European Journal of Oncology Nursing最新文献

{"title":"Impact of sarcopenia and obesity on overall survival in patients with head and neck cancer receiving radiotherapy: A longitudinal study","authors":"","doi":"10.1016/j.ejon.2024.102679","DOIUrl":"10.1016/j.ejon.2024.102679","url":null,"abstract":"<div><h3>Purpose</h3><p>To analyze the impact of sarcopenia and obesity on overall survival (OS) in patients with head and neck cancer (HNC) receiving radiotherapy (RT).</p></div><div><h3>Methods</h3><p>This prospective longitudinal study recruited 494 patients using convenient sampling. Weight and body composition were assessed before RT (T₁), and at the end of RT (T₂) using bioelectrical impedance analysis (BIA). The appendicular skeletal mass index was used to define sarcopenia, while the body mass index and fat mass index were used to define obesity. Patient OS was followed and described using Kplan-Meier analysis. Cox proportional hazard regression was used to analyze influencing factors of OS.</p></div><div><h3>Results</h3><p>The median follow-up time was 26.2 months (<em>IQR</em>: 18.4–34.4 months). Multivariable models indicated that sarcopenia/obesity type assessed at T₁ was not significantly associated with OS. Multivariable models involving body composition at T₂ showed that age (<em>P</em> &lt; 0.001), tumor site (<em>P</em> = 0.003), tumor stage (<em>P</em> = 0.024), and sarcopenia/obesity type (<em>P</em> = 0.040) were significantly associated with OS, while sarcopenic patients without obesity at T₂ had worse OS.</p></div><div><h3>Conclusions</h3><p>Patients with sarcopenia and no obesity at the end of RT might have worse OS. Healthcare professionals should enhance HNC patients’ management during RT, helping them maintain a certain amount of muscle mass and fat mass to improve their survival.</p></div>","PeriodicalId":51048,"journal":{"name":"European Journal of Oncology Nursing","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142040548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary consumption patterns in breast cancer survivors: Pilot evaluation of diet, supplements and clinical factors","authors":"","doi":"10.1016/j.ejon.2024.102678","DOIUrl":"10.1016/j.ejon.2024.102678","url":null,"abstract":"<div><h3>Purpose</h3><p>Adherence to dietary intake guidelines is recommended for optimal nutrition and outcomes in breast cancer survivors. The purpose of this study was to examine dietary quality in a cohort of breast cancer survivors related to current guidelines, guiding further education-based research.</p></div><div><h3>Methods</h3><p>This exploratory evaluation examined compliance with current dietary guidelines. Data collected included demographics, medical histories and repeated, three-day 24-h dietary recalls. Women with early-stage breast cancer (n = 97) who completed breast cancer treatment between 6 and 24 months were recruited. Descriptive statistics and frequencies were calculated for demographic and lifestyle characteristics, reported fish consumption, body mass index categories, supplement consumption, and adequacy of macronutrient and micronutrient consumption (classified as below, meeting, or exceeding needs).</p></div><div><h3>Results</h3><p>In this cohort, 28.9% were classified as overweight and 35% were obese. The mean dietary macronutrient consumption was 44.3% (±8.9%) carbohydrates, 36.6% (±7.3%) fat, and 17.3% (±4.7%) protein. Additionally, 32.3% participants consumed &gt;45 g sugar/d. The mean n-6 to n-3 ratio was 8.0 (±3.3):1. Further, 38% of survivors reported consuming less than 1 serving of fish per week. Participants consumed between 0 and 1.03 servings of fish per day, with an average consumption of 0.16 (±0.26) servings per day and 61.5% (n = 59) consuming 0 servings per day. The mean daily combined dietary and supplement consumption of multiple micronutrients was below the Recommended Daily Allowance for Vitamin D (30%), Calcium (52.6%), Magnesium (42.1%), and Vitamin E (80%).</p></div><div><h3>Conclusion</h3><p>Breast cancer survivors 0.5–2 years post-treatment are not meeting recommended nutrition consumption guidelines for a number of nutrients. Findings suggested that nutrition therapy targeting weight loss through reduced sugar, total and saturated fat, while increasing foods rich in omega-3, and ensuring adequate micronutrient consumption would promote better nutritional consumption patterns and improve overall health during survivorship.</p></div>","PeriodicalId":51048,"journal":{"name":"European Journal of Oncology Nursing","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141780925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the impact of educational eHealth and mHealth interventions on health outcomes in continuity of care for enterostomy patients: A meta-analysis","authors":"","doi":"10.1016/j.ejon.2024.102676","DOIUrl":"10.1016/j.ejon.2024.102676","url":null,"abstract":"<div><h3>Purpose</h3><p>To evaluate the effectiveness of educational eHealth and mHealth interventions on self-care ability, quality of life (QoL), ostomy complications and other health outcomes in enterostomy patients.</p></div><div><h3>Methods</h3><p>A comprehensive database search yielded 7385 records, which were narrowed down to 13 RCTs through stringent PRISMA-guided selection. These studies, conducted globally from 2015 to 2023, involved a total of 1530 participants and employed various eHealth and mHealth platforms, from mobile apps to telehealth systems. Primary outcomes assessed were self-care ability, QoL, and ostomy complications, mostly analyzed using a random-effects model due to inherent study heterogeneity.</p></div><div><h3>Results</h3><p>The meta-analysis showed significant improvements in self-care ability (SMD = 0.85, CI = [0.23, 1.47], P = 0.007) and QoL (SMD = 0.64, CI = [0.50, 0.79], P &lt; 0.001) among participants receiving eHealth and mHealth interventions compared to those receiving standard care. eHealth and mHealth interventions also led to a reduction in ostomy complications (SMD = 0.18, CI = [0.12, 0.27], P &lt; 0.001). Secondary outcomes revealed significant improvements in stoma adjustment (SMD = 1.13, CI = [0.70, 1.56], P &lt; 0.001) and self-efficacy (SMD = 0.51, CI = [0.38, 0.64], P &lt; 0.001). The effects on psychological well-being were mixed, with some studies showing benefits in reducing depression and anxiety symptoms, albeit with high heterogeneity.</p></div><div><h3>Conclusions</h3><p>eHealth and mHealth interventions appear effective in improving essential health outcomes for enterostomy patients, though the heterogeneity among studies suggests that results should be interpreted with caution. The effectiveness of these interventions underscores the need for their integration into routine care, tailored to individual patient needs and local healthcare settings. Further research is required to determine the most effective eHealth and mHealth modalities and to explore their long-term benefits and scalability.</p></div>","PeriodicalId":51048,"journal":{"name":"European Journal of Oncology Nursing","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1462388924001741/pdfft?md5=e40b3eff44044f3daf6d255e6cd418ed&pid=1-s2.0-S1462388924001741-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141841436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationships among self-disclosure, social support and psychological distress in caregivers of patients with advanced lung cancer: A mediating model","authors":"","doi":"10.1016/j.ejon.2024.102677","DOIUrl":"10.1016/j.ejon.2024.102677","url":null,"abstract":"<div><h3>Objectives</h3><p>To examine the relationship between self-disclosure, social support, and psychological distress among caregivers of patients with advanced lung cancer, the study also examined the factors that impact psychological distress and the effect of social support on the relationship between self-disclosure and psychological distress.</p></div><div><h3>Methods</h3><p>A total of 288 caregivers of patients with advanced lung cancer were selected using a convenience sampling method from December 2022 to July 2023 at a tertiary hospital in China. Participants' self-disclosure, perceived social support, and psychological distress were assessed by corresponding questionnaires, respectively. Mediating effects were detected using Amos 26.0 software.</p></div><div><h3>Results</h3><p>The total scores for psychological distress, perceived social support, and self-disclosure of caregivers were 28.62 ± 6.45, 55.22 ± 7.81, and 38.39 ± 5.64, respectively. Correlation analysis suggested that psychological distress in caregivers was negatively correlated with both perceived social support and self-disclosure. Multiple linear regression analyses revealed that self-disclosure and perceived social support were influential factors of caregivers' psychological distress. Moreover, perceived social support partially mediated the relationship between self-disclosure and psychological distress, accounting for 54.37% of the total effect.</p></div><div><h3>Conclusion</h3><p>Caregivers of patients with advanced lung cancer experience significant psychological distress. Self-disclosure can affect caregivers' psychological distress directly and indirectly through perceived social support. Healthcare professionals should be attentive to caregivers' psychological distress and carry out relevant nursing measures to improve caregivers' self-disclosure and social support to promote their physical and mental health.</p></div>","PeriodicalId":51048,"journal":{"name":"European Journal of Oncology Nursing","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141732287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meals are more than nutrition for children with a malignant or non-malignant disorder with a gastrostomy tube: A qualitative study","authors":"","doi":"10.1016/j.ejon.2024.102663","DOIUrl":"10.1016/j.ejon.2024.102663","url":null,"abstract":"<div><h3>Purpose</h3><p>To elucidate mealtime experiences of children hospitalized with a malignant or severe non-malignant disorder —and their parents—after a gastrostomy tube insertion.</p></div><div><h3>Methods</h3><p>A qualitative design involving a child-centred care approach was used. Parents of children aged 1–18 years old who had received a gastrostomy tube during treatment for a malignant or non-malignant disorder were included, as were the children themselves when aged 5–18 years old. Semi-structured interviews with 21 families were carried out and a thematic analysis performed.</p></div><div><h3>Results</h3><p>The findings were presented in four themes: changed meal conditions, a troublesome sensory dimension, aggravating obstacles and solving the unmanageable. Hospitalization involves challenges regarding environmental aspects, hospital food and side effects, contributing to impaired nutritional intake and aggravated mealtime situations.</p></div><div><h3>Conclusions</h3><p>Hospital environment and hospital food have a profound impact on children's nutritional intake and mealtime situations. In addition, sensory aspects and side effects aggravate the child's motivation to eat, resulting in demanding meals. The families described a gastrostomy tube as a valuable strategy for improving mealtime situations.</p></div>","PeriodicalId":51048,"journal":{"name":"European Journal of Oncology Nursing","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1462388924001613/pdfft?md5=de9c54dc311f3068d0c8a4287c878ecf&pid=1-s2.0-S1462388924001613-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141700588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Care for sexual health in oncology survey: Discussions about sexual health with people with cancer in the context of the obligation to provide informed consent","authors":"","doi":"10.1016/j.ejon.2024.102669","DOIUrl":"10.1016/j.ejon.2024.102669","url":null,"abstract":"<div><h3>Purpose</h3><p>The purpose of this paper is to describe the impacts of cancer treatment on sexual health in a sample of people who had been treated for mixed types of cancer; to describe discussions they had with professionals about sexual health that occurred during cancer care; and to consider the extent to which these discussions were sufficient to enable participants to give informed consent for the sexual side effect of cancer treatment.</p></div><div><h3>Method</h3><p>A cross-sectional, online survey using a convenience sample of people with cancer was recruited via UK cancer charities. Eligibility criteria included having received treatment and follow-up care for any type of cancer in the UK during the previous 10 years. Univariate analysis was conducted using SPSS.</p></div><div><h3>Results</h3><p>136 people with cancer participated in this survey. The majority of participants reported having experienced a worsening of their sexual lives, which bothered them. Whilst 33.6% of the sample (n = 125) reported having discussed sexual health during their cancer care, only 5.4% reported that a healthcare professional initiated a pre-treatment discussion about the sexual side effects of cancer treatment.</p></div><div><h3>Conclusions</h3><p>These results suggest that the proportion of participants who were provided with sufficient information to give informed consent for the sexual side effects of cancer treatment was very low. This indicates that healthcare professionals may require specific advice on how to include this topic during the informed consent process.</p></div>","PeriodicalId":51048,"journal":{"name":"European Journal of Oncology Nursing","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1462388924001674/pdfft?md5=9020a4e74c6b5dc78ddd50a26a15ba38&pid=1-s2.0-S1462388924001674-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141706139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exergame-based rehabilitation for cancer patients undergoing abdominal surgery: Effects on pain, anxiety, depression, and fatigue - A pilot study","authors":"","doi":"10.1016/j.ejon.2024.102665","DOIUrl":"10.1016/j.ejon.2024.102665","url":null,"abstract":"<div><h3>Purpose</h3><p>This study aimed to determine the efficacy of an exergame rehabilitation program on pain, anxiety or depression, and fatigue in oncology patients undergoing abdominal surgery.</p></div><div><h3>Methods</h3><p>The randomized controlled trial evaluated the efficacy of exergame rehabilitation on Pain, Anxiety, Depression, and Fatigue in oncology patients undergoing abdominal surgery. Patients were recruited from October 2022–March 2023 and were randomly assigned to the intervention group (postoperative traditional rehabilitation plus an exergame rehabilitation program) or control group (postoperative traditional rehabilitation). Data were collected at three different times: on admission, in the first 48 h, and on the 7th day after surgery.</p><p>Primary outcomes were evaluated and monitored with different validated instruments: numeric rating scale (NRS) for pain, Hospital Anxiety and Depression Scale (HADS) to assess the level of anxiety and depression, and the Fatigue Assessment Scale (FAS) to assess physical and psychological fatigue. The length of stay and program completion were secondary outcomes.</p></div><div><h3>Results</h3><p>A total of 128 postoperative patients were recruited. Of these, 58 patients were excluded from the study due to clinical complications related to the surgical procedure (n = 53) or healthcare staff-related reasons (n = 5). Both the control and intervention groups were the same size (n = 35). Lower pain scores were observed on the 7th postoperative day in the group subject to the “exergame rehabilitation program” (<em>p</em> = 0.006). No statistically significant differences were observed for anxiety and depression between the 2 groups. Regarding fatigue, statistically significant differences were observed on admission (<em>p</em> = 0.03), which disappeared 48 h after surgery (<em>p</em> = 0.143). Differences between the groups were observed again on the 7th day after surgery (<em>p</em> = 0.005).</p></div><div><h3>Conclusions</h3><p>The intervention using exergames was effective in reducing the postoperative pain of the patient undergoing major abdominal surgery and in restoring the levels of fatigue before surgical intervention. However, no differences were observed for anxiety or depression. Future studies with larger samples should be carried out.</p></div>","PeriodicalId":51048,"journal":{"name":"European Journal of Oncology Nursing","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1462388924001637/pdfft?md5=7e4e63c358a83c701a45a47cbd1175b5&pid=1-s2.0-S1462388924001637-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141622609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevention of weight loss in patients with head and neck cancer in ongoing radiation or chemoradiation therapy—A systematic review and meta-analysis","authors":"","doi":"10.1016/j.ejon.2024.102668","DOIUrl":"10.1016/j.ejon.2024.102668","url":null,"abstract":"<div><h3>Purpose</h3><p>This systematic review (PROSPERO: CRD4202345740) identified and synthesised existing evidence on nutrition interventions performed by healthcare professionals, and the contents of the interventions that prevented weight loss in patients with HNC undergoing RT/CRT.</p></div><div><h3>Methods</h3><p>We included quantitative studies. PubMed, CINAHL, Cochrane Library, and Scopus were searched, and the outcomes of interest were weight change and nutritional status. A narrative synthesis was undertaken to elaborate on the findings across the included studies. Furthermore, a meta-analysis was conducted.</p></div><div><h3>Results</h3><p>A total of 27 studies were identified. Most focused on the effect of oral nutritional supplements (ONS) and individualised nutrition counselling (INC). A beneficial effect of <span>ONS</span> combined with weekly <span>INC</span> were identified, and compliance, management of adverse effects, involvement of family as well as the knowledge and approach of the healthcare professionals were identified as key elements when supporting the management of nutrition intake in <span>HNC</span> patients during RT/CRT. The meta-analysis showed a non-significant effect of ONS, yet significant when combined with INC, and no overall effect of INC, but significant effect in the RCTs.</p></div><div><h3>Conclusion</h3><p>Our results suggest an optimal effect of <span>ONS</span> combined with weekly <span>INC</span>, requiring a focus on enhancing compliance as well as support from a multidisciplinary team to manage adverse treatment effects. Compliance must be emphasised to provide maximum support to the patient, as well as focus on the knowledge of the health care professionals performing the intervention. Further research on strategies to enhance patient compliance and involvement is needed.</p></div>","PeriodicalId":51048,"journal":{"name":"European Journal of Oncology Nursing","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141629963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body image, illness uncertainty and symptom clusters in surgically treated breast cancer survivors: An exploratory factor analysis and correlational study","authors":"","doi":"10.1016/j.ejon.2024.102662","DOIUrl":"10.1016/j.ejon.2024.102662","url":null,"abstract":"<div><h3>Purpose</h3><p>To determine the relationship among body image, illness uncertainty, and symptom clusters in surgically treated breast cancer survivors.</p></div><div><h3>Methods</h3><p>A correlational, descriptive study was conducted in a convenience sample of 60 women surgically treated breast cancer survivors recruited in a private hospital and a survivor center. A questionnaire of sociodemographic characteristics, MUIS-C Scale, and QLQ-C30 and Module BR-23 were used. Variable characteristics and associations were analyzed with descriptive statistics and Pearson correlation coefficient, and exploratory factor analysis using unweighted least squares and Promax rotation was used for symptom clustering.</p></div><div><h3>Results</h3><p>A three-factor structure was found: an anxiety symptom cluster, a breast symptom cluster, and an arm symptoms, depression, and fatigue symptom cluster, explaining 46,47% of the variance. Significant correlations were found among body image and illness uncertainty (<em>r</em> = −0,390, <em>p</em> &lt; 0,01), body image and the anxiety symptom cluster (<em>r</em> = 0,613, <em>p</em> &lt; 0,01), illness uncertainty and the anxiety symptom cluster (<em>r</em> = −0,421, <em>p</em> &lt; 0,01), the breast symptom cluster (<em>r</em> = −0,425, <em>p</em> &lt; 0,01), and the arm symptoms – depression – fatigue symptom cluster (r = −0,443, <em>p</em> &lt; 0,01).</p></div><div><h3>Conclusion</h3><p>The relationships among all variables were statistically significant. Nurses providing care to BC survivors need to address the multidimensionality of the symptom experience and its correlates to better assist their patients. Further research is needed to elucidate the biopsychosocial underpinnings of those relationships.</p></div>","PeriodicalId":51048,"journal":{"name":"European Journal of Oncology Nursing","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141689560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty and all-cause and cancer-related mortality in cancer patients: A prospective cohort study","authors":"Fei-Hong Hu ,&nbsp;Li-Ping Feng ,&nbsp;Yi-Jie Jia ,&nbsp;Meng-Wei Ge ,&nbsp;Lu-Ting Shen ,&nbsp;Peng Liu ,&nbsp;Hong-Lin Chen","doi":"10.1016/j.ejon.2024.102667","DOIUrl":"https://doi.org/10.1016/j.ejon.2024.102667","url":null,"abstract":"<div><h3>Purpose</h3><p>To evaluate the associations between frailty and all-cause and cancer-related mortality. Additionally, the objective is to compare the magnitude of these associations between older adults and younger adults.</p></div><div><h3>Methods</h3><p>We gathered baseline data from NHANES (1999–2018) and developed a cumulative index consisting of 39 items to evaluate frailty. The National Death Index database was utilized to track the survival status of individuals. The Cox regression model was employed to estimate the associations between frailty status and all-cause and cancer-related mortality.</p></div><div><h3>Results</h3><p>Ultimately<strong>,</strong> 3398 cancer patients were included in the analysis, comprising 910 younger adults and 2488 older adults. Compared to non-frail patients, the elevated all-cause and cancer-related mortality among pre-frail patients was not statistically significant (HRs = 1.312, 95%CI: 0.956–1.800, P = 0.092; HRs = 1.462, 0.811–2.635, P = 0.207). However, a significant elevation of both all-cause and cancer-related mortality risk was observed among frail patients (HRs = 2.213, 1.617–3.030, P &lt; 0.001; HRs = 2.463, 95%CI = 1.370–4.429, P = 0.003). Frailty individuals demonstrated a more pronounced association with the prediction of all-cause mortality in younger (HRs = 2.230, 1.073–4.634, P = 0.032) than in older adults (HRs = 2.090, 1.475–2.960, P &lt; 0.001). Sensitivity analysis consistently revealed robust results. RCS plots suggested a progressively escalating dose-response correlation between frailty and both all-cause and cancer-related mortality risk.</p></div><div><h3>Conclusions</h3><p>Pre-frailty did not result in an increase in mortality risks compared to non-frailty. However, frailty caused a higher all-cause and cancer-related mortality risk than non-frailty. Identifying those at risk and implementing targeted interventions may contribute to extending healthy life expectancy, regardless of age.</p></div>","PeriodicalId":51048,"journal":{"name":"European Journal of Oncology Nursing","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141605798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}