Noropsikiyatri Arsivi-Archives of Neuropsychiatry最新文献

{"title":"Posttraumatic Stress, Posttraumatic Growth, and Heart Rate Variability Among Breast Cancer Survivors.","authors":"İmran Gökçen Yılmaz Karaman, Cennet Yastıbaş Kaçar, Gülay Dirik, İremnur Ersan, Nazan Demir, Gurbet Özge Mert","doi":"10.29399/npa.28713","DOIUrl":"10.29399/npa.28713","url":null,"abstract":"<p><strong>Introduction: </strong>Breast cancer as a life-threatening disease is the most frequent malignant disease among women all over the world. Resulting in post-traumatic stress disorder (PTSD) symptoms, breast cancer may also be related to positive changes like post-traumatic growth (PTG). The present study aims to evaluate heart rate variability (HRV) parameters among female survivors of breast cancer regarding its relationship with PTSD and PTG.</p><p><strong>Method: </strong>Forty-three women with stage 1-2-3 breast cancer were recruited. Heart rate variability parameters were measured with a 24-hour ECG. Post-traumatic stress disorder checklist for DSM-5 (PCL-5) and Post-traumatic Growth Inventory (PTGI) were utilized to measure PTSD and PTG.</p><p><strong>Results: </strong>The mean value of PCL-5 was 49.56; the mean value of PTGI was 71.56. Correlation analysis showed that PCL-5 was associated with SDNN (r=-0.310, p=0.043), LF (r=-0.349 p=0.022), and mean heart rate (r=0.396 p=0.009). Post-traumatic growth inventory scores were associated with LF/HF ratio (r=0.310 p=0.043). Linear regression analysis demonstrated that PCL-5 and PTGI scores predicted SDNN and mean heart rate.</p><p><strong>Conclusion: </strong>PTSD and PTG symptoms are related to HRV parameters among female survivors of breast cancer. While PTSD symptoms are related to lower HRV and higher mean heart rate, PTG symptoms are associated with higher HRV and lower mean heart rate.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 2","pages":"150-155"},"PeriodicalIF":1.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-Analysis of the Effect of Blonanserin in Treating Patients with Schizophrenia.","authors":"Bo Shi, Zhirong Yang, Yixia Zhu, Chaoming Jiang, Dawu Yuan, Jin Zhang","doi":"10.29399/npa.28774","DOIUrl":"10.29399/npa.28774","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to investigate the efficacy and safety of blonanserin in patients with schizophrenia.</p><p><strong>Methods: </strong>Electronic databases (PubMed, Web of Science, Cochrane Library, Embase) were searched. Studies evaluating the efficacy and safety of blonanserin in treating schizophrenia were inclued. The combined effect sizes were calculated using relative risk (RR), risk difference (RD) or mean difference (MD).</p><p><strong>Results: </strong>Overall, 13 prospective studies involving 2,479 patients with schizophrenia were summarised and analysed. We selected five commonly used antipsychotic drugs, namely haloperidol, risperidone, olanzapine, paliperidone and aripiprazole. The meta-analysis showed that compared with a placebo, blonanserin significantly improved the Positive and Negative Syndrome Scale (PANSS) total scores (MD:-7.91; 95% confidence interval [CI]:-15.56, -0.26) and positive scores (MD:-2.48; 95% CI:-4.79, -0.18), and it was comparable with other Antipsychotic drugs regarding PANSS total scores, positive scores and general psychopathology scores. Additionally, the difference between blonanserin and haloperidol (MD:-0.75; 95% CI:-1.00, -0.50) on PANSS negative score changes was statistically significant. At the same time, the safety analysis revealed that compared with risperidone, blonanserin was associated with a lower risk of increased blood prolactin (RR:0.66; 95% CI: 0.51, 0.86), hyperprolactinemia (RR: 0.30; 95% CI: 0.11, 0.78) and weight gain (RD: -0.04; 95% CI: -0.07, -0.01) as well as a higher risk of akathisia (RD: 0.10; 95% CI: 0.04, 0.17). Moreover, it exhibited side-effects similar to those of other antipsychotic drugs regarding constipation, dizziness, headache, insomnia, muscle rigidity and hypersalivation.</p><p><strong>Conclusion: </strong>Blonanserin is effective and safe in the treatment of schizophrenia, which is beneficial for guiding the clinical practice of schizophrenia treatment. However, more high-quality studies are needed in the future to validate its effect.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 2","pages":"195-204"},"PeriodicalIF":1.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric case of Kelch-like protein 11 (KLHL11) encephalitis with long-term follow-up: pitfalls in diagnosis of pediatric autoimmune encephalitis.","authors":"Elif Şanlı, Maria Pechlivanidou, Hakkı Akbeyaz, Merve Savaş, Gülnur Takış, John Tzartos, Onur Tuğçe Poyraz Fındık, Erdem Tüzün, Dilşad Türkdoğan","doi":"10.29399/npa.28870","DOIUrl":"10.29399/npa.28870","url":null,"abstract":"","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 2","pages":"97-99"},"PeriodicalIF":1.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Turkish Validity and Reliability of Multidimensional Assessment of Interoceptive Awareness in Youth.","authors":"Merve Onat, Dilek Konuksever, Hanife Avcı, Bahri Erdi Tanış, Esra Çöp, Gülser Şenses Dinç, Eda Özaydın","doi":"10.29399/npa.28855","DOIUrl":"10.29399/npa.28855","url":null,"abstract":"<p><strong>Introduction: </strong>Interoceptive awareness is defined as the processing of internal bodily signals and one's tendency to perceive these signals. In our study, it is aimed to conduct Turkish adaptation, reliability, and validity analysis of the Multidimensional Assessment of Interoceptive Awareness in Youth (MAIA-Y).</p><p><strong>Methods: </strong>275 young people between the ages of 11-17 participated in our study. Confirmatory factor analysis (CFA) was applied to confirm the factor structure of the Turkish version of MAIA-Y (MAIA-YT). Divergent validity was evaluated with Pearson correlation matrix plot. Internal consistency was determined using the \"Cronbach's alpha\" value. Paired sample t test or Wilcoxon test, Spearman's Correlation Coefficient, Intraclass Correlation Coefficient (ICC) value and Bland-Altman graphical approach were used to evaluate test-retest reliability. The significance value was set at a p-value of <0.05.</p><p><strong>Results: </strong>In our study, the fit measures are determined as χ²/df=1.612, CFI=0.898, GFI=0.869, TLI=0.882, IFI=0.901 and RMSEA=0.047, according to CFA. In accordance with the Pearson correlation matrix plot, there is a negative relationship between MAIA-YT subscales and State-Trait Anxiety Inventory for Children. The Cronbach's alpha coefficients for internal consistency were found to be between 0.303-0.792 for the subscales of MAIA-YT and 0.793 for the whole scale, and in general the MAIA-YT was found to have reliable internal consistency. Intraclass correlation coefficients for test-retest reliability were found between 0.515-0.731. According to the Bland Altman graphs, the agreement between the test-retest results was found to be at a reliable level.</p><p><strong>Conclusion: </strong>The MAIA-YT is a valid and reliable instrument for evaluation of interoceptive awareness in Turkish adolescents.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 2","pages":"164-171"},"PeriodicalIF":1.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Psychological Resilience on Treatment Compliance and Functionality in Patients with Bipolar Disorder.","authors":"Mehmet Baltacıoğlu, Meltem Puşuroğlu","doi":"10.29399/npa.28766","DOIUrl":"10.29399/npa.28766","url":null,"abstract":"<p><strong>Introduction: </strong>Bipolar disorder (BD) is a serious psychiatric disorder that is common worldwide, and it is characterized by depressive and manic or hypomanic episodes. This study aimed to investigate the effect of psychological resilience on treatment adherence and functionality in patients diagnosed with BD.</p><p><strong>Methods: </strong>The sample of the study consisted of a total of 111 patients, 56 women and 55 men, who were followed up with a diagnosis of BD. A Sociodemographic and Clinical Characteristics Form, the Young Mania Rating Scale (YMRS), the Hamilton Depression Rating Scale (HDRS), the Resilience Scale for Adults (RSA), the Functioning Assessment Short Test (FAST), and the Morisky Medication Adherence Scale (MMAS) were used as data collection tools.</p><p><strong>Results: </strong>A significant negative relationship was found between the RSA scores and FAST scores of the patients (r_s=-0.762; p<0.001). It was observed that resilience predicted functionality and treatment adherence. It was determined that each 1-unit increase in RSA scores caused a 0.021unit decrease in functionality scores (p<0.001). It was observed that each 1-unit increase in RSA total scores increased the probability of good treatment adherence by 1.336 times (p<0.001).</p><p><strong>Conclusion: </strong>In our study, it was observed that high psychological resilience had positive effects on functionality and treatment adherence in patients with BD.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 2","pages":"136-144"},"PeriodicalIF":1.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrinsic Functional Connectivity Patterns of The Object-Selective Visual Areas.","authors":"Ulaş Ay, Tamer Demiralp","doi":"10.29399/npa.28795","DOIUrl":"10.29399/npa.28795","url":null,"abstract":"<p><strong>Introduction: </strong>It has been shown by numerous investigations that the occipitotemporal area has a particular object perception area called the lateral occipital complex, which is composed of lateral occipital (LO) and posterior fusiform (pF) cortices. The aim of this study is to examine the intrinsic functional connectivity (iFC) patterns of the object-selective LO and pF regions in order to shed light on the underlying neural mechanisms of object recognition.</p><p><strong>Methods: </strong>15 healthy participants were included in the study. A standard localizer task was used to identify LO and pF regions. Magnetic resonance imaging (MRI) data were collected using two different imaging protocols: high-resolution anatomical image and functional MRI (fMRI) data. Data preprocessing steps were carried out in accordance with standard procedures. After determining the LO and pF regions with activation analyses on the task-based fMRI data, the iFCs of these regions were investigated with functional connectivity analyses carried out on the resting-state fMRI recording.</p><p><strong>Results: </strong>iFC analyzes revealed that LO and pF regions have different connectivity patterns. Lateral occipital had a widely distributed connectivity network, whereas pF showed a more localized connectivity pattern. Lateral occipital had more extensive occipitotemporal, occipitoparietal and motor connections compared to pF. In contrast to this distribution pattern, the connections of the right and left LO were generally concentrated on the ipsilateral sides, while the connections of the pF were bilateral.</p><p><strong>Conclusion: </strong>The results of the study revealed complex iFC patterns of the LO and pF differentiating their functional roles in object perception/recognition. While the pF revealed bilaterally distributed iFC along the ventral visual stream, the extensive and lateralized iFC of the LO suggests its role in integrating visual information including object-related attention and action recognition.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 2","pages":"100-108"},"PeriodicalIF":1.0,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Distal Hereditary Motor Neuropathy with HSPB1 Mutation in Coexistence with Myotonia and Myopathy.","authors":"Handan Uzunçakmak-Uyanık, Ersin Tan, Çağrı Mesut Temuçin","doi":"10.29399/npa.28654","DOIUrl":"10.29399/npa.28654","url":null,"abstract":"<p><p>Distal hereditary motor neuropathies (dHMNs), also named as distal spinal muscular atrophy, are a group of disorders that cause degeneration of motor nerves. Currently, only 15% to 32.5% of patients with dHMN have been genetically identified. The most common cause of dHMNs gene mutations is HSPB1 mutation. In HSPB1 mutation, which is also one of the myopathogens via satellite cell pathology, dHMNS may coexist with neuromuscular junction disorder, motor neuron disease, satellite cell dysfunction and therefore myopathic findings. No case of myopathy and myotonia with HSPB1 mutation has been reported in the literature yet. We present a case with electrophysiologic findings in HSPB1 mutation by discussing the possible mechanisms underlying myotonic discharges and myopathic findings.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 2","pages":"205-206"},"PeriodicalIF":1.0,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating The Brain Regions Related to Early Onset Psychosis: A Voxel-Based Morphometry Study Considering The Effect of Hereditary Burden and Environmental Risk Factors.","authors":"Mehmet Can Erata, Damla Kasap Üstündağ, Elif Yerlikaya Oral, Özgül Uslu, Yiğit Erdoğan, Ayşegül Tonyalı, Gül Karaçetin, Ali Saffet Gönül","doi":"10.29399/npa.28885","DOIUrl":"10.29399/npa.28885","url":null,"abstract":"<p><strong>Introduction: </strong>Schizophrenia is both a neurodevelopmental and neurodegenerative disorder that manifests a complex spectrum of symptoms, significantly impacting mental health. In early-onset psychosis, similar to adult studies, neuroimaging focuses on ventral prefrontal cortical areas and posterior temporoparietal regions, crucial for understanding the neurodevelopmental mechanisms of these conditions in such drug-naive patients. This enables magnetic resonance imaging to be acquired before significant neurodegenerative changes occur, in contrast to chronic schizophrenia cases. Therefore, our study helps advance understanding of disease mechanisms in this patient population.</p><p><strong>Methods: </strong>We recruited forty-one subjects (17 females, 24 males; mean age=16 years; age range: 12-17 years) who were diagnosed with first-episode psychosis (FEP). We examined the relationship between gene and environmental risk scores (GERS) and whole-brain gray matter (GM) volumes through voxel-based morphometry (VBM).</p><p><strong>Results: </strong>We found a positive correlation between GM volumes of the left medial frontal gyrus, right anterior prefrontal cortex, left superior frontal gyrus, left operculum of the inferior frontal gyrus, left superior parietal lobe, and left supramarginal gyrus with the GERS. We found a negative correlation between GM volumes of the left superior frontal gyrus, left cerebellum, and the GERS.</p><p><strong>Conclusion: </strong>Our findings contribute to the understanding of structural abnormalities associated with schizophrenia, aligning with existing literature highlighting GM changes in frontal, parietal, and temporal cortices, as well as limbic structures. Our study underscores the importance of integrating structural and functional neuroimaging approaches to elucidate the pathophysiology of early-onset schizophrenia, emphasizing regions like the dorsolateral prefrontal cortex, ventrolateral prefrontal cortex, and posterior parietal areas.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 3","pages":"209-215"},"PeriodicalIF":1.1,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12424451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145066516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parietal Cortex Volume and Functions in Major Depression and Bipolar Disorder: A Cloud-Based Magnetic Resonans Imaging Study.","authors":"Fatma Kiliç, Fatma Kartal, Mehmet Fatih Erbay, Rıfat Karlidağ","doi":"10.29399/npa.28253","DOIUrl":"10.29399/npa.28253","url":null,"abstract":"<p><strong>Introduction: </strong>The present study aimed to compare the Parietal Lobe (PL) volumes and Cancellation Test (CT) performances of euthymic patients with Bipolar Disorder-1 (BD) and Major Depressive Disorder (MDD), and healthy controls.</p><p><strong>Methods: </strong>The present study included 63 participants in three groups; two patient groups in remission involving patients with BD and MDD diagnosed according to DSM-5 and a control group with healthy individuals. Sociodemographic Data Form, CT, and Hand Preference Questionnaire were applied to all participants. Participant PL volumes were measured with the Cloud-Based Brain Magnetic Resonance Image Segmentation - Parcellation System.</p><p><strong>Results: </strong>Both patient groups exhibited lower PL volume when compared to the control group, and there was no difference between the patient groups based on PL volume. It was determined that MDD and BB patients scored less in the CT when compared to the control group. There was a weak correlation between right and left PL volumes and CT performances.</p><p><strong>Conclusion: </strong>The present study findings demonstrated that BD and MDD patients in remission exhibited lower PL volume and CT performance when compared to healthy controls, emphasizing that PL could be structurally and functionally significant in the pathophysiology of mood disorders.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"14 1","pages":"47-54"},"PeriodicalIF":1.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10943943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85241498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autoimmune Etiologies with The Potential to Transform Psychiatric Practice: Experiences from a Neuropsychiatry Unit.","authors":"Rifat Serav İlhan, Berker Duman","doi":"10.29399/npa.29053","DOIUrl":"10.29399/npa.29053","url":null,"abstract":"","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 1","pages":"1-2"},"PeriodicalIF":1.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11877387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}