Noropsikiyatri Arsivi-Archives of Neuropsychiatry最新文献

{"title":"Can Vascular Vertigo Be Recognized by Artificial Intelligence Methods?","authors":"Aslihan Taskıran-Sag, Hilal Arslan, Hare Yazgı, Erdal Eroglu, Kadriye Serife Ugur","doi":"10.29399/npa.29122","DOIUrl":"10.29399/npa.29122","url":null,"abstract":"<p><strong>Introduction: </strong>The diversity of underlying causes poses a medical challenge in the differential diagnosis of dizziness. For many patients, the time to reach a diagnosis is quite long and includes several tests. This imposes a significant financial burden on the healthcare system while delaying the recognition and treatment of some neurological emergencies. In this paper, we present a machine learning-based method to aid in the early recognition of vascular causes of vertigo, which require timely management.</p><p><strong>Methods: </strong>Using data such as age, gender, accompanying symptoms, comorbidities, and commonly known blood parameters, a machine learning-based preliminary evaluation method was designed to predict the most appropriate group for the patient. After identifying the effective features using statistical methods, various machine learning methods (decision tree, logistic regression, support vector machines, k-nearest neighbor, multilayer perceptron, and ensemble learning methods) were employed to determine dizziness groups.</p><p><strong>Results: </strong>Experimental results present that age, serum albumin, presence of headache, hypertension and diabetes are crucial features to classify vascular vertigo patients.Accuracies range from 81.7% to 86% and the best result is achieved with the logistic regression method. The decision tree, support vector machines, k-nearest neighbor, multilayer perceptron, and ensemble methods reached accuracies of 83%, 85.5%, 84%, 81.7%, and 82.8%, respectively.</p><p><strong>Conclusion: </strong>Our study provides reasonable evidence suggesting that machine learning models may be useful in predicting vascular vertigo cases before hospital admission. Further studies are needed to confirm these findings and improve accuracy.Our model may be beneficial for ambulance personnel, practitioners and for the specialists facing atypical and difficult cases of dizziness.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"63 ","pages":"246-252"},"PeriodicalIF":1.0,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12951507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Childhood Trauma, Dissociation, Attachment and Alexithymia in Patients with Bipolar Affective Disorder.","authors":"Mustafa Kurt, Demet Gülpek","doi":"10.29399/npa.28924","DOIUrl":"10.29399/npa.28924","url":null,"abstract":"<p><strong>Introduction: </strong>Environmental and genetic factors, relationships and experiences established in the early years of life are involved in the etiology of bipolar affective disorder (BAD). The aim was to determine the frequency of childhood traumas, attachment styles, alexithymia and dissociative symptoms in BAD patients, to compare them with the healthy population, and to examine the direct and indirect relationships of childhood traumas with BAD.</p><p><strong>Methods: </strong>The study included 100 patients diagnosed with BAD according to DSM-IV TR diagnostic criteria and who had been euthymic for the last 2 months, and 100 healthy individuals matched for age and gender. The participants were administered the Sociodemographic Data Form, Childhood Trauma Questionnaire, Dissociative Experiences Scale, Toronto Alexithymia Scale, Experiences in Close Relationships Inventory-II, Hamilton Depression Scale and Young Mania Scale.</p><p><strong>Results: </strong>In the BAD group, childhood traumas, insecure attachment types, dissociative symptoms and alexithymia were found to be significantly higher than in healthy individuals. A positive relationship was found between physical abuse, dissociation and alexithymia levels and the number of attacks. Being physically abused was associated with earlier onset of the disease. A positive relationship was found between emotional abuse, physical neglect and total trauma score and dissociation. Trauma types other than sexual abuse were found to be associated with difficulty in recognizing and expressing emotions. It has been found that there is a relationship between emotional abuse and avoidant attachment dimensions. Alexithymia levels were found to be high in patients with early-onset BAD. It has been found that having a family history of psychopathology increases the risk of developing BAD, while externally oriented thinking and marital status protect against the disease.</p><p><strong>Conclusions: </strong>There is a relationship between childhood traumas, attachment types, dissociative and alexithymic characteristics in BAD. Our study reveals that emotional and physical abuse in childhood affects the development of BAD and the course of the disease, and the importance of holistic evaluation of the individual in terms of clinical course and treatment process.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 4","pages":"360-367"},"PeriodicalIF":1.1,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12694786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145745543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma Oxytocin Levels in Body-Focused Repetitive Behavior Disorders and Their Relationship with Disease Severity, Attachment and Emotion Regulation.","authors":"Özlem Nur Akgül, Efruz Pirdoğan Aydın, Kayıhan Oğuz Karamustafalıoğlu, Ömer Akil Özer, Pınar Yılmaz, Erdinç Serin","doi":"10.29399/npa.29025","DOIUrl":"10.29399/npa.29025","url":null,"abstract":"<p><strong>Introduction: </strong>Oxytocin (OXT) is thought to play a role in processes such as social bonding, empathy, and emotional regulation, as well as in the pathophysiology of repetitive/grooming behaviors. The aim of this study is to compare plasma OXT levels in individuals with body-focused repetitive behavior disorder (BFRBD) to those in a healthy control group, and to examine the relationship of OXT with disease severity, emotional regulation, and attachment styles.</p><p><strong>Methods: </strong>This study included 35 patients aged 18-45 diagnosed with BFRBD who visited the psychiatry outpatient clinic, and 35 healthy controls with matched age, gender, and partner-status. Participants were assessed using the Beck depression inventory (BDI), difficulties in emotion regulation scale (DERS-16), experiences in close relationships inventory-II (ECR-II), and Hendrick relationship satisfaction scale (HRSS), and plasma OXT levels were measured.</p><p><strong>Results: </strong>Oxytocin levels in patients with BFRBD were found to be significantly lower than in healthy controls (p<0.001). Patients had higher scores for insecure attachment and difficulties in emotional regulation (p<0.01). Additionally, a negative correlation was observed between the severity of skin-picking behavior and OXT levels (p=0.033).</p><p><strong>Conclusion: </strong>The insufficiency of OXT levels in BFRBD patients and its association with disease severity suggest that OXT may play a role in the psychopathology of BFRBD. Further research is needed to explore the role of OXT and its therapeutic potential in this disorder.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 4","pages":"374-380"},"PeriodicalIF":1.1,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12694811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145745520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender Inequality and Crude Suicide Rates in Türkiye: A Nationwide Retrospective Ecological Study.","authors":"Cennet Yastıbaş Kaçar, İmran Gökçen Yılmaz Karaman, Blanca Bolea Alamanac","doi":"10.29399/npa.28914","DOIUrl":"10.29399/npa.28914","url":null,"abstract":"<p><strong>Introduction: </strong>Suicide is a serious public health problem worldwide, with most suicides occurring in low- and middle-income countries. This nationwide ecological study aimed to explore the relationship between crude suicide rates of the sexes and gender inequality.</p><p><strong>Method: </strong>The data on age and gender-stratified crude suicide rates in all 81 provinces of Türkiye were retracted from the Turkish Statistical Institute database. Gender inequality was measured using Türkiye's provincial-level Gender Equality Index (GEI). Additionally, the following variables were considered gender inequality indicators: early marriages, fertility rate, and marriage/divorce rates; data were obtained from the Turkish Statistical Institute database. Data from 2019 were used to avoid the confounding effect of the COVID-19 pandemic.</p><p><strong>Results: </strong>The associations between gender inequality and crude suicide rate differed between women and men. There was a positive correlation between crude suicide rate and GEI in men aged 45-64 (r=0.294 p<0.01), but no correlations were found in other groups of age and gender. Early marriage rates (r=0.341 p<0.01) and fertility rate (r=0.333 p<0.01) were positively associated with crude suicide rates in women aged 15-44, while divorce/marriage rate (r=-0.256 p<0.05) was negatively related to these rates. Divorce/marriage rate was associated with an increase in men's suicides in both the 45-64 (r=0.452 p<0.01) and 65 and over (r=0.290 p<0.01) age groups.</p><p><strong>Conclusion: </strong>Gender inequality indicators were related to suicide. That relationship may vary across different age and gender groups. The findings may be limited to low- and middle-income countries. Suicide prevention interventions should be designed to account for age group, gender, and cultural characteristics of the place of residence concerning gender.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 4","pages":"348-353"},"PeriodicalIF":1.1,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12694855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145745308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Late-Onset Depression on Brain Activity During an Episodic Memory Task.","authors":"Zeynep Naz Güleç, Melis Ercan, Yiğit Erdoğan, Kaya Oğuz, Aslıhan Uyar, Birce Begüm Burhanoğlu, Özgül Uslu, Mehmet Can Erata, Mehmet Çağdaş Eker, Ali Saffet Gönül","doi":"10.29399/npa.28903","DOIUrl":"10.29399/npa.28903","url":null,"abstract":"<p><strong>Introduction: </strong>Late-onset depression (LOD) has been implicated in irreversible cognitive decline, potentially mirroring early Alzheimer's Disease (AD) pathology. This study aimed to investigate brain activity differences during an episodic memory (EM) task in LOD patients compared to healthy controls (HC).</p><p><strong>Methods: </strong>We recruited 15 LOD patients and 13 HC matched for age and gender. Participants completed a face-name association task during functional magnetic resonance imaging (fMRI) focusing on both the encoding and retrieval phases of EM.</p><p><strong>Results: </strong>The statistical contrast between the groups revealed that the HC group showed increased activity in the left visual association cortex (VAC) and left caudate compared to the LOD group during the encoding task. During the face recognition task, the HC group showed increased activity in the right caudate, and during the name recognition task, they showed increased activity in the right frontal eye field (FEF) compared to the LOD group.</p><p><strong>Conclusion: </strong>The differences observed between the HC and LOD groups in the VAC, caudate, and FEF suggest early changes in maintaining attention, goal-directed learning, EM formation, and coordination of information from storage to retrieval before apparent impairment develops in LOD. Although we did not find statistically significant activations in areas linked to increased vulnerability to AD, our findings of hypoactivation in regions responsible for visual processing and attentional orienting in LOD patients are consistent with hypoactivation patterns observed in AD patients in previous research. These results enhance our understanding of the neural mechanisms underlying memory impairments in LOD and their potential overlap with AD pathology.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 4","pages":"302-309"},"PeriodicalIF":1.1,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12694785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145745541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review and Meta-Analysis of Arterial Spin Labeling Magnetic Resonance Imaging Studies in Psychosis Spectrum Disorders.","authors":"Murat İlhan Atagün, Şükrü Alperen Korkmaz, Ebrar Özden Biçer, Bilgehan Özaydın","doi":"10.29399/npa.29047","DOIUrl":"10.29399/npa.29047","url":null,"abstract":"<p><strong>Introduction: </strong>Alterations in cerebral blood flow (CBF) in subjects with psychosis spectrum disorders (PSD) and clinical high-risk (CHR) states may provide insights into the pathophysiology of these disorders. Arterial spin labeling (ASL) facilitated a more comprehensive examination of CBF in these subjects. This meta-analysis synthesizes findings on CBF in PSDs and CHR states, addressing literature gaps.</p><p><strong>Methods: </strong>A systematic literature search of the PubMed database was performed using a protocol based on the PRISMA statement and the recommendations of the MOOSE group. Studies eligible for inclusion in the review involved: I) individuals with PSD, first-episode psychosis or CHR state, II) had healthy controls for comparison, III) neuroimaging should be performed with MRI using the pseudo-continuous ASL method, IV) resting cerebral blood flow (rCBF) should be recorded. Information related to participants, CBF analyses, and results were systematically extracted.</p><p><strong>Results: </strong>The PubMed search for the meta-analysis identified 69 publications, including 24 articles that met the inclusion criteria for the meta-analysis, representing 491 SSD patients, 185 CHR states, and 554 controls. Studies included rCBFs for the whole brain, gray matter, and striatum. The meta-analysis results indicated that patients with PSD had decreased gray matter rCBF compared to controls (Hedge's g=0.33, 95% CI [0.08, 0.57]), but no difference in the whole brain (Hedge's g=0.09, 95% CI [-0.70, 0.88] and striatum rCBF (Hedge's g=0.38, 95% CI [-0.23, 1.00]). Additionally, subjects with CHR state showed no differences in the striatum rCBF compared to the controls (Hedge's g=-0.15, 95% CI [-0.80, 0.51]).</p><p><strong>Conclusions: </strong>This suggests that although perfusion changes in gray matter are present in PSD, they may not extend to wider brain regions or specific structures such as the striatum. Furthermore, the results imply that rCBF may be differentially regulated in subjects with PSD and CHR. Updated findings highlight hemodynamic correlations in PSD pathophysiology.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 4","pages":"381-389"},"PeriodicalIF":1.1,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12694856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145745254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autism Spectrum Disorder in a Child with Floating-Harbor Syndrome: A Case Report.","authors":"Hüsna Kaan, Murat Coskun","doi":"10.29399/npa.29177","DOIUrl":"10.29399/npa.29177","url":null,"abstract":"<p><strong>Introduction: </strong>The genetic basis of autism spectrum disorder (ASD) is highly heterogeneous and continues to be elucidated through syndromic associations. Floating-Harbor Syndrome (FHS) is a rare genetic disorder caused by SRCAP mutations and is characterized by short stature, expressive language delays, and distinct craniofacial features. This report aims to present the diagnostic process and clinical challenges of a child diagnosed with both FHS and ASD.</p><p><strong>Case: </strong>A 9-year-old boy presented with social communication difficulties, restricted interests, and sensory hypersensitivity. Psychometric testing demonstrated average intellectual functioning (.</p><p><strong>Iq: </strong>94), while behavioral assessments revealed significant hyperactivity and behavioral dysregulation, in addition to severe autism as measured by the Childhood Autism Rating Scale (CARS). Based on DSM-5 criteria, he was diagnosed with ASD. Persistently elevated amylase and lipase levels prompted genetic evaluation, which confirmed FHS with an SRCAP mutation.</p><p><strong>Discussion: </strong>This case underscores the diagnostic challenges of differentiating syndrome-specific features from true comorbid ASD when overlapping symptoms such as language delay and behavioral problems are present. These findings highlight the importance of comprehensive psychiatric and genetic evaluation in children with complex developmental profiles, and highlights the need for systematic screening for neurodevelopmental disorders in rare genetic syndromes.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"63 ","pages":"299-301"},"PeriodicalIF":1.0,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12951514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of Genetic Aetiology in Intellectual Developmental Disorder with Trio-Whole Exome Sequencing Approach.","authors":"Isik Gorker, Engin Atlı, Leyla Bozatlı, Selma Demir, Sinem Yalcıntepe, Emine Ikbal Atlı, Can Kosukcu, Hakan Gurkan","doi":"10.29399/npa.29064","DOIUrl":"10.29399/npa.29064","url":null,"abstract":"<p><strong>Introduction: </strong>Intellectual development disorder (IDD) is a heterogeneous condition, and genetic studies are essential to unravel the underlying cellular pathway for brain development and functioning in its etiology. This study aimed to investigate the possible genetic alterations contributing to IDD by performing next generation sequencing (NGS) in affected individuals and their parents, with a particular focus on the discovery of novel disease-associated genes.</p><p><strong>Methods: </strong>Cases diagnosed with IDD according to DSM-5 criteria, who had normal results in conventional cytogenetic analyses, array comparative genomic hybridization and Fragile X (<i>FMR1</i>) testing, were analyzed by using Trio-Whole Exome Sequencing (Trio-WES). Genomic DNA was extracted, amplicon libraries were generated, and sequencing was conducted on a NGS platform.</p><p><strong>Results: </strong>We detected pathogenic and/or likely pathogenic variations in <i>MANBA, TLK2, NAA15, CSF1R, DRD4, TRIO</i> genes in 5 of 7 cases included in the study. Protein stability prediction analysis were performed for the p.(Arg339Gln) variant in <i>TLK2</i> and p.(Asn1406Ser) variant in TRIO gene. Both variants were predicted to reduce protein stability and classified as \"destabilizing.\"</p><p><strong>Conclusion: </strong>Trio-WES provided a substantial contribution to the molecular diagnosis of IDD. These findings highlight the utility of whole exome sequencing as a powerful tool for uncovering novel disease-associated genes.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"63 ","pages":"73-79"},"PeriodicalIF":1.1,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12849280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146087216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Adaptive Role of Entorhinal Cortical Thickness in Post-COVID 19 Cognitive Impairment.","authors":"Şeyda Çankaya, Lütfiye İpek, Sevilay Ayyıldız, Dila Sayman, Ramazan Karaca, Behçet Ayyıldız, Halil Aziz Velioğlu, Ece Özdemir Öktem, Lütfü Hanoğlu, Burak Yuluğ","doi":"10.29399/npa.28813","DOIUrl":"10.29399/npa.28813","url":null,"abstract":"<p><strong>Introduction: </strong>Only limited information is still available concerning cognitive dysfunctions and cortical thickness in individuals who recovered from mild COVID-19 infections and did not require hospitalization. Our aim was to evaluate if the highly adaptive potential of cortical thickness might play a critical role in COVID-19-related cognitive disorder in a compensatory manner.</p><p><strong>Methods: </strong>Fifteen individuals with no history of medical, neurological, or psychiatric disease and with positive COVID-19 test results, and sixteen healthy age and education-matched healthy controls identified from the official hospital health system were evaluated in terms of cognitive scores using Alzheimer Disease's Assessment Scale-cognitive subscale (ADAS-Cog) and brain MRI cortical thickness measurements using FreeSurfer, Version 7.4.0.</p><p><strong>Results: </strong>An increased cortical thickness in the right entorhinal cortex (EC) and impaired cognition (increased ADAS score) were observed in the post-COVID 19 group as compared to the controls confirmed by the student's t test (respectively, p=0.006, p<0.001).The apparent correlation observed between cognitive impairment and increased entorhinal cortical thickness in our COVID-19 patients might suggest a continuum pathophysiology between healthy and COVID-19 affected brains that was not evident in previous COVID-19 cases with cognitive impairment.</p><p><strong>Conclusion: </strong>Our findings of increased entorhinal cortical thickness, together with impaired cognitive scores, may indicate a flexible role of EC thickness in compensatory mechanisms of cognition.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 4","pages":"310-314"},"PeriodicalIF":1.1,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12694853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145745490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropsychiatric Adverse Effects of Electroconvulsive Therapy: A Retrospective Study.","authors":"Ceyhan Oflezer, Özge Canbek, Zümrüt Ela Arslan Kaşdoğan, Hasan Gökçay, Yusuf Besim Sıkar, Melih Avcı, Zeynep Defne Gürbüz","doi":"10.29399/npa.29050","DOIUrl":"10.29399/npa.29050","url":null,"abstract":"<p><strong>Introduction: </strong>Electroconvulsive therapy (ECT) is an important treatment modality in psychiatry. Despite the efficacy of ECT, its use worldwide is less than expected. Although limited access and stigma are the main factors contributing to this controversy, cognitive side effects are an important issue for clinicians who administer ECT. The present study aims to provide an assessment of the frequency of neuropsychiatric adverse effects associated with ECT.</p><p><strong>Methods: </strong>A retrospective evaluation of 2935 files of patients who underwent ECT between January 1, 2013 and December 31, 2017 was performed. Specific data obtained from patient records, such as sociodemographic characteristics, Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition diagnoses, scale scores, medical evaluations, length of hospital stay, previous ECT history and indications for ECT administration, stimulus parameters, seizure duration, and neuropsychiatric adverse effects were evaluated.</p><p><strong>Results: </strong>A significant proportion of patients experienced no neuropsychiatric adverse effects across multiple sessions, with the proportion increasing steadily from 70.7% after one session to 97.3% after ten sessions. Additionally, the group that showed neuropsychiatric adverse effects underwent a significantly higher number of previous ECT sessions (p<0.001), longer duration of hospitalization after the last ECT session (p<0.001), and overall duration of hospitalization (p<0.001).</p><p><strong>Conclusion: </strong>The fact that the majority of patients in this study did not experience any neuropsychiatric adverse effects during more than one ECT session and that the frequency of adverse effects decreased as ECT sessions progressed may contribute clinicians to approach ECT application more confidently.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 4","pages":"333-340"},"PeriodicalIF":1.0,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12694784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145745537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}