{"title":"Subclinical Trigeminal Dysfunction in Multiple Sclerosis Detected by Pulp Sensibility Testing.","authors":"Kadriye Demirkaya, Meryem Tuba Sönmez, Duygu Arslan Mehdiyev, Neslihan Demir, Şeref Demirkaya","doi":"10.29399/npa.29369","DOIUrl":"10.29399/npa.29369","url":null,"abstract":"<p><strong>Introduction: </strong>Trigeminal involvement in multiple sclerosis (MS) may remain clinically silent despite measurable functional disturbance. Subclinical dysfunction of afferent pathways can precede overt neurological findings. We aimed to investigate whether pulp sensibility testing can detect subclinical trigeminal afferent dysfunction in patients with MS who have no clinical evidence of trigeminal neuropathy.</p><p><strong>Methods: </strong>Thirty-nine patients with MS (19 relapsing-remitting and 20 progressive) and 27 healthy controls were included. Electric pulp testing (EPT) and cold stimulation were applied to the right maxillary central incisor in all participants. For EPT, sensory threshold values were recorded. For the cold test, response latency was measured in seconds. Correlation analyses were performed to assess associations with age and disease duration.</p><p><strong>Results: </strong>Compared with controls, patients with MS demonstrated higher EPT thresholds and prolonged cold response times. Within the MS cohort, both measures were greater in progressive disease. The difference reached statistical significance for cold testing (7.15±3.60 vs 4.89±2.58 s, p=0.038), whereas EPT values showed a similar but non-significant trend (9.80±4.15 vs 7.84±4.59, p=0.084). Age correlated weakly with cold response latency (r<sub>s</sub>=0.321, p=0.046) and EPT values (r<sub>s</sub>=0.326, p=0.043). Disease duration showed a weak correlation with EPT (r<sub>s</sub>=0.334, p=0.037), but not with cold responses.</p><p><strong>Conclusion: </strong>Despite the limitations of our study, our results indicate that pulp sensibility testing may provide meaningful information regarding the functional status of trigeminal afferent pathways. The more pronounced alterations observed in the progressive disease subgroup are consistent with cumulative conduction disturbance along the trigeminal system. Further studies directly comparing this approach with trigeminal SEP and high-resolution brainstem MRI are needed to better define its diagnostic value and clinical relevance.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"63 ","pages":"474-478"},"PeriodicalIF":1.0,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13358925/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148438805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Deniz Çınaroğlu, İzgü Başbekleyen, Osman Sezer Çınaroğlu, Esra Başkurt, Zeynep Tanrıverdi, Cihat Uzunköprü, Yeşim Beckmann
{"title":"Effects of Stroke Awareness on Onset-to-Hospital Time and Healthcare Costs in Acute Ischemic Stroke: A Cross-Sectional Study.","authors":"Deniz Çınaroğlu, İzgü Başbekleyen, Osman Sezer Çınaroğlu, Esra Başkurt, Zeynep Tanrıverdi, Cihat Uzunköprü, Yeşim Beckmann","doi":"10.29399/npa.29207","DOIUrl":"10.29399/npa.29207","url":null,"abstract":"<p><strong>Introduction: </strong>Early diagnosis and treatment are essential for the effective treatment of ischemic stroke. The objective of this study was to assess the effect of stroke knowledge among patients and caregivers on hospital arrival, clinical outcomes, and healthcare costs.</p><p><strong>Methods: </strong>This is a cross-sectional study of 219 patients with ischemic stroke and their family members. Awareness of stroke was measured using a structured questionnaire, and the participants were divided into two groups: those with a high level of awareness of stroke and those with a low level of awareness of stroke. The primary outcome measures were time to hospital arrival, modified Rankin Scale (mRS) scores at 1 and 3 months, and the total treatment cost within 3 months.</p><p><strong>Results: </strong>Patients in the high-awareness group presented to the hospital much earlier (58±21.8 min vs. 185±40.3 min, p=0.001), displayed better functional outcome at 1 month (mRS: 1.64 vs. 2.19, p=0.01) and at 3 months (mRS: 1.52 vs. 1.95, p=0.01) and lower treatment costs ($998 vs. $1679, p=0.001). Interestingly, calling the emergency service as a first response was associated with significantly lower costs. On the other hand, low awareness was associated with delayed intervention, worse clinical outcomes, and greater economic strain.</p><p><strong>Conclusion: </strong>A better understanding of the signs of a stroke by patients and their caregivers leads to faster treatment, improved recovery, and lower costs. Stroke awareness can be enhanced through public health efforts, potentially leading to a significant reduction in the clinical and economic burden of stroke.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"63 ","pages":"328-332"},"PeriodicalIF":1.0,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13065084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147678510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Therapeutic Spectrum of Intermittent Apomorphine in Parkinson's Disease: Neuropsychiatric, Behavioral, and Cognitive Analyses.","authors":"Esra Demir Ünal","doi":"10.29399/npa.29252","DOIUrl":"10.29399/npa.29252","url":null,"abstract":"<p><strong>Introduction: </strong>Intermittent subcutaneous (SC) apomorphine is a fast-acting dopamine agonist used in the management of motor fluctuations in advanced Parkinson's disease (PD). While its motor benefits are well established the effects on non-motor domains and the modifying role of chronological age remain less certain. This prospective observational study aimed to evaluate the effectiveness of intermittent SC apomorphine on motor and non-motor outcomes in idiopathic PD patients with persistent motor fluctuations despite optimized oral therapy, and to examine whether age influenced therapeutic response.</p><p><strong>Methods: </strong>Thirty-five idiopathic PD patients treated with intermittent SC apomorphine were followed for twelve weeks and assessed at baseline and week 12. Motor outcomes included Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part III and diary-based daily \"off\" and \"on\" time without dyskinesia. Non-motor outcomes comprised the Montreal Cognitive Assessment (MoCA), Beck Depression Inventory (BDI), Parkinson's Disease Questionnaire (PDQ-8), and Parkinson's Disease Sleep Scale (PDSS). Subgroup analyses compared outcomes between patients aged <45 and ≥45 years and interaction effects were explored.</p><p><strong>Results: </strong>MDS-UPDRS Part III scores improved from 45.71 (SD 11.93) to 29.86 (SD 12.24) (p <0.001). Mean daily \"off\" time decreased from 5.60 (1.65) to 2.26 (0.95) hours, while \"on\" time without dyskinesia raise from 10.34 (1.76) to 13.89 (0.93) hours (both p <0.001). Non-motor outcomes also improved: BDI declined from 23.03 (5.70) to 18.09 (4.87), MoCA increased from 15.74 (5.51) to 18.03 (6.05), and PDQ-8 from 22.80 (5.60) to 17.54 (5.84) (all p <0.001). Parkinson's disease sleep scale showed no significant change. No significant age-by-treatment interaction effects were detected.</p><p><strong>Conclusion: </strong>Intermittent subcutaneous apomorphine was associated with significant improvements in multidimensional aspects, including motor and various non-motor domains, which are closely related to cognition, mood, and quality of life in PD. Benefits were consistent across age groups, indicating chronological age does not influence efficacy.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"63 ","pages":"333-340"},"PeriodicalIF":1.0,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13065100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147678493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pembrolizumab Experience in a Patient with Progressive Multifocal Leukoencephalopathy Following Multiple Myeloma Treatment: A Case Report and Literature Review.","authors":"Meryem Senem Yıldız, Eshgin Maharramov, Fatma Gökçem Yıldız, Ersin Tan, Nazire Pınar Acar Özen, Rahşan Göçmen, Aslı Tuncer","doi":"10.29399/npa.29259","DOIUrl":"10.29399/npa.29259","url":null,"abstract":"<p><strong>Introduction: </strong>Progressive multifocal leukoencephalopathy (PML) is a progressive demyelinating infection of the central nervous system. PML arises in immunosuppressive conditions or circumstances necessitating immunosuppressive treatment, such as malignancies. Recently, data have been published regarding the use of different immune checkpoint inhibitors (ICIs) for the treatment of PML. However, the extent to which ICIs impact and improve PML in individual patients remains uncertain.</p><p><strong>Case: </strong>A 68-year-old female patient, diagnosed with multiple myeloma in 2012 and with a history of using various chemotherapeutic agents, presented with dizziness, gait disturbances, and speech difficulties. The patient was diagnosed with PML and started on pembrolizumab treatment. This treatment led to improvements in both clinical symptoms and imaging findings.</p><p><strong>Conclusion: </strong>Regardless of the underlying cause in PML, the use of ICIs can improve the clinical course of the disease and prolong the patient's lifespan.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"63 ","pages":"350-353"},"PeriodicalIF":1.0,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13065086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147678492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of Gender on Risk Factors and Stroke Etiology in Young Ischemic Stroke Patients: A Retrospective Observational Study.","authors":"Yasemin Akıncı, Gregory Anash, Derya Uludüz, Fatma Birsen İnce, Mehmet Baki Göksan","doi":"10.29399/npa.29246","DOIUrl":"10.29399/npa.29246","url":null,"abstract":"<p><strong>Introduction: </strong>The lack of clarity regarding the upper age limit for defining ischemic stroke in young individuals, and the absence of a gender-based distinction, make it difficult to determine the true incidence of stroke in young people and to standardize the approach to elucidating its etiology. This study aimed to examine the risk factors and etiology of ischemic stroke in young individuals, as well as to evaluate their distribution by gender.</p><p><strong>Methods: </strong>This retrospective, observational, single-center study evaluated stroke risk factors and etiologies in 200 patients aged 18-55 diagnosed with ischemic stroke, and their distribution among male and female patients.</p><p><strong>Results: </strong>The mean age was higher in males, who accounted for 58.5% of the patients. Smoking, alcohol use, and coronary artery disease (CAD) were more common in men, while anemia, migraine, and oral contraceptive use were more common in women. The most common etiological subgroup was stroke of other determined etiology (SODE) which was more common in women. Small vessel occlusion (SVO) was more common in men. In women, the mean ages of etiological subgroups were similar, but in men, the large artery atherosclerosis (LAA) group had a significantly higher mean age than the stroke of undetermined etiology and SODE groups.</p><p><strong>Conclusion: </strong>Risk factors and etiology showed significant differences by gender. The proportion of etiological subgroups is consistent with earlier studies where the upper age limit was lower, suggesting that 55 years of age may be an appropriate upper age limit for young stroke. However, the finding that SVO and CAD, in which classical vascular risk factors play a major role, were more frequent in men, and that the mean age of men with LAA was older than that of men in other subgroups, indicates that the upper age limit for young stroke should most likely be lower in men.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"63 ","pages":"368-374"},"PeriodicalIF":1.0,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13065092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147678523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Binnur Karabıyık, Özge Şahmelikoğlu Onur, Nesrin Karamustafalıoğlu
{"title":"Binge Eating Disorder in Bipolar I Disorder: Prevalence, Childhood Trauma, and Clinical Correlates.","authors":"Binnur Karabıyık, Özge Şahmelikoğlu Onur, Nesrin Karamustafalıoğlu","doi":"10.29399/npa.29253","DOIUrl":"10.29399/npa.29253","url":null,"abstract":"<p><strong>Introduction: </strong>Bipolar I disorder (BD-I) frequently co-occurs with eating disorders, particularly binge eating disorder (BED), which may adversely affect the clinical course, including recurrence risk and functional impairment. Research exploring the specific association between BED and childhood trauma (CT) in BD-I remains limited. This study aimed to investigate the prevalence of BED among euthymic BD-I patients and to examine its associations with CT and clinical characteristics.</p><p><strong>Methods: </strong>This cross-sectional study recruited 150 euthymic BD-I patients diagnosed according to DSM-5 criteria. Sociodemographic data, illness-related variables, psychiatric comorbidities, and medication use were collected. Binge eating disorder was assessed through the Structured Clinical Interview for DSM-5 (SCID-5) and validated eating disorder scales. Childhood trauma was evaluated using the Childhood Trauma Questionnaire (CTQ). Statistical analyses included group comparisons and multivariate logistic regression.</p><p><strong>Results: </strong>Binge eating disorder prevalence in the sample was 19.3%. Female sex, higher body weight, and elevated body mass index were significantly associated with BED. Compared to patients without BED, those with BED reported higher rates of psychotic episodes, rapid cycling, and suicide attempts. Childhood trauma questionnaire total scores, particularly physical abuse subscale scores, were significantly higher in the BED group. Logistic regression analysis revealed that female sex, a history of physical abuse, and higher eating disorder scale scores were independent predictors of BED.</p><p><strong>Conclusions: </strong>Our findings indicate that BED constitutes a distinct and clinically consequential profile in euthymic BD-I patients, one that is strongly shaped by both increased illness severity and CT. This relationship underlines the necessity of integrating systematic assessments of eating pathology and trauma exposure into the standard clinical evaluation of BD-I patients to ensure timely recognition and the delivery of effective, precision-based therapeutic interventions.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"63 ","pages":"380-386"},"PeriodicalIF":1.0,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13065102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147678501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Muhammed Furkan Erbay, Ali Karayağmurlu, Pınar Karan, Nusret Soylu
{"title":"Post-Traumatic Stress Disorder in Residential Care After an Earthquake: A Follow-Up Study.","authors":"Muhammed Furkan Erbay, Ali Karayağmurlu, Pınar Karan, Nusret Soylu","doi":"10.29399/npa.29175","DOIUrl":"10.29399/npa.29175","url":null,"abstract":"<p><strong>Introduction: </strong>Earthquakes are frequent and devastating disasters, causing significant physical and psychiatric consequences, particularly posttraumatic stress disorder (PTSD). To the authors' knowledge, this study is the first to investigate PTSD in adolescents raised in residential care after a natural disaster.</p><p><strong>Methods: </strong>48 adolescents in residential care and 54 living with families, aged 12-18 years, participated. Initial interviews were conducted one month after the earthquake, with follow-ups at three months. Assessment tools included the Childhood Trauma Questionnaire (CTQ), Children's PTSD Reaction Index, and Schedule for Affective Disorders and Schizophrenia for School-Age Children.</p><p><strong>Results: </strong>Posttraumatic stress disorder severity significantly decreased in family-raised adolescents (t=3.986, p <0.001), but no change was seen in residential care adolescents (t=0.584, p=0.563). Comorbid psychiatric disorders were less frequent in family-raised adolescents (χ²=18.785, p=0.001). While no significant difference in total CTQ scores was found (z=-0.417, p=0.677), subscales showed significant differences between two groups. A backward binary logistic regression analysis revealed that lower levels of physical neglect were a statistically significant predictor of PTSD (p=0.024). Although not reaching statistical significance, increased sexual abuse (p=0.075) emerged as a relevant predictor of PTSD.</p><p><strong>Conclusion: </strong>Adolescents in residential care had more persistent PTSD symptoms, greater childhood adversity, and higher psychiatric comorbidities than those in family care. Decrement in physical neglect and increased sexual abuse were PTSD predictors, although only the former reached statistical significance. Further research with larger samples and longer follow-ups is needed.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"63 ","pages":"321-327"},"PeriodicalIF":1.0,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13065101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147678548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
İlker Güneysu, Burcu Eser, Sare Aydın, Figen Ünal Demir
{"title":"The Role of Metacognitive Processes in Personality Traits: A Dimensional Perspective Based on the DSM-5 Alternative Model.","authors":"İlker Güneysu, Burcu Eser, Sare Aydın, Figen Ünal Demir","doi":"10.29399/npa.29257","DOIUrl":"10.29399/npa.29257","url":null,"abstract":"<p><strong>Introduction: </strong>This study examined the relationships between maladaptive personality traits, as conceptualized within the DSM-5 Alternative Model for Personality Disorders (AMPD), and metacognitive processes in a non-clinical adult sample.</p><p><strong>Methods: </strong>The sample consisted of 275 adults aged 18-65 years recruited from non-psychiatric outpatient clinics. Participants completed the Personality Inventory for DSM-5, the Metacognitions Questionnaire-30, the Metacognitive Strategies subscale of the Cognitive Attentional Syndrome-1 questionnaire, the Patient Health Questionnaire-9, and the Generalized Anxiety Disorder-7. Pearson correlation analyses were conducted to examine associations between variables, and hierarchical multiple regression analyses were used to evaluate the relationships between metacognitive factors and personality traits while accounting for depression and anxiety symptoms.</p><p><strong>Results: </strong>Correlation analyses revealed significant associations between maladaptive personality traits and metacognitive variables, with distinct patterns observed across different personality dimensions. Regression analyses showed that several metacognitive factors remained significantly related to specific personality traits after controlling for depression and anxiety. In particular, the Need to Control Thoughts was associated with Antagonism, Disinhibition, and Psychoticism, whereas beliefs regarding the uncontrollability and danger of worry and metacognitive coping strategies were related to Negative Affectivity. Metacognitive factors showed limited associations with Detachment.</p><p><strong>Conclusion: </strong>The findings suggest that metacognitive processes are meaningfully related to maladaptive personality traits and that these associations extend beyond general emotional distress. Metacognitive characteristics, particularly those involving attempts to regulate and control internal experiences, may represent relevant processes for understanding personality-related difficulties.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"63 ","pages":"361-367"},"PeriodicalIF":1.0,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13065099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147678490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nilüfer Akgün Ünal, Elif Türkdönmez Ak, Ömer Ünal, Erdal Ağar, Mustafa Ayyıldız
{"title":"Sex-Dependent Effects of Rivastigmine on Melatonin Receptors in Middle-Aged Rats.","authors":"Nilüfer Akgün Ünal, Elif Türkdönmez Ak, Ömer Ünal, Erdal Ağar, Mustafa Ayyıldız","doi":"10.29399/npa.29283","DOIUrl":"10.29399/npa.29283","url":null,"abstract":"<p><strong>Introduction: </strong>Melatonin (5-methoxy-N-acetyltryptamine) is closely linked to the body's natural circadian rhythm. Dementia is significantly more common among older individuals. Rivastigmine (RIVA) functions as a reversible inhibitor of acetylcholinesterase and butyrylcholinesterase, prescribed to help alleviate the symptoms of dementia. The mechanism behind RIVA's neuroendocrine interactions remains unclear despite its efficacy in treating specific symptoms. Our research aimed to investigate the effects of RIVA on memory, anxiety, and the expression of melatonin receptor genes MT1 and MT2 in middle-aged, 13-month-old male and female rats.</p><p><strong>Methods: </strong>Rats were administered intraperitoneal injections of 2 mg/kg RIVA or saline once a day for ten days in succession. Twenty-four hours after the final injection, rats underwent the Y-maze and elevated plus maze tests, after which tissue samples were collected for qPCR analysis.</p><p><strong>Results: </strong>Behavioral tests revealed sex-specific responses; elevated plus maze test results indicated that RIVA did not alter exploratory behavior in female rats but decreased it in male rats compared to controls. At the same time, RIVA treatment resulted in significant decreases of MT1 and MT2 gene expression in the hippocampus of both sexes, but cortical expression showed different patterns in males and system.</p><p><strong>Conclusion: </strong>RIVA treatment in middle-aged rats may cause changes in MT1 and MT2 gene expression concomitant with behavioral alterations. The variation in melatonin receptor expression across sexes indicates a potential sex-dependent impact in aging populations, suggesting an interaction between cholinergic and melatonergic systems.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"63 ","pages":"354-360"},"PeriodicalIF":1.0,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13065091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147678552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Validity and Reliability of the Turkish Version of the Brief Pittsburgh Sleep Quality Index.","authors":"Cansu Ünsal Mavi, Berhan Akdağ, Büşra Kök, Ece Özlem Öztürk, Ömer Aydemir","doi":"10.29399/npa.29240","DOIUrl":"10.29399/npa.29240","url":null,"abstract":"<p><strong>Introduction: </strong>The present study aimed to examine the psychometric properties of the Brief Pittsburgh Sleep Quality Index (B-PSQI) in a Turkish adult population.</p><p><strong>Methods: </strong>The sample included 296 adults: 163 healthcare professionals at Silifke State Hospital (Sample 1) and 133 individuals applying for a health committee report (Sample 2).</p><p><strong>Results: </strong>Confirmatory factor analyses confirmed the unidimensional structure of the B-PSQI in both samples. The B-PSQI scores were highly correlated with the PSQI scores in both samples, with r values of 0.905 and 0.925. The B-PSQI scores also demonstrated strong correlations with the Insomnia Severity Index scores in Sample 1 (r=0.774) and Sample 2 (r=0.762). Furthermore, B-PSQI scores were positively correlated with depressive and anxiety symptoms. The reliability of the scale was acceptable, with Cronbach's alpha and McDonald's omega values exceeding 0.70. A score of ≥4 on the B-PSQI provided the optimal balance between sensitivity (85.0% and 95.9%) and specificity (89.3% and 85.7%) for detecting individuals with poor sleep quality.</p><p><strong>Conclusion: </strong>The current findings suggest that the B-PSQI is a valid and reliable instrument for assessing sleep quality among Turkish adults. Further research in diverse populations is warranted to corroborate these findings.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"63 ","pages":"387-392"},"PeriodicalIF":1.0,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13065093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147678626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}