Noropsikiyatri Arsivi-Archives of Neuropsychiatry最新文献

{"title":"Association Between Circadian Onset Time and Clinical Outcomes in Acute Ischemic Stroke.","authors":"Nijat Abbaszade, Mine Hayriye Sorgun, Umut Bozkurt, Ömer Eray Yalap, Ceren Ayperi Gündoğmuş, Hilal Çöklü, Oğuzhan Taş, Ali Cem Ekşi, Fatma Tuğra Karaarslan Türk, Beril Özdemir, Canan Togay Işıkay","doi":"10.29399/npa.29278","DOIUrl":"10.29399/npa.29278","url":null,"abstract":"<p><strong>Introduction: </strong>It has been demonstrated that the circadian rhythm influences the onset of ischemic stroke, however its impact on treatment strategies and clinical outcomes remains uncertain. The aim of this study was to investigate the association between the circadian timing of stroke onset and vascular risk profiles, stroke severity, prognosis, and treatment methods in patients with acute ischemic stroke.</p><p><strong>Methods: </strong>We retrospectively reviewed acute ischemic patients with stroke admitted to our University Hospital Stroke Unit (August 2017-December 2023). Patients were grouped by stroke onset time: Group 1 (wake-up/00:00-awakening), Group 2 (awakening-12:00), Group 3 (12:00-18:00), and Group 4 (18:00-00:00). Demographic and clinical characteristics, and acute stroke treatments, including intravenous thrombolysis (IV tPA) and thrombectomy were recorded. Outcomes were assessed using the modified Rankin Scale (mRS) at the first follow-up. Following univariate analyses, multivariable binary logistic regression identified independent predictors of IV tPA administration.</p><p><strong>Results: </strong>Among 1047 admissions, 751 patients met the inclusion criteria. There were 212 patients (28.2%) in Group 1, 231 patients (30.8%) in Group 2, 158 patients (21%) in Group 3, and 150 patients (20%) in Group 4. The prevalence of hypertension was significantly lower in Group 3 (p=0.0027). Multivariable analysis identified higher admission National Institutes of Health Stroke Scale scores (OR 1.202, p <0.001) and stroke onset time as independent predictors of IV tPA administration. Group 1 patients were significantly less likely to receive IV tPA (p <0.001), with no significant differences in etiology, mortality, or follow-up mRS scores.</p><p><strong>Conclusion: </strong>This study shows that IV tPA is less frequently administered to patients who experienced ischemic stroke during sleep. This finding highlights the need for tools that can enable earlier detection of stroke occurring during sleep. Despite the differences in IV tPA administration rates, stroke onset time did not significantly impact overall patient prognosis, including mortality and functional outcomes.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"63 ","pages":"443-447"},"PeriodicalIF":1.0,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13358905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148438884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Rotarod Tests and Myelin Basic Protein in the Confirmation of the Cuprizone-Induced Rat Multiple Sclerosis Model and the Relationship of These Parameters with Dietary Zinc Status.","authors":"Sueda Ecem Yılmaz, Haluk Gümüş, Saltuk Buğra Baltacı, Gözde Acar, Rasim Moğulkoç, Abdulkerim Kasım Baltacı","doi":"10.29399/npa.29236","DOIUrl":"10.29399/npa.29236","url":null,"abstract":"<p><strong>Introduction: </strong>Experimental autoimmune encephalomyelitis (EAE) is widely used for studies of human inflammatory demyelinating diseases. The cuprizone model is one of the most frequently used. The cuprizone model is a toxic demyelination model. The most significant challenge in this experimental model is demonstrating the development of MS in animals with experimental evidence. Two tests stand out in demonstrating the development of disease in cuprizone-induced rat MS models. The first is the Rotarod test. The Rotarod test is an experimental test that has become frequently used in recent years in the field of neuroscience to demonstrate motor function disorders. The second is the determination of MBP levels at the tissue or blood level. The aim of this study is to investigate the role of rotarod tests and myelin basic protein (MBP) analysis in confirming multiple sclerosis (MS) in a cuprizone-induced rat model, and also the relationship of these parameters with dietary zinc status.</p><p><strong>Methods: </strong>In the study, approved by the ethics committee, forty-six adult male Wistar rats were divided into five groups. Groups 1 and 2 received Carboxy-methyl-cellulose (CMC) solution. Multiple sclerosis was induced in Groups 3, 4, and 5 by daily gavage of cuprizone in CMC solution (1% of feed intake) for 8 weeks. Group 4 received a zinc-deficient diet, while Group 5 received daily intraperitoneal zinc sulfate supplementation. Myelin basic protein gene expression in animals was determined using Real-Time PCR.</p><p><strong>Results: </strong>Results showed that MS-induced rats in Groups 3 and 4 exhibited significantly shorter rotarod fall times and higher corpus callosum MBP gene expression compared to other groups (p<0.05). Notably, zinc supplementation in Group 5 reversed these effects (p<0.05).</p><p><strong>Conclusion: </strong>These findings confirm that 8 weeks of cuprizone administration induces an MS-like condition in rats, and zinc supplementation effectively ameliorates these MS symptoms.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"63 ","pages":"468-473"},"PeriodicalIF":1.0,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13358909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148438896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultra-High Performance Liquid Chromatography Mass Spectrometry-based Metabolic Profiling in Urine for Bipolar Disorder with Manic Episode.","authors":"Talha Ağaç, Metin Demirel, Fatmanur Köktaşoğlu, Halime Dulun Ağaç, Şahabettin Selek, Mustafa Solmaz","doi":"10.29399/npa.29271","DOIUrl":"10.29399/npa.29271","url":null,"abstract":"<p><strong>Introduction: </strong>Bipolar disorder is a complex psychiatric condition marked by recurrent episodes of mania and depression. Despite its prevalence, the underlying pathophysiology remains poorly understood, and there is still a lack of objective biomarkers for diagnosis. Metabolomics is a promising approach for exploring biological alterations associated with specific mood states. This study aimed to investigate differences in the urinary metabolome between patients with bipolar disorder in the manic phase and healthy controls.</p><p><strong>Methods: </strong>Urine samples were collected from 22 manic bipolar disorder patients and 31 healthy controls. Samples were analyzed using Ultra-High Performance Liquid Chromatography Mass Spectrometry. The data were processed using MZmine and TidyMass, and then subjected to statistical and multivariate analyses in MetaboAnalyst 5.0. Metabolites showing significant fold changes were then evaluated using a receiver operating characteristic analysis.</p><p><strong>Results: </strong>The levels of two phosphatidylcholine derivatives, 1.2-dioleoyl-sn-glycero-3-phosphatidylcholine and 1-stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine, were significantly higher in the manic group (p<0.05). Receiver Operating Characteristic analysis revealed that these metabolites had limited discriminatory performance when evaluated individually.</p><p><strong>Conclusion: </strong>The findings suggest that the manic phase of bipolar disorder is associated with alterations in urinary lipid-related metabolites. While the identified metabolites exhibited modest diagnostic value individually, they could potentially reflect phase-specific metabolic changes relevant to bipolar disorder. These exploratory results warrant further investigation in larger longitudinal studies that include different mood states.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"63 ","pages":"426-430"},"PeriodicalIF":1.0,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13358914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148438894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malingering and Executive Dysfunction in Trauma Patients: Diagnostic Challenges with the M-FAST.","authors":"Mesut Keskin, Deniz Büyükgök, Cüneyt Destan Cenger, Neşe Direk","doi":"10.29399/npa.29185","DOIUrl":"10.29399/npa.29185","url":null,"abstract":"<p><strong>Introduction: </strong>Many people who have been exposed to trauma apply to psychiatry and forensic medicine outpatient clinics for treatment and forensic reports. These people may exaggerate their psychiatric symptoms consciously or unconsciously for various reasons. It is imperative for clinicians to comprehend this condition in the context of treatment regulation and forensic processes. This study aimed to evaluate the relationship between the Miller Forensic Assessment of Symptoms Test (M-FAST) score and clinical, sociodemographic variables and Stroop test and Block Design Test (BDT).</p><p><strong>Methods: </strong>The present study was conducted on a sample of patients over the age of 18 who had applied to the forensic medicine and psychiatry outpatient clinics for trauma-related reasons and had accepted to participate in the study. The patients were asked to complete Symptom Checklist-90 (SCL-90). M-FAST, The Stroop Test, and BDT were administered. The Stroop test and BDT were administered to assess the correlation between cognitive abilities and the M-FAST score. Those with an M-FAST score of seven or higher were considered possible malingerers. Clinician who examined the patient decided whether they were a malingerer, without knowing their M-FAST score.</p><p><strong>Results: </strong>All clinical and sociodemographic variables were divided into two groups (present or absent) and compared according to M-FAST scores. Prevalence of possible malingerer was determined to be 33%. Possible malingerer were more likely to be male, have psychiatric comorbidities, and show poorer executive and visuospatial functioning. M-FAST scores positively correlated with psychopathology and Stroop interference, and negatively with BDT performance. Regression and ROC analyses supported the M-FAST's fair diagnostic accuracy (AUC=0.79).</p><p><strong>Conclusion: </strong>Unlike prior studies, our research emphasizes how cognitive functioning impacts malingering assessment in trauma-affected, treatment-seeking. To the best of our knowledge, this is the first study to utilize M-FAST in patients seeking treatment for reasons other than forensic reasons.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"63 ","pages":"408-414"},"PeriodicalIF":1.0,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13358916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148438886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Speech-In-Noise Skills with Temporal Fine Structure Test in Patients with Depression.","authors":"Gökçe Saygı Uysal, Yasemin Hoşgören Alıcı, Işılay Öz, Meral Didem Türkyılmaz, Hatice Seyra Erbek","doi":"10.29399/npa.29124","DOIUrl":"10.29399/npa.29124","url":null,"abstract":"<p><strong>Introduction: </strong>Communication between individuals is based on communication in noisy environments. However, audiological tests used for the evaluation of hearing levels or determination of hearing loss are usually applied in a quiet environment. This study aims to evaluate whether depression has an effect on speech-in-noise perception and supra-threshold auditory processing abilities, even in individuals without advanced age or hearing loss.</p><p><strong>Methods: </strong>The study group comprised 29 individuals who did not have hearing loss but were diagnosed with depression. The control group consisted of 29 individuals who did not have hearing loss or a depression diagnosis. All participants underwent the Temporal Fine Structure adaptive frequency (TFS-AF) test to assess supra-threshold auditory processing abilities. The results were then compared between the study and control groups.</p><p><strong>Results: </strong>The study revealed significant differences in TFS sensitivity scores between the study and control groups, with test scores in the depression group being significantly lower than those in the control group (p=0.000).</p><p><strong>Conclusion: </strong>Depression can significantly affect auditory performance. Depression, alongside factors like hearing loss and aging, can impact auditory functions like speech intelligibility. Therefore, a more holistic approach that considers emotional status is essential for comprehensively evaluating listening skills and auditory functions, even in individuals without hearing loss.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"63 ","pages":"402-407"},"PeriodicalIF":1.0,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13358924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148438813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between Traumatic Experiences and Weight Loss Outcomes in Obesity.","authors":"Aslı Tuğba Esen, Uğur Bayram Korkmaz, Merve Karakaya, Ümit Çavdar, Esin Evren Kılıçaslan","doi":"10.29399/npa.29302","DOIUrl":"10.29399/npa.29302","url":null,"abstract":"<p><strong>Introduction: </strong>Obesity and lifetime exposure to violence are preventable public health issues. The relationship between exposure to violence and obesity treatment outcomes has not been extensively investigated. The aim of this study was to examine the effect of childhood trauma and violence during adulthood on short -term weight loss success among individuals with obesity.</p><p><strong>Methods: </strong>The study included 89 female patients diagnosed with obesity who had no active psychiatric disorders. Participants were assessed using the Structured Clinical Interview for DSM-5, Clinical Version (SCID-5-CV). Childhood trauma was measured with the Childhood Trauma Questionnaire (CTQ-28). Exposure to physical, emotional, sexual, and economic violence during adulthood was evaluated using a researcher-developed questionnaire. After a three-month follow-up period, participants who achieved at least 5% weight loss, a short-term treatment target recommended for reducing morbidity were compared with those who did not.</p><p><strong>Results: </strong>A substantial proportion of participants (85.4%) reported experiencing at least one type of childhood trauma, and more than half (51.7%) had been exposed to at least one type of violence in adulthood. Participants who failed to achieve ≥5% weight loss had significantly higher CTQ subscale scores for physical abuse, emotional abuse, sexual abuse, physical neglect, and emotional neglect (p <0.05). A significant association was also observed between childhood trauma and subsequent exposure to violence in adulthood (p <0.01). Effective weight loss was less common among individuals exposed to physical, emotional, economic, or sexual violence during adulthood; however, multivariate analyses revealed that only economic violence was a significant risk factor for unsuccessful weight loss (aOR=5.65[2.05-15.55]).</p><p><strong>Conclusion: </strong>This study highlights the high prevalence of exposure to different types of lifetime violence among women with obesity and demonstrates a significant association between trauma history and diminished weight loss outcomes. Integrating trauma-focused approaches into obesity treatment may contribute to improving both treatment and prevention processes.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"63 ","pages":"436-442"},"PeriodicalIF":1.0,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13358913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148438899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased Myeloid-Derived Suppressor Cells in Newly Diagnosed Multiple Sclerosis: Immunophenotyping and Functional Validation.","authors":"Nazire Pınar Acar Özen, Hamdullah Yanık, Aslı Tuncer","doi":"10.29399/npa.29385","DOIUrl":"10.29399/npa.29385","url":null,"abstract":"<p><strong>Introduction: </strong>Myeloid-derived suppressor cells (MDSCs) are key regulators of immune responses during chronic inflammation. Their role in early multiple sclerosis (MS) remains incompletely defined. We aimed to evaluate circulating monocytic (M-MDSC) and polymorphonuclear (PMN-MDSC) levels in newly diagnosed, treatment-naïve MS patients and to assess their functional suppressive capacity.</p><p><strong>Methods: </strong>Eighteen newly diagnosed MS patients and ten age- and sex-matched healthy controls were included. Peripheral blood MDSC subsets were quantified by flow cytometry. Clinical characteristics, MRI findings, and cerebrospinal fluid (CSF) parameters were recorded. Proof-of-concept functional validation was performed using T-cell proliferation assays assessed using CFSE fluorescence dilution by flow cytometry.</p><p><strong>Results: </strong>Both M-MDSC and PMN-MDSC percentages were significantly higher in MS patients compared with controls (p<0.001 for both). Myeloid-derived suppressor cell levels did not differ according to sex and showed no correlation with time from symptom onset, MRI activity, or CSF parameters. Functionally, sorted MDSC subsets suppressed activated T-cell proliferation.</p><p><strong>Conclusion: </strong>Newly diagnosed, untreated MS patients exhibit an expansion of circulating MDSCs with preserved suppressive capacity. These findings suggest that early MS may involve a systemic immunoregulatory response that is not fully captured by conventional clinical or radiological measures.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"63 ","pages":"448-453"},"PeriodicalIF":1.0,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13358915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148438846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maxillary Tooth Sizes and Dental Anomalies in Schizophrenia Patients: A Case-Control Study.","authors":"Hasan Gökçay, Özlem Oflezer, Mustafa Nuray Namlı, Ceyhan Oflezer, İlayda İlday","doi":"10.29399/npa.29306","DOIUrl":"10.29399/npa.29306","url":null,"abstract":"<p><strong>Introduction: </strong>From the perspective of the developmental correlation between the face and brain, quantitative craniofacial findings such as tooth size may indicate important stages of neurodevelopment in the pathogenesis of schizophrenia. The aim of this study was to evaluate and compare maxillary tooth size and some dental anomalies in patients with schizophrenia in a blinded manner with non-psychiatric controls.</p><p><strong>Methods: </strong>A total of 200 participants (100 patients with schizophrenia and 100 control subjects) aged 18-45 were included in the study. Plaster dental models were prepared from the measurements of the maxillary dental arch. The mesiodistal (MD) and buccolingual (BL) dimensions of the maxillary teeth were measured on dental casts by two observers using digital calipers. In addition to dimensional assessments, dental abnormalities such as tooth rotation, diastema, tooth crowding, and peg-shaped lateral incisors were also recorded.</p><p><strong>Results: </strong>There was no statistically significant difference between the groups in terms of age and sex (p >0.05). Statistical analyses showed that patients with schizophrenia exhibited significantly smaller measurements in both MD (P <0.001) and BL (p <0.001) dimensions across all teeth evaluated. Furthermore, multivariate binomial logistic regression revealed MD size (B=-2.020, p <0.001) and the presence of diastema (Β=1.656, p <0.001) as significant independent predictors of schizophrenia.</p><p><strong>Conclusion: </strong>Reduction in tooth size and increased presence of diastema in patients with schizophrenia may contribute to the hypothesis that there are possible variations that may represent specific markers of embryological dysmorphogenesis underlying schizophrenia.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"63 ","pages":"454-460"},"PeriodicalIF":1.0,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13358907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148438841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Genetic Disorder Presenting with Neuropsychiatric Involvement and Drug-Resistant Epilepsy: The First Adult Patient with Adenylosuccinate Lyase Deficiency in Türkiye.","authors":"Ebru Altındağ, Betül Baykan","doi":"10.29399/npa.29186","DOIUrl":"10.29399/npa.29186","url":null,"abstract":"","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"63 ","pages":"415-416"},"PeriodicalIF":1.0,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13358904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148438830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Electrophysiological Characteristics of Guillain-Barré Syndrome Across Pre-Pandemic, Pandemic, and Post-Pandemic Periods: A Ten-Year Retrospective Cohort Study.","authors":"Nevin Pazarcı, Esra Nur Kargın","doi":"10.29399/npa.29357","DOIUrl":"10.29399/npa.29357","url":null,"abstract":"<p><strong>Introduction: </strong>The COVID-19 pandemic markedly altered patterns of exposure to respiratory and gastrointestinal pathogens, healthcare-seeking behaviors, and environmental immune triggers. Guillain-Barré syndrome (GBS), an immune-mediated polyradiculoneuropathy frequently preceded by an infectious event, may therefore exhibit changes in clinical presentation or electrophysiologic subtype distribution. However, it remains unclear whether the clinical and electrophysiological characteristics of GBS have changed across pandemic periods.</p><p><strong>Methods: </strong>This retrospective cohort included adults diagnosed with GBS between March 2015 and October 2025 at a tertiary referral center. Patients were grouped into pre-pandemic, pandemic, and post-pandemic periods. Clinical features, antecedent events, severity scores, and electrophysiologic subtypes (classified using Uncini criteria) were compared. Group comparisons were performed using chi-square, Fisher's exact test, and non-parametric tests where appropriate.</p><p><strong>Results: </strong>Seventy patients were included: 31 pre-pandemic, 24 during the pandemic, and 15 post-pandemic. Age, sex, CSF findings, clinical and electrophysiological subtype distribution were similar across groups. Sensory and motor symptom subcategories and deep tendon reflexes did not differ. Antecedent event types differed significantly across periods (p=0.015). Admission Hughes score, MRC sum score, and mEGRIS score showed significant differences, indicating more severe presentation in the pre-pandemic group. Post-hoc comparisons suggested that these differences were primarily driven by comparisons between pre- and post-pandemic groups.</p><p><strong>Conclusion: </strong>Despite pandemic-related epidemiological changes, the fundamental clinical and electrophysiological characteristics of GBS remained stable. However, differences in initial disease severity may reflect changes in environmental exposures and healthcare-seeking behavior rather than intrinsic alterations in disease pathophysiology.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"63 ","pages":"461-467"},"PeriodicalIF":1.0,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13358922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148438875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}