Noropsikiyatri Arsivi-Archives of Neuropsychiatry最新文献

{"title":"Sleep Disorders in Patients with Epilepsy.","authors":"Aytül Mutlu, Aysel Büşra Şişman, Sefer Günaydın, Belgin Petek Balcı","doi":"10.29399/npa.28732","DOIUrl":"10.29399/npa.28732","url":null,"abstract":"<p><strong>Introduction: </strong>This study aims to investigate obstructive sleep apnoea syndrome (OSAS), quality of sleep, excessive daytime sleepiness (EDS) and quality of life in patients with epilepsy.</p><p><strong>Methods: </strong>One hundred and eleven epilepsy patients, diagnosed with ILAE (international league against epilepsy) criteria, were included in this study. The mean age of the patients was 37.6 ±13.1 (19-77) years. Fifty-four of the patients were (48.6%) men and 57 were (51.5%) women. Age, gender, education level, body mass index, seizure frequency, types of seizures, electroencephalography (EEG) findings, seizures during sleep, and number of anti-seizure drugs were recorded. Berlin Questionnaire (BQ) was used to screen OSAS. Sleep and quality of life were assessed with Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS) and Quality of Life in Epilepsy-31(QOLIE-31) scales.</p><p><strong>Results: </strong>Thirty-six percent of the patients' quality of sleep was poor and 20.7% had mild EDS. Low risk of OUAS was found in 89.2% of the patients. Quality of life was poor according to QOLIE-31. QOLIE 31 and PSQI total score had a statistically significant low negative correlation with BQ. PSQI total score had a statistically significant, low negative correlation with QOLIE-31. Poor sleep quality, EDS, OUAS and quality of life showed no correlation with demographic features, duration of disease, types of seizures, seizure frequency, number of anti-seizure drugs.</p><p><strong>Conclusion: </strong>The poor quality of sleep was 36% in our study. Poor quality of sleep, excessive daytime sleepiness and obstructive sleep apnoea syndrome had no correlation with the demographic and clinical features of the patients with epilepsy but showed low correlation with quality of life.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 2","pages":"172-178"},"PeriodicalIF":1.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Comparison of Functional Connectivity in Parkinson's Disease Patients with and without Parkin Gene Mutations.","authors":"Merve Çebi, Ulaş Ay, Ani Kiçik, Emel Erdoğdu, Fatih Tepgeç, Zehra Oya Uyguner, Zeynep Tüfekçioğlu, Bedia Samancı, Başar Bilgiç, Murat Emre, Tamer Demiralp, Haşmet A Hanağası","doi":"10.29399/npa.28719","DOIUrl":"10.29399/npa.28719","url":null,"abstract":"<p><strong>Introduction: </strong>Mapping the functional connectivity of brain regions became appealing in recent research in neurology. Accordingly, a growing body of evidence shows resting-state functional connectivity (rsFC) changes in neurodegenerative disorders including Parkinson's Disease (PD). As characterised by extensive and progressive dopaminergic loss in the substantia nigra, PD emerges with serious motor and non-motor dysfunctions. In the literature, the minority of PD cases have been associated with certain genetic mutations. The aim of this study was to investigate the rsFC in a group of PD patients having Parkin gene mutation.</p><p><strong>Method: </strong>Twelve PD patients with Parkin mutation (PP-PD), 12 PD patients without Parkin mutation (PN-PD) and 12 healthy controls (HC) were included in the study. All participants underwent a resting-state functional magnetic resonance imaging as well as a neuropsychological assessment and clinical examination.</p><p><strong>Results: </strong>Results indicated that PP-PD had longer disease duration, a higher rate of dyskinesia and lower scores on complex visual perception tests. The resting state networks showed that all PD (consisting of PP-PD and PN-PD) and PP-PD groups had increased functional connectivity in the frontoparietal network as compared to the HC. In addition, the PP-PD group displayed decreased functional connectivity in the dorsal attention network compared to the PN-PD.</p><p><strong>Conclusion: </strong>In conclusion, our data suggests that PD with Parkin gene mutation might be emerging with distinct resting state functional connectivity changes in the brain.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 2","pages":"131-135"},"PeriodicalIF":1.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Diabetic Aged Female Rats, Resveratrol Supplementation Prevents Retinal Tissue Damage By Increasing Antioxidant Activity Through SIRT1 Gene Expression.","authors":"Adem Atacak, Haluk Gümüş, Elif Gülbahçe Mutlu, Saltuk Buğra Baltacı, Rasim Moğulkoç, Abdulkerim Kasım Baltacı","doi":"10.29399/npa.28586","DOIUrl":"10.29399/npa.28586","url":null,"abstract":"<p><strong>Introduction: </strong>The present study was carried out to investigate how resveratrol administration affects retinal SIRT1 levels and retinal tissue damage in diabetic elderly female rats.</p><p><strong>Methods: </strong>A total of 24 elderly female rats were divided equally into 4 groups (G): G1, Control; G2, Control + Resveratrol; G3, Diabetes; G4, Diabetes + Resveratrol. Experimental diabetes was induced by a single intraperitoneal injection of streptozotocin (STZ) in G3 and G4. The G2 and G4 were given intraperitoneal (ip) resveratrol (5 mg/kg/day) for 4 weeks in addition to the normal diet. After 4-weeks of resveratrol treatment, Sirtuin 1 (SIRT1) gene expression and malondialdehyde (MDA) ve glutathione (GSH) levels were determined by PCR and ELISA, respectively, in retinal tissue samples of the animals.</p><p><strong>Results: </strong>The highest retinal MDA values were in the diabetes group (G3), the highest retinal GSH levels were in the Diabetes + Resveratrol group (G4). The retinal MDA and GSH levels of the other groups were not different from each other. The highest retinal SIRT1 expression values were in the Diabetes + Resveratrol (G4) group. The retinal SIRT1 expression values of the diabetes group (G3) were lower than G4, and higher than the G1 and G2. Retinal SIRT1 expression values of the G1 and G2 were not different from each other.</p><p><strong>Conclusion: </strong>Resveratrol supplementation prevented retinal tissue damage that occurs in diabetic-aged female rats. This antidiabetic effect of resveratrol supplementation occurs by increasing both antioxidant activity and SIRT1 expression in diabetic-aged rats.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 2","pages":"145-149"},"PeriodicalIF":1.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Laboratory Characteristics of Patients with Neurosarcoidosis.","authors":"Ahmed Serkan Emekli, Tuncay Gündüz, Bedia Samancı, Murat Kürtüncü","doi":"10.29399/npa.28649","DOIUrl":"10.29399/npa.28649","url":null,"abstract":"<p><strong>Introduction: </strong>Neurosarcoidosis (NS) represents the most severe complication of sarcoidosis. NS exhibits a diverse array of clinical and radiological features that mimic many inflammatory, infectious, and neoplastic neurological disorders. In our study, we evaluated the demographic, clinical, laboratory, and imaging features of patients with NS.</p><p><strong>Methods: </strong>In this retrospective observational study, we included patients with definite and probable NS with at least 6-months of follow-up. Diagnostic tests, including cerebrospinal fluid analysis and imaging findings, lesion localization, therapeutic interventions, and disease course were evaluated. The modified Rankin scale was employed as a metric to assess the severity of the disease.</p><p><strong>Results: </strong>Fourteen patients met the inclusion criteria; two were definitively diagnosed with NS through brain biopsy, while twelve received a probable NS diagnosis based on biopsies of non-neuronal tissues. The predominant initial manifestation of NS was cranial neuropathy (64.3%), with facial palsy emerging as the most prevalent subset (35.7%). Five patients exhibited parenchymal involvement, while leptomeningeal involvement was noted in two. All patients were treated with corticosteroids, with nine individuals (64.3%) necessitating additional immunosuppressive interventions. Stable disease or improvement was observed in the majority of patients (85.7%), albeit one case resulted in mortality.</p><p><strong>Conclusion: </strong>We observed favorable outcomes in the majority of patients. Nevertheless, it's imperative to acknowledge that NS can lead to both mortality and severe morbidity. Recognizing clinical patterns is vital for accurate diagnosis and effective treatment. However, there is an existing gap in management, underscoring the necessity for randomized controlled trials aimed at elucidating optimal treatment strategies.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 2","pages":"156-163"},"PeriodicalIF":1.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Dual Diagnosis of Substance Use Disorders on Circadian Rhythm and Sleep Quality in Patients with Bipolar Disorder.","authors":"Başak Yiğitbay, Filiz İzci","doi":"10.29399/npa.28831","DOIUrl":"10.29399/npa.28831","url":null,"abstract":"<p><strong>Introduction: </strong>In this study, it was aimed to evaluate the effect of comorbid substance use disorders (SUD), sleep quality and circadian rhythm in patients with type 1 bipolar disorder (BD) in the euthymic period.</p><p><strong>Method: </strong>A total of 100 patients with a diagnosis of BD were divided into two groups of 50 patients each: the group with the sole diagnosis of BD (Group 1) and the group with the secondary diagnosis of SUD (Group 2). Structured Clinical Interview for DSM-5 (R) Disorders - Clinician Version (SCID-5-CV) conducted with 100 patients in the remission period for diagnostic clarity and identification of the SUD comorbidity. Sociodemographic Data Form, Young Mania Rating Scale (YMRS), Hamilton Depression Rating Scale (HDRS), Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN), Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), Morningness Eveningness Questionnaire (MEQ) were used.</p><p><strong>Results: </strong>Groups were compared in terms of sleep quality and circadian rhythm characteristics; PSQI and ESS to evaluate sleep quality and daytime sleepiness; MEQ and BRIAN were used to determine chronotype and biological rhythm characteristics. Pittsburgh sleep quality index showing decreased sleep quality in group 2, ESS showing increased sleepiness and BRIAN showing biological rhythm irregularity were significantly higher (p<0.05). There was no significant difference between both groups in MEQ, which determined the chronotype preference. In addition, further comparisons were made by dividing Group 2 according to dominant substance use as alcohol, cannabis and other (amphetamine, opiate) Sleep (p=0.011) and social subscale values (p<0.001) from the BRIAN subscales of Group 1 were lower than in the cannabis group. The PSQI value of Group 1 was lower than that of Cannabis and other groups (p<0.001). In addition, the MEQ value of Group 1 was found to be lower than in the alcohol group (p=0.007). The evening chronotype was more prevalent in Group 1 and the morning chronotype was more prevalent in the patients with comorbid alcohol use disorder.</p><p><strong>Conclusion: </strong>It was determined that dual diagnosis of SUD negatively affected sleep quality, increased daytime sleepiness and caused deterioration in circadian rhythm, and there was no significant change in chronotype preference in patients with BD. In addition, in patients accompanied by cannabis use; it was determined that there was a greater deterioration in biological rhythm and sleep quality.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 2","pages":"179-184"},"PeriodicalIF":1.0,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining Psychological Group Interventions for Adult Epilepsy Patients: A Systematic Review.","authors":"Ömer Demir, Özlem Sertel Berk","doi":"10.29399/npa.28754","DOIUrl":"10.29399/npa.28754","url":null,"abstract":"<p><strong>Introduction: </strong>The health-related quality of life (HRQoL) is adversely affected in people living with epilepsy (PLWE). Psychological interventions are widely used to enhance HRQoL. The current study aims to review studies examining the effects of psychological group interventions in PLWE.</p><p><strong>Method: </strong>We included randomized controlled quantitative studies published between 2000 and 2023 investigating the effectiveness of psychological group interventions in PLWE aged 18 and over. A total of 10 randomized controlled studies met the inclusion criteria of the review.</p><p><strong>Results: </strong>The reviewed studies included self-management interventions, psychotherapeutic interventions, psychoeducational interventions, and combined interventions involving different types of interventions. The most frequently targeted outcome variables in the interventions were quality of life (QoL) (90%), depression (60%), and self-management (30%). Analyses of the reviewed studies revealed that 67% of interventions targeting quality of life (QoL) improvement, 50% of interventions targeting depression reduction, and 100% of interventions targeting self-management skill enhancement were successful. Furthermore, in studies involving an active control group in which a different group intervention was applied, many of the gains achieved in the intervention groups were also achieved in the active control groups. Interventions conducted online yielded similarly successful results to face-to-face interventions.</p><p><strong>Conclusion: </strong>Evidence suggests that psychological group interventions are beneficial for adult individuals living with epilepsy in terms of many outcome variables. Furthermore, positive outcomes observed in active control groups suggest that group interventions can significantly improve QoL for PLWE beyond the specific content delivered.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 2","pages":"185-194"},"PeriodicalIF":1.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Use of Mismatch Negativity in Conjunction with Neuropsychological Tests to Discriminate Alzheimer's Dementia, Mild Cognitive Impairment and Healthy Aging.","authors":"Duygu Özbayrak-Karapınar, Özden Arısoy, Nebil Yıldız","doi":"10.29399/npa.28775","DOIUrl":"10.29399/npa.28775","url":null,"abstract":"<p><strong>Introduction: </strong>Alzheimer's dementia (AD) is the most common type of dementia and it is important to detect AD by an appropriately cheap and non-invasive method in the mild cognitive impairment (MCI) phase, which is accepted as the prodromal phase of AD. We aimed to investigate whether AD patients, amnestic MCI (aMCI) patients, and healthy controls (HCs) could be distinguished from each other by using mismatch negativity (MMN) together with neuropsychological tests.</p><p><strong>Methods: </strong>Twenty-one individuals with mild AD, 26 with aMCI, and 18 HCs matched for age, sex, and education were included. Sociodemographic data, neuropsychological tests, Basic Activities of Daily Living (BADL) and Instrumental Activities of Daily Living (IADL) scores, and MMN parameters acquired using an auditory oddball paradigm with an interstimulus interval of 1 second were evaluated for all three groups.</p><p><strong>Results: </strong>There was no difference in terms of MMN latencies but frontal MMN amplitude was significantly lower in AD patients compared to the aMCI and HC groups. Linear regression analysis revealed that IADL scores were predicted by the Fz amplitude and Mini Mental State Examination and apathy scores. Logistic regression analysis showed that Fz amplitude, verbal fluency, and Neuropsychiatric Inventory total scores distinguished AD patients from HCs, while the Stroop 5 completion time distinguished those with MCI from HCs. Age, Fz amplitude, and verbal fluency performance distinguished AD patients from individuals with MCI.</p><p><strong>Conclusion: </strong>MMN might be a useful approach in differentiating AD from MCI and healthy aging when used together with neuropsychological tests rather than being used alone because it may be affected by confounding factors such as age, severity of temporoparietal neurodegeneration, and duration of the interstimulus interval.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 2","pages":"109-118"},"PeriodicalIF":1.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posttraumatic Stress, Posttraumatic Growth, and Heart Rate Variability Among Breast Cancer Survivors.","authors":"İmran Gökçen Yılmaz Karaman, Cennet Yastıbaş Kaçar, Gülay Dirik, İremnur Ersan, Nazan Demir, Gurbet Özge Mert","doi":"10.29399/npa.28713","DOIUrl":"10.29399/npa.28713","url":null,"abstract":"<p><strong>Introduction: </strong>Breast cancer as a life-threatening disease is the most frequent malignant disease among women all over the world. Resulting in post-traumatic stress disorder (PTSD) symptoms, breast cancer may also be related to positive changes like post-traumatic growth (PTG). The present study aims to evaluate heart rate variability (HRV) parameters among female survivors of breast cancer regarding its relationship with PTSD and PTG.</p><p><strong>Method: </strong>Forty-three women with stage 1-2-3 breast cancer were recruited. Heart rate variability parameters were measured with a 24-hour ECG. Post-traumatic stress disorder checklist for DSM-5 (PCL-5) and Post-traumatic Growth Inventory (PTGI) were utilized to measure PTSD and PTG.</p><p><strong>Results: </strong>The mean value of PCL-5 was 49.56; the mean value of PTGI was 71.56. Correlation analysis showed that PCL-5 was associated with SDNN (r=-0.310, p=0.043), LF (r=-0.349 p=0.022), and mean heart rate (r=0.396 p=0.009). Post-traumatic growth inventory scores were associated with LF/HF ratio (r=0.310 p=0.043). Linear regression analysis demonstrated that PCL-5 and PTGI scores predicted SDNN and mean heart rate.</p><p><strong>Conclusion: </strong>PTSD and PTG symptoms are related to HRV parameters among female survivors of breast cancer. While PTSD symptoms are related to lower HRV and higher mean heart rate, PTG symptoms are associated with higher HRV and lower mean heart rate.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 2","pages":"150-155"},"PeriodicalIF":1.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-Analysis of the Effect of Blonanserin in Treating Patients with Schizophrenia.","authors":"Bo Shi, Zhirong Yang, Yixia Zhu, Chaoming Jiang, Dawu Yuan, Jin Zhang","doi":"10.29399/npa.28774","DOIUrl":"10.29399/npa.28774","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to investigate the efficacy and safety of blonanserin in patients with schizophrenia.</p><p><strong>Methods: </strong>Electronic databases (PubMed, Web of Science, Cochrane Library, Embase) were searched. Studies evaluating the efficacy and safety of blonanserin in treating schizophrenia were inclued. The combined effect sizes were calculated using relative risk (RR), risk difference (RD) or mean difference (MD).</p><p><strong>Results: </strong>Overall, 13 prospective studies involving 2,479 patients with schizophrenia were summarised and analysed. We selected five commonly used antipsychotic drugs, namely haloperidol, risperidone, olanzapine, paliperidone and aripiprazole. The meta-analysis showed that compared with a placebo, blonanserin significantly improved the Positive and Negative Syndrome Scale (PANSS) total scores (MD:-7.91; 95% confidence interval [CI]:-15.56, -0.26) and positive scores (MD:-2.48; 95% CI:-4.79, -0.18), and it was comparable with other Antipsychotic drugs regarding PANSS total scores, positive scores and general psychopathology scores. Additionally, the difference between blonanserin and haloperidol (MD:-0.75; 95% CI:-1.00, -0.50) on PANSS negative score changes was statistically significant. At the same time, the safety analysis revealed that compared with risperidone, blonanserin was associated with a lower risk of increased blood prolactin (RR:0.66; 95% CI: 0.51, 0.86), hyperprolactinemia (RR: 0.30; 95% CI: 0.11, 0.78) and weight gain (RD: -0.04; 95% CI: -0.07, -0.01) as well as a higher risk of akathisia (RD: 0.10; 95% CI: 0.04, 0.17). Moreover, it exhibited side-effects similar to those of other antipsychotic drugs regarding constipation, dizziness, headache, insomnia, muscle rigidity and hypersalivation.</p><p><strong>Conclusion: </strong>Blonanserin is effective and safe in the treatment of schizophrenia, which is beneficial for guiding the clinical practice of schizophrenia treatment. However, more high-quality studies are needed in the future to validate its effect.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 2","pages":"195-204"},"PeriodicalIF":1.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric case of Kelch-like protein 11 (KLHL11) encephalitis with long-term follow-up: pitfalls in diagnosis of pediatric autoimmune encephalitis.","authors":"Elif Şanlı, Maria Pechlivanidou, Hakkı Akbeyaz, Merve Savaş, Gülnur Takış, John Tzartos, Onur Tuğçe Poyraz Fındık, Erdem Tüzün, Dilşad Türkdoğan","doi":"10.29399/npa.28870","DOIUrl":"10.29399/npa.28870","url":null,"abstract":"","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 2","pages":"97-99"},"PeriodicalIF":1.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}