Noropsikiyatri Arsivi-Archives of Neuropsychiatry最新文献

{"title":"Posterior Atrophy is a Neuroimaging Marker of Mild Cognitive Impairment in Parkinson's Disease.","authors":"Ulaş Ay, Zerrin Yıldırım, Ani Kicik, Emel Erdogdu, Başar Bilgiç, Hasmet Hanagasi, Esin Ozturk-Isık, Tamer Demiralp, Hakan Gurvit","doi":"10.29399/npa.28821","DOIUrl":"10.29399/npa.28821","url":null,"abstract":"<p><strong>Introduction: </strong>Although there are several studies on the neuroanatomical mechanisms underlying Parkinson's disease (PD)-associated cognitive impairment, the clinical usefulness of the findings from these investigations is limited. In this study, we aimed to identify magnetic resonance imaging (MRI) markers that can be practically utilized for diagnosing PD-associated cognitive impairment using a visual rating scale (VRS).</p><p><strong>Methods: </strong>Anatomical MRIs of cognitively normal (PD-CN), and PD with mild cognitive impairment (PD-MCI) patients were visually evaluated for six bilateral cortical regions. Then, hypothesis-driven cortical thickness analysis (CTA) was performed in the regions obtained from VRS.</p><p><strong>Results: </strong>As a consequence of VRS, a significant difference was found between the two groups with regards to right posterior atrophy (PA) scores (pFDR-corr = 0.042, Cohen's d= 1.06). Hypothesis-driven CTA confirmed the result of VRS by revealing cortical thinning at the precuneus and parieto-occipital sulcus junction (Max. T= 6.171, P= 0.0006, MNI_{x, y, z} = 11.0, -62.2, 25.4). The area under the curve was 0.75, showing a good association between the PD-MCI and the right PA score. The cut-off for maximum accuracy was ≥ 2, based on the highest sum of sensitivity (0.68) and specificity (0.72).</p><p><strong>Conclusions: </strong>Our findings indicate that right PA atrophy may be helpful for clinicians in the diagnosis of PD-associated cognitive impairment.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"63 ","pages":"137-143"},"PeriodicalIF":1.0,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12951501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NQO1 and NQO2 Gene Polymorphisms Related to Methamphetamine-Associated Psychosis in the Makassar Population, Indonesia.","authors":"Dani Haryanto Ludong, Tri Supartını, Ismail Ismaıl","doi":"10.29399/npa.29016","DOIUrl":"10.29399/npa.29016","url":null,"abstract":"<p><strong>Introduction: </strong>This study investigates the relationship between NQO1 and NQO2 gene polymorphisms and methamphetamine-associated psychosis (MAP) in the Makassar population.</p><p><strong>Methods: </strong>Case-Control Study to determine the role of the NQO1 and NQO2 genes in the onset of psychotic symptoms due to methamphetamine abuse. The control group consists of individuals who consume methamphetamine without psychotic characteristics (n=139), while the case group consists of individuals who consume methamphetamine with psychotic characteristics (n=128).</p><p><strong>Results: </strong>The NQO1 gene polymorphism demonstrates a significant association with the duration of MAP, with the TT genotype and the T allele occurs more frequently in prolonged cases. The CT genotype is linked to an increased risk of spontaneous relapse, while the TT genotype is more prevalent among patients with polysubstance abuse. Additionally, the NQO2 (I/D) gene polymorphism indicates a trend towards differential genotype distribution in patients with MAP, with the DD genotype appearing more frequently in prolonged cases, and the I allele associated with a heightened risk of spontaneous relapse.</p><p><strong>Conclusion: </strong>These findings suggest that polymorphisms in the NQO1 and NQO2 genes may play a role in the susceptibility to and clinical manifestations of MAP within the Makassar population.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"63 ","pages":"201-208"},"PeriodicalIF":1.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12951488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Motor Symptoms in Myasthenia Gravis Patients: Evaluation of Auditory and Olfactory Functions.","authors":"Özlem Akdoğan, Alene Sar, Tuğrul Eren, Enise Akdemir, Nihal Seden Boyoğlu, Melih Tütüncü, Ufuk Emre Toprak, Ömer Uysal","doi":"10.29399/npa.29067","DOIUrl":"10.29399/npa.29067","url":null,"abstract":"<p><strong>Introduction: </strong>Myasthenia gravis (MG) is an autoimmune disease characterized by conduction defects at the neuromuscular junction. Recent studies suggest that impairment in acetylcholine neurotransmission occurs not only at the neuromuscular junction but also in the central and peripheral nervous systems. In this context, we aimed to investigate the presence of auditory and olfactory dysfunction, which are non-motor symptoms (NMS), alongside motor symptoms in patients with MG.</p><p><strong>Methods: </strong>A total of 30 MG patients and 30 healthy controls were enrolled in the study. Demographic characteristics of all participants were recorded. Olfactory functions were assessed using the Connecticut Chemosensory Clinical Research Center (CCCRC) test, while auditory functions were evaluated through pure tone audiometry (PTA) and tympanometric assessment. Additionally, patients were evaluated with MG Foundation of America (MGFA) Clinical Classification, MG-Composite scoring (MGC) and MG-Quality of Life Questionnaire 15-item scale Turkish version (MG-QOL15-T).</p><p><strong>Results: </strong>No statistically significant difference was found between the MG and control groups for the n-Butanol threshold test score, identification test score, and total test score, which are components of the CCCRC test. There was no significant correlation between the age of disease onset and olfactory scores. A statistically significant moderate negative correlation was found between disease duration and both identification and total olfactory scores (r=-0.447, p=0.013 and r=-0.374, p=0.042, respectively). In the PTA test, the hearing threshold at 2000 Hz frequency in the right ear of patients was higher compared to the control group, and this difference was found to be statistically significant. No association was found between the patients' olfactory and auditory functions with the MG-QOL15- T.</p><p><strong>Conclusion: </strong>This study suggests partial impairment in olfactory and auditory functions, NMS, in MG patients; however, these findings do not seem to effect the patients' quality of life. It should be considered that MG may be accompanied not only by motor symptoms but also by NMS.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"63 ","pages":"219-225"},"PeriodicalIF":1.0,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12951500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CHI3L1 and CXCL13 Levels of Serum and CSF in Treatment-Naïve Multiple Sclerosis: Associations with Disease Activity.","authors":"Ezgi Vural, Ali Yaman, Can Ilgın, Gülin Sünter, Goncagül Haklar, Dilek Günal, Kadriye Ağan","doi":"10.29399/npa.28889","DOIUrl":"10.29399/npa.28889","url":null,"abstract":"<p><strong>Introduction: </strong>Cytokines, intracellular polypeptides, and chemokines, which belong to a small protein superfamily, are crucial in regulating inflammation and cell migration. Profiling these molecules can offer significant insights into the inflammatory process and aid in predicting disease outcomes. This study seeks to quantify cytokine and chemokine levels in serum and cerebrospinal fluid (CSF) samples from treatment-naïve patients, both with and without poor prognostic indicators, to identify biomarkers indicative of disease activity.</p><p><strong>Methods: </strong>A prospective, observational, cross-sectional study was carried out involving patients diagnosed with Multiple sclerosis (MS) or non-inflammatory neurological disorders at Marmara University Faculty of Medicine.</p><p><strong>Multiple sclerosis patients were further classified into two groups based on previously established clinical and radiological criteria: </strong>those with poor prognostic outcomes and those without. Levels of IL-8, IL-12/IL-23p40, IL-21, CHI3L1, and CXCL13 were measured in both CSF and serum samples using the ELISA method. Statistical analyses were conducted using Stata version 15.1.</p><p><strong>Results: </strong>A total of 56 patients participated in the study. CHI3L1 (p=0.003) and CXCL13 (p<0.001) levels in CSF were significantly elevated in MS patients compared to the control group. Among the MS cohort, serum CXCL13 levels positively correlated with the EDSS score (p=0.04, r=0.39) and the number of spinal cord lesions (p=0.009, r=0.48). Additionally, a significant negative correlation was observed between CSF CXCL13 levels and patient age in the MS group (p=0.03, r=-0.42).</p><p><strong>Conclusion: </strong>Increased CSF levels of CHI3L1 and CXCL13 may serve as potential diagnostic markers for Relapsing-Remitting MS (RRMS) patients. Given the ease of collecting serum samples, further research is necessary to explore the relationship between serum CXCL13 levels, EDSS scores, and spinal cord lesions in larger cohorts.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"63 ","pages":"152-157"},"PeriodicalIF":1.0,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12951485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffusion Tensor Imaging and Fiber Tractography Analysis in Patients with Pelizaeus-Merzbacher Disease.","authors":"Hacı Ali Erdoğan, Alp Dinçer, Pınar Topaloğlu, İbrahim Acır, Zuhal Yapıcı","doi":"10.29399/npa.29069","DOIUrl":"10.29399/npa.29069","url":null,"abstract":"<p><strong>Introduction: </strong>Pelizaeus-Merzbacher Disease (PMD) is a hypomyelinating disorder with X-linked recessive inheritance caused by mutations in the proteolipid protein 1 (PLP1) gene on chromosome Xq22. In the early stages of PMD, head tremor and pendular nystagmus are observed, while in the later stages, psychomotor developmental delay, choreoathetosis, ataxia, and spasticity are added to the clinical presentation. This study aimed to investigate the relationship between diffusion tensor imaging-fiber tractography (DTI-FT) findings, the clinical and pathogenetic features in PMD patients.</p><p><strong>Methods: </strong>Nineteen patients diagnosed with PMD between 1995-2006 and 19 healthy controls were included in our study. Both patient and control groups underwent 3 Tesla Magnetic Resonance Imaging (MRI), DTI, and FT examinations. By using DTI regions of interest (ROI) were drawn in the corticospinal tract, right inferior occipitofrontal fasciculus (RIOFF), middle cerebellar peduncle, and right cingulum. The mean fractional anisotropy (FA) values of the tractographies which obtained from the ROIs were calculated. Clinical and genetic features were compared with mean FA values.</p><p><strong>Results: </strong>Significant differences were found between the PMD and control groups in the FA values of the corticospinal tract (CST), corpus callosum, right inferior occipitofrontal fasciculus, middle cerebellar peduncle and right cingulum. This patient group had significantly higher FA values. Patients with severe disabilities showed marked reductions in anisotropy at the corticospinal tract level.</p><p><strong>Conclusion: </strong>The significantly reduced FA values in the white matter regions in the patient group are sufficient to suggest predominantly white matter involvement in PMD. The markedly lower CST FA values in patients with severe disabilities indicate that CST may serve as an important localization for determining disease severity. Studies using DTI-FT in similar patient groups will non-invasively enhance our understanding of structural differences.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"63 ","pages":"226-231"},"PeriodicalIF":1.0,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12951515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency and Etiologies of Peripheral Type Cranial Neuropathy in the Neurology Inpatient Clinic.","authors":"Saniye Karabudak, Zeliha Matur, Pınar Özçelik, Yüksel Erdal, Aslı Yaman Kula, Vildan Güzel, Mecbure Nalbantoğlu, Ferda Uslu, Gülşen Akman","doi":"10.29399/npa.28931","DOIUrl":"10.29399/npa.28931","url":null,"abstract":"<p><strong>Introduction: </strong>Peripheral type cranial neuropathies (PCNP) other than idiopathic peripheral facial paralysis are quite rare. In this study, we analysed patients with PCNP who were treated in our inpatient clinic.</p><p><strong>Methods: </strong>The patients who were hospitalized, examined and treated in our clinic between 1/1/2018 and 31/12/2023 were examined retrospectively. Sixty-three (34 men) out of total 3593 patients were found to have isolated PCNP. Demographic data, aetiologies, cerebrospinal fluid (CSF) findings, treatments and course of these patients were documented.</p><p><strong>Results: </strong>The average age of the patients was 56.25±15.55 years. Forty-three patients had single (unilateral/bilateral) and 20 had multiple PCNP. The most common involvement was seen in the VI. cranial nerve (24 isolated, 16 with other cranial neuropathies). The most common etiology was autoimmune/inflammatory (25 patients), followed by peripheral nerve ischemia (23 patients), infectious (6 patients), and tumoral infiltration (5 patients). Two patients with multiple PCNP had tumoral infiltration, Herpes infection in 2, COVID-19 in 2, Brucellosis in 1, and tuberculous meningitis in 1. Ischemic causes were most commonly associated with diabetes-related microvascular damage. Magnetic resonance imaging (MRI) examination revealed tumoral infiltration in 5 patients. Other MRI findings were cavernous sinus involvement and contrast enhancement of cranial nerves. CSF was examined in 53 patients; CSF protein was high in 20; pleocytosis was observed in one.</p><p><strong>Conclusion: </strong>Among peripheral cranial nerves, VIth is the most commonly involved, alone/together with other cranial nerves (CN). Inflammatory causes most commonly play a role in the etiology of PCNP. Malignancy and infectious etiologies should be considered first in patients with multiple cranial neuropathies (CNPs).</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"63 ","pages":"187-191"},"PeriodicalIF":1.0,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12951489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship of Modulation Generated in Brain Intrinsic Connectivity Networks by Simple Sensory Stimuli and Cognitive Performance.","authors":"Selen Gür Özmen, Emre Harı, Elif Kurt, Hakan Gürvit, Tamer Demiralp","doi":"10.29399/npa.29010","DOIUrl":"10.29399/npa.29010","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to investigate the modulation of simple sensory stimuli on brain intrinsic connectivity networks in the Alzheimer's disease continuum (ADC) using functional magnetic resonance imaging (fMRI).</p><p><strong>Methods: </strong>fMRI and neuropsychological assessment data of 88 cases in ADC were analysed. fMRI data were recorded in a session including blocks of light stimuli flickering at 20 Hz frequency and in the resting state from 21 Alzheimer's disease dementia (ADD), 34 mild cognitive impairment (MCI) and 33 subjective cognitive impairment (SCI). CONN (functional connectivity toolbox) software was used for functional connectivity analyses of fMRI data. Bonferroni correction was applied according to the number of ROIs in functional connectivity analyses and the significance threshold was determined as pFWE <0.0033.</p><p><strong>Results: </strong>As a result of the analysis of the resting state data, decreased connectivity was detected between the posterior cingulate cortex seed of the default mode network and the temporal and parietal areas in ADD compared to the SCI and MCI groups. Decreased functional connectivity was detected between the anterior insula and anterior cingulate cortex seeds of the salience network and the temporal, frontal and cingulate cortices in ADD compared to the SCI and MCI groups. However, in the data of flickering light stimulation at a frequency of 20 Hz, increased functional connectivity was detected between the right lateral prefrontal cortex seed of the frontoparietal network, which could not be captured with the resting state data, and the precuneus in the MCI group compared to the SCI group.</p><p><strong>Conclusions: </strong>The increase in connectivity between the frontoparietal network and precuneus may be a compensatory response in the early stages of the disease. In addition, it was thought that fMRI images performed using simple sensory stimuli were more sensitive to cognitive decline in the early stages of the disease compared to resting state data and could have biomarker potential.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"63 ","pages":"192-200"},"PeriodicalIF":1.0,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12951513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Psychometric Properties of the Turkish Versions of the Brief Hopelessness Scale with Positive and Negative Valence among Adolescents.","authors":"Asiye Arıcı Gürbüz, Seda Bozduman Çelebi, Nazmiye İnce, Hülya Binokay, Berhan Akdağ, Serkan Güneş, Lut Tamam","doi":"10.29399/npa.29189","DOIUrl":"10.29399/npa.29189","url":null,"abstract":"<p><strong>Introduction: </strong>The present study aims to evaluate the psychometric properties of the Turkish versions of the Brief Hopelessness Scale with positive and negative valence, Brief-H-Pos and Brief-H-Neg, in adolescents who presented to child and adolescent psychiatry outpatient clinics.</p><p><strong>Method: </strong>The study sample consisted of 248 adolescents aged 12 to 17 years who presented to child and adolescent psychiatry outpatient clinics in two urban centers: Adana and Istanbul. To assess concurrent validity, Pearson's correlation coefficients were calculated to examine the relationships among the Brief-H-Pos, Brief-H-Neg, Beck Hopelessness Scale (BHS), and Beck Depression Inventory (BDI) scores. Reliability was evaluated using Cronbach's alpha, the Spearman-Brown coefficient, and item-total correlations. Receiver Operating Characteristic (ROC) curve analyses were conducted to determine the diagnostic utility of the Brief-H-Pos and Brief-H-Neg in identifying adolescents with suicidal ideation.</p><p><strong>Results: </strong>Both the Brief-H-Pos (r = 0.674) and Brief-H-Neg (r = 0.703) demonstrated strong correlations with BDI scores. Additionally, the Brief-H-Pos (r = 0.745) and Brief-H-Neg (r = 0.753) were highly correlated with the BHS, supporting convergent validity. The internal consistency of the Brief-H-Pos was acceptable, with both Cronbach's alpha and the Spearman-Brown coefficient equal to 0.826. Cronbach's alpha for the Brief-H-Neg was 0.816, and the Spearman-Brown coefficient was 0.778. The area under the curve (AUC) for the Brief-H-Pos and Brief-H-Neg was 0.745 and 0.780, indicating good discriminative capacity. DeLong's test showed that there was no significant difference between the AUC values of the Brief-H-Pos, Brief-H-Neg, and BHS, suggesting comparable discriminative ability.</p><p><strong>Conclusion: </strong>Both Brief-H-Pos and Brief-H-Neg are valid and reliable instruments for assessing hopelessness in Turkish adolescents. These results also suggest that both brief instruments demonstrate comparable diagnostic capability to the BHS in identifying suicidal ideation, despite their reduced length.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"63 ","pages":"302-307"},"PeriodicalIF":1.0,"publicationDate":"2025-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12951503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facial Hyposchematia Without Spatial Neglect.","authors":"Emre Kumral, Dilek Evyapan","doi":"10.29399/npa.29070","DOIUrl":"10.29399/npa.29070","url":null,"abstract":"<p><strong>Introduction: </strong>Hyposchematia is a rare disorder characterized by the underestimation of the size of a part of the body. To date, isolated facial hyposchematia has not been described. The pathophysiology of this syndrome remains poorly understood.</p><p><strong>Methods: </strong>We investigated body schema disturbances and neuroimaging features of 2400 ischemic stroke patients.</p><p><strong>Results: </strong>We found three patients who felt that the left side of their face was disproportionately smaller than the right side. There were no directly observable objective findings in the affected patients. In drawing tasks, the left side of the face in all patients was depicted as more compressed than the right side. In all three patients, the facial hyposchematia was attributed to lesions affecting frontal-insular circuits involved in the upper part of extrapersonal space and self-related systems.</p><p><strong>Conclusion: </strong>These cases demonstrate that distortions and underestimation of extra-personal and personal spaces can affect specific body parts, such as the face, in isolation.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"63 ","pages":"80-83"},"PeriodicalIF":1.1,"publicationDate":"2025-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12849218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146087926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined Central and Peripheral Demyelination with a Favorable Outcome: A Case with 10-Year Follow-up.","authors":"Özlem Kurtkaya Koçak, Emine Altın, Muhammed Yıldırım, Tahir Kurtuluş Yoldaş","doi":"10.29399/npa.28952","DOIUrl":"10.29399/npa.28952","url":null,"abstract":"<p><strong>Introduction: </strong>Combined central and peripheral demyelination (CCPD) is a rare and heterogeneous condition, often associated with a poor prognosis. Contrary to the popular reports, we present a case of CCPD with a favorable prognosis and a 10-year follow-up.</p><p><strong>Case: </strong>A 29-year-old female patient presented with progressive limb weakness following a Brucella infection. She was subsequently diagnosed with motor type chronic inflammatory demyelinating polyneuropathy (CIDP), which was characterized by motor conduction blocks and demyelinating motor conduction abnormalities in a nerve conduction study (NCS). In the following years, the patient was diagnosed with CCPD with relapse and remissions, with or without CIDP attacks and multiple cranial neuropathy, cervical myelitis, and optic neuritis attacks. Despite exhibiting motor CIDP, she did not respond to intravenous immunoglobulin (IVIg) therapy, and all her episodes were removed with intravenous methylprednisolone (IVMP).</p><p><strong>Conclusion: </strong>Our case has been in remission with azathioprine therapy for the last three years and is notable for its prolonged course, good prognosis, and potential association with Brucella infection.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"63 ","pages":"22-25"},"PeriodicalIF":1.1,"publicationDate":"2025-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12849213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146087978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}