Noropsikiyatri Arsivi-Archives of Neuropsychiatry最新文献

{"title":"A Dual Eye Tracking Study of Joint Attention in Adults with Autism Spectrum Disorder.","authors":"Öykü Mançe Çalışır, Murat Perit Çakır, Cengiz Acartürk, Eşref Cem Atbaşoğlu","doi":"10.29399/npa.28839","DOIUrl":"10.29399/npa.28839","url":null,"abstract":"<p><strong>Introduction: </strong>Joint attention (JA) is a fundamental aspect of social interaction and a cornerstone of social communication. This study explores factors influencing JA in adults with Autism Spectrum Disorder (ASD) using an interactive, dual eye-tracking paradigm during a tangram puzzle computer gameplay. The JA performance of adults with ASD and a typically developing non-clinical control group (TD-NCC) was assessed alongside partner familiarity (familiar / stranger), partner roles (presenter / operator) and gaze cue (present / absent). Two main objectives were: 1) to evaluate JA through gaze recurrence (GR) in adults with ASD, and 2) to examine the effect of partner familiarity on JA by comparing the performance in the task conducted with either a familiar or an unfamiliar partner (stranger).</p><p><strong>Methods: </strong>The sample consisted of 42 participants (21 adults with ASD; ages 18-50, 9 females and 12 males and 21 TD-NCC; ages 21-50, 11 females and 10 males). Two non-intrusive desktop eye trackers simultaneously recorded gaze during the JA tangram task. Gaze recurrence was used as an indicator of JA. The gaze cue (present/absent) was a semi-transparent indicator showing where to look. Additionally, to control for potential eye pathophysiology in JA, saccade and anti-saccade tasks were applied to the eye movements of each participant.</p><p><strong>Results: </strong>The Linear Mixed Effect Model revealed that GR was significantly lower in the ASD group compared to controls. However, the presence of a gaze cue significantly improved the ASD group's GR, especially when interacting with a familiar partner under gaze-cue on conditions.</p><p><strong>Conclusion: </strong>Understanding factors influencing JA in autism may foster further exploratory studies and significantly impact future research. Eye movements may serve as objective, quantitative, and non-invasive biomarkers for ASD, particularly in interactive gaming contexts.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 3","pages":"220-227"},"PeriodicalIF":1.1,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12424458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145066498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pineal Gland and Melatonin are Associated with Serum Element Metabolism in Rats.","authors":"Aylin Üstün, Zeynep Köykun, Haluk Gümüş, Bayram Yılmaz, Rasim Moğulkoç, Abdulkerim Kasım Baltacı","doi":"10.29399/npa.28765","DOIUrl":"10.29399/npa.28765","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study is to investigate the relationship of melatonin supplementation with serum element metabolism in pinealectomized rats.</p><p><strong>Methods: </strong>The research was conducted on 32 adult male Spraque-Dawley rats. The study protocol was approved by the local animal ethics committee.Animals were divided into four equal groups. Control (Group 1), Melatonin (Group 2), Pinealectomy \"Px\" (Group 3), Pinealectomy+melatonin (Group 4). Animals in groups 2 and 4 were given intraperitoneal (ip) melatonin support (4 weeks/day; 3 mg/kg melatonin). Animals in groups 3 and 4 underwent pinealectomy under general anesthesia. At the end of the applications, serum element levels were determined by atomic emission (μg/dl) in the blood samples taken from the sacrificed animals.</p><p><strong>Results: </strong>While pinealectomy increased chromium and manganese levels in Group 3 (p<0.001), it caused significant suppression of magnesium, calcium and zinc levels (p<0.001). Melatonin supplementation in pinealectomized animals (Group 4) treated the impairments in the mentioned parameters.</p><p><strong>Conclusion: </strong>The results of the current study show that the melatonin hormone secreted from the pineal gland has a regulatory effect on serum element metabolism. This study is the first to examine the relationship between the pineal gland and element metabolism as a whole.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 3","pages":"270-273"},"PeriodicalIF":1.1,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12424455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145066228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"İstanbul Seririyatı (1919-1952): Medical Periodical Digitalization, Index and Open Access Project.","authors":"Cem Hakan Başaran, Fatih Artvinli","doi":"10.29399/npa.29035","DOIUrl":"10.29399/npa.29035","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;İstanbul Seririyatı (1919-1952) was a pioneering and comprehensive medical journal in the field of neuropsychiatry in Türkiye. Published monthly for 33 years, the journal comprises a total of 389 issues and over 10,000 pages. This project aimed to digitize the entire archive of the journal and make it freely accessible. This article provides an overview of the journal \"Istanbul Seririyati\" and the website www.istanbulseririyati.com, where its archive has been recently made available online, also addressing its historical context and significance.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;The project, which spanned approximately six years, focused on locating all issues of the journal and compiling a complete collection. The primary goal was to obtain the most difficult-to-find Ottoman Turkish issues published between 1919 and 1929, which were collected from various individuals, institutions, libraries, antiquarian booksellers, auctions, and online marketplaces. Once acquired, they were professionally scanned and converted into PDF format. From 1929 onwards, the journal was published in Latin-script Turkish, and Optical Character Recognition (OCR) technology was applied to facilitate text searchability whenever possible. The project was structured in four phases: identifying and gathering all journal issues, scanning and digitalizing them, creating a detailed index for each issue, and establishing an online platform for free and open access to the archive. For each issue, the medical section has been indexed with details including the author, title, and page numbers, and a structured keyword system was developed to enhance searchability within the archive.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The complete archive of İstanbul Seririyatı (www.istanbulseririyati.com) has now been made available online. The website offers advanced search functionalities based on year, issue, topic, author, concept, and keyword, ensuring ease of use for both researchers and enthusiasts. Users can read journal issues online and also download them. The website's blog section features articles exploring İstanbul Seririyatı's historical legacy, examples from various years, and in-depth discussions of its content. Moreover, selected articles from the 1919-1929 Ottoman Turkish issues have been transliterated into modern Turkish, making them more accessible to contemporary readers. It can be said that a serious historical gap in this field has been filled with online access to İstanbul Seririyatı, which sheds light on the birth and development years of neuropsychiatry in Türkiye.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;İstanbul Seririyatı serves as a vital resource for tracking discussions and transformations in neuropsychiatry and various other branches of medicine. The journal was organized into two main sections: medical and paramedical. By bringing together physicians from various medical disciplines, particularly neuropsychiatry, İstanbul Seririyatı served ","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 3","pages":"286-289"},"PeriodicalIF":1.1,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12424461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145066250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological Empowerment in Breast Cancer Survivors: Posttraumatic Growth and Related Factors.","authors":"Nevzat Çamlı, Gülfizar Sözeri Varma, Osman Zülkif Topak, Gamze Gököz Doğu, Tuğçe Toker Uğurlu, Nail Özhan, Muhammet Gündüz","doi":"10.29399/npa.28818","DOIUrl":"10.29399/npa.28818","url":null,"abstract":"<p><strong>Introduction: </strong>Diagnosis and treatment of breast cancer is traumatic for both patients and their relatives. It is crucial to understand the factors that enhance the psychological resilience of breast cancer survivors. This study aims to investigate posttraumatic growth following breast cancer and its relationship with psychiatric disorders, social support, and stigma.</p><p><strong>Methods: </strong>The study included 100 female breast cancer patients and 100 relatives. Patients underwent a DSM-5-based structured psychiatric interview and were assessed with the Posttraumatic Growth Inventory (PTGI), the Hospital Anxiety-Depression Scale (HADS), the Cancer Patient Perceived Social Support Scale (CPPSSS), and Cancer-related Attitudes Measurement Questionnaire (CRAMQ)-patient version. The patient's relatives were administered the PTGI, HADS, and CRAMQ-community versions.</p><p><strong>Results: </strong>Psychiatric disorders were diagnosed in 40% of individuals with breast cancer, most commonly major depressive disorder (22%). Posttraumatic growth demonstrated a negative correlation with age and a positive association with being employed. The presence of psychiatric disorders and elevated anxiety levels are associated with reduced personal growth. Perceived emotional/confidence social support were associated with increased growth. A subscale of stigma 'impossibility of recovery', led to a positive shift in life philosophy and interpersonal relationships. Additionally, both patients' age and the level of growth in their relatives were found to predict posttraumatic growth in the patients (B=-0.499, p=0.021; B=0.211, p=0.044, logistic regression).</p><p><strong>Conclusion: </strong>Posttraumatic growth is negatively associated with age and the presence of a psychiatric disorder, and positively associated with employment and social support. Additionally, relatives' posttraumatic growth and patients' age predict posttraumatic growth in patients. Stigmatising the perception of \"impossibility of recovery\" is associated with positive psychological change, possibly reflecting a more traumatic perception of the cancer diagnosis, a reduction in denial, and increased acceptance of the illness. This acceptance of mortality may lead to deeper personal transformation for a more meaningful life and improved interpersonal relationships.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 3","pages":"234-240"},"PeriodicalIF":1.1,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12424454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145066256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidative Stress and Thiol-disulphide Hemostasis in Children with Anxiety Disorders.","authors":"Armagan Aral, Bahattin Avcı, Neriman Kesim, Oğuzhan Şimşek","doi":"10.29399/npa.28937","DOIUrl":"10.29399/npa.28937","url":null,"abstract":"<p><strong>Introduction: </strong>Anxiety disorders (AD) constitute a significant part of mental health problems; however, their pathogenesis remains not fully elucidated. The balance between the oxidative and antioxidative systems are disrupted in children with AD. The total oxidant/antioxidant status (TOS/TAS) and thiol/disulphide homeostasis (TDH) show oxidative stress through different mechanisms. To date, research in this context has tended to focus on adults rather than children. Despite this, understanding oxidative stress in pediatric populations is increasingly emphasized. Therefore, this research aims to investigate TOS/TAS and TDH in children with AD.</p><p><strong>Methods: </strong>The study included 40 treatment-naive children with AD and 40 healthy controls matched by age and sex. Sociodemographic data and The Screen for Child Anxiety-Related Emotional Disorders (SCARED) were used for assessment.</p><p><strong>Results: </strong>The results showed that TOS and the Oxidative Stress Index (OSI) were elevated, and TAS was reduced in children with AD compared to controls. However, when evaluated in terms of TDH, there was no significant difference. Logistic regression analysis identified TOS as a significant predictor of AD (p=0.027; OR=5.49, 95% CI: 1.21-24.84). Although dynamic-disulphide level improved the model's predictive accuracy, they did not reach statistical significance (p=0.063).</p><p><strong>Conclusion: </strong>These findings suggest a potential oxidative dysfunction in AD. The study highlights the potential utility of TOS as a robust biomarker for distinguishing pediatric AD from HC. Furthermore, the absence of significant changes in TDH suggests that oxidative stress in pediatric AD may primarily involve alternative pathways. This may involve a complex interplay of DNA damage, lipid peroxidation, and protein oxidation processes contributing to the oxidative stress observed in AD. To explore the potential for using oxidative stress markers as novel targets for treatment and diagnostic tools for AD, prospective, large-scale, randomized trials are required.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 3","pages":"264-269"},"PeriodicalIF":1.1,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12424453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145066226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Prolonged Delirium Tremens.","authors":"Sevtap Tolaman, Rasim Tunçel, Barış Örs, Damla İşman Haznedaroğlu","doi":"10.29399/npa.28896","DOIUrl":"10.29399/npa.28896","url":null,"abstract":"<p><p>Delirium tremens represents the most severe condition of alcohol withdrawal, with the associated highest mortality rate. The primary treatment for cases of delirium tremens consists of benzodiazepines. Within the literature, prolonged cases of delirium tremens have been identified that do not respond to high-dose benzodiazepine treatments or respond late. Different treatment modalities, such as propofol, dexmedetomidine, and parenteral antipsychotic administrations, are being attempted in the management of these cases. In this case, a case of prolonged delirium tremens with insufficient response to benzodiazepine treatment will be presented.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 3","pages":"290-292"},"PeriodicalIF":1.1,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12424464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145066522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurovascular Changes in the Retina of Parkinson's Disease Patients: A Comprehensive Study on Disease Severity, Levodopa Dosage, and Stroke Risk.","authors":"Ulviye Kıvrak, Banu Özen Barut, İlknur Sungu, İlknur Güçlü Altun, Büşra Telek, Şaban Şimşek","doi":"10.29399/npa.28994","DOIUrl":"10.29399/npa.28994","url":null,"abstract":"<p><strong>Introduction: </strong>This study aims to investigate retinal neuronal and vascular structural alterations in Parkinson's disease (PD) patients concerning disease duration and severity, levodopa dosage, and stroke risk.</p><p><strong>Methods: </strong>This retrospective study included 40 PD patients and 40 age- and sex-matched controls. Retinal parameters, including central foveal thickness (CFT), macular thickness (MT), retinal nerve fiber layer (RNFL), and retinal vascular density, were measured using optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA). Disease severity was assessed using the Hoehn & Yahr (H&Y) scale, and stroke risk was evaluated using the Stroke Risk Assessment (SRA) tool.</p><p><strong>Results: </strong>PD patients demonstrated significantly reduced MT in the temporal quadrant and reduced vascular density in both the superficial (SCP) and deep (DCP) capillary plexuses compared to controls. Additionally, the superficial and deep foveal avascular zone (FAZ) areas showed notable enlargement. A negative correlation between disease duration and both the temporal and nasal quadrants of the SCP and a positive correlation between disease severity and deep FAZ area was observed, while disease severity exhibited negative correlations with temporal MT, average and superior quadrant RNFL. Levodopa dosage was inversely correlated with inferior and temporal MT and temporal SCP and DCP and positively correlated with the deep FAZ area. No significant correlation was found between the SRA score and retinal vascular changes.</p><p><strong>Conclusion: </strong>This study is the first to evaluate retinal neuronal and vascular changes in PD regarding stroke risk assessment. Our findings suggest that retinal changes are associated with disease severity and duration in PD patients. Further prospective studies with larger sample sizes are needed to validate these findings and explore the potential role of OCTA in early detection and stroke prevention in PD.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 3","pages":"241-248"},"PeriodicalIF":1.1,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12424465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145066248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is Neurodegeneration Accelerated? Investigating COVID-19's Impact on Dementia via Functional Connectivity.","authors":"Aynur Müdüroğlu Kırmızıbekmez, Alparslan Önder, Mustafa Yasir Özdemir, Önder Yüksel Eryiğit, Ertan Yurdakoş","doi":"10.29399/npa.29085","DOIUrl":"10.29399/npa.29085","url":null,"abstract":"<p><strong>Introduction: </strong>COVID-19 has been associated with various neurological complications, including cognitive impairments such as memory deficits, attention difficulties, and executive dysfunction. These symptoms raise concerns about potential long-term effects, particularly in individuals with preexisting neurodegenerative conditions. Emerging evidence suggests that systemic inflammation, blood-brain barrier (BBB) dysfunction, and neuroinflammation may contribute to cognitive decline in COVID-19 patients. However, the impact of COVID-19 on functional brain connectivity, particularly in dementia patients, remains unclear.This study aims to investigate the differences in functional connectivity across different frequency bands (delta, theta, alpha, beta, and gamma) in dementia patients with and without a history of COVID-19 (D-COVID and D-nCOVID) compared to a healthy control (HC) group. The study explores whether COVID-19 accelerates neurodegenerative processes by disrupting functional brain networks.</p><p><strong>Methods: </strong>Functional connectivity was assessed using electroencephalography (EEG)-based network analysis in three groups: D-COVID, D-nCOVID, and HC. Connectivity metrics were compared across frequency bands, with a focus on local efficiency (LE) and global network alterations. The Kruskal-Wallis test assessed statistical significance, while the Dunn test was used for post-hoc analysis.</p><p><strong>Results: </strong>Findings indicate a significant reduction in functional connectivity across multiple brain regions in dementia patients, with the D-COVID group exhibiting more pronounced declines. The observed decrease in connectivity suggests that COVID-19 may accelerate neurodegenerative processes. Additionally, the HC group demonstrated stronger connectivity and higher LE metrics, highlighting the widespread impact of dementia on brain networks.</p><p><strong>Conclusion: </strong>These findings support the hypothesis that COVID-19 contributes to cognitive decline by exacerbating neurodegenerative mechanisms. The disruption of functional brain connectivity observed in D-COVID patients aligns with previous studies suggesting that SARS-CoV-2 may indirectly promote neuronal degeneration. Further longitudinal studies are needed to determine the long-term cognitive consequences of COVID-19 and potential therapeutic interventions to mitigate these effects.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 3","pages":"274-278"},"PeriodicalIF":1.1,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12424452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145066205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Live Cell-Based Flow Cytometry Assay Versus Commercial Cell-Based Indirect Immunofluorescence Assay of Aquaporin-4 Antibody in Neuromyelitis Optica: A Comparative Study.","authors":"İpek Güngör Doğan, Mesut Yiğit, Damla Çetinkaya Tezer, Özlem Gülaçtı, Şevval Ayhan, İpek Duygu Türkdemir, Betül Çelik, Beril Taşdelen, Cihat Uzunköprü, Mehmet Fatih Yetkin, Melih Tütüncü, Meltem Kilercik, Serkan Demir","doi":"10.29399/npa.28951","DOIUrl":"10.29399/npa.28951","url":null,"abstract":"<p><strong>Introduction: </strong>Neuromyelitis Optica (NMO) is an inflammatory disorder affecting the central nervous system, notably the optic nerve and spinal cord. Seropositive NMO is marked by serum IgG antibodies against aquaporin-4 (AQP4). The accurate identification of AQP4-IgG is crucial for distinguishing NMO from other demyelinating diseases of the central nervous system. However, traditional diagnostic assays have limitations in sensitivity and specificity. Here, we introduce our in-house flow cytometry live cell-based assay (FC-LCBA) for detecting AQP4 antibodies with enhanced sensitivity and specificity. Our objective is to report the accuracy and compare the efficacy of our newly developed in-house FC-LCBA against the commercial cell-based indirect immunofluorescence assay (IIFA) in detecting AQP4 antibodies.</p><p><strong>Methods: </strong>This single-blind study was approved by the ethical committee and involved 101 serum samples. Twenty-five samples (including retests) from 17 patients evaluated in the NMO spectrum who had at least one positive cell-based IIFA test during the diagnosis or follow-up are tested in parallel with our in-house FC-LCBA and cell-based IIFA. In addition, 36 serum samples from myelin oligodendrocyte glycoprotein-associated disease (MOGAD) patients and 40 serum samples from healthy subjects are also referred for specificity analysis.</p><p><strong>Results: </strong>Our in-house FC-LCBA displayed superior sensitivity, detecting positive results even when the cell-based IIFA yielded negative results in patients under immunosuppressive treatments. Additionally, FC-LCBA exhibited high specificity for NMO, showing negligible antibody levels in patients with MOGAD diagnosis and healthy individuals. The assay's stability was confirmed through consistent results in retests.</p><p><strong>Conclusion: </strong>Our in-house FC-LCBA emerges as a promising diagnostic tool for detecting AQP4 antibodies, offering improved sensitivity, specificity, and reliability, instilling confidence in its potential.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 3","pages":"259-263"},"PeriodicalIF":1.1,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12424466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145066202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating Sex and Gender in Medical Research: SAGER Guidelines.","authors":"İmran Gökçen Yılmaz Karaman","doi":"10.29399/npa.29184","DOIUrl":"10.29399/npa.29184","url":null,"abstract":"","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 3","pages":"207-208"},"PeriodicalIF":1.1,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12424463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145066513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}