Noropsikiyatri Arsivi-Archives of Neuropsychiatry最新文献

{"title":"Indicators of Parkinsonian Visual Hallucinations: Enhanced Beta and Gamma Coherence.","authors":"Reyyan Uysal Kaba, Bahar Güntekin, Tuba Aktürk, Nesrin Helvacı Yılmaz, Lütfü Hanoğlu","doi":"10.29399/npa.28847","DOIUrl":"10.29399/npa.28847","url":null,"abstract":"<p><strong>Introduction: </strong>Visual hallucinations are one of the common non-motor symptoms of Parkinson's disease. Although various theories have been proposed, the pathological mechanism is not fully understood. This study aimed to investigate spontaneous brain activity in hallucinated and non-hallucinated patients with Parkinson's disease (PD) by using EEG and also its relevance to the behavioral and neuropsychological status of patients.</p><p><strong>Methods: </strong>A total of 30 people were included in the study: 10 hallucinated PD patients, 10 non-hallucinated PD patients, and 10 healthy controls. Spontaneous EEG data were recorded in eyes-open and eyes-closed conditions. A neuropsychological battery was used to evaluate visual and verbal memory, visuo-spatial abilities, executive functions, and behavioral/emotional status of participants.</p><p><strong>Results: </strong>The hallucinated group did not show an increase in alpha power activity in response to eye closure, although healthy controls showed a significant increase in alpha power in eyes closed condition. Parkinson's disease patients with hallucinations showed significantly higher intra-hemispheric beta and gamma coherence and the non-hallucinated group demonstrated significantly lower inter-hemispheric alpha coherence. Additionally, Hallucinated PD patients showed higher NPI (Neuropsychiatric Inventory) scores and RBD-SQ (REM Behavior Disorder Screening Questionnaire) scores, lower motor scores (Unified Parkinson's Disease Rating Scale - UPDRS), and a higher number of Stroop Test errors compared to non-hallucinated PD patients.</p><p><strong>Conclusion: </strong>Increased abnormal resting-state EEG activity and a tendency towards greater impairment of executive functions were seen in hallucinated PD patients. These results can be interpreted as an abnormal resting activity in cortical networks that may underlie their visual hallucinations symptoms.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 4","pages":"324-332"},"PeriodicalIF":1.1,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12694778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145745413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MOG and GFAP Antibodies are not Present in Headache with Neurological Deficits and Cerebrospinal Fluid Lymphocytosis (HaNDL).","authors":"Maria Pechlivanidou, Elif Şanlı, Murat Kürtüncü, John Tzartos, Socrates Tzartos, Erdem Tüzün","doi":"10.29399/npa.29188","DOIUrl":"10.29399/npa.29188","url":null,"abstract":"","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 4","pages":"293-294"},"PeriodicalIF":1.1,"publicationDate":"2025-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12694782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145745529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective Review of 56 Patients with Sensory Ganglionopathy.","authors":"Handan Uzunçakmak-Uyanık, Çağrı Mesut Temuçin, Ersin Tan, Rahşan Göçmen, Fatma Gökçem Yıldız","doi":"10.29399/npa.29105","DOIUrl":"10.29399/npa.29105","url":null,"abstract":"<p><strong>Introduction: </strong>Sensory ganglionopathy (SG) is a rare and specific subgroup of the peripheral nervous system diseases. Electrophysiology shows a widespread amplitude decrease in sensory nerve action potential (SNAP) or absence of SNAPs in SG. SG diagnosis has a special importance in the context of etiology. We aimed to contribute to diagnosing SG as early as possible with the help of other supportive diagnostic work-up without the need for invasive methods by reviewing data of patients with electrophysiologically diagnosed SG.</p><p><strong>Methods: </strong>The medical records of 56 patients with SG diagnosed by electrodiagnostic (EDx) tests were reviewed. EDx findings were compared with our laboratory normal values. Also EDx findings of patients with 23 pure SG patients and 9 SG with motor axonal involvement were analyzed.</p><p><strong>Results: </strong>Etiology was determined in 35 (62.5%) of all patients besides a considerable idiopathic preponderance (n=14; 25%). Comparison of ulnar nerve DMLs of 23 pure SG patients and 9 SG with motor axonal involvement patients, was not statistically significant (p=0.064). Needle EMG findings of lower extremity were grade 1 in 52.9% and grade 3 in 5.8%. Of the patients who underwent upper extremity needle EMG, grade 1 was detected in 53.8% and grade 3 was detected in 7.6%.</p><p><strong>Conclusion: </strong>In order to diagnose SG as early as possible without the need for invasive methods and to elucidate its etiology, a thorough electrophysiological screening should be performed with the help of other supportive diagnostic tools.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"63 ","pages":"129-136"},"PeriodicalIF":1.1,"publicationDate":"2025-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12849222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146087897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Fatigue Levels and Cognition in Patients with Epilepsy.","authors":"Ayşe Ceren Fincan, Mehmet İlker Yön","doi":"10.29399/npa.28899","DOIUrl":"10.29399/npa.28899","url":null,"abstract":"<p><strong>Introduction: </strong>Fatigue is a common symptom reported in epilepsy. The effect of fatigue on cognitive functions in patients with epilepsy (PWE) is unknown. The aim of this study is to examine the relationship between fatigue and cognitive functions in PWE.</p><p><strong>Methods: </strong>Thirty-three PWE and twenty-two healthy controls participated in the study. Psychological examinations (Fatigue Impact Scale, Hospital Anxiety and Depression Scale, Epworth Sleepiness Scale, Quality of Life) and cognitive tests (Wisconsin Card Sorting Test, Serial Digit Learning Test, Stroop Test, Raven's Progressive Matrices Test) were administered to the participants.</p><p><strong>Results: </strong>The results revealed that fatigue scores were significantly higher in PWE compared to the control group (p< .001). Fatigue was found to be associated with anxiety (p<.001), depression (p<.001) and quality of life (p<.05). The results demonstrated a significant difference between the groups in terms of Raven scores (p<.001), and a significant correlation between fatigue and Raven scores in the general epilepsy group (p<.001). Fatigue was found to be correlated with Stroop Test (p<.05) and Raven's Test in the focal epilepsy group (p<.001).</p><p><strong>Conclusion: </strong>In conclusion, PWE experience higher levels of fatigue compared to healthy controls and this fatigue has a relationship with visuospatial perception. Fatigue is also associated with attention and visuospatial perception in patients with focal epilepsy. However, it remains unclear whether cognitive impairments are a direct consequence of fatigue or whether cognitive impairments contribute to fatigue.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 4","pages":"368-373"},"PeriodicalIF":1.1,"publicationDate":"2025-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12694815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145745471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adaptation of the Caregiver Version of the Starkstein Apathy Scale (SAS) into Turkish and Investigation of Its Reliability and Validity in Parkinson's Disease.","authors":"Gülsüm Uzer, Erol Yıldırım, Mustafa Otrar, Lütfü Hanoğlu","doi":"10.29399/npa.29079","DOIUrl":"10.29399/npa.29079","url":null,"abstract":"<p><strong>Objective: </strong>Our study aimed to adapt the caregiver version of the Starkstein Apathy Scale (SAS) to Turkish culture and examine its validity and reliability.</p><p><strong>Method: </strong>45 patients were diagnosed with Parkinson's Disease (PD), and 40 healthy individuals and their relatives participated in the study. The questions were changed from first-person to third-person statements without any changes. Confirmatory factor analysis was performed for construct validity in the validity analysis. Discriminant validity was performed with a healthy control group. The relationship with the Neuropsychiatric Inventory (NPI) apathy subtest was examined for criterion-dependent validity analysis. In the reliability analysis of the scale, Cronbach's alpha internal consistency analysis was performed. A Receiver Operating Characteristic (ROC) analysis was conducted to determine the cut-off value of the scale.</p><p><strong>Results: </strong>During the validity and reliability studies, it was observed that items 3 and 13 were incompatible with other factors, reduced the model fit, and were removed from the scale due to low internal consistency. In the analysis with 12 items, a three-factor structure was obtained as 'motivation', 'behavioral', and 'cognitive'. In confirmatory factor analysis, the fit values of the scale were Comparative Fit Index (CFI) =1.000, Normed Fit Index (NFI) = 0.963, and Root Mean Square Error Approximation (RMSEA)= 0.000. Consequently, the study, the Cronbach's alpha coefficient of the scale was found to be 0.84. The discriminant validity analysis found a difference between the clinical and control groups. A positive correlation was found with the NPI Apathy subscale used for criterion-dependent validity. A cut-off value of 11 points with a sensitivity of 71.15% and specificity of 95% was recommended for 12 items.</p><p><strong>Conclusion: </strong>Our study showed that the SAS Caregiver is a valid and reliable scale for PD patients and can be utilized in clinical and scientific studies.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"63 ","pages":"101-107"},"PeriodicalIF":1.1,"publicationDate":"2025-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12849256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146087962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Communication on Social Functioning in Schizophrenia: Verbal and Nonverbal Aspects.","authors":"Zeynep Nur Demirok, Erdoğdu Akça, Ömer Demirok, Yağmur Sağ, Mehmet Kemal Kuşçu","doi":"10.29399/npa.28963","DOIUrl":"10.29399/npa.28963","url":null,"abstract":"<p><strong>Inroduction: </strong>Communication skills are vital to social functioning. Patients with schizophrenia, who often exhibit impairments in social functioning, experience difficulties in both verbal and nonverbal communication. This study aimed to compare the influence of nonverbal sensitivity and verbal communication disturbance on the social functioning of schizophrenia patients.</p><p><strong>Methods: </strong>The study included 38 schizophrenia patients (SCH) and 40 healthy controls (HC). Nonverbal and verbal abilities were assessed using the Mini Profile of Nonverbal Sensitivity (Mini-PONS) and the Communication Disturbance Index (CDI), respectively. Social functioning was measured with the Social Functioning Scale (SFS), and symptom severity was evaluated using the Positive and Negative Syndrome Scale (PANSS).</p><p><strong>Results: </strong>Schizophrenia patients exhibited significantly lower nonverbal sensitivity and higher verbal communication disturbance compared to healthy controls. Mini-PONS and CDI scores were significantly correlated with SFS scores in the schizophrenia group but not in healthy controls. Regression models revealed that PANSS and Mini-PONS scores significantly predicted social functioning in schizophrenia patients. Furthermore, symptom severity fully mediated the relationship between verbal communication disturbance and social functioning.</p><p><strong>Conclusion: </strong>Nonverbal communication impairments exert a more pronounced effect on the decline in social functioning among schizophrenia patients. These findings underscore the importance of addressing communication deficits to improve social outcomes in this population.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 4","pages":"315-323"},"PeriodicalIF":1.1,"publicationDate":"2025-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12694777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145745536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Sexual Dysfunctions in Substance Use Disorder.","authors":"Tufan Buran, Bilge Targıtay Öztürk, Başak Bağcı, Aslı Tuğba Esen, Berna Binnur Akdede","doi":"10.29399/npa.29168","DOIUrl":"10.29399/npa.29168","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to determine the prevalence of sexual dysfunction (SD) in patients diagnosed with substance use disorder (SUD) and to examine its association with sociodemographic and clinical characteristics.</p><p><strong>Methods: </strong>A total of 176 patients (157 males, 19 females) aged between 18 and 45 years and diagnosed with SUD were included in the study. The patients were divided into three groups: those with single SUD, those with multiple SUD, and those receiving buprenorphine-naloxone (BPN) treatment. Patient information was recorded in a data collection form. Patients were asked to complete the Hospital Anxiety and Depression Scale (HADS). To evaluate sexual functions, the International Index of Erectile Function (IIEF), the Premature Ejaculation Diagnostic Tool (PEDT), and the Arizona Sexual Experiences Scale-Male Version (ASEX-M) were administered to male patients; the Female Sexual Function Index (FSFI), and the Arizona Sexual Experiences Scale-Female Version (ASEX-F) were administered to female patients.</p><p><strong>Results: </strong>Among male patients, the prevalence of erectile dysfunction (ED) was found to be 49.7%, and the prevalence of premature ejaculation (PE) was 48.4%. No significant differences were found between the groups in terms of the prevalence of ED (p=0.970) and PE (p=0.287). Similarly, no significant differences were observed in the scores of IIEF (p=0.957), PEDT (p=0.476), and ASEX-M (p=0.852). In male patients, a negative correlation was identified between the severity of anxiety symptoms and the IIEF subscale scores of overall satisfaction (r=-0.171, p=0.032). Depression symptom severity was negatively correlated with the IIEF total score (r=-0.381, p < 0.001), as well as with the subscale scores of erectile function (r=-0.349, p<0.001), sexual desire (r=-0.228, p=0.004), intercourse satisfaction (r=-0.217, p=0.006), overall satisfaction (r=-0.375, p<0.001), and orgasmic function (r=-0.337, p<0.001). The prevalence of SD among female patients was found to be 78.9%.</p><p><strong>Conclusion: </strong>Sexual dysfunction outcomes were comparable among individuals with single SUD, multiple SUD and those undergoing BPN treatment. Moreover, the negative impact of co-occurring depressive and anxiety symptoms on sexual functioning highlights the need for a multidimensional approach to the assessment and management of sexual health in individuals with SUD.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"63 ","pages":"285-293"},"PeriodicalIF":1.0,"publicationDate":"2025-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12951510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Sleep Quality and Prodromal Symptoms in Euthymic Patients with Bipolar Disorder.","authors":"Yağmur Sever Fidan, Filiz İzci, Metin Aslan, Sümeyye Yasemin Çallı, Mehmet Akif Şakiroglu, Barış Pire, Arda Kızılsert","doi":"10.29399/npa.29153","DOIUrl":"10.29399/npa.29153","url":null,"abstract":"<p><strong>Introduction: </strong>Although sleep quality is known to be impaired in individuals diagnosed with bipolar disorder (BD) during manic, depressive, and even euthymic phases, limited research has explored its association with prodromal symptoms. This study aims to investigate the relationship between sleep quality and the frequency and severity of prodromal symptoms in patients diagnosed with bipolar disorder during euthymic periods.</p><p><strong>Methods: </strong>The study included 98 patients with euthymic BD in remission. The participants completed the sociodemographic data form, Pittsburgh Sleep Quality Index (PSQI), Bipolar Prodrome Symptom Scale (BPSS), Young Mania Rating Scale (YMRS), and Hamilton Depression Rating Scale (HDRS).</p><p><strong>Results: </strong>The mean age of the patients was 42.20 ± 11.902. In the patient group with PSQI score>5, BPSS-frequency and BPSS-severity scores were found to be significantly higher (p<0.05). Both BPSS-frequency and severity scores showed significant positive correlations with PSQI scores (p<0.001), and BPSS-frequency score was positively correlated with HDRS scores (p<0.05). No significant differences were observed in BPSS, HDRS, or YMRS scores according to the duration of the disorder (p>0.05).</p><p><strong>Conclusion: </strong>Based on the findings of our study, we conclude that as sleep quality deteriorates during the euthymic phase in patients with BD, the frequency and severity of prodromal symptoms also increase. It is suggested that sleep disturbances in this patient population should be closely monitored even during the euthymic period, as sleep disorders themselves may serve as prodromal symptoms and potentially exacerbate the onset of other prodromal manifestations. Therefore, detailed assessment of sleep problems between episodes-and timely intervention when necessary-may be critical for early detection and prevention of mood episode relapse.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"63 ","pages":"270-276"},"PeriodicalIF":1.0,"publicationDate":"2025-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12951496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of Hemorrhagic Transformation and Functional Outcomes Using Arterial Spin Labeling MRI in Acute Middle Cerebral Artery Infarction.","authors":"Mehmet İlker Yön, Serdar Baraklı, Pınar Çeltikçi, Karabekir Ercan","doi":"10.29399/npa.29174","DOIUrl":"10.29399/npa.29174","url":null,"abstract":"<p><strong>Introduction: </strong>Arterial spin labeling (ASL) MRI, a non-invasive perfusion imaging method, may potentially identify patients at high risk for hemorrhagic transformation (HT) by quantifying cerebral blood flow (CBF). We aimed to investigate the role of ASL MRI perfusion parameters in predicting HT and functional outcomes in acute middle cerebral artery (MCA) infarction.</p><p><strong>Methods: </strong>A retrospective study was conducted involving 23 patients admitted within 24 hours of MCA infarction onset. Acute imaging included noncontrast cranial CT, diffusion-weighted imaging (DWI) and multiphase CT angiography. Approximately one week after symptom onset, follow-up imaging was performed with DWI and ASL MRI. Infarct volumes were manually calculated. Menon collateral scores and ASL-derived perfusion parameters, including hyperperfused area CBF and relative CBF (rCBF), were assessed. Functional outcomes were evaluated using modified Rankin Scale (mRS) at the end of 1st week, 1st month and 3rd month and Barthel Index at the end of 3rd month follow-up.</p><p><strong>Results: </strong>HT developed in 15 patients (65.2%). HT was associated with significantly larger infarct volumes (p=0.021), lower Menon scores (p=0.006), higher rCBF values (p=0.014), and worse functional outcomes indicated by worse functional outcomes at the end of 3rd month follow-up, indicated by higher mRS scores (p=0.044) and lower Barthel Index scores (p=0.036).</p><p><strong>Conclusion: </strong>ASL MRI parameters, particularly hyperperfused area CBF and relative CBF, along with collateral circulation and infarct volume measurements, may effectively predict the risk of HT and functional outcomes in acute MCA infarction. These parameters can enhance clinical decision-making and improve patient management strategies.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"63 ","pages":"294-298"},"PeriodicalIF":1.0,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12951492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prognostic Value of the CHA2DS2-VASc Score for Predicting In-Hospital Mortality and Short-Term Outcomes in Patients with Acute Ischemic Stroke.","authors":"Yesim Eylev Akboga, Hesna Bektas","doi":"10.29399/npa.28900","DOIUrl":"10.29399/npa.28900","url":null,"abstract":"<p><strong>Introduction: </strong>Acute ischemic stroke (AIS) is a common fatal neurological disease worldwide. This study aimed to investigate the prognostic value of the CHA2DS2-VASc score in patients with AIS.</p><p><strong>Methods: </strong>Two hundred and fifty patients admitted to the emergency department with a diagnosis of AIS without AF were prospectively enrolled in the study.</p><p><strong>Results: </strong>The CHA2DS2-VASc score, NIHSS score, initial stroke severity (ISS), cerebral infarct volume (CIV), and modified Rankin Scale (mRS) were significantly higher, whereas left ventricular ejection fraction (LVEF) and Barthell index (BI) were significantly lower in the in-hospital mortality (+) group. There was a statistically significant positive correlation of the CHA2DS2-VASc score with NIHSS score (r=0.389; p<0.001), ISS (r=0.417; p<0.001), mRS (r=0.362; p<0.001) and SIV (r=0.214; p<0.001) whereas a significant negative correlation of the CHA2DS2-VASc score with BI (r= -0.371; p<0.001). In multivariable Cox-regression analysis, we found that the CHA2DS2-VASc score (HR: 1.816; 95% CI: 1.209-2.726; p<0.001), congestive heart failure, NIHSS score, and BI were independent predictors of in-hospital mortality. Finally, in the Kaplan-Meier survival analysis, in-hospital mortality was significantly higher in patients with the CHA2DS2-VASc score ≥6 (log-rank p<0.001).</p><p><strong>Conclusion: </strong>The CHA2DS2-VASc score was established to be an independent predictor of in-hospital mortality and short-term outcomes in AIS patients without AF.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"63 ","pages":"9-15"},"PeriodicalIF":1.1,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12849287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146087893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}