Noropsikiyatri Arsivi-Archives of Neuropsychiatry最新文献

{"title":"Sleep Disorders in Patients with Epilepsy.","authors":"Aytül Mutlu, Aysel Büşra Şişman, Sefer Günaydın, Belgin Petek Balcı","doi":"10.29399/npa.28732","DOIUrl":"10.29399/npa.28732","url":null,"abstract":"<p><strong>Introduction: </strong>This study aims to investigate obstructive sleep apnoea syndrome (OSAS), quality of sleep, excessive daytime sleepiness (EDS) and quality of life in patients with epilepsy.</p><p><strong>Methods: </strong>One hundred and eleven epilepsy patients, diagnosed with ILAE (international league against epilepsy) criteria, were included in this study. The mean age of the patients was 37.6 ±13.1 (19-77) years. Fifty-four of the patients were (48.6%) men and 57 were (51.5%) women. Age, gender, education level, body mass index, seizure frequency, types of seizures, electroencephalography (EEG) findings, seizures during sleep, and number of anti-seizure drugs were recorded. Berlin Questionnaire (BQ) was used to screen OSAS. Sleep and quality of life were assessed with Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS) and Quality of Life in Epilepsy-31(QOLIE-31) scales.</p><p><strong>Results: </strong>Thirty-six percent of the patients' quality of sleep was poor and 20.7% had mild EDS. Low risk of OUAS was found in 89.2% of the patients. Quality of life was poor according to QOLIE-31. QOLIE 31 and PSQI total score had a statistically significant low negative correlation with BQ. PSQI total score had a statistically significant, low negative correlation with QOLIE-31. Poor sleep quality, EDS, OUAS and quality of life showed no correlation with demographic features, duration of disease, types of seizures, seizure frequency, number of anti-seizure drugs.</p><p><strong>Conclusion: </strong>The poor quality of sleep was 36% in our study. Poor quality of sleep, excessive daytime sleepiness and obstructive sleep apnoea syndrome had no correlation with the demographic and clinical features of the patients with epilepsy but showed low correlation with quality of life.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 2","pages":"172-178"},"PeriodicalIF":1.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Comparison of Functional Connectivity in Parkinson's Disease Patients with and without Parkin Gene Mutations.","authors":"Merve Çebi, Ulaş Ay, Ani Kiçik, Emel Erdoğdu, Fatih Tepgeç, Zehra Oya Uyguner, Zeynep Tüfekçioğlu, Bedia Samancı, Başar Bilgiç, Murat Emre, Tamer Demiralp, Haşmet A Hanağası","doi":"10.29399/npa.28719","DOIUrl":"10.29399/npa.28719","url":null,"abstract":"<p><strong>Introduction: </strong>Mapping the functional connectivity of brain regions became appealing in recent research in neurology. Accordingly, a growing body of evidence shows resting-state functional connectivity (rsFC) changes in neurodegenerative disorders including Parkinson's Disease (PD). As characterised by extensive and progressive dopaminergic loss in the substantia nigra, PD emerges with serious motor and non-motor dysfunctions. In the literature, the minority of PD cases have been associated with certain genetic mutations. The aim of this study was to investigate the rsFC in a group of PD patients having Parkin gene mutation.</p><p><strong>Method: </strong>Twelve PD patients with Parkin mutation (PP-PD), 12 PD patients without Parkin mutation (PN-PD) and 12 healthy controls (HC) were included in the study. All participants underwent a resting-state functional magnetic resonance imaging as well as a neuropsychological assessment and clinical examination.</p><p><strong>Results: </strong>Results indicated that PP-PD had longer disease duration, a higher rate of dyskinesia and lower scores on complex visual perception tests. The resting state networks showed that all PD (consisting of PP-PD and PN-PD) and PP-PD groups had increased functional connectivity in the frontoparietal network as compared to the HC. In addition, the PP-PD group displayed decreased functional connectivity in the dorsal attention network compared to the PN-PD.</p><p><strong>Conclusion: </strong>In conclusion, our data suggests that PD with Parkin gene mutation might be emerging with distinct resting state functional connectivity changes in the brain.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 2","pages":"131-135"},"PeriodicalIF":1.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Diabetic Aged Female Rats, Resveratrol Supplementation Prevents Retinal Tissue Damage By Increasing Antioxidant Activity Through SIRT1 Gene Expression.","authors":"Adem Atacak, Haluk Gümüş, Elif Gülbahçe Mutlu, Saltuk Buğra Baltacı, Rasim Moğulkoç, Abdulkerim Kasım Baltacı","doi":"10.29399/npa.28586","DOIUrl":"10.29399/npa.28586","url":null,"abstract":"<p><strong>Introduction: </strong>The present study was carried out to investigate how resveratrol administration affects retinal SIRT1 levels and retinal tissue damage in diabetic elderly female rats.</p><p><strong>Methods: </strong>A total of 24 elderly female rats were divided equally into 4 groups (G): G1, Control; G2, Control + Resveratrol; G3, Diabetes; G4, Diabetes + Resveratrol. Experimental diabetes was induced by a single intraperitoneal injection of streptozotocin (STZ) in G3 and G4. The G2 and G4 were given intraperitoneal (ip) resveratrol (5 mg/kg/day) for 4 weeks in addition to the normal diet. After 4-weeks of resveratrol treatment, Sirtuin 1 (SIRT1) gene expression and malondialdehyde (MDA) ve glutathione (GSH) levels were determined by PCR and ELISA, respectively, in retinal tissue samples of the animals.</p><p><strong>Results: </strong>The highest retinal MDA values were in the diabetes group (G3), the highest retinal GSH levels were in the Diabetes + Resveratrol group (G4). The retinal MDA and GSH levels of the other groups were not different from each other. The highest retinal SIRT1 expression values were in the Diabetes + Resveratrol (G4) group. The retinal SIRT1 expression values of the diabetes group (G3) were lower than G4, and higher than the G1 and G2. Retinal SIRT1 expression values of the G1 and G2 were not different from each other.</p><p><strong>Conclusion: </strong>Resveratrol supplementation prevented retinal tissue damage that occurs in diabetic-aged female rats. This antidiabetic effect of resveratrol supplementation occurs by increasing both antioxidant activity and SIRT1 expression in diabetic-aged rats.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 2","pages":"145-149"},"PeriodicalIF":1.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Dual Diagnosis of Substance Use Disorders on Circadian Rhythm and Sleep Quality in Patients with Bipolar Disorder.","authors":"Başak Yiğitbay, Filiz İzci","doi":"10.29399/npa.28831","DOIUrl":"10.29399/npa.28831","url":null,"abstract":"<p><strong>Introduction: </strong>In this study, it was aimed to evaluate the effect of comorbid substance use disorders (SUD), sleep quality and circadian rhythm in patients with type 1 bipolar disorder (BD) in the euthymic period.</p><p><strong>Method: </strong>A total of 100 patients with a diagnosis of BD were divided into two groups of 50 patients each: the group with the sole diagnosis of BD (Group 1) and the group with the secondary diagnosis of SUD (Group 2). Structured Clinical Interview for DSM-5 (R) Disorders - Clinician Version (SCID-5-CV) conducted with 100 patients in the remission period for diagnostic clarity and identification of the SUD comorbidity. Sociodemographic Data Form, Young Mania Rating Scale (YMRS), Hamilton Depression Rating Scale (HDRS), Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN), Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), Morningness Eveningness Questionnaire (MEQ) were used.</p><p><strong>Results: </strong>Groups were compared in terms of sleep quality and circadian rhythm characteristics; PSQI and ESS to evaluate sleep quality and daytime sleepiness; MEQ and BRIAN were used to determine chronotype and biological rhythm characteristics. Pittsburgh sleep quality index showing decreased sleep quality in group 2, ESS showing increased sleepiness and BRIAN showing biological rhythm irregularity were significantly higher (p<0.05). There was no significant difference between both groups in MEQ, which determined the chronotype preference. In addition, further comparisons were made by dividing Group 2 according to dominant substance use as alcohol, cannabis and other (amphetamine, opiate) Sleep (p=0.011) and social subscale values (p<0.001) from the BRIAN subscales of Group 1 were lower than in the cannabis group. The PSQI value of Group 1 was lower than that of Cannabis and other groups (p<0.001). In addition, the MEQ value of Group 1 was found to be lower than in the alcohol group (p=0.007). The evening chronotype was more prevalent in Group 1 and the morning chronotype was more prevalent in the patients with comorbid alcohol use disorder.</p><p><strong>Conclusion: </strong>It was determined that dual diagnosis of SUD negatively affected sleep quality, increased daytime sleepiness and caused deterioration in circadian rhythm, and there was no significant change in chronotype preference in patients with BD. In addition, in patients accompanied by cannabis use; it was determined that there was a greater deterioration in biological rhythm and sleep quality.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 2","pages":"179-184"},"PeriodicalIF":1.0,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posttraumatic Stress, Posttraumatic Growth, and Heart Rate Variability Among Breast Cancer Survivors.","authors":"İmran Gökçen Yılmaz Karaman, Cennet Yastıbaş Kaçar, Gülay Dirik, İremnur Ersan, Nazan Demir, Gurbet Özge Mert","doi":"10.29399/npa.28713","DOIUrl":"10.29399/npa.28713","url":null,"abstract":"<p><strong>Introduction: </strong>Breast cancer as a life-threatening disease is the most frequent malignant disease among women all over the world. Resulting in post-traumatic stress disorder (PTSD) symptoms, breast cancer may also be related to positive changes like post-traumatic growth (PTG). The present study aims to evaluate heart rate variability (HRV) parameters among female survivors of breast cancer regarding its relationship with PTSD and PTG.</p><p><strong>Method: </strong>Forty-three women with stage 1-2-3 breast cancer were recruited. Heart rate variability parameters were measured with a 24-hour ECG. Post-traumatic stress disorder checklist for DSM-5 (PCL-5) and Post-traumatic Growth Inventory (PTGI) were utilized to measure PTSD and PTG.</p><p><strong>Results: </strong>The mean value of PCL-5 was 49.56; the mean value of PTGI was 71.56. Correlation analysis showed that PCL-5 was associated with SDNN (r=-0.310, p=0.043), LF (r=-0.349 p=0.022), and mean heart rate (r=0.396 p=0.009). Post-traumatic growth inventory scores were associated with LF/HF ratio (r=0.310 p=0.043). Linear regression analysis demonstrated that PCL-5 and PTGI scores predicted SDNN and mean heart rate.</p><p><strong>Conclusion: </strong>PTSD and PTG symptoms are related to HRV parameters among female survivors of breast cancer. While PTSD symptoms are related to lower HRV and higher mean heart rate, PTG symptoms are associated with higher HRV and lower mean heart rate.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 2","pages":"150-155"},"PeriodicalIF":1.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric case of Kelch-like protein 11 (KLHL11) encephalitis with long-term follow-up: pitfalls in diagnosis of pediatric autoimmune encephalitis.","authors":"Elif Şanlı, Maria Pechlivanidou, Hakkı Akbeyaz, Merve Savaş, Gülnur Takış, John Tzartos, Onur Tuğçe Poyraz Fındık, Erdem Tüzün, Dilşad Türkdoğan","doi":"10.29399/npa.28870","DOIUrl":"10.29399/npa.28870","url":null,"abstract":"","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 2","pages":"97-99"},"PeriodicalIF":1.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Psychological Resilience on Treatment Compliance and Functionality in Patients with Bipolar Disorder.","authors":"Mehmet Baltacıoğlu, Meltem Puşuroğlu","doi":"10.29399/npa.28766","DOIUrl":"10.29399/npa.28766","url":null,"abstract":"<p><strong>Introduction: </strong>Bipolar disorder (BD) is a serious psychiatric disorder that is common worldwide, and it is characterized by depressive and manic or hypomanic episodes. This study aimed to investigate the effect of psychological resilience on treatment adherence and functionality in patients diagnosed with BD.</p><p><strong>Methods: </strong>The sample of the study consisted of a total of 111 patients, 56 women and 55 men, who were followed up with a diagnosis of BD. A Sociodemographic and Clinical Characteristics Form, the Young Mania Rating Scale (YMRS), the Hamilton Depression Rating Scale (HDRS), the Resilience Scale for Adults (RSA), the Functioning Assessment Short Test (FAST), and the Morisky Medication Adherence Scale (MMAS) were used as data collection tools.</p><p><strong>Results: </strong>A significant negative relationship was found between the RSA scores and FAST scores of the patients (r_s=-0.762; p<0.001). It was observed that resilience predicted functionality and treatment adherence. It was determined that each 1-unit increase in RSA scores caused a 0.021unit decrease in functionality scores (p<0.001). It was observed that each 1-unit increase in RSA total scores increased the probability of good treatment adherence by 1.336 times (p<0.001).</p><p><strong>Conclusion: </strong>In our study, it was observed that high psychological resilience had positive effects on functionality and treatment adherence in patients with BD.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 2","pages":"136-144"},"PeriodicalIF":1.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrinsic Functional Connectivity Patterns of The Object-Selective Visual Areas.","authors":"Ulaş Ay, Tamer Demiralp","doi":"10.29399/npa.28795","DOIUrl":"10.29399/npa.28795","url":null,"abstract":"<p><strong>Introduction: </strong>It has been shown by numerous investigations that the occipitotemporal area has a particular object perception area called the lateral occipital complex, which is composed of lateral occipital (LO) and posterior fusiform (pF) cortices. The aim of this study is to examine the intrinsic functional connectivity (iFC) patterns of the object-selective LO and pF regions in order to shed light on the underlying neural mechanisms of object recognition.</p><p><strong>Methods: </strong>15 healthy participants were included in the study. A standard localizer task was used to identify LO and pF regions. Magnetic resonance imaging (MRI) data were collected using two different imaging protocols: high-resolution anatomical image and functional MRI (fMRI) data. Data preprocessing steps were carried out in accordance with standard procedures. After determining the LO and pF regions with activation analyses on the task-based fMRI data, the iFCs of these regions were investigated with functional connectivity analyses carried out on the resting-state fMRI recording.</p><p><strong>Results: </strong>iFC analyzes revealed that LO and pF regions have different connectivity patterns. Lateral occipital had a widely distributed connectivity network, whereas pF showed a more localized connectivity pattern. Lateral occipital had more extensive occipitotemporal, occipitoparietal and motor connections compared to pF. In contrast to this distribution pattern, the connections of the right and left LO were generally concentrated on the ipsilateral sides, while the connections of the pF were bilateral.</p><p><strong>Conclusion: </strong>The results of the study revealed complex iFC patterns of the LO and pF differentiating their functional roles in object perception/recognition. While the pF revealed bilaterally distributed iFC along the ventral visual stream, the extensive and lateralized iFC of the LO suggests its role in integrating visual information including object-related attention and action recognition.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 2","pages":"100-108"},"PeriodicalIF":1.0,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Distal Hereditary Motor Neuropathy with HSPB1 Mutation in Coexistence with Myotonia and Myopathy.","authors":"Handan Uzunçakmak-Uyanık, Ersin Tan, Çağrı Mesut Temuçin","doi":"10.29399/npa.28654","DOIUrl":"10.29399/npa.28654","url":null,"abstract":"<p><p>Distal hereditary motor neuropathies (dHMNs), also named as distal spinal muscular atrophy, are a group of disorders that cause degeneration of motor nerves. Currently, only 15% to 32.5% of patients with dHMN have been genetically identified. The most common cause of dHMNs gene mutations is HSPB1 mutation. In HSPB1 mutation, which is also one of the myopathogens via satellite cell pathology, dHMNS may coexist with neuromuscular junction disorder, motor neuron disease, satellite cell dysfunction and therefore myopathic findings. No case of myopathy and myotonia with HSPB1 mutation has been reported in the literature yet. We present a case with electrophysiologic findings in HSPB1 mutation by discussing the possible mechanisms underlying myotonic discharges and myopathic findings.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 2","pages":"205-206"},"PeriodicalIF":1.0,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating The Brain Regions Related to Early Onset Psychosis: A Voxel-Based Morphometry Study Considering The Effect of Hereditary Burden and Environmental Risk Factors.","authors":"Mehmet Can Erata, Damla Kasap Üstündağ, Elif Yerlikaya Oral, Özgül Uslu, Yiğit Erdoğan, Ayşegül Tonyalı, Gül Karaçetin, Ali Saffet Gönül","doi":"10.29399/npa.28885","DOIUrl":"10.29399/npa.28885","url":null,"abstract":"<p><strong>Introduction: </strong>Schizophrenia is both a neurodevelopmental and neurodegenerative disorder that manifests a complex spectrum of symptoms, significantly impacting mental health. In early-onset psychosis, similar to adult studies, neuroimaging focuses on ventral prefrontal cortical areas and posterior temporoparietal regions, crucial for understanding the neurodevelopmental mechanisms of these conditions in such drug-naive patients. This enables magnetic resonance imaging to be acquired before significant neurodegenerative changes occur, in contrast to chronic schizophrenia cases. Therefore, our study helps advance understanding of disease mechanisms in this patient population.</p><p><strong>Methods: </strong>We recruited forty-one subjects (17 females, 24 males; mean age=16 years; age range: 12-17 years) who were diagnosed with first-episode psychosis (FEP). We examined the relationship between gene and environmental risk scores (GERS) and whole-brain gray matter (GM) volumes through voxel-based morphometry (VBM).</p><p><strong>Results: </strong>We found a positive correlation between GM volumes of the left medial frontal gyrus, right anterior prefrontal cortex, left superior frontal gyrus, left operculum of the inferior frontal gyrus, left superior parietal lobe, and left supramarginal gyrus with the GERS. We found a negative correlation between GM volumes of the left superior frontal gyrus, left cerebellum, and the GERS.</p><p><strong>Conclusion: </strong>Our findings contribute to the understanding of structural abnormalities associated with schizophrenia, aligning with existing literature highlighting GM changes in frontal, parietal, and temporal cortices, as well as limbic structures. Our study underscores the importance of integrating structural and functional neuroimaging approaches to elucidate the pathophysiology of early-onset schizophrenia, emphasizing regions like the dorsolateral prefrontal cortex, ventrolateral prefrontal cortex, and posterior parietal areas.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 3","pages":"209-215"},"PeriodicalIF":1.1,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12424451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145066516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}