Comparison of Serum USP9x and TGF-β Levels in Children with Autism Spectrum Disorders with Healthy Controls.

IF 1 4区医学 Q4 CLINICAL NEUROLOGY

Noropsikiyatri Arsivi-Archives of Neuropsychiatry Pub Date : 2024-11-28 eCollection Date: 2024-01-01 DOI:10.29399/npa.28650

Mehmet Karadağ, Fatma Subaşı Turgut, Zehra Çiftçi, Zehra Hangül, Seyithan Taysi

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引用次数: 0

Abstract

Introduction: USP9X has been associated with neurodevelopmental disorders due to its role in synaptic development and neural function. This study aimed to compare USP9X and TGF-β levels in children with autism and healthy controls, and explore their relationship with autism severity.

Methods: Serum USP9X and TGF-β levels were measured in 41 healthy control children (aged 3-12 years) and 41 children with autism.

Results: Our study revealed a significant increase in USP9X levels (p=0.001) among children with autism compared to controls. However, TGF-β levels showed no significant difference between the two groups. Furthermore, we observed a positive correlation between difficulty in making eye contact subscale and blood levels of both USP9X and TGF-β.

Conclusions: This study is the first to compare serum USP9X levels in children with autism to healthy controls. Our findings suggest USP9X's potential role in autism development, emphasizing the need for further research on its involvement in neurodevelopmental processes.

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自闭症谱系障碍儿童与健康对照组血清USP9x和TGF-β水平的比较

简介：由于USP9X在突触发育和神经功能中的作用，它与神经发育障碍有关。本研究旨在比较自闭症儿童和健康对照组的 USP9X 和 TGF-β 水平，并探讨它们与自闭症严重程度的关系：41名健康对照组儿童（3-12岁）和41名自闭症儿童的血清USP9X和TGF-β水平：我们的研究发现，与对照组相比，自闭症儿童的 USP9X 水平明显升高（p=0.001）。然而，两组儿童的 TGF-β 水平无明显差异。此外，我们还观察到，自闭症儿童在进行眼神交流时遇到的困难与血液中 USP9X 和 TGF-β 的水平呈正相关：本研究首次比较了自闭症儿童与健康对照组的血清 USP9X 水平。我们的研究结果表明，USP9X 在自闭症的发展过程中具有潜在作用，因此有必要进一步研究 USP9X 在神经发育过程中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Noropsikiyatri Arsivi-Archives of Neuropsychiatry CLINICAL NEUROLOGY-

CiteScore

1.70

自引率

9.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Archives of Neuropsychiatry (Arch Neuropsychiatry) is the official journal of the Turkish Neuropsychiatric Society. It is published quarterly, and four editions annually constitute a volume. Archives of Neuropsychiatry is a peer reviewed scientific journal that publishes articles on psychiatry, neurology, and behavioural sciences. Both clinical and basic science contributions are welcomed. Submissions that address topics in the interface of neurology and psychiatry are encouraged. The content covers original research articles, reviews, letters to the editor, and case reports.