.001, respectively). The incidence of POCD was comparable between groups (26% in GI and 24% in GII). Memory performance, visuospatial functions, and language skills tests were significantly higher in GII compared to GI. CONCLUSION: General anesthesia and epidural analgesia combined with general anesthesia resulted in similar POCD in elderly patients undergoing abdominal surgery. However, in combined anesthesia group memory, language skills and visuospatial functions appeared to be better preserved. Effective pain control might contribute to preventing cognitive decline in some domains.","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"38 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80345445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Majör depresyon ve anksiyete bozukluğu hastalarında gece yeme sendromu

IF 1.1 4区医学

Noropsikiyatri Arsivi-Archives of Neuropsychiatry Pub Date : 2014-01-01 DOI: 10.4274/NPA.Y7204

Suat Kucukgoncu, Emrem Bestepe

引用次数: 2

Non-epileptik psikojen nöbetler: Klinik pratikte çözülmesi zor tani{dotless}sal bir problem

IF 1.1 4区医学

Noropsikiyatri Arsivi-Archives of Neuropsychiatry Pub Date : 2012-01-01 DOI: 10.4274/NPA.Y6687

Alberto Verrotti, Piero Pavone, Sergio Agostinelli, Giuliana Nanni, Giuseppe Gobbi

引用次数: 0

Personality and primary dysmenorrhea: a study using a five-factor model in Chinese university women 性格与原发性痛经:中国女大学生五因素模型的研究

IF 1.1 4区医学

Noropsikiyatri Arsivi-Archives of Neuropsychiatry Pub Date : 2012-01-01 DOI: 10.4274/NPA.Y5965

Weiwei Liang, Ying-chun Zhang, Huajun Li, Jing Chu, Zhenwei Qin, L. Lou, Zhi-qian Li, Xiaohui Zou, Wei He, Wei Wang

{"title":"Personality and primary dysmenorrhea: a study using a five-factor model in Chinese university women","authors":"Weiwei Liang, Ying-chun Zhang, Huajun Li, Jing Chu, Zhenwei Qin, L. Lou, Zhi-qian Li, Xiaohui Zou, Wei He, Wei Wang","doi":"10.4274/NPA.Y5965","DOIUrl":"https://doi.org/10.4274/NPA.Y5965","url":null,"abstract":"Ad dress for Cor res pon den ce/Ya z›fl m a Ad re si: Wei WANG, DSc, Zhejiang University School of Medicine, Department of Clinical Psychology and Psychiatry, Hangzhou, Zhejiang, China Gsm: +57188208188 E-mail: drwang@doctor.com or wangmufan@msn.com Re cei ved/ G e liş ta ri h i: 30.12.2010 Ac cep ted/ K a bul ta ri h i: 19.07.2011 © Arc hi ves of Neu ropsy chi atry, pub lis hed by Ga le nos Pub lis hing. / Nö rop si ki yat ri Ar fli vi Der gi si, Ga le nos Ya y› ne vi ta ra f›n dan ba s›l m›fl t›r. ÖZET Am aç: Primer dismenoresi olanların, beş-faktör modelinde tanımlandığı gibi kişilik farklılıklarının olup olmadığını açık değildir. Yön tem : Anksiyetesi veya depresyonu olmayan primer dismenoreli 49 ve dismenoresi olmayan sağlıklı 142 üniversiteli kadın, Zuckerman-Kuhlman Kişilik Sorgulaması (ZKPQ) ve Dismenorenin İşlevsel ve Duygusal Ölçümü (FEMD) testleri ile değerlendirildi. Depresyon eğilimi Plutchik-van Praag Depresyon Envanteri (PVP), ağrı şiddeti görsel Analog Ölçeği ile Ölçüldü. Bul gu lar: Dismenoreli grupta, iki FEMD ölçeği, ZKPQ Nörotizm-Anksiyete ve İmpulsif Duyum Araştırma ölçekleri, görsel analog ölçeği ve PVP puanları kontrol grubuna göre yüksekti. Dismenore grubunda FEMD Duygusal ölçeği ile ZKPQ Aktivite ölçeği arasında pozitif korelasyon vardı. So nuç: Saf dismenoreli kadınlarla yapılan çalışmamızda, bu bozukluğun artmış Nörotizm-Anksiyete ve İmpulsif Duyum Yönelimi ile karakterize olduğu gösterilmiştir. (Nö rop si ki yat ri Ar fli vi 2012;49: 92-95) Anah tar ke li m e ler: Aktivite, impulsif duyum yönelimi, nörotizm-anksiyete, primer dismenore","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"186 1","pages":"92-95"},"PeriodicalIF":1.1,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77683645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Nöropsikiyatrik Belirtilerle İlişkili Tüberküloz Lenfadenit: Bir Katatoni Olgusu

IF 1.1 4区医学

Noropsikiyatri Arsivi-Archives of Neuropsychiatry Pub Date : 2011-12-15 DOI: 10.4274/NPA.Y5768

Yavuz Selvi, P. Özdemir, Abdullah Atli̇, Lütfullah Beşiroğlu

引用次数: 0