International Journal of Eating Disorders最新文献

{"title":"Smartphone Applications for Eating Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Telma Cruz, Cristiana Duarte, Tiago B Ferreira, Carina Santos, Mariana V Martins","doi":"10.1002/eat.24488","DOIUrl":"https://doi.org/10.1002/eat.24488","url":null,"abstract":"<p><strong>Objective: </strong>Given the rising prevalence of eating disorders (EDs), smartphone applications (apps) have received growing clinical attention, but their overall effectiveness remains undetermined. This study aimed to conduct a meta-analysis of randomized controlled trials (RCTs) evaluating the efficacy of app interventions for EDs and to identify the psychological approaches featured in these interventions.</p><p><strong>Method: </strong>The online databases SCOPUS, PubMed, and EBSCO were searched for trials published up to February 2025. This review followed PRISMA guidelines, and meta-analyses were conducted using post-intervention assessment data. Pooled effect sizes were calculated with 95% confidence intervals.</p><p><strong>Results: </strong>Seventeen studies met the inclusion criteria, and 14 were included in the quantitative synthesis. Trials involving not formally diagnosed samples indicated that app-based interventions were more efficacious than controls in reducing global levels of ED symptomatology, shape and weight concerns, dietary restraint, binge eating, and compensatory behaviors. No significant effects were found for body dissatisfaction/disturbance or drive for thinness. Self-help interventions showed generally comparable improvements. In formally diagnosed samples, only objective binge eating was analyzed, with a medium effect observed when the app was incorporated into guided self-help. The use of an adjunctive app was not shown to have benefit above and beyond traditional therapy. Most interventions were based on cognitive-behavioral therapy principles.</p><p><strong>Discussion: </strong>This review supports the efficacy of app-based interventions in reducing key ED symptoms, particularly within the binge-eating spectrum and among at-risk individuals. Nonetheless, given the limited number of studies, further research with high-quality RCTs, larger samples, and proper follow-ups is needed.</p>","PeriodicalId":51067,"journal":{"name":"International Journal of Eating Disorders","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Consensus to Innovation: Advancing the Science of Eating-Disorder Measurement.","authors":"Kelsie T Forbush, Sonakshi Negi, Marianna L Thomeczek, Angeline R Bottera, Emily E Like","doi":"10.1002/eat.24482","DOIUrl":"https://doi.org/10.1002/eat.24482","url":null,"abstract":"<p><p>This commentary is a response to the article written by Reilly et al. (2025). The authors discuss the Eating Disorder Examination (EDE), asserting that critiques of the EDE reflect a larger assessment issue within the field. Their solutions were centered on establishing consensus regarding assessment goals, guidelines, and decision-making frameworks. We propose that to move the field forward, assessment efforts strive for the ambitious and necessary goal of creating an omnibus tool that comprehensively captures the full spectrum of eating-disorder presentations. Our arguments are grounded in three key points: (1) there is a pressing need to apply evidence-based approaches in scale development; (2) the EDE's widespread use does not warrant its continued endorsement; and (3) it is essential for the field to critically examine the consequences of continued reliance on the EDE. We provide illustrative examples from other fields in which newer measures were developed and widely adopted, leading to improvements in those fields. We call on the field to embrace curiosity and continuous learning in the pursuit of more rigorous measurement. Advancing scale development practices will enhance our understanding of what constitutes eating-disorder psychopathology and also improve quality-of-care.</p>","PeriodicalId":51067,"journal":{"name":"International Journal of Eating Disorders","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trial, Error, and Insight: Using the Pilot Study of the HOPE Program to Inform Next Steps for Digital Single-Session Research for Eating Disorders.","authors":"Bridianne O'Dea, Madelaine K de Valle","doi":"10.1002/eat.24487","DOIUrl":"https://doi.org/10.1002/eat.24487","url":null,"abstract":"<p><p>Digital single-session interventions (D-SSIs) are emerging as promising tools for bridging treatment gaps in youth mental health. Negi and Forbush's recent pilot study introduces \"Help for Overcoming Problem Eating\" (HOPE), a D-SSI targeting binge-spectrum eating disorders in university students. Their findings suggest preliminary acceptability, feasibility, and symptom improvements, contributing to the growing evidence-base for D-SSIs in disordered eating. This commentary outlines five key challenges that must be addressed to translate pilot findings into real-world impact. First, the uptake of D-SSIs is often low, likely due to help-seeking barriers and septicism towards this approach. Peer-led, promotional campaigns may boost engagement of D-SSIs in young people. Second, despite their brevity, D-SSI completion is not assured. Strategies such as automated reminders, peer or AI-guided support, and youth co-design may improve adherence. Third, economic evaluations are rare but critical for determining whether D-SSIs offer cost-effective support within resource-limited student services. Fourth, trials should examine mechanisms and durability of change, with complementary D-SSIs offering promising directions. Finally, meaningful integration into care pathways is critical. D-SSIs may serve as stand-alone supports, early engagement tools, or components of stepped-care models. Lack of response could signal the need for intensive care, while successful use may increase openness to further help-seeking. Addressing these challenges with informative, implementation-ready trials will be key to realizing the full potential of D-SSIs in addressing eating disorders in university students and advancing youth mental health care more broadly.</p>","PeriodicalId":51067,"journal":{"name":"International Journal of Eating Disorders","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the Diagnostic Checklist: A Large-Scale Analysis of Under-Recognized Weight Loss Behaviors in Individuals With Eating Disorders.","authors":"Saakshi Kakar, Una Foye, Helena L Davies, Elisavet Palaiologou, Chelsea M Malouf, Laura Meldrum, Iona Smith, Gursharan Kalsi, Karina L Allen, Gerome Breen, Moritz Herle, Christopher Hübel","doi":"10.1002/eat.24477","DOIUrl":"https://doi.org/10.1002/eat.24477","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to explore the diverse range of weight loss behaviors that extend beyond traditional diagnostic criteria, highlighting the variability in symptom presentation.</p><p><strong>Method: </strong>We text mined free-text responses from 1675 participants with anorexia nervosa, bulimia nervosa, or binge-eating disorder in the Genetic Links to Anxiety and Depression (GLAD) Study and the Eating Disorders Genetics Initiative UK (EDGI UK). In secondary analyses, we investigated differences by eating disorder and gender.</p><p><strong>Results: </strong>Frequently endorsed behaviors included structured diets (619 endorsements) and calorie counting (422 endorsements), but also less commonly considered behaviors like compression garments (147 endorsements) and self-harm (88 endorsements). We identified four overarching themes: restriction-based approaches, medical intervention, body manipulation, and food avoidance. The most frequently reported weight loss behaviors and resultant themes did not differ among eating disorders or genders, closely resembling those in the broader sample. Notably, 81 participants with binge-eating disorder, which typically lacks the endorsement of recurrent compensatory behaviors, reported weight loss and compensatory behaviors.</p><p><strong>Discussion: </strong>Our findings identify a crucial gap in current diagnostic assessments, which may hamper recognition and lead to underdiagnosis of eating disorders. By incorporating our insights into an inclusive assessment process that expects and accommodates novel behaviors, clinicians could capture a broader spectrum of behaviors, thus improving diagnostic accuracy. However, our sample homogeneity implies the need for more diverse samples. Our study contributes essential insights for enhancing diagnostic criteria.</p>","PeriodicalId":51067,"journal":{"name":"International Journal of Eating Disorders","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of Anorexia Nervosa and Obsessive-Compulsive Disorder Comorbidity and Order of Diagnosis in a Danish National Cohort.","authors":"Lisa Yujia Zhu, Janne Tidselbak Larsen, Judith Becker Nissen, James J Crowley, Manuel Mattheisen, Cynthia M Bulik, Liselotte Vogdrup Petersen, Zeynep Yilmaz","doi":"10.1002/eat.24486","DOIUrl":"https://doi.org/10.1002/eat.24486","url":null,"abstract":"<p><strong>Objective: </strong>Anorexia nervosa (AN) and obsessive-compulsive disorder (OCD) are highly comorbid; however, limited research has examined etiological pathways specific to individuals with AN developing OCD or individuals with OCD developing AN. This exploratory study aimed to identify factors influencing AN-OCD comorbidity with a focus on the order of diagnosis.</p><p><strong>Method: </strong>Using Danish national registers, 6449 individuals with AN and 9352 individuals with OCD were examined to assess the risk of subsequent OCD and AN. Explored predictors included parental characteristics, birth characteristics, childhood adversity, autoimmune and autoinflammatory diseases, psychiatric disorders, and prescriptions. Hazard ratios (HR) were calculated using Cox regression. Parallel analyses were conducted for the risk of subsequent anxiety disorder to determine predictors unique to AN-OCD comorbidity.</p><p><strong>Results: </strong>Among individuals with AN, high birth weight (HR = 3.06) was uniquely associated with increased risk of subsequent OCD. For individuals with OCD, a history of other eating disorders (HR = 7.47) was associated with elevated risk of developing AN, whereas anxiety disorders in first-degree (HR = 0.32) and female first-degree relatives (HR = 0.22) were uniquely protective against AN.</p><p><strong>Discussion: </strong>These exploratory findings suggest that distinct pathways may be involved in the order of onset for AN-OCD comorbidity. Specifically, for individuals with AN who subsequently developed OCD, high birth weight appeared to increase risk, whereas for individuals with OCD who later developed AN, familial anxiety disorders seemed to play a protective role. Findings could inform early screening and prevention efforts for individuals with AN at high risk for OCD, and vice versa.</p>","PeriodicalId":51067,"journal":{"name":"International Journal of Eating Disorders","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Validity of Maladaptive Exercise Definitions: A 10-Year Longitudinal Cohort Study.","authors":"Ziyu Ivan Zhao, Harmony F Vides-Varini, Pamela K Keel","doi":"10.1002/eat.24489","DOIUrl":"https://doi.org/10.1002/eat.24489","url":null,"abstract":"<p><strong>Objective: </strong>Prior efforts to define maladaptive exercise indicate that compensatory and compulsive features and exercising for appearance are associated with disordered eating in cross-sectional studies. However, the predictive validity of these definitions in adults requires examination. This study employs a 10-year longitudinal cohort design to evaluate whether these established definitions of maladaptive exercise predict disordered eating and weight-related outcomes.</p><p><strong>Methods: </strong>Men (n = 592) and women (n = 1467) completed surveys of exercise and disordered eating in 2002, and 74% completed surveys at the 10-year follow-up. Exercise amount (duration and frequency), compensatory, appearance, and compulsive exercise were tested as prospective predictors of body mass index (BMI), Drive for Thinness, and Bulimia.</p><p><strong>Results: </strong>Exercise for appearance prospectively predicted higher BMI, Drive for Thinness, and Bulimia at follow-up. Compensatory exercise also uniquely predicted higher BMI at follow-up, and compulsive exercise demonstrated no unique prospective associations with disordered eating or weight-related outcomes.</p><p><strong>Discussion: </strong>The unique effect of appearance exercise highlights the importance of addressing exercise motivations to reduce disordered eating risk. Such work may highlight that exercising for weight control or body definition predicts higher BMI and more disordered eating over the long term. Future studies should employ longitudinal designs, with multiple waves of follow-up, to examine potential bidirectional influences between maladaptive exercise and disordered eating as well as the long-term health consequences of maladaptive exercise.</p>","PeriodicalId":51067,"journal":{"name":"International Journal of Eating Disorders","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smartphone-Supported Cognitive-Behavioral Therapy in Binge-Eating Disorder: An Exploratory Randomized Trial.","authors":"Anja Hilbert, Ulrike Klotz, Sina Sadeghi, Adrienne S Juarascio, Toralf Kirsten","doi":"10.1002/eat.24479","DOIUrl":"https://doi.org/10.1002/eat.24479","url":null,"abstract":"<p><strong>Objective: </strong>To assess the feasibility of a smartphone app delivering just-in-time adaptive interventions as an adjunct to cognitive-behavioral therapy (CBT) adapted to binge-eating disorder (BED), estimate its effects assuming superiority over CBT alone, and document safety and target engagement.</p><p><strong>Method: </strong>A single-center, assessor-blinded, parallel feasibility study randomized adults aged 18-65 years with full-syndrome or subthreshold BED to smartphone-supported CBT (SmartCBT) or standard CBT (DRKS00024597). Both arms received 16 individual 50-min CBT sessions over 4 months. Assessments were conducted at baseline (T0), midtreatment (T1), posttreatment (T2), and 3-month follow-up (T3). Feasibility was determined regarding recruitment, attrition, dropout, adherence, assessment completion, app use, and acceptance. Further, eating disorder symptoms, mental and physical health, weight management behavior, safety, and target engagement (i.e., skill use) were assessed.</p><p><strong>Results: </strong>Over a 7-month recruitment period, 28 of 50 eligible volunteers were included and randomized 1:1 to SmartCBT or CBT. In the modified intent-to-treat sample (N = 25; SmartCBT: 13, CBT: 12), the feasibility of SmartCBT was further supported regarding attrition, dropout, adherence, treatment completion, app use, and acceptance; however, assessment completion was moderate. Clinical improvements were found in both arms, but differential results were affected by baseline differences and moderate assessment completion in the SmartCBT arm. Safety was documented, and support for target engagement was found.</p><p><strong>Conclusions: </strong>This exploratory study provides evidence for the feasibility of app-supported CBT for BED. With few procedural refinements, the protocol can be used in a confirmatory randomized-controlled trial with long-term follow-up to evaluate efficacy and determine treatment mechanisms.</p><p><strong>Trial registration: </strong>German Clinical Trials Register, https://www.drks.de, DRKS00024597.</p>","PeriodicalId":51067,"journal":{"name":"International Journal of Eating Disorders","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prevalence of Eating Disorders and Disordered Eating in Adults Seeking Obesity Treatment: A Systematic Review With Meta-Analyses.","authors":"Hannah Melville, Natalie B Lister, Sol Libesman, Anna Lene Seidler, Hoi Yuk Cheng, Yuen Lam Kwan, Sarah P Garnett, Louise A Baur, Hiba Jebeile","doi":"10.1002/eat.24483","DOIUrl":"https://doi.org/10.1002/eat.24483","url":null,"abstract":"<p><strong>Objective: </strong>To estimate the prevalence of eating disorders and disordered eating in adults seeking obesity treatment.</p><p><strong>Method: </strong>Databases, MEDLINE, Embase, and PsycINFO, were searched to 20th March 2025. Studies reporting the prevalence of eating disorders or disordered eating at presentation to obesity treatment in adults (≥ 18 years) with overweight (BMI 25 to < 30 kg/m²) or obesity (BMI ≥ 30 kg/m²), with ≥ 325 participants to ensure a representative sample, were included. A random-effects model was used to pool prevalence estimates of eating disorders and disordered eating.</p><p><strong>Results: </strong>85 studies were included (n = 94,295, 75.9% female, median (IQR) age 44 (5) years, BMI 46 (10) kg/m²). When assessed by clinical interview, the pooled prevalence of binge-eating disorder (Diagnostic and Statistical Manual of Mental Disorders-5) was 14% (95% CI: 7 to 22, prediction interval [PI]%: 0 to 43, k = 10, n = 8534), and bulimia nervosa 1% (95% CI: 0 to 1, PI%: 0 to 2, k = 9, n = 9448, τ² = 0). When assessed using the Binge Eating Scale, the prevalence of self-reported moderate severity binge eating was 26% (95% CI: 23 to 28, PI%: 18 to 33, k = 12, n = 8113, τ² = 0.001) and severe binge eating was 12% (95% CI: 8 to 16, PI%: 0 to 31, k = 18, n = 12,136, τ² = 0.01).</p><p><strong>Discussion: </strong>Obesity and eating disorders or disordered eating do co-occur. There was variability between studies and between the prevalence of eating disorders and disordered eating in adults presenting for obesity treatment. It is critical that clinicians are well resourced to effectively identify individuals with eating disorders and disordered eating and provide appropriate treatment pathways.</p>","PeriodicalId":51067,"journal":{"name":"International Journal of Eating Disorders","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomized Controlled Trial of Weight Management Versus Weight Management With Concurrent Cognitive-Behavioral Therapy for Binge-Eating Disorder in US Veterans With High Weight.","authors":"Robin M Masheb, Eugenia Buta, Jennifer L Snow, Lindsay F Munro, Mark Lawless, Erica A Abel, Nicole E McWain, Alison Marsh, Amanda Cary, Carlos M Grilo, Susan D Raffa, Christopher B Ruser","doi":"10.1002/eat.24476","DOIUrl":"https://doi.org/10.1002/eat.24476","url":null,"abstract":"<p><strong>Objective: </strong>To determine the effectiveness of adding a brief psychological eating-disorder treatment (CBT) to weight management for addressing DSM-5 binge-eating disorder (BED) in US military Veterans with high weight.</p><p><strong>Method: </strong>One hundred and nine Veterans, with DSM-5 BED, seeking weight management services were randomly assigned to VA's Weight Management Program (MOVE!), or MOVE! plus a brief, clinician-led cognitive-behavioral therapy (MOVE! + CBT). Primary (eating disorder psychopathology and binge eating), secondary (mental health, quality of life, and eating- and appearance-related), and exploratory (weight) outcomes were analyzed with mixed-effects models for four timepoints (baseline, 3-month [post-treatment], and 9- and 15-month follow-ups).</p><p><strong>Results: </strong>MOVE! + CBT reported significantly less overall eating disorder psychopathology compared to MOVE! at all post-randomization timepoints: difference at 3 months -0.18 (-0.3, -0.06, p = 0.003), 9 months -0.15 (-0.3, 0, p = 0.05), and 15 months -0.27 (-0.42, -0.12, p < 0.001). There were no differences between groups in binge-eating frequency. MOVE! + CBT remission rates were 28% at 3 months, 42% at 9 months, and 27% at 15 months. MOVE! remission rates were 22% at 3 months, 26% at 9 months, and 20% at 15 months. MOVE! + CBT was superior at post-treatment through 15 months on eating-, weight-, and shape-related (p's < 0.05), but few other, secondary outcomes. A 5% weight loss ranged from 26% to 38% for MOVE! + CBT, and 17% to 33% for MOVE!.</p><p><strong>Discussion: </strong>Weight management alone and with concurrent CBT resulted in significant improvements in BED. The addition of CBT enhanced some specific outcomes but not weight loss. Findings provide evidence-based clinical guidance and population-level impact for addressing BED in the context of high weight, especially among Veteran populations.</p><p><strong>Trial registration: </strong>Clinical Trial Registry Number: NCT03234881(Weight Loss Treatment for Veterans with Binge Eating).</p>","PeriodicalId":51067,"journal":{"name":"International Journal of Eating Disorders","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence of Altered Biobehavioral Threat Processes in Adolescents With Eating Disorders: A Scoping Review.","authors":"Sasha Gorrell, Sapna Ramappa, Brianne Richson, Elizabeth Dougherty, Simar Singh, Kate Lindstrom, Maya Day, Emma Rasmussen, Lisa M Anderson","doi":"10.1002/eat.24485","DOIUrl":"https://doi.org/10.1002/eat.24485","url":null,"abstract":"<p><strong>Objective: </strong>Etiological models of eating disorders (EDs) suggest there is considerable overlap between anxiety and EDs. In particular, shared clinical features across these psychiatric diagnoses suggest that common threat processes (i.e., changes in affect, cognition, and physiology, or behavior in response to a feared stimulus) underlie their maintenance. Compared to anxiety disorders, however, less is known about the neurobiological bases of threat that may give rise to and maintain ED symptoms, particularly among adolescents. Addressing this knowledge gap will aid in informing future research and interventional efforts.</p><p><strong>Methods: </strong>We searched four online databases to review studies published through March 2025 comprising all potential types of assessment of biobehavioral activity associated with threat (e.g., neuroimaging, skin conductance) in clinical samples of adolescents with EDs.</p><p><strong>Results: </strong>From 2546 articles identified, N = 19 studies met inclusion criteria. A majority of investigations employed functional neuroimaging to study adolescent girls with anorexia nervosa, compared with age-matched controls. We classified and synthesized evidence within categories of non-ED-specific threat (harm avoidance) or ED-specific threat (bodily- or food-related threat, or their combination). Most studies demonstrated altered ED-specific threat processing in adolescent girls with anorexia nervosa compared to controls, as well as associations between neural threat response and ED symptomology. The study focused on non-ED-specific threat found no noted differences in threat response in cases versus controls.</p><p><strong>Discussion: </strong>Given the apparent relevance of threat processing in EDs, future inquiry is needed to resolve remaining questions and yield new insights with clinical relevance across transdiagnostic adolescent ED presentations.</p>","PeriodicalId":51067,"journal":{"name":"International Journal of Eating Disorders","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}